期刊
STEROID ENZYMES AND CANCER
卷 1155, 期 -, 页码 316-323出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2008.03679.x
关键词
Parkinson's disease (PD); high performance liquid chromatography (HPLC); striatum; brain stem; cerebellum; cortex; hippocampus; 6-OHDA; monoamines
资金
- Ateneo di Palermo research funding [ORPA068JJ5]
6-Hydroxydopamine (6-OHDA) is a neurotoxic compound commonly used to induce dopamine (DA) depletion in the nigrostriatal system, mimicking Parkinson's disease (PD) in animals. The aim of the present study was to evaluate the 7-day effect of unilateral nigral lesion on rat brain monoamine neurochemistry. Five brain regions were examined: the brain stem, cerebellum, hippocampus, striatum, and cortex. 6-OHDA-unilateral lesion dramatically modified DA, serotonin (5-HT) and their metabolites contents in both sides of the different brain nuclei. Furthermore, unilateral 6-OHDA lesion reduced DA and 5-HT contents and produced a robust inversion of their turnover in the nonlesioned side compared to sham-operated rats. These data suggest that 6-OHDA unilateral nigral lesion produces bilateral monoamine level modifications, and this piece of evidence should be taken into account when one interprets data from animal models of unilateral PD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据