Article
Cell Biology
Martyna Okuniewska, Victoria Fang, Audrey Baeyens, Varsha Raghavan, June-Yong Lee, Dan R. Littman, Susan R. Schwab
Summary: The text discusses the role of S1P receptor 1 in T cell exit from lymph nodes and vascular permeability regulation. It also highlights the therapeutic potential of targeting S1PR1 for autoimmune diseases. The importance of SPNS2 in supplying lymph S1P and supporting T cell exit is emphasized, but further research is needed to determine its necessity during immune responses.
Article
Biochemistry & Molecular Biology
Rachel S. Resop, Bradley Salvatore, Shawn J. Kim, Brent R. Gordon, Bianca Blom, Dimitrios N. Vatakis, Christel H. Uittenbogaart
Summary: HIV-1 infection leads to upregulation of S1P receptor 1 (S1PR1) in the human thymus, potentially increasing the number and speed of thymocyte egress. This may have implications for immune function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Summary: SPHK1 is a conserved lipid enzyme that catalyzes the formation of S1P, and has been implicated in oncogenic functions, particularly in breast cancer. Recent evidence suggests a role for SPHK1 in regulating CSCs, indicating the therapeutic potential of targeting SPHK1 in refractory cancers enriched with CSCs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Olga A. Sukocheva, Dong Gui Hu, Robyn Meech, Anupam Bishayee
Summary: Breast cancer MCF-7 cell-line-derived mammospheres exhibit enriched CD44+/CD24- cells resembling breast cancer stem cells, expressing high levels of S1P3. Growth-promoting agents induce SphK1 and S1P3 translocation to the nucleus, while TNF alpha inhibits their nuclear translocation and promotes apoptosis in mammospheres. The study suggests inhibiting SphK1 and S1P3 nuclear translocation as a novel approach to prevent BCSC proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
Chelsea A. Saito-Reis, Victoria D. Balise, Erica M. Pascetti, Magdalena Jiminez, Jennifer M. Gillette
Summary: The study identifies CD82 as a novel regulator of HSPC mobilization, showing enhanced HSPC mobilization in CD82KO mice and an effect on S1PR(1) surface regulation. Combining AMD3100 and anti-CD82 treatments can enhance the mobilization of mouse HSPCs and human CD34+ cells.
Article
Cell Biology
Fei Li, Yifan Zhang, Zhoujun Lin, Lizhong Yan, Qiao Liu, Yin Li, Xiaolin Pei, Ya Feng, Xiao Han, Juan Yang, Fangxu Zheng, Tianjiao Li, Yupeng Zhang, Zhenkun Fu, Di Shao, Jane Yu, Chenggang Li
Summary: This study identified rapamycin-insensitive sphingosine metabolic signatures in LAM cells and demonstrated that therapeutic targeting of aberrant SPHK1/S1P/S1PR3 signaling may have potent therapeutic benefit for patients with TSC/LAM or other hyperactive mTOR neoplasms with autophagy inhibition.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen
Summary: Sphingosine-1-phosphate (S1P) is a crucial sphingolipid molecule that regulates cardiovascular functions through binding and activating multiple G protein-coupled receptors in different cell types. It affects cell proliferation, migration, differentiation, and apoptosis through various downstream signaling pathways. Abnormal S1P levels are associated with cardiovascular disorders, and further research is needed to explore the potential therapeutic use of S1P in these diseases.
Article
Immunology
Gillis Greiwe, Eileen Moritz, Katharina Amschler, Annika Poppe, Harun Sarwari, Axel Nierhaus, Stefan Kluge, Hermann Reichenspurner, Christian Zoellner, Edzard Schwedhelm, Guenter Daum, Bjoern Tampe, Martin Sebastian Winkler
Summary: This study found that major cardiac surgery disrupts serum S1P levels, with post-surgery low S1P levels potentially serving as a new marker for evaluating the severity of surgery-induced inflammation. Patients whose S1P levels did not recover to preoperative levels had longer ICU stays and more severe postoperative inflammation. Additionally, the study suggests that high-dose heparin during surgery may have an inhibitory effect on circulating S1P levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rosaria Bassi, Stefania Brambilla, Cristina Tringali, Paola Giussani
Summary: The study found that GBM cells overexpressing EGFR have higher levels of S1P and increased SK1 activity, leading to resistance to the standard chemotherapeutic drug temozolomide. This suggests a functional link between EGFR and S1P signaling pathways in enhancing the survival properties of GBM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo
Summary: Psoriasis is a chronic skin condition that lacks a complete cure. Recent studies have identified sphingolipid metabolites as significant contributors to psoriasis, particularly ceramide and sphingosine-1-phosphate (S1P). The modulation of S1P and its receptor has shown potential in improving psoriasis inflammation.
Article
Medicine, Research & Experimental
Daniela Judith Romero, Lucila Gisele Pescio, Bruno Jaime Santacreu, Jazmin Maria Mosca, Norma Beatriz Sterin-Speziale, Nicolas Octavio Favale
Summary: Epithelial renal cells can adopt different cellular phenotypes through epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET). Sphingosine-1-phosphate (S1P) plays a crucial role in cell migration and differentiation, and its functions vary depending on the stage of cell differentiation and activation of S1P receptor 2 (S1PR2). Activation of S1PR2 promotes migration in fully differentiated cells but inhibits migration in non-differentiated cells. These findings provide new insights into the modulation of renal epithelial cell plasticity and have implications for research in various diseases.
Article
Biochemistry & Molecular Biology
Federica Pierucci, Antony Chirco, Elisabetta Meacci
Summary: Irisin is a hormone-like myokine that is produced in skeletal muscle in response to exercise. Sphingosine-1-phosphate (S1P), a bioactive lipid, plays a crucial role in the formation and release of irisin. It also has autocrine and paracrine effects on myoblast proliferation and differentiation. These findings suggest that the S1P/S1PR axis could be a potential therapeutic target for muscle dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yuehan Ma, Na Chang, Yuran Liu, Fuquan Liu, Chengbin Dong, Lei Hou, Changbo Qi, Lin Yang, Liying Li
Summary: IQ motif-containing guanosine triphosphatase (GTPase)-activating protein 1 (IQGAP1) is a cytosolic scaffolding protein involved in cell migration. In this study, it was found that IQGAP1 expression is significantly elevated in MCDHF-diet-induced mouse fibrotic livers, and there are positive correlations between IQGAP1 and fibrosis hallmarks expressions in human and mouse fibrotic livers. Silencing of IQGAP1 reduces BMSC migration, providing a potential therapeutic strategy for liver fibrosis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Cell Biology
Xuehui Fan, Lili Liu, Yue Shi, Fanghan Guo, Xiao He, Xiuli Zhao, Di Zhong, Guozhong Li
Summary: Sphingosine 1-phosphate (S1P) is a sphingolipid metabolite found in various cells and body fluids, with five receptors, S1P1-S1P5, exhibiting tissue selectivity. Among these receptors, S1P3 plays a crucial role in processes related to inflammation, cell migration, tumor invasion and metastasis, and other pathophysiological processes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)