期刊
NATURAL GENETIC ENGINEERING AND NATURAL GENOME EDITING
卷 1178, 期 -, 页码 186-193出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.05004.x
关键词
gene structure; biological codes; subgenic modules; nuons; gene evolution; retroposition; highly conserved sequences
资金
- Nationales Genomforschungsnetz [0313358A]
While once almost synonymous, there is an increasing gap between the expanding definition of what constitutes a gene and the conservative and narrowly defined terms code or coding, which for a long time, almost exclusively constituted the open reading frame. Much confusion results from this disparity, especially in light of the plethora of noncoding RNAs (more correctly termed non-protein-coding RNAs) that usually are encoded and transcribed by their own genes. A simple solution would be to adopt Ed Trifonov's less constrained definition of a code as any sequence pattern that can have a biological function. Such consideration favors not only a more complex view of the gene as an entity composed of many more or less conserved subgenic modules, but also a concept of modular evolution of genes and entire genomes.
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