期刊
CHALLENGES OF SYSTEMS BIOLOGY: COMMUNITY EFFORTS TO HARNESS BIOLOGICAL COMPLEXITY
卷 1158, 期 -, 页码 205-214出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2008.03758.x
关键词
network inference; transcription factor binding site prediction; data integration
类别
资金
- NIH/NIAID [HHSN272200700038C]
- NIH/NIGMS [R01-GM072855, P50 GM076547]
- Academy of Finland [213462, 120411, 122973]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM072855, P50GM076547] Funding Source: NIH RePORTER
We present a computational framework for predicting targets of transcription factor regulation. The framework is based on die integration of a number of sources of evidence, derived from DNA-sequence and gene-expression data, Losing a weighted sum approach. Sources of evidence are prioritized based on a training set, and their relative contributions are dien optimized. The performance of the proposed framework is demonstrated in the context of BCL6 target prediction. We show that this framework is able to uncover BCL6 targets reliably when biological prior information is utilized effectively, particularly in the case of sequence analysis. The framework results ill a considerable gain in performance over scores in which sequence information was not incorporated. This analysis shows that with assessment or the quality and biological relevance of the data, reliable predictions can be obtained with this computational framework.
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