Review
Biochemistry & Molecular Biology
Fariba Kokabi, Safieh Ebrahimi, Farshad Mirzavi, Nazanin Ghiasi Nooghabi, Seyedeh Fatemeh Hashemi, Seyed Isaac Hashemy
Summary: Diabetes is the world's fastest-growing disease characterized by persistent hyperglycemia and chronic complications. Substance P and its receptor system have been found to be involved in diabetes pathogenesis and can have both destructive and protective effects on the disease. Understanding the functional relevance of this system in diabetes may lead to new therapeutic options for diabetes and its associated chronic conditions.
Review
Oncology
Marilina Garcia-Aranda, Teresa Tellez, Lauraine McKenna, Maximino Redondo
Summary: Improving the response, quality of life, and survival of oncologic patients is a significant scientific challenge. This review evaluates the potential of repurposing the already marketed NK-1R antagonist aprepitant to overcome resistance to anticancer treatments. The role of Substance P (SP) and its preferred receptor, Neurokinin 1 Receptor (NK-1R), in human cancer is discussed, along with the potential of NK-1R antagonists as anticancer treatments.
Article
Immunology
Wen-Wen Zhang, Teng Chen, Shi-Yi Li, Xin-Yue Wang, Wen-Bo Liu, Yu-Quan Wang, Wen-Li Mi, Qi-Liang Mao-Ying, Yan-Qing Wang, Yu-Xia Chu
Summary: The role of NK3R in the LHb in trigeminal neuralgia and pain-associated anxiety was investigated. It was found that abnormal activity in LHb neurons contributes to orofacial allodynia and anxiety-like behaviors, which can be attenuated by NK3R activation. The fPAG (NKB) -> LHb circuit, mediated by the release of NKB from the fPAG, regulates orofacial allodynia and pain-induced anxious behaviors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kentaro Kurogochi, Masami Uechi, Kensuke Orito
Summary: Situational syncope, induced by a specific situation, involves disorders of the autonomic nervous system. This study using a rat model suggests that a neurokinin-1 receptor antagonist, fosaprepitant, may suppress the circulatory response to colorectal distension by inhibiting the vagal reflex pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Ishwar Atre, Naama Mizrahi, Berta Levavi-Sivan
Summary: The study reveals the crucial role of NKB receptors in fish reproduction and identifies the key binding residues and factors involved. Both in vitro and in vivo studies show that these residues are essential for receptor activity.
Review
Genetics & Heredity
Milica Radosavljevic, Dubravka Svob Strac, Jasna Jancic, Janko Samardzic
Summary: Pharmacotherapy for neuropsychiatric disorders, such as anxiety and depression, is highly variable among individuals and often results in side effects. Pharmacogenetics, as a part of personalized medicine, aims to optimize therapy by targeting genetic variations involved in drug metabolism and efficacy. Recent studies have shown that genotype-guided decisions can improve the effectiveness and safety of antidepressant and anxiolytic treatments. Additionally, the emerging field of pharmacoepigenetics investigates how epigenetic mechanisms may influence individual drug responses. Understanding the epigenetic variability of patients' response to pharmacotherapy can lead to the selection of more effective drugs and minimize adverse reactions, ultimately improving treatment outcomes.
Article
Medicine, Research & Experimental
Hu-Jiang Shi, Dan-Lian Wu, Rong Chen, Na Li, Li-Juan Zhu
Summary: The study found that fluoxetine modifies mood behaviors and hippocampal neuroplasticity by disrupting the nNOS-CAPON interaction, which is associated with postsynaptic 5-HT1AR activation.
Review
Biochemistry & Molecular Biology
Amir R. Afshari, Ali Motamed-Sanaye, Hamed Sabri, Arash Soltani, Sepideh Karkon-Shayan, Sarvin Radvar, Hossein Javid, Hamid Mollazadeh, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: The current standard of care for glioblastoma multiforme (GBM) is inadequate, with overall survival less than one year under current treatments. Understanding the molecular pathogenesis of GBM is crucial for future therapeutic approaches. The interaction between neurotransmitter substance P (SP) and its receptor NK-1R is proposed as a potential mechanism for treating GBM.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xue Bai, Gerard Batalle, Olga Pol
Summary: The study demonstrates the anxiolytic and antidepressant properties of DADS and GYY4137 during neuropathic pain, revealing their analgesic actions through inhibition of inflammatory, apoptotic, and oxidative responses. These findings support the use of these treatments for managing affective disorders accompanying chronic neuropathic pain.
