Article
Microbiology
Wei Wang, Xin Chen, Jie Pan, Xianhui Zhang, Liyun Zhang
Summary: This study found a high prevalence of EBV and CMV in Chinese IBD patients, and their prevalence is associated with clinical disease activities. Additionally, viral load in the intestinal mucosa is correlated with mucosal status. Quantitative real-time PCR is an effective method for monitoring EBV and CMV infection in IBD patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Jennifer A. Slyker, Brandon Guthrie, Mark Pankau, Kenneth Tapia, Dalton Wamalwa, Sarah Benki-Nugent, Evelyn Ngugi, Meei-Li Huang, Irene Njuguna, Agnes Langat, Grace John-Stewart, Dara Lehman
Summary: The study found that co-infections of CMV and EBV were associated with higher HIV reservoir levels in Kenyan children with suppressed HIV RNA, suggesting that delaying or controlling CMV and EBV infections may be novel strategies to limit HIV reservoir formation.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Agnieszka Jablonska, Branislav Zagrapan, Edyta Paradowska, Christoph Neumayer, Wolf Eilenberg, Christine Brostjan, Markus Klinger, Josif Nanobachvili, Ihor Huk
Summary: The study found that CMV infection may stimulate local inflammation in the aorta but is not a direct cause of most abdominal aortic aneurysms.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Clinical Neurology
Marianna Vitkova, Ibrahima Diouf, Charles Malpas, Dana Horakova, Eva Kubala Havrdova, Francesco Patti, Serkan Ozakbas, Guillermo Izquierdo, Sara Eichau, Vahid Shaygannejad, Marco Onofrj, Alessandra Lugaresi, Raed Alroughani, Alexandre Prat, Catherine Larochelle, Marc Girard, Pierre Duquette, Murat Terzi, Cavit Boz, Francois Grand'Maison, Patrizia Sola, Diana Ferraro, Pierre Grammond, Helmut Butzkueven, Katherine Buzzard, Olga Skibina, Bassem Yamout, Rana Karabudak, Oliver Gerlach, Jeannette Lechner-Scott, Davide Maimone, Roberto Bergamaschi, Vincent Van Pesch, Gerardo Iuliano, Elisabetta Cartechini, Maria Jose Sa, Radek Ampapa, Michael Barnett, Stella E. Hughes, Cristina M. Ramo-Tello, Suzanne Hodgkinson, Daniele L. A. Spitaleri, Thor Petersen, Ernest Gerard Butler, Mark Slee, Chris McGuigan, Pamela Ann McCombe, Franco Granella, Edgardo Cristiano, Julie Prevost, Bruce Taylor, Josaa Luis Sanchez-Menoyo, Guy Laureys, Liesbeth Van Hijfte, Steve Vucic, Richard A. Macdonell, Orla Gray, Javier Olascoaga, Norma Deri, Yara Dadalti Fragoso, Cameron Shaw, Tomas Kalincik
Summary: This study investigated the association between latitude of residence, UVB exposure, and the severity of multiple sclerosis (MS). The findings revealed that in temperate zones, latitude is associated with the severity of MS, and this association is mainly driven by UVB exposure.
Article
Dentistry, Oral Surgery & Medicine
Jaideep Mahendra, Little Mahendra, Dhana Divya, Paavai Ilango, Nalini Devarajan, Abirami Thanigaimalai
Summary: This study evaluates and compares the levels of lipocalin, adiponectin, and periodontal viruses in generalized periodontitis patients with and without diabetes mellitus. The results show that patients with diabetes and periodontitis have higher prevalence of EBV and CMV, as well as decreased levels of adiponectin, indicating an aggravation of the diabetic status among periodontitis patients and reinforcing the Periodontitis-DM continuum.
Article
Immunology
Jing-Rui Zhou, Da-Yu Shi, Rong Wei, Yu Wang, Chen-Hua Yan, Xiao-Hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, Yu-Qian Sun
Summary: Reactivation of both cytomegalovirus and Epstein-Barr virus is common after hematopoietic stem cell transplantation and is associated with poor outcomes, including lower overall survival and leukemia-free survival rates. Co-reactivation of these viruses is also linked to prolonged viral duration and poor CD4+CD25+ T cell reconstitution post-transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yoshimi Enose-Akahata, Limin Wang, Fahad Almsned, Kory R. Johnson, Yair Mina, Joan Ohayon, Xin Wei Wang, Steven Jacobson
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), and the cause of MS remains unknown. This study investigated the antibody responses against various viruses in the cerebrospinal fluid (CSF) and serum of MS patients, and found significant differences compared to healthy volunteers, as well as a pattern of antibody responses against multiple viruses, including Epstein-Barr virus. These findings indicate that virus-specific antibody signatures might reflect the disease-associated inflammatory milieu in the CSF of patients with neuroinflammatory diseases.
