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Genetics & Heredity
Varun Suresh, Bhavana Muralidharan, Saurabh J. Pradhan, Mahima Bose, Leora D'Souza, Arpan Parichha, Puli Chandramouli Reddy, Sanjeev Galande, Shubha Tole
Summary: We investigated the differences between the hippocampal primordium (Hcp) and the neocortical primordium (Ncp) in the mouse during early neurogenesis. Our results showed that the Hcp was more accessible than the Ncp at this stage. We identified LHX2 as a candidate transcription factor that regulates gene expression in the Hcp and Ncp, controlling fundamental aspects of development.
Editorial Material
Cell Biology
Alexander Atamian, Marcella Birtele, Giorgia Quadrato
Summary: This study compares different methods for deriving human cortical organoids and finds that combining WNT and dual SMAD inhibition is more effective in inducing cortical identity in 3D human pluripotent stem-cell aggregates compared to dual SMAD inhibition alone.
NATURE CELL BIOLOGY
(2022)
Article
Biology
Mariah L. Hoye, Lorenzo Calviello, Abigail J. Poff, Nna-Emeka Ejimogu, Carly R. Newman, Maya D. Montgomery, Jianhong Ou, Stephen N. Floor, Debra L. Silver
Summary: Mutations in the DDX3X gene play a crucial role in cortical development and are associated with DDX3X syndrome. The study shows that DDX3X controls translational and cell cycle control of neural progenitors, influencing neurogenesis and cortical development.
Article
Cell Biology
Zhenmeiyu Li, Guoping Liu, Lin Yang, Mengge Sun, Zhuangzhi Zhang, Zhejun Xu, Yanjing Gao, Xin Jiang, Zihao Su, Xiaosu Li, Zhengang Yang
Summary: The human cerebral cortex is responsible for our exceptional cognitive abilities. The remarkable increase in the size of the human cerebral cortex is mainly due to longer neurogenic period facilitated by increased cortical radial glial cells expressing BMP7. BMP7 promotes neurogenesis, inhibits gliogenesis, and mutually inhibits SHH signaling, which promotes cortical gliogenesis.
Article
Cell Biology
Leah Schembs, Ariane Willems, Kerstin Hasenpusch-Theil, James D. Cooper, Katie Whiting, Karen Burr, Sunniva M. K. Bostrand, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Thomas Theil
Summary: This study reveals the importance of primary cilia in dorsal and ventral patterning in human corticogenesis, identifies the tissue-specific role of the INPP5E gene as a negative regulator of SHH signaling, and suggests implications for the pathogenesis of neurodevelopmental disorders.
Article
Neurosciences
Samantha M. Shelton, Alexandra R. Soucy, Ronni Kurzion, Ella Zeldich, John H. Connor, Tarik F. Haydar
Summary: The study using a novel murine model of fetal ZIKV infection identified the time course of virus infection and the identity of cells that are initially infected or spared during neocortical neurogenesis. Results showed that ZIKV primarily infects apical radial glial cells early on, while basal intermediate progenitor cells reach peak infection rates after three days of exposure to the virus.
Article
Multidisciplinary Sciences
Cemil Kerimoglu, Linh Pham, Anton B. Tonchev, M. Sadman Sakib, Yuanbin Xie, Godwin Sokpor, Pauline Antonie Ulmke, Lalit Kaurani, Eman Abbas, Huong Nguyen, Joachim Rosenbusch, Alexandra Michurina, Vincenzo Capece, Meglena Angelova, Nenad Maricic, Beate Brand-Saberi, Miriam Esgleas, Mareike Albert, Radoslav Minkov, Emil Kovachev, Ulrike Teichmann, Rho H. Seong, Wieland B. Huttner, Huu Phuc Nguyen, Anastassia Stoykova, Jochen F. Staiger, Andre Fischer, Tran Tuoc
Summary: The increase in human neocortex size due to the evolutionarily enhanced proliferative ability of basal progenitors (BPs) is regulated by histone H3 acetylation, particularly H3K9ac. Higher H3K9ac levels in human bIPs compared to murine bIPs lead to increased bIP proliferation, affecting cortical architecture and size differences between species. This demonstrates a previously unknown mechanism of epigenetic regulation in controlling cortical expansion.
Article
Genetics & Heredity
Sathish Venkataramanappa, Dagmar Schuetz, Friederike Saaber, Praveen Ashok Kumar, Philipp Abe, Stefan Schulz, Ralf Stumm
Summary: Mutations in the DONSON gene have been linked to skeletal abnormalities and microcephaly. Deletion of Donson in cortical progenitors led to extensive cell death and abnormalities in cortical development. Targeting Donson may be a potential strategy for experimental and therapeutic purposes.
