Editorial Material
Multidisciplinary Sciences
Brita Kilburg-Basnyat
Summary: The student stated that they don't think industry is a good fit because they are not motivated by money. As an industry scientist, this surprised me. I was attending a conference event to help graduate students and postdocs explore career options and connect with professionals from various fields. Most attendees were eager to learn about their options and some were seriously considering industry. I was glad to assist them in figuring out if it was the right path for them and how to get there. The dismissive comment from the student caught me off-guard, however, I suspect others may have felt the same way. After a brief pause, I shared my own journey.
Editorial Material
Geography
Johannes Herburger
Summary: Compactness has been a central element of urban development for over a century, but the current focus on compact cities mainly addresses symptoms of unsustainable development without addressing social inequality. By integrating the concept of centrality with the compact city, a better understanding of compact cities as multi-scalar fields of relations can be achieved.
DIALOGUES IN HUMAN GEOGRAPHY
(2023)
Editorial Material
Neurosciences
Puneet Opal
Summary: Pilotto et al. demonstrate in this study that excitatory/inhibitory imbalance contributes to the development of SCA1. Through in vivo imaging in mice, they show that hyperexcitable molecular layer interneurons overinhibit Purkinje cells, leading to neurodegeneration.
Review
Surgery
Richard Hunger, Barbara Seliger, Shuji Ogino, Rene Mantke
Summary: The study found a significant inverse relationship between the extent of risk adjustment and the volume effect, suggesting the presence of unmeasured confounding and overestimation of volume effects. Data from the research showed that patient-specific factors were the most important influencing factors for short-term mortality.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Surgery
Ryan C. Broderick, Arielle M. Lee, Rachel R. Blitzer, Beiqun Zhao, Jenny Lam, Joslin N. Cheverie, Bryan J. Sandler, Garth R. Jacobsen, Mark W. Onaitis, Kaitlyn J. Kelly, Michael Bouvet, Santiago Horgan
Summary: The study assessed the overall and disease-free survival of patients undergoing salvage esophagectomy compared to planned esophagectomy. It found that while salvage esophagectomy had comparable outcomes in survival rates, there was a higher risk of local recurrence associated with it.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Biochemistry & Molecular Biology
Annabelle Wurmser, Srinjan Basu
Summary: This article discusses the relationship between cis-regulatory elements and enhancers, emphasizing the need to shift from a static to a dynamic view of this relationship. Recent studies have revealed the impact of chromatin movement on transcription, highlighting the influence of condensate microenvironments on the chromatin binding kinetics of proteins.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Pediatrics
Juste Lukoseviciute-Barauskiene, Monika Zemaitaityte, Vaida Sumakariene, Kastytis Smigelskas
Summary: Adolescents' perceptions of mental health are not only based on their own emotions and behaviors, but also influenced by their relationships with others. This study used semi-structured, in-depth interviews and thematic analysis to reveal the way adolescents view their mental health.
Article
Obstetrics & Gynecology
Jaden R. Kohn, Anja S. Frost, Anastasia Tambovtseva, Megan Hunt, Katharine Clark, Christina Wilson, Mostafa A. Borahay
Summary: This study aimed to identify the factors that drive total hospital charges for benign hysterectomy. A retrospective cohort study was conducted at five hospitals in Maryland. Patient, perioperative, and hospital characteristics were included as predictor variables in a multiple linear regression model. The results showed that perioperative and hospital factors significantly influenced the total hospital charges for benign hysterectomy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Economics
David Deller, Monica Giulietti, Graham Loomes, Catherine Waddams Price, Anna Moniche, Joo Young Jeon
Summary: Many consumers are not taking advantage of lower energy prices in liberalized retail markets. Factors inhibiting switching were identified and the expectation of high switching rates in unregulated markets may be unrealistic. The findings have implications for energy market design and regulation, including the imposition of price caps on default retail tariffs in the UK and parts of Australia in 2019.
Review
Cell Biology
Anees Rahman Cheratta, Faisal Thayyullathil, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Sehamuddin Galadari
Summary: The tumor suppressor Par-4, in addition to its role as an apoptosis inducer, has new functions in regulating autophagy, senescence, and metastasis. Understanding the increasing mechanisms of Par-4 reveals how its interaction with different regulators influences cell fate. The emergence of a new secretory pathway and its clinical implications are also discussed in this review.
