期刊
STRESS, NEUROTRANSMITTERS, AND HORMONES: NEUROENDOCRINE AND GENETIC MECHANISMS
卷 1148, 期 -, 页码 148-153出版社
WILEY-BLACKWELL
DOI: 10.1196/annals.1410.074
关键词
forced swim; tryptophan hydroxylase-2; 5-HT transporter; 5-HT1A receptors; brain; dorsal raphe nucleus
资金
- RFBR [N 06-04-48234]
Repeated forced swim resulted in a decrease in the concentrations of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid in the hypothalamus and amygdala 24 h after the second swim session. This stressor also increased the mRNA levels for tryptophan hydroxylase-2, the rate-limiting enzyme in neuronal 5-HT synthesis, and 5-HT transporter in the midbrain as well as 5-HT1A receptor in the frontal cortex. Some of these serotonergic changes may be involved in the mechanisms of a depressive-like behavior induced by a stress of repeated swim in these animals.
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