期刊
Neural Signaling: Opportunities for Novel Diagnostic Approaches and Therapies
卷 1144, 期 -, 页码 1-5出版社
BLACKWELL PUBLISHING
DOI: 10.1196/annals.1418.000
关键词
G protein-coupled receptors; receptor structure; receptor-associated proteins; receptor oligomerization; ligand binding; allosteric modulation
资金
- National Institutes of Health [DK32878, DK46577]
- Fiterman Foundation
- Mayo Clinic
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK032878, R37DK032878, R01DK046577] Funding Source: NIH RePORTER
G protein-coupled receptors are present on every excitable and regulatable cell in the body and represent important potential sites for drug action. This group of molecules already represents the most common target for currently approved drugs. With recent advances in our understanding of detailed molecular structure, mechanisms of activation, unique molecular associations, and cellular and biochemical mechanisms of regulation of these receptors, development and refinement of receptor-active drugs should benefit substantially. In this report, key past accomplishments and possible future directions for this field of research are reviewed.
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