Article
Neurosciences
Yuanyuan Dang, Yong Wang, Xiaoyu Xia, Yi Yang, Yang Bai, Jianning Zhang, Jianghong He
Summary: This study demonstrated the efficacy of deep brain stimulation (DBS) in enhancing recovery from minimally conscious state (MCS) by improving functional connectivity and brain networks.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Fabrice Ferre, Lizette Heine, Edouard Naboulsi, Florent Gobert, Maude Beaudoin-Gobert, Frederic Dailler, William Buffieres, Alexandra Corneyllie, Benjamine Sarton, Beatrice Riu, Jacques Luaute, Stein Silva, Fabien Perrin
Summary: Research shows that approximately 30% of patients with acquired disorders of consciousness are able to process self-referential auditory stimuli, which may be related to consciousness recovery.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Piotr Knapik, Dawid Borowik, Daniel Ciesla, Ewa Trejnowska
Summary: A significant percentage of patients are discharged from ICU with disorders of consciousness. Discharge in a VS and MCS was relatively frequent, and more likely among patients who were admitted unconscious and due to cardiac arrest or craniocerebral trauma.
Article
Rehabilitation
Manon Carriere, Roberto Llorens, Maria Dolores Navarro, Jose Olaya, Joan Ferri, Enrique Noe
Summary: Accurately describing the behavioral signs indicating transition from unresponsive wakefulness syndrome/vegetative state to minimally conscious state or emergence from minimally conscious state after severe brain injury is crucial for prognosis. This study examined a large sample of patients with chronic disorders of consciousness and identified the behavioral signs that led to a change in diagnosis, as well as the factors influencing this transition. The study found that transition to minimally conscious state was mostly indicated by visual fixation, localization to noxious stimulation, visual pursuit, and object manipulation. Emergence from minimally conscious state was characterized by functional communication and object use. Clinicians should pay attention to the visual and motor subscales to detect behavioral recovery.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Clinical Neurology
Matthew Kolisnyk, Karnig Kazazian, Karina Rego, Sergio L. Novi, Conor J. Wild, Teneille E. Gofton, Derek B. Debicki, Adrian M. Owen, Loretta Norton
Summary: Resting-state functional magnetic resonance imaging was used to predict neurologic recovery in unresponsive patients with severe brain injury. The study found that the method accurately predicted the outcome of patients and could affect discussions surrounding withdrawal of life-sustaining measures.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
A. Fontan, L. Lindgren, T. Pedale, C. Brorsson, F. Bergstrom, J. Eriksson
Summary: The nature of consciousness remains enigmatic, with the relationship between consciousness content and level unclear. Experimental observations show that sedatives affect conscious and non-conscious processing differently, prompting a reevaluation of methods for studying consciousness through neural responses.
Review
Clinical Neurology
Camillo Porcaro, Idan Efim Nemirovsky, Francesco Riganello, Zahra Mansour, Antonio Cerasa, Paolo Tonin, Bobby Stojanoski, Andrea Soddu
Summary: This article reviews the importance and methods of using neuroimaging and electrophysiological techniques to diagnose patients with disorders of consciousness (DOC) and differentiate between Vegetative State/Unresponsive Wakefulness Syndrome (VS/UWS) and Minimally Conscious State (MCS). By analyzing studies conducted within the last 10 years, the article summarizes the promising results achieved in improving diagnostic accuracy with these techniques and emphasizes the need to incorporate them into standard clinical practice, as well as the importance of data sharing.
FRONTIERS IN NEUROLOGY
(2022)
Review
Health Care Sciences & Services
Gautam R. Produturi, Joshua S. Kurtz, Nolan J. Brown, Ashley E. Choi, Lina I. Ibrahim, Julian Gendreau, Shane Shahrestani, Ronald Sahyouni, Joel Castellanos, Mickey E. Abraham
Summary: The study analyzed clinical trials on minimally conscious state (MCS) and found that stimulation interventions, such as transcranial magnetic stimulation, were the most commonly evaluated treatments. Behavioral therapy and pharmaceutical interventions received less attention in the research.
ANNALS OF PALLIATIVE MEDICINE
(2022)
Article
Computer Science, Artificial Intelligence
Camillo Porcaro, Marco Marino, Simone Carozzo, Miriam Russo, Maria Ursino, Valentina Ruggiero, Carmela Ragno, Stefania Proto, Paolo Tonin
Summary: Accurate diagnosis of disorders of consciousness is crucial for tailored treatment programs. Using tools like EEG and a nonlinear method such as Higuchi's Fractal Dimension can improve diagnostic accuracy for distinguishing between MCS and VS groups. HFD has been found to be more sensitive than linear methods and shows promise in reducing misdiagnosis.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2022)
Article
Neurosciences
Chuan Xu, Hangcheng Li, Jiaxin Gao, Lingling Li, Fangping He, Jie Yu, Yi Ling, Jian Gao, Jingqi Li, Lucia Melloni, Benyan Luo, Nai Ding
Summary: When listening to speech, cortical activity can track constructed linguistic units, and this can predict the outcome for patients with consciousness disorders. Statistical learning can occur in patients with minimal consciousness and may be used to induce neural plasticity.
