Article
Multidisciplinary Sciences
Volha Mezhnina, Oghogho P. Ebeigbe, Nikkhil Velingkaar, Allan Poe, Yana Sandlers, Roman V. Kondratov
Summary: The study reveals that caloric restriction and time-restricted feeding can induce rhythmic production of ketone bodies in the blood, which is regulated by PPARα and FGF21 and involves the circadian clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Food Science & Technology
Luanfeng Wang, Fang Wang, Ling Xiong, Haizhao Song, Bo Ren, Xinchun Shen
Summary: In recent years, dietary restriction (DR) has gained popularity for its potential to improve metabolism and promote longevity. However, the role of gut microbiota in DR has been less explored. This review discusses the effects of different DR patterns on the gut microbiota and the underlying mechanisms by which DR affects metabolic health. It also suggests the development of personalized microbiome-directed DR and advanced sequencing technologies for accurate analysis. DR effectively modulates the gut microbiota and improves metabolic syndrome, inflammatory bowel disease, and cognitive impairment. Further research is needed to fully understand the mechanisms behind the benefits of DR.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Aleksandra Mladenovic Djordjevic, Natasa Loncarevic-Vasiljkovic, Efstathios S. Gonos
Summary: It is well established that lifestyle and dietary habits have a significant impact on life span, aging rate, and age-related diseases. Dietary restriction and healthy dietary patterns have been linked to increased survival and longevity, with the ability to modify oxidative stress levels. However, the debate regarding the role of dietary restriction as a golden standard for prolonging life span and ameliorating aging effects continues.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Food Science & Technology
Sepideh Aminzadeh-Gohari, Barbara Kofler, Chiara Herzog
Summary: There is increasing evidence that dietary restriction can extend both lifespan and healthspan, and this is achieved through molecular mechanisms such as removal of senescent cells, metabolic reprogramming, and epigenetic rejuvenation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Hye-Yeon Lee, Bora Lee, Eun-Ji Lee, Kyung-Jin Min
Summary: Dietary restriction (DR) is a widely accepted strategy to increase lifespan and stress resistance in eukaryotic organisms. This study investigated the effects of parental DR on the fitness of their offspring and found that the offspring displayed increased body weight, stress resistance, and lifespan. However, the development and fecundity of the offspring were not affected. Interestingly, parental DR led to a reduction in the feeding rate of their offspring. These findings suggest that the effects of DR can extend to the offspring and should be considered in studies on aging.
Review
Food Science & Technology
Hui Duan, Jinwei Li, Leilei Yu, Liuping Fan
Summary: Dietary restriction can delay aging by regulating nutrient-sensing pathways and gut microbiota. However, the effects of DR regimens on longevity remain controversial, with some studies suggesting that intermittent fasting influences longevity, while others suggest that restricted-carbohydrate or -protein diets determine health and longevity. Individual differences and DR-related factors play a significant role in explaining the controversial effects.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cell Biology
Natasha A. Grande de Franca, Yves Rolland, Sophie Guyonnet, Philipe de Souto Barreto
Summary: The hallmarks of aging are a set of interconnected mechanisms that can be influenced by lifestyle factors, such as dietary strategies. This review aimed to summarize the evidence on the impact of dietary restriction or specific dietary patterns on these hallmarks. Dietary restriction has been shown to modulate genomic instability, proteostasis, nutrient sensing, cellular senescence, and intercellular communication. Limited evidence exists on the role of dietary patterns, with studies mainly focusing on the Mediterranean Diet, plant-based diets, and the ketogenic diet. It is crucial to determine the effects of nutritional strategies on lifespan and healthspan considering feasibility, long-term adherence, and potential side effects.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Smilja Todorovic, Valentina Simeunovic, Milica Prvulovic, Tamara Dakic, Tanja Jevdjovic, Srdjan Sokanovic, Selma Kanazir, Aleksandra Mladenovic
Summary: Insulin plays a key role in peripheral glucose regulation, but also affects brain function and cognitive performance. Dietary restriction has been shown to delay neurodegenerative processes associated with aging, but the timing and duration of the restriction may be important factors in its effectiveness.
Article
Geriatrics & Gerontology
Ziad S. Mahmassani, Alec McKenzie, Jonathan J. Petrocelli, Naomi M. de Hart, Dennis K. Fix, Joshua J. Kelly, Lisa M. Baird, Michael T. Howard, Micah J. Drummond
Summary: Periods of inactivity in older adults lead to resistance to nutrient metabolism, causing abnormalities in skeletal muscle transcription and translation, which contributes to muscle dysfunction. Leucine can alter the translation of genes related to inactivity, as well as increase the translational efficiency of certain transcripts independent of mRNA abundance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Cell Biology
Maria B. Birkisdottir, Dick Jaarsma, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Sandra Imholz, Conny T. van Oostrom, Bhawani Nagarajah, Eliana Portilla Fernandez, Anton J. M. Roks, Ype Elgersma, Harry van Steeg, Jose A. Ferreira, Jeroen L. A. Pennings, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Martijn E. T. Dolle
Summary: Experimental results show that although dietary restriction and rapamycin can extend the lifespan of some organisms, rapamycin cannot increase the lifespan and healthspan of progeroid DNA repair-deficient mice like dietary restriction does.
Article
Biochemistry & Molecular Biology
Friedrich Becker, Marthe M. Behrends, K. Lenhard Rudolph
Summary: Dietary restriction (DR) is a powerful intervention for improving health and lifespan, but its benefits are limited if started in late life. Research aims to determine if fasting periods are necessary and which dietary components are crucial for the improvement of cellular and organismal functions. The aging process and cellular memory may limit the effectiveness of DR at old age.
Article
Geriatrics & Gerontology
Eleanor J. Phillips, Mirre J. P. Simons
Summary: Dietary restriction and rapamycin treatment have different effects on immune function. Rapamycin treatment improves post-infection survival rate, while dietary restriction may reduce it. These results suggest the potential benefits of rapamycin for the immune system, while caution is needed in considering the immune costs of dietary restriction. Further clinical trials of rapamycin to boost immunity in humans are warranted.
Article
Genetics & Heredity
Zhilei Yin, Xinpeng Guo, Yang Qi, Pu Li, Shujun Liang, Xiangru Xu, Xuequn Shang
Summary: The study shows that dietary restriction and rapamycin treatment can maintain DNA methylation in a younger state, potentially slowing down the aging process. Through functional enrichment analysis, it is found that dietary restriction and rapamycin treatment may delay aging by influencing DNA methylation and gene expression in the same gene and biological process.
Article
Geriatrics & Gerontology
Elif Tugce Karoglu-Eravsar, Melek Umay Tuz-Sasik, Michelle M. Adams
Summary: Using the zebrafish model, research found that dietary restriction can increase healthspan and slow down the effects of aging on cells and synapses. Aging reduces certain protein levels, while different dietary regimens have varying effects.
NEUROBIOLOGY OF AGING
(2021)
Review
Cell Biology
Deeksha Malhan, Britt Schoenrock, Muege Yalcin, Dieter Blottner, Angela Relogio
Summary: Alterations in the circadian system are common in aging on Earth and also observed in astronauts during and after space exploration. However, little is known about the common molecular alterations underlying terrestrial aging and space-related aging. This review focuses on the role of the circadian clock in visual, cardiovascular, central nervous, and musculoskeletal systems and summarizes the known molecular alterations associated with spaceflight.