CELL DEATH & DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Nikhil Panda, Larisa Shagabayeva, Cameron E. Comrie, Nicole Phan, Philicia Moonsamy, Chi-Fu Jeffrey Yang, Felix G. Fernandez, Christopher R. Morse
Summary: This study found that the costs of minimally invasive esophagectomy are mainly influenced by preoperative risk factors and postoperative outcomes. The main predictors of operative costs include age, body mass index, forced expiratory volume in 1 second, and year of surgery, while predictors of postoperative costs include postoperative renal failure, respiratory failure, pneumonia, and reoperation.
ANNALS OF THORACIC SURGERY
(2022)
Article
Gastroenterology & Hepatology
Heikki Huhta, Minna Nortunen, Sanna Merilainen, Olli Helminen, Joonas H. Kauppila
Summary: Higher annual hospital volume of pancreatic surgery is associated with improved short- and long-term survival for pancreatic ductal adenocarcinoma.
Article
Surgery
Elisa Bannone, Giovanni Marchegiani, Giampaolo Perri, Giuseppa Procida, Pier Giuseppe Vacca, Alice Cattelani, Roberto Salvia, Claudio Bassi
Summary: Postoperative serum hyperamylasaemia (POH) may lead to higher postoperative burden, especially when occurring simultaneously with postoperative pancreatic fistula (POPF). Risk factors for additional POPF, once POH has occurred, include body mass index, male sex, increased amylase in drain fluid postoperatively, and elevated C-reactive protein levels.
Article
Surgery
Hillary Lia, Melanie Hammond Mobilio, Frank Rudzicz, Carol-Anne Moulton
Summary: Surgeons can improve intraoperative teamwork by actively utilizing structured communication tools such as the surgical safety checklist (SSC). Surgeons who engage with their team and facilitate group discussion using the SSC are able to prevent tensions that may arise from lack of situation awareness and familiarity with team member experience levels. By harnessing their role as leaders and utilizing the SSC effectively, surgeons can create a better team environment.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Lauren M. Perry, Sarah B. Bateni, Richard J. Bold, Jeffrey S. Hoch
Summary: The study found that patients undergoing pancreatic surgery at high-volume centers experienced a 5.4-month survival benefit, with an additional cost of $17,529 per year of survival. For decision-makers willing to pay more than $20,000 for an additional year of life, high-volume centers appear to be cost-effective in improving survival outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Pediatrics
Sonia Singh, Franz E. Babl, Stephen J. C. Hearps, Jeffrey S. Hoch, Kim Dalziel, John A. Cheek
Summary: The incidence of paediatric head injuries in Australia has significantly increased over the past five years, with acute care costs reaching $154 million. Falls are the most common mechanism of injury, accounting for 47% of acute care costs, followed by transportation-related injuries at 35%. Population-based efforts for road safety and injury prevention are crucial.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Article
Pediatrics
Sonia Singh, Franz E. Babl, Li Huang, Stephen Hearps, John Alexander Cheek, Jeffrey S. Hoch, Vicki Anderson, Kim Dalziel
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Public, Environmental & Occupational Health
Anna Finnes, Jeffrey S. Hoch, Pia Enebrink, JoAnne Dahl, Ata Ghaderi, Anna Nager, Inna Feldman
Summary: This study assessed the long-term cost-effectiveness of acceptance and commitment therapy (ACT), a workplace dialog intervention (WDI), and ACT+WDI compared to treatment as usual (TAU) for common mental disorders, and investigated any differences in cost-effectiveness between diagnostic groups.
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
(2022)
Review
Economics
Blanchard Conombo, Jason R. Guertin, Pier-Alexandre Tardif, Marc-Aurele Gagnon, Cecile Duval, Patrick Archambault, Simon Berthelot, Francois Lauzier, Alexis F. Turgeon, Henry T. Stelfox, Michael Chasse, Jeffrey S. Hoch, Belinda Gabbe, Howard Champion, Fiona Lecky, Peter Cameron, Lynne Moore
Summary: This research systematically reviewed the economic value of in-hospital clinical practices in acute injury care and found that almost half of the clinical interventions studied in acute injury care may not be cost-effective. Additionally, the study identified more cost-effectiveness research in certain medical fields.