Article
Geriatrics & Gerontology
Yi Yang, Yangyang Dai, Qiheng He, Shan Wang, Xueling Chen, Xiaoli Geng, Jianghong He, Feng Duan
Summary: The study explores the association between altered network structures and clinical symptoms of disorders of consciousness (DoC) and demonstrates the feasibility of using network metrics to differentiate patients with different subtypes of DoC.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Maria Daniela Cortese, Francesco Arcuri, Idan E. Nemirovsky, Lucia Francesca Lucca, Paolo Tonin, Andrea Soddu, Francesco Riganello
Summary: NCS and NCS-R can be used to assess patients' behavioral responses to pain, with changes in behavioral abilities potentially indicating improvement in CRS-R diagnosis. Evaluating responses to nociceptive stimuli in DOC patients may be effective in assessing their evolving conscious state.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Aurore Thibaut, Rajanikant Panda, Jitka Annen, Leandro R. D. Sanz, Lionel Naccache, Charlotte Martial, Camille Chatelle, Charlene Aubinet, Estelle A. C. Bonin, Alice Barra, Marie-Michele Briand, Benedetta Cecconi, Sarah Wannez, Johan Stender, Steven Laureys, Olivia Gosseries
Summary: A study investigated brain activity in non-responsive brain-injured patients, finding that a significant proportion of them showed partial preservation of brain metabolism, labeled as MCS*. Patients with MCS* had better outcomes, global functional connectivity, and grey matter preservation compared to those with VS/UWS. MCS* patients had lower brain metabolism in posterior brain regions compared to MCS patients.
ANNALS OF NEUROLOGY
(2021)
Article
Neurosciences
Daniel Golkowski, Rebecca Willnecker, Jennifer Rosler, Andreas Ranft, Gerhard Schneider, Denis Jordan, Ruediger Ilg
Summary: Through the study of global brain communication patterns, it was found that specific patterns with high covariance in sensory and motor areas or low overall covariance are closely related to intact consciousness. The dynamic changes of these patterns are significantly associated with activity within the frontoparietal network of the brain, known to play a crucial role in conscious perception.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2021)
Article
Clinical Neurology
Yuan Peng, Jingpu Zhao, Xiao Lu, Juntao Dong, Shunxi Zhang, Jin Zhang, Huihua Liu, Xiuyuan Zheng, Xin Wang, Yue Lan, Tiebin Yan
Summary: The study suggests that transcranial direct current stimulation (tDCS) may be an effective treatment for improving the consciousness state in patients with minimally conscious state (MCS). tDCS can modulate functional connectivity (FC) not only at the stimulation site (left dorsolateral prefrontal cortex, DLPFC), but also in distant regions.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Jeffrey N. Chiang, Yujia Peng, Hongjing Lu, Keith J. Holyoak, Martin M. Monti
Summary: The ability to generate and process semantic relations is crucial to human cognition. This study compared neural activities in making analogy judgments based on different computational models and found that a frontoparietal network plays a key role in encoding semantic relations.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2021)
Article
Psychology, Clinical
Evan S. Lutkenhoff, Anna Nigri, Davide Rossi Sebastiano, Davide Sattin, Elisa Visani, Cristina Rosazza, Ludovico D'Incerti, Maria Grazia Bruzzone, Silvana Franceschetti, Matilde Leonardi, Stefania Ferraro, Martin M. Monti
Summary: This study explores the association between long-term impairment of consciousness, spontaneous brain oscillations, and underlying subcortical damage in patients with a disorder of consciousness. The findings suggest that electroencephalographic measures can provide valuable information for diagnosing and understanding the underlying brain pathology of this patient cohort.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neurosciences
Joel Frohlich, Julia S. Crone, Micah A. Johnson, Evan S. Lutkenhoff, Norman M. Spivak, John Dell'Italia, Joerg F. Hipp, Vikesh Shrestha, Jesus E. Ruiz Tejeda, Courtney Real, Paul M. Vespa, Martin M. Monti
Summary: This study confirms the validity of the ABCD model in predicting behavioral recovery in patients with moderate-to-severe traumatic brain injury. It outperforms data-driven clustering methods and may be equally effective as a more simplified categorization. Additionally, a correlation between EEG findings and functional magnetic resonance imaging provides further evidence for investigation in larger studies.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Martin Max Monti, Caroline Schnakers
Summary: For the first time, the American Academy of Neurology and the European Academy of Neurology have recognized the value of advanced neuroimaging and electrophysiology techniques (AIEs) in diagnosing patients with a disorder of consciousness (DOC). However, due to the limited availability of these techniques outside advanced medical centers, it is important to provide physicians with a framework for deciding when AIEs are suitable. This article proposes an algorithmic flowchart based on the new guidelines to determine the appropriateness of AIEs for individual patients with DOC and ensure evidence-based best practices are followed.