Article
Multidisciplinary Sciences
Christina Kyrousi, Adam C. O'Neill, Agnieska Brazovskaja, Zhisong He, Pavel Kielkowski, Laure Coquand, Rossella Di Giaimo, Pierpaolo D' Andrea, Alexander Belka, Andrea Forero Echeverry, Davide Mei, Matteo Lenge, Cristiana Cruceanu, Isabel Y. Buchsbaum, Shahryar Khattak, Guimiot Fabien, Elisabeth Binder, Frances Elmslie, Renzo Guerrini, Alexandre D. Baffet, Stephan A. Sieber, Barbara Treutlein, Stephen P. Robertson, Silvia Cappello
Summary: The study demonstrates that de novo variants of LGALS3BP are associated with reduced cortical complexity and area in humans, and that LGALS3BP is involved in regulating the position of neural progenitor cells. This finding sheds light on the understanding of basal progenitor cell formation and function, as well as its impact on brain structural development.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Franz Markert, Alexander Storch
Summary: Oxygen tension affects cortical development, and hyperoxygenation during mid-neurogenesis phase accelerates cortical development and increases the number of cortical layer 5 neurons until birth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kazuhiko Sawada
Summary: The present study found that neonatal exposure to valproic acid (VPA) may promote the proliferation of basal radial glia (bRG) in the premature cortex of ferrets, and these neural cells can differentiate into upper layer cortical neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wenqiang Fan, Jeronimo Jurado-Arjona, Gregorio Alanis-Lobato, Sophie Peron, Christian Berger, Miguel A. Andrade-Navarro, Sven Falk, Benedikt Berninger
Summary: Most adult hippocampal neural stem cells (NSCs) remain quiescent, but the activity of the transcriptional co-activator Yap1 is enriched in active NSCs. Genetic deletion of Yap1 reduces the proportion of active NSCs, indicating its role in regulating the transition from quiescence to activation. Overexpression of a gain-of-function Yap1 mutant leads to cell cycle entry in NSCs and astrocytes, and dysregulated Yap1 activity represses neurogenesis and induces glioblastoma stem cell-like characteristics.
Article
Developmental Biology
Li He, Jennifer Jones, Weiguo He, Bryan C. Bjork, Jiayu Wen, Qi Dai
Summary: PRDM16 is a crucial transcriptional regulator that promotes the transition from early to late phase of neurogenesis in the mouse neocortex. It regulates a subset of genes involved in neuronal specification, cell cycle regulation, and neuronal migration by limiting chromatin accessibility of permissive enhancers. This study provides evidence to support the temporal shift in gene expression program of neural progenitors to achieve neural cell diversity.
Article
Pharmacology & Pharmacy
Tibor Harkany, Valentina Cinquina
Summary: The endocannabinoid system plays a key role in neurodevelopment by regulating neurogenic events that determine the number, placement, and connectivity of neurons. The use of plant-derived cannabinoids may interfere with the endocannabinoid system's regulatory functions, leading to developmental errors and impacting the ability of neural circuits. Maternal cannabis use during pregnancy may result in lifelong psychiatric phenotypes in offspring.
CANNABIS AND CANNABINOID RESEARCH
(2021)
Article
Neurosciences
Priscilla Bluemel, Jonathan Wickel, Benedikt Gruenewald, Mihai Ceanga, Silke Keiner, Otto W. Witte, Christoph Redecker, Christian Geis, Albrecht Kunze
Summary: Sepsis associated encephalopathy (SAE) is a major complication of sepsis survivors, leading to depletion of neural stem cells and increased gliogenesis in the dentate gyrus, which may accelerate the aging process in the hippocampus.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Maria Paula Aronne, Tamara Guadagnoli, Paula Fontanet, Sergio Gustavo Evrard, Alicia Brusco
EXPERIMENTAL NEUROLOGY
(2011)
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Biology
Sergio G. Evrard, Alicia Brusco
CYTOSKELETON OF THE NERVOUS SYSTEM
(2011)
Article
Pediatrics
Sergio Gustavo Evrard
ARCHIVOS ARGENTINOS DE PEDIATRIA
(2010)
Review
Neurosciences
Sergio Gustavo Evrard, Maite Duhalde-Vega, Patricia Tagliaferro, Sebastidn Mirochnic, Laura Romina Caltana, Alicia Brusco
EXPERIMENTAL NEUROLOGY
(2006)
Article
Neurosciences
Patricia Tagliaferro, Alberto Javier Ramos, Emmanuel S. Onaivi, Sergio Gustavo Evrard, Javier Lujilde, Alicia Brusco
Article
Developmental Biology
SG Evrard, MD Vega, AJ Ramos, P Tagliaferro, A Brusco
DEVELOPMENTAL BRAIN RESEARCH
(2003)