Article
Microbiology
Archana Panikkar, Katie E. Lineburg, Jyothy Raju, Keng Yih Chew, George R. Ambalathingal, Sweera Rehan, Srividhya Swaminathan, Pauline Crooks, Laetitia Le Texier, Leone Beagley, Shannon Best, Matthew Solomon, Katherine K. Matthews, Sriganesh Srihari, Michelle A. Neller, Kirsty R. Short, Rajiv Khanna, Corey Smith
Summary: Adoptive T-cell immunotherapy has shown promising results in treating viral complications, especially in immunocompromised patients. Expanding T cells from healthy individuals provides a new approach to antiviral immunotherapy with rapid and customized treatment options. Recent research indicates that SARS-CoV-2-specific T cells play a crucial role in protecting against COVID-19, suggesting the potential of using HLA-matched virus-specific T cells for treating active COVID-19 or at-risk patients.
Article
Oncology
Luigi Marongiu, Sascha Venturelli, Heike Allgayer
Summary: This study analyzed the relationship between viral infections and colorectal cancer and inflammatory bowel disease. Epstein-Barr virus was strongly associated with inflammatory bowel disease, and cytomegalovirus with both colorectal cancer and inflammatory bowel disease. Other viruses such as polyomaviruses and Hepatitis B virus were also involved to a lesser extent in the risk of colorectal cancer and inflammatory bowel disease. The study highlights the importance of considering viral infections in the etiology of these diseases.
Article
Gastroenterology & Hepatology
Miki Miura, Hirotaka Shimizu, Daisuke Saito, Jun Miyoshi, Minoru Matsuura, Takahiro Kudo, Daisuke Hirayama, Masashi Yoshida, Katsuhiro Arai, Itaru Iwama, Hiroshi Nakase, Toshiaki Shimizu, Tadakazu Hisamatsu
Summary: This study was the first multicenter survey of EBV infection in Japanese patients with IBD, revealing that approximately 30% of the patients were EBV-uninfected. Age was found to be a significant factor for anti-VCA IgG seropositivity.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Medicine, Research & Experimental
Rachele Ciccocioppo, Caterina Mengoli, Elena Betti, Giuditta Comolli, Irene Cassaniti, Antonio Piralla, Peter Kruzliak, Martin Caprnda, Lodovica Pozzi, Gino Roberto Corazza, Antonio Di Sabatino, Fausto Baldanti
Summary: The study revealed that impaired EBV-specific immunity is evident in patients with ulcerative colitis (UC), especially in those who are refractory to therapy. Mucosal loads of EBV and HCMV were significantly higher in refractory UC patients and correlated with disease activity indexes.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Immunology
Yuhua Ru, Jinjin Zhu, Tiemei Song, Yiyang Ding, Ziling Zhu, Yi Fan, Yang Xu, Aining Sun, Huiying Qiu, Zhengming Jin, Xiaowen Tang, Yue Han, Chengcheng Fu, Suning Chen, Xiao Ma, Feng Chen, Jia Chen, Depei Wu
Summary: After haploindentical donor hematopoietic cell transplantation, the reactivation rates of EBV and CMV are higher and may have distinctive risk factors compared to HLA-matched HCT. Male recipients and acute graft-versus-host disease are independent risk factors for EBV and CMV reactivation. CMV reactivation is associated with worsened treatment-related mortality and progression-free survival, significantly impacting the survival of ALL patients. In the EBV+/CMV- subgroup, ALL patients have a lower relapse rate and better overall survival and progression-free survival compared to AML patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Alda Saldan, Carlo Mengoli, Dino Sgarabotto, Marny Fedrigo, Annalisa Angelini, Giuseppe Feltrin, Antonio Gambino, Gino Gerosa, Luisa Barzon, Davide Abate
Summary: This study found an association between CMV and EBV infections and early-onset AMR, suggesting these viral infections as relevant risk factors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Ori Barzilai, Natalie DiStefano, Eric Lis, Yoshiya Yamada, D. Michael Lovelock, Andrew N. Fontanella, Mark H. Bilsky, Ilya Laufer
JOURNAL OF NEUROSURGERY-SPINE
(2018)
Article
Clinical Neurology
Ibrahim Hussain, Ori Barzilai, Anne S. Reiner, Natalie DiStefano, Lily McLaughlin, Shahiba Ogilvie, Mark Bilsky, Ilya Laufer