Review
Oncology
Miguel Angel Gonzalez-Moles, Pablo Ramos-Garcia, Francisco Esteban
Summary: The upregulation of SP and NK-1R are shown to be oncogenic events in head and neck cancer, potentially acting in the early stages of malignization. The findings also underscore translational opportunities for SP/NK-1R as potential therapeutic targets in head and neck cancer.
Article
Biology
Nicol Urbanska, Patrik Simko, Andrea Leskanicova, Martina Karasova, Zuzana Jendzelovska, Rastislav Jendzelovsky, Dajana Rucova, Mariana Kolesarova, Michal Goga, Martin Backor, Terezia Kiskova
Summary: This study analyzed the potential of Atranorin (ATR) in a depression-like state in male Wistar rats and found that it may have antidepressant/anxiolytic effects. ATR was shown to act as an antioxidant and significantly change animal behavior, while also increasing hippocampal neurogenesis and the number of mature neurons. Further studies are required in this area.
Article
Nutrition & Dietetics
Chorpeth Chalermwongkul, Charinya Khamphukdee, Juthamart Maneenet, Supawadee Daodee, Orawan Monthakantirat, Chantana Boonyarat, Yutthana Chotritthirong, Suresh Awale, Anake Kijjoa, Yaowared Chulikhit
Summary: Major depressive disorder (MDD) is a prevalent worldwide disease with unclear etiology. Herbal medicine is gaining interest as an alternative antidepressant, and Oroxylum indicum extract containing baicalin and baicalein shows potential as an effective treatment for MDD by normalizing the HPA axis function and improving neurogenesis.
Article
Chemistry, Multidisciplinary
Yue Shi, Xi Wang, Yueming Meng, Junjie Ma, Qiyu Zhang, Gang Shao, Lingfei Wang, Xurui Cheng, Xiangyu Hong, Yong Wang, Zhibin Yan, Yihai Cao, Jian Kang, Caiyun Fu
Summary: The study reveals the potential efficacy of NK-1R antagonists in colorectal cancer treatment, demonstrating their ability to induce cell death, inhibit tumor growth, and enhance sensitivity to chemotherapy.
Article
Pharmacology & Pharmacy
Ruhan Deniz Topuz, Mehmet Zahid Cetinkaya, Dilsat Erumit, Kubra Duvan Aydemir, Ozgur Gunduz, Cetin Hakan Karadag, Ahmet Ulugol
Summary: Dipyrone exhibited antidepressant and anxiolytic effects in mice exposed to chronic unpredictable mild stress, with its anxiolytic effect possibly mediated through CB1 receptors and its antidepressant action possibly mediated through TRPV1 receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lin Chen, Shizao Fei, Opeyemi Joshua Olatunji
Summary: This study investigated the effects of MSE on diabetes-induced anxiety and depression-like behaviors. The UPLC/ESI/TOF-MS analysis revealed that MSE contains abundant polyphenolic constituents. The results indicated that MSE treatment reduced blood glucose levels, improved depressive and anxiety-like behaviors, and attenuated oxidative stress and pro-inflammatory cytokines in the brains of diabetic rats.
