期刊
MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE
卷 1201, 期 -, 页码 8-12出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05628.x
关键词
Akt; cGMP; ERK1/2; mitochondria; nitric oxide; sonic hedgehog
资金
- National Science Council in Taiwan [NSC95-2314-B-010-093MY3, NSC97-2314-B-010-008MY3]
- Ministry of Education [95A-C-P30]
- Department of Health, Taipei City Government [97002-62-040]
- Cheng Hsin General Hospital [98F117CY20]
3-Nitropropionic acid (3-NP) is an irreversible inhibitor of mitochondrial succinate dehydrogenase that has been used to explore the molecular mechanisms of cell death associated with mitochondrial dysfunction and neurodegeneration for Huntington's disease (HD). Brain-derived neurotrophic factor (BDNF) is a neurotrophin that may regulate neuronal survival and differentiation. Experimental evidence derived from both clinical as well as basic research suggests a close association between BDNF deficiency and HD pathogenesis. In this review, we focus on recent progress in the molecular mechanisms responsible for the BDNF-mediated neuroprotective effects against mitochondrial dysfunction induced by 3-NP. Delineation of BDNF-mediated neuroprotective actions against 3-NP toxicity may add in the development of therapeutic intervention for HD where mitochondrial dysfunction is known to play a crucial role in pathogenesis of this devastating disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据