Article
Clinical Neurology
Ori Barzilai, Lily McLaughlin, Mary-Kate Amato, Anne S. Reiner, Shahiba Q. Ogilvie, Eric Lis, Yoshiya Yamada, Mark H. Bilsky, Ilya Laufer
Editorial Material
Clinical Neurology
Ori Barzilai
WORLD NEUROSURGERY
(2018)
Article
Oncology
Ori Barzilai, Anne L. Versteeg, Arjun Sahgal, Laurence D. Rhines, Mark H. Bilsky, Daniel M. Sciubba, James M. Schuster, Michael H. Weber, Peter Pal Varga, Stefano Boriani, Chetan Bettegowda, Michael G. Fehlings, Yoshiya Yamada, Michelle J. Clarke, Paul M. Arnold, Ziya L. Gokaslan, Charles G. Fisher, Ilya Laufer
Review
Clinical Neurology
Patrick D. Kelly, Scott L. Zuckerman, Yoshiya Yamada, Eric Lis, Mark H. Bilsky, Ilya Laufer, Ori Barzilai
NEUROSURGICAL REVIEW
(2020)
Article
Oncology
Ori Barzilai, Anne L. Versteeg, C. Rory Goodwin, Arjun Sahgal, Laurence D. Rhines, Daniel M. Sciubba, James M. Schuster, Michael H. Weber, Aron Lazary, Michael G. Fehlings, Michelle J. Clarke, Paul M. Arnold, Stefano Boriani, Chetan Bettegowda, Ziya L. Gokaslan, Charles G. Fisher, Ilya Laufer
Article
Clinical Neurology
Robert J. Rothrock, Ori Barzilai, Anne S. Reiner, Eric Lis, Adam M. Schmitt, Daniel S. Higginson, Yoshiya Yamada, Mark H. Bilsky, Ilya Laufer
Summary: The study found that postoperative survival among patients with spinal metastases has improved over the past 20 years, particularly in patients with kidney, breast, lung, and colon tumors metastatic to the spine. Patients with synchronous metastatic disease had better survival compared to those with metachronous disease. These results emphasize the need for long-term outcome consideration in treatment decisions for patients undergoing surgery for spinal metastatic tumors.
Article
Clinical Neurology
William C. Newman, John Berry-Candelario, Jemma Villavieja, Anne S. Reiner, Mark H. Bilsky, Ilya Laufer, Ori Barzilai
Summary: Surgical resection of benign intradural extramedullary spine tumors results in significant improvement in symptom control, including pain severity, pain interference, and overall pain experience. The study found rapid and durable improvements in patient-reported outcomes following surgery.
Article
Clinical Neurology
Benjamin Rapoport, Christina Sze, Xi Chen, Ibrahim Hussain, Mark H. Bilsky, Ilya Laufer, Alvin C. Goh, Ori Barzilai
Summary: The study described a robot-assisted retroperitoneal approach for lumbar nerve sheath tumor resection, achieving complete en bloc tumor removal without bone removal or spinal fusion. This minimally invasive alternative involved interdisciplinary collaboration and adjunctive technologies such as intraoperative ultrasound and neurophysiologic monitoring.
OPERATIVE NEUROSURGERY
(2021)
Article
Oncology
Ori Barzilai, Axel Martin, Anne S. Reiner, Ilya Laufer, Adam Schmitt, Mark H. Bilsky
Summary: This study compares the genomic tumor landscape between spinal metastases and the corresponding primary tumors as well as between spinal metastases and visceral metastases. The results show a high concordance rate for genetic alterations between spinal metastases and primary tumors, especially for driver mutations.
Article
Clinical Neurology
Vikram B. Chakravarthy, Ben Schachner, Anubhav Amin, Anne S. Reiner, Yoshiya Yamada, Adam Schmitt, Daniel S. Higginson, Ilya Laufer, Mark H. Bilsky, Ori Barzilai
Summary: This study evaluates the clinical outcomes of hybrid therapy for spinal metastases from colorectal cancer (CRC). The results show that hybrid therapy can effectively control the disease, but patients may experience disease progression outside the treated level.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Ori Barzilai, Stefano Boriani, Charles G. Fisher, Arjun Sahgal, Jorrit Jan Verlaan, Ziya L. Gokaslan, Aron Lazary, Chetan Bettegowda, Laurence D. Rhines, Ilya Laufer
GLOBAL SPINE JOURNAL
(2019)
Article
Clinical Neurology
Ori Barzilai, Mary-Kate Amato, Lily McLaughlin, Anne S. Reiner, Shahiba Q. Ogilvie, Eric Lis, Yoshiya Yamada, Mark H. Bilsky, Ilya Laufer
NEURO-ONCOLOGY PRACTICE
(2018)
Article
Clinical Neurology
Ori Barzilai, Mark H. Bilsky, Ilya Laufer
GLOBAL SPINE JOURNAL
(2020)