Article
Medicine, General & Internal
Joerg Schaufler, Marianne Ronovsky, Giorgia Savalli, Maureen Cabatic, Simone B. Sartori, Nicolas Singewald, Daniela D. Pollak
ANNALS OF MEDICINE
(2016)
Article
Anatomy & Morphology
Csaba Adori, Swapnali Barde, Szilvia Vas, Karl Ebner, Jie Su, Camilla Svensson, Aleksander A. Mathe, Nicolas Singewald, Rainer R. Reinscheid, Mathias Uhlen, Kim Kultima, Gyorgy Bagdy, Tomas Hokfelt
BRAIN STRUCTURE & FUNCTION
(2016)
Review
Behavioral Sciences
C. P. Murphy, N. Singewald
GENES BRAIN AND BEHAVIOR
(2018)
Article
Clinical Neurology
Anupam Sah, Sergey Sotnikov, Maria Kharitonova, Claudia Schmuckermair, Rebekka P. Diepold, Rainer Landgraf, Nigel Whittle, Nicolas Singewald
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2019)
Review
Neurosciences
Nicolas Singewald, Andrew Holmes
PSYCHOPHARMACOLOGY
(2019)
Article
Neurosciences
Ines Schoberleitner, Anna Mutti, Anupam Sah, Alexandra Wille, Francisco Gimeno-Valiente, Paolo Piatti, Maria Kharitonova, Luis Torres, Gerardo Lopez-Rodas, Jeffrey J. Liu, Nicolas Singewald, Christoph Schwarzer, Alexandra Lusser
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Judith Camats-Perna, Predrag Kalaba, Karl Ebner, Simone B. Sartori, Harish Vuyyuru, Nilima Y. Aher, Vladimir Dragacevic, Nicolas Singewald, Mario Engelmann, Gert Lubec
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Article
Neurosciences
Yu Kasugai, Elisabeth Vogel, Heide Hoertnagl, Sabine Schoenherr, Enrica Paradiso, Markus Hauschild, Georg Goebel, Ivan Milenkovic, Yvan Peterschmitt, Ramon Tasan, Guenther Sperk, Ryuichi Shigemoto, Werner Sieghart, Nicolas Singewald, Andreas Luethi, Francesco Ferraguti
Review
Pharmacology & Pharmacy
Simone B. Sartori, Nicolas Singewald
PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Cristina Lemos, Ahmad Salti, Ines M. Amaral, Veronica Fontebasso, Nicolas Singewald, Georg Dechant, Alex Hofer, Rana El Rawas
Summary: Social interaction can be beneficial in preventing drug abuse by reducing stress levels. The study found that social interaction decreased stress levels and reversed the preference for cocaine induced by stress. This suggests that social interaction could be an important component in the treatment of substance use disorders.
Article
Biochemistry & Molecular Biology
Anouk Pierre, Andries Van Schuerbeek, Wissal Allaoui, Sven Van Laere, Nicolas Singewald, Ann Van Eeckhaut, Ilse Smolders, Dimitri De Bundel
JOURNAL OF NEUROCHEMISTRY
(2020)
Article
Endocrinology & Metabolism
A. Pierre, Y. Regin, A. Van Schuerbeek, E. M. Fritz, K. Muylle, T. Beckers, I. J. Smolders, N. Singewald, D. De Bundel
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Neurosciences
Nicolas Singewald, Simone B. Sartori, Andreas Reif, Andrew Holmes
Summary: Psychiatric disorders associated with trauma, stress, and anxiety are increasing worldwide, leading to significant morbidity. Current medication-based therapeutic approaches for anxiety disorders and PTSD are effective but have unwanted side effects and do not address underlying pathophysiology. There is renewed interest in designing novel drug treatments in this field, targeting various neurochemical systems. This article provides an overview of the current state of drug development, highlighting the importance of neurobiology and neuroplasticity in achieving lasting therapeutic effects.
Article
Psychiatry
Sinead Rooney, Anupam Sah, Michael S. Unger, Maria Kharitonova, Simone B. Sartori, Christoph Schwarzer, Ludwig Aigner, Helmut Kettenmann, Susanne A. Wolf, Nicolas Singewald
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Neurosciences
Conor P. Murphy, Xiang Li, Verena Maurer, Michael Oberhauser, Ronald Gstir, Luis Eduardo Wearick-Silva, Thiago Wendt Viola, Simon Schafferer, Rodrigo Grassi-Oliveira, Nigel Whittle, Alexander Huttenhofer, Timothy W. Bredy, Nicolas Singewald
BIOLOGICAL PSYCHIATRY
(2017)