Article
Multidisciplinary Sciences
Daniel Toker, Ioannis Pappas, Janna D. Lendner, Joel Frohlich, Diego M. Mateos, Suresh Muthukumaraswamy, Robin Carhart-Harris, Michelle Paff, Paul M. Vespa, Martin M. Monti, Friedrich T. Sommer, Robert T. Knight, Mark D'Esposito
Summary: This study identifies a critical point near which waking cortical oscillatory dynamics operate, known as the edge-of-chaos critical point, and discusses the impact of this critical point on consciousness and its potential clinical applications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Norman M. Spivak, Joseph L. Sanguinetti, Martin M. Monti
Summary: This article summarizes the use of focused ultrasound in neuromodulation and discusses different approaches for targeting, delivering, and validating focused ultrasound. It focuses on the parameter space and ongoing theories of ultrasonic neuromodulation. Furthermore, it explores the current and future applications of this technique.
Review
Neurosciences
John Dell'Italia, Joseph L. Sanguinetti, Martin M. Monti, Alexander Bystritsky, Nicco Reggente
Summary: Low intensity focused ultrasound (LIFU) has been recognized as a non-invasive neuromodulation technology with superior spatial specificity. This review introduces the underlying mechanics of acoustic energy and neuronal membranes, as well as categorizes empirical studies to evaluate theoretical mechanisms supporting LIFU's effects.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Correction
Critical Care Medicine
Andrea I. Luppi, Joshua Cain, Lennart R. B. Spindler, Urszula J. Gorska, Daniel Toker, Andrew E. Hudson, Emery N. Brown, Michael N. Diringer, Robert D. Stevens, Marcello Massimini, Martin M. Monti, Emmanuel A. Stamatakis, Melanie Boly
NEUROCRITICAL CARE
(2022)
Article
Neurosciences
Josh A. Cain, Norman M. Spivak, John P. Coetzee, Julia S. Crone, Micah A. Johnson, Evan S. Lutkenhoff, Courtney Real, Manuel Buitrago-Blanco, Paul M. Vespa, Caroline Schnakers, Martin M. Monti
Summary: The use of low-intensity focused ultrasound (LIFU) neuromodulation to stimulate the thalamus can improve behavioral responsiveness in patients with disorders of consciousness (DOCs). Functional MRI showed decreased BOLD signals in the frontal cortex and basal ganglia during thalamic LIFU. The altered connectivity of the sonicated thalamus was related to the degree of recovery observed after LIFU.
Article
Neurosciences
Marina Weiler, Raphael F. Casseb, Brunno M. de Campos, Julia S. Crone, Evan S. Lutkenhoff, Paul M. Vespa, Martin M. Monti
Summary: This study evaluated the ability of different preprocessing strategies to mitigate noise-related signal in functional connectivity of traumatic brain injury (TBI) patients. The pipelines combining spike regression with physiological regressors were found to be the most effective. It was also observed that excluding high-motion participants reduced the importance of the choice of denoising pipeline but resulted in substantial data loss.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Martin M. Monti, Norman M. Spivak, Brian L. Edlow, Yelena G. Bodien
Summary: In the past 30 years, there has been an increasing trend in clinical trials to assess novel interventions not only based on statistical significance, but also on clinically meaningful changes for patients. However, in the context of Disorders of Consciousness (DOC), there is currently no consensus on what constitutes a minimal clinically important difference (MCID). To address this issue, researchers have developed a probability-based approach using published diagnostic guidelines to establish a MCID and applied it to the Coma Recovery Scale-Revised (CRS-R), the most validated and frequently used scale in DOC.
Article
Critical Care Medicine
Martin M. Monti, Rachel Beekman, Norman M. Spivak, Aurore Thibaut, Caroline Schnakers, John Whyte, Erika Molteni
Summary: This study reports the development of a case report form (CRF) by the Therapeutic Interventions Working Group, which aims to systematize the assessment of novel interventions intended to increase consciousness or rate of recovery in patients with disorders of consciousness.
NEUROCRITICAL CARE
(2023)
Meeting Abstract
Critical Care Medicine
Emily Dennis, Alexander Olsen, Maheen Adamson, Houshang Amiri, Erin Bigler, Karen Caeyenberghs, Kristen Dams-O'Connor, Evelyn Deutscher, Ekaterina Dobryakova, Helen Genova, Jordan Grafman, Asta Haberg, Cooper Hodges, Andrei Irimia, Neda Jahanshad, Ruchira Jha, Hannah Lindsey, Abdalla Mohamed, Martin Monti, Mary Newsome, Gershon Spitz, Paul Thompson, David Tate, Elisabeth Wilde, Frank Hillary
JOURNAL OF NEUROTRAUMA
(2022)
Meeting Abstract
Clinical Neurology
Jasmine A. T. DiCesare, Mahsa Malekmohammadi, Daniel Toker, Hiro Sparks, Andrew Hudson, Martin Monti, Nader Pouratian
Article
Music
Andrew Frane, Martin M. Monti
Summary: The research showed that rhythms with the same pitch for all notes were reproduced more accurately, but most participants found melodic rhythms easier to remember. Additionally, sequences containing a Scotch snap were reproduced less accurately in general.