Article
Pediatrics
Sonia Singh, Stephen Hearps, Daniel K. Nishijima, John Alexander Cheek, Meredith Borland, Stuart Dalziel, James Holmes, Nathan Kuppermann, Franz E. Babl, Jeffrey S. Hoch
Summary: The study found that planned observation in children with minor head trauma is cost-effective for reducing CT use, especially for those in the PECARN intermediate-risk and high-risk categories.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Health Care Sciences & Services
Helen McTaggart-Cowan, Madeleine T. King, Richard Norman, Daniel S. J. Costa, A. Simon Pickard, Rosalie Viney, Stuart J. Peacock
Summary: The Canadian value set for FACT-8D derived from a discrete choice experiment showed that pain, nausea, and work problems have the largest impact on utility, and the worst possible health state has a utility score considerably worse than being dead. This provides important insights and foundation for cancer research and evaluation.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Mathematical & Computational Biology
Shuai Chen, Jeffrey S. Hoch
Summary: This study focuses on methods for censored cost-effectiveness data in the context of new medical interventions evaluation. The proposed methods include the net-benefit regression framework and a doubly robust estimator for average causal incremental net benefit, showing valid inference in observational studies. Extensive numerical studies confirm the finite-sample performance of these methods and demonstrate their application with real data examples.
STATISTICS IN MEDICINE
(2022)
Review
Health Care Sciences & Services
Lynne Moore, Jason Robert Guertin, Pier-Alexandre Tardif, Noah Michael Ivers, Jeffrey Hoch, Blanchard Conombo, Jesmin Antony, Henry Thomas Stelfox, Simon Berthelot, Patrick Archambault, Alexis Turgeon, Rohit Gandhi, J. M. Grimshaw
Summary: This study aimed to assess the economic benefits of audit and feedback (A&F) interventions for improving compliance to healthcare guidelines. The findings suggest that A&F interventions may have a high potential for cost-effectiveness, especially in studies based on health outcomes and with high reporting quality. However, publication bias may have led to an overestimation of their economic value.
BMJ QUALITY & SAFETY
(2022)
Article
Immunology
Sheeva Johnson, Jeffrey S. Hoch, Wissam J. Halabi, Jeffrey Ko, Jan Nolta, Maneesh Dave
Summary: This study developed a decision tree model to compare the cost-effectiveness of MSCs and FD for pCD, and found that both autologous and allogeneic MSCs are more cost-effective than FD. Even in the worst-case scenario, MSCs still save costs compared to FD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Cheryl Forchuk, Abraham Rudnick, Deborah Corring, Daniel Lizotte, Jeffrey S. S. Hoch, Richard Booth, Barbara Frampton, Rupinder Mann, Jonathan Serrato
Summary: This mixed-method study evaluated a smart home technology intervention for people living in the community with mental illness and physical comorbidities, providing appropriate support in the home and health monitoring capabilities for healthcare providers. Thirteen participants were recruited and provided with smartphones, touchscreen monitors, and health devices. Descriptive statistics showed improvements in physical and mental health, as well as enhanced communication with care providers and friends/family. The study also addressed technical difficulties, ethics analyses, policy implications, and economic costs.
Review
Psychiatry
Jiyeong Kim, Lois M. D. Aryee, Heejung Bang, Steffi Prajogo, Yong K. Choi, Jeffrey S. Hoch, Elizabeth L. Prado
Summary: This systematic review and meta-analysis aimed to evaluate the effectiveness of digital mental health interventions in reducing depression and anxiety symptoms in low- and middle-income countries (LMICs). The findings showed that digital mental health tools were moderately to highly effective in reducing depression and anxiety symptoms in LMICs.
JMIR MENTAL HEALTH
(2023)
Article
Oncology
Jiyeong Kim, Eleni Linos, Debra A. Fishman, Melanie S. Dove, Jeffrey S. Hoch, Theresa H. Keegan
Summary: This study aims to assess the prevalence of online patient-provider communication (OPPC) during COVID-19 among cancer survivors and adults without a history of cancer. The results showed an increase in the use of email/internet and electronic health records for communication among cancer survivors during COVID-19. However, certain vulnerable subgroups had lower rates of OPPC, such as those with low income, no usual source of care, or reporting depression.
Article
Oncology
Heather K. Barr, Andrea M. Guggenbickler, Jeffrey S. Hoch, Carolyn S. Dewa
Summary: This paper discusses the cost-effectiveness analysis of new cancer treatments in real-world settings and the statistical uncertainty that often accompanies the results. It identifies five methods to characterize statistical uncertainty and explores their usage in previous studies. Understanding the necessity and meaning of uncertainty in real-world cost-effectiveness analysis can improve patient outcomes.
Meeting Abstract
Oncology
G. Mitera, C. Earle, J. S. Hoch, M. Dobrow
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Jeffrey S. Hoch, Heather K. Barr, Andrea M. Guggenbickler, Carolyn S. Dewa
Summary: This study examines the cost-effectiveness and potential impact of smoking cessation programs (SCPs) for cancer patients. The findings suggest that SCPs can be an economically attractive way to improve outcomes for cancer patients when offered alongside standard cancer care.