Article
Oncology
Amanda L. Nash, Diane L. Bloom, Brittany M. Chapman, Stephanie B. Wheeler, Kandace P. McGuire, Clara N. Lee, Kevin Weinfurt, Donald L. Rosenstein, Jennifer K. Plichta, Julie C. Jacobson Vann, E. Shelley Hwang
Summary: This study explored the experiences of the partners of women who undergo CPM. Most partners hoped their wives would choose a bilateral mastectomy, but the final decision was up to the women. The male partners had difficulty understanding the physical and emotional changes of mastectomy, making communication about sexuality and intimacy challenging.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Damiano Gentile, Agnese Losurdo, Andrea Sagona, Monica Zuradelli, Wolfgang Gatzemeier, Erika Barbieri, Alberto Testori, Valentina Errico, Paolo Bianchi, Ersilia Biondi, Rosalba Torrisi, Armando Santoro, Corrado Tinterri
Summary: This study compared the oncological outcomes of BRCA-mutation carriers treated with breast-conserving therapy (BCT) or mastectomy. It also analyzed the role of bilateral salpingo-oophorectomy (BSO) and identified independent predictive factors for BC treatment. The results showed that there was no significant difference in disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS) between patients treated with BCT or mastectomy. Patients treated with BSO had better DDFS and OS compared to ovarian conservation. Three predictive factors for BCT were identified: age <= 41 years, genetic testing performed post-operatively, and breast tumors <= 21 mm.
Article
Surgery
Hannah Kapur, Rebecca Warburton, Jin-Si Pao, Carol Dingee, Leo Chen, Elaine McKevitt
Summary: Contralateral prophylactic mastectomy (CPM) is not recommended for average-risk women with breast cancer due to lack of evidence for survival benefit, yet recent studies demonstrate increasing CPM rates. Patients receiving CPMs tend to have higher reconstruction rates and be younger in age.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Alison S. Baskin, Ton Wang, Brooke C. Bredbeck, Brandy R. Sinco, Nicholas L. Berlin, Lesly A. Dossett
Summary: For women with small, unilateral breast cancer, most are suitable candidates for breast conserving surgery (BCS) but a significant portion opt for mastectomy, with a rising percentage choosing contralateral prophylactic mastectomy (CPM). Factors such as patient characteristics, tumor attributes, and facility features may influence the decision-making regarding CPM.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Oncology
Marjanka K. Schmidt, Jennifer E. Kelly, Anne Bredart, David A. Cameron, Jana de Boniface, Douglas F. Easton, Birgitte Offersen, Fiorita Poulakaki, Isabel T. Rubio, Francesco Sardanelli, Rita Schmutzler, Tanja Spanic, Britta Weigelt, Emiel J. T. Rutgers
Summary: After a unilateral breast cancer diagnosis, more and more patients are choosing to have contralateral prophylactic mastectomy (CPM), the removal of the healthy breast. Breast cancer specialists need to provide guidance to women considering CPM. This manifesto discusses the challenges of CPM and offers recommendations to improve outcomes for women with unilateral breast cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Anita Mamtani, Daniel D. D. Sjoberg, Alain Vincent, Behfar Ehdaie, Deepak Malhotra, Andrew Vickers, Monica Morrow
Summary: Despite the lack of oncologic benefit, the use of contralateral prophylactic mastectomy (CPM) among women with unilateral breast cancer is increasing. This trend is driven by patient fears of recurrence and desire for peace of mind. Traditional educational strategies have been ineffective in reducing CPM rates.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Jennifer Q. Zhang, Carlos Henrique Dos Anjos, Varadan Sevilimedu, Angelena Crown, Kimberly A. Amoroso, Melissa L. Pilewskie, Mark E. Robson, Mary L. Gemignani
Summary: This study identified a high rate of contralateral prophylactic mastectomy (CPM) among breast cancer patients with ATM, CHEK2, and PALB2 gene alterations, including variants of uncertain significance (VUS). Premenopausal status and pathogenic alterations were associated with an increased use of CPM.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Akshara Singareeka Raghavendra, Hala F. Alameddine, Clark R. Andersen, Jesse C. Selber, Abenaa M. Brewster, Carlos H. Barcenas, Abigail S. Caudle, Banu K. Arun, Debu Tripathy, Nuhad K. Ibrahim
Summary: Partners, physicians, and the media significantly influence women with unilateral breast cancer's decision to undergo CPM surgery, with physicians having a greater influence and partners and the media having a lower influence compared to self-determination. Educational aids and programs are needed to help women make informed decisions regarding CPM efficacy.
Article
Oncology
Peter J. Krasniak, Minh Nguyen, Sarah Janse, Crystal Phommasathit, Kaleigh Clevenger, Savannah Renshaw, Doreen M. Agnese, Tasleem J. Padamsee, Clara N. Lee
Summary: The rate of contralateral prophylactic mastectomy (CPM) is increasing in the U.S. among patients with non-familial, unilateral breast cancer, despite no survival benefit. This study aimed to assess the impact of emotions on a patient's decision to undergo CPM.
Review
Surgery
Katherine B. Santosa, Jeremie D. Oliver, Adeyiza O. Momoh
Summary: Contralateral prophylactic mastectomy (CPM) rates in the United States have been on the rise, influenced by multiple factors. The authors have shed light on the current state and summarized the literature, outlining future directions for research and knowledge dissemination.
Review
Surgery
Alexander Murphy, Paul A. Asadourian, Joseph A. Mellia, Christine H. Rohde
Summary: This study suggests that the diseased breast is more prone to complications after unilateral plus contralateral prophylactic mastectomy. The complication risk is higher for patients undergoing unilateral plus contralateral prophylactic mastectomy compared to unilateral mastectomy alone, especially for those with no reconstruction, prosthetic-based reconstruction, and autologous reconstruction. Further research is needed to determine the impact of complications on the timing of adjuvant therapy.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Multidisciplinary Sciences
Pol Maria Rommens, Mehdi Boudissa, Sven Kraemer, Miha Kisilak, Alexander Hofmann, Daniel Wagner
Summary: The study found that operative treatment of FFP can reduce mortality rates, although patients in the operative group had longer length of stay and more in-hospital complications. Non-operative patients were more mobile and independent at discharge. Quality of life and mobility were comparable between the groups at follow up.
Article
Oncology
Kelly A. Metcalfe, Andrea Eisen, Aletta Poll, Alexandra Candib, David McCready, Tulin Cil, Frances Wright, Rochelle Demsky, Talia Mancuso, Ping Sun, Steven A. Narod
Summary: This study found that women use risk assessment and negative BRCA1/BRCA2 genetic test results to guide their surgical decisions. The uptake of CPM decreased for women who were initially considering CPM before genetic testing after receiving a negative BRCA1/BRCA2 genetic test result. The study also showed that the mother's breast cancer status influenced the decision to undergo CPM.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Public, Environmental & Occupational Health
J. Jansen, A. Serafