Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Paul M. Ridker, Manas Rane
Summary: IL-6 is a pivotal cytokine in innate immunity with a proatherogenic role in cardiovascular disease. Research has explored mechanisms of IL-6 signaling, murine models, and human epidemiological data regarding its utility as a biomarker of vascular risk.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rossella Salemi, Giuseppe Gattuso, Barbara Tomasello, Alessandro Lavoro, Agostino Gaudio, Massimo Libra, Salvatore Santo Signorelli, Saverio Candido
Summary: This study investigated the involvement of IL-6 trans-signaling in DVT and found a strong correlation between the Asp358Ala variant and sIL6-R levels. The high frequency of the Asp358Ala mutation and elevated IL-6 levels in DVT patients may explain the association between IL-6 overactivation and DVT outcome. These findings provide a proof of concept for targeting IL-6 trans-signaling as a new strategy for DVT adjuvant therapy.
Editorial Material
Immunology
Travis E. Faust, Dorothy P. Schafer
Summary: The study reveals that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
Article
Physiology
Paulina Villar-Fincheira, Aaron J. Paredes, Tomas Hernandez-Diaz, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Fernanda Sanhueza-Olivares, Felipe Contreras-Briceno, Jorge Mandiola, Nicole Bruneau, Lorena Garcia, Maria Paz Ocaranza, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong
Summary: The study aims to evaluate the effects of exercise on plasma IL-6 and sIL-6R levels, and their relationship with vascular remodeling. Results show that post-marathon HT athletes had higher post-race plasma sIL-6R levels than LT athletes, suggesting a possible role of IL-6 in vascular remodeling, with a proposed association between IL-6 and aortic dilation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Sarah Rehou, Abdikarim Abdullahi, Marc G. Jeschke
Summary: This study aimed to investigate the role of sIL-6R in burn injury. The results showed that patients with a higher IL-6/sIL-6R ratio had significantly higher mortality. This suggests that IL-6 signaling via its membrane-bound receptor with an anti-inflammatory function is important.
Article
Immunology
Kristen M. Kelly, Jennifer A. Smith, Briana Mezuk
Summary: The study using Mendelian Randomization found a causal relationship between soluble interleukin-6 receptor and depression, potentially through different signaling pathways. The results suggest involvement of the IL-6 signaling pathway in depression and further research is needed.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Chemistry, Analytical
Marjan Majdinasab, Marc Lamy de la Chapelle, Jean Louis Marty
Summary: Interleukin 6 (IL-6) is a pleiotropic cytokine that exerts pathological pro-inflammatory effects and plays important roles in various biological processes. The detection of IL-6 in small quantities with high selectivity is crucial in medical and biological fields. Conventional laboratory methods such as ELISAs and CLIAs are complex, expensive, and time-consuming, while biosensors offer a simple, rapid, economical, and user-friendly alternative due to their high sensitivity, quick detection time, ease of use, and miniaturization capability.
Article
Oncology
Victor M. Schuettfort, Benjamin Pradere, Quoc-Dien Trinh, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Reza Sari Motlagh, Michael Rink, Pierre Karakiewicz, Piotr Chlosta, Jeremy Yuen-Chun Teoh, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Marco Moschini, Shahrokh F. Shariat
Summary: The study confirmed that elevated preoperative plasma levels of IL6 and IL6sR are associated with worse oncological disease survival in patients treated with RC for UCB in a large multicenter study. Both biomarkers have the potential to identify patients with adverse pathological features, improve the predictive accuracy of prognostic models, and guide clinical decision making.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Medicine, General & Internal
Anthony C. Gordon, Farah Al-Beidh, Kathryn M. Rowan, Alistair D. Nichol, Yaseen M. Arabi, Djillali Annane, Ahi Beane, Wilma Van Bentum-Puijk, Lindsay R. Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte A. Bradbury, Frank M. Brunkhorst, Adrian Buzgau, Allen C. Cheng, Michelle A. Detry, Eamon J. Duffy, Lise J. Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M. Higgins, Thomas E. Hills, Christopher M. Horvat, Francois Lamontagne, Patrick R. Lawler, Helen L. Leavis, Kelsey M. Linstrum, Edward Litton, Elizabeth Lorenzi, John C. Marshall, Florian B. Mayr, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Susan C. Morpeth, Srinivas Murthy, Katrina Orr, Rachael L. Parke, Jane C. Parker, Asad E. Patanwala, Ville Pettill, Emma Rademaker, Marlene S. Santos, Christina T. Saunders, Christopher W. Seymour, Manu Shankar-Hari, Wendy L. Sligl, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Steve A. Webb, Lennie P. G. Derde
Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yanxia Li, Jing Zhao, Yuan Yin, Ke Li, Chenchen Zhang, Yajuan Zheng
Summary: Fibrosis is a detrimental outcome of most chronic inflammatory disorders, and IL-6 plays a significant role in these diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Lina Ma, Lolita S. Nidadavolu, Huanle Yang, Jackie Langdon, Reyhan Westbrook, Benjamin M. W. Tsui, Taek-Soo Lee, Jared Hinson, Shizhang Ling, Ruth Marx-Rattner, Yuqiong Wu, Tu Nguyen, Jessica Tan, Mohammed Khadeer, Ruin Moaddel, Anne Le, Jeremy D. Walston, Peter M. Abadir
Summary: Selective knockdown of IL-6 in a frail mouse with chronic inflammation can reverse some changes associated with chronic inflammation, but it also leads to higher mortality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Juliane Lokau, Christoph Garbers
Summary: IL-6 and IL-11 are important pleiotropic cytokines that signal through specific receptors, with unique structures. Research has shown that chimeric receptors containing the stalk region of IL-11R can be blocked by a protease inhibitor other than ADAM10 during cleavage.
Article
Cell Biology
Tongzhou Liang, Taiqiu Chen, Jincheng Qiu, Wenjie Gao, Xianjian Qiu, Yuanxin Zhu, Xudong Wang, Yanbo Chen, Hang Zhou, Zhihuai Deng, Pengfei Li, Caixia Xu, Yan Peng, Anjing Liang, Peiqiang Su, Bo Gao, Dongsheng Huang
Summary: Evidence suggests that ROR alpha plays a crucial role in cartilage development and OA pathogenesis by regulating the expression of cartilage matrix components. Blocking ROR alpha can reverse cartilage damage and elevate the expression of cartilage matrix components. Additionally, ROR alpha affects the IL-6/STAT3 signaling pathway, highlighting its potential as a treatment target in OA therapy.
CELL DEATH & DISEASE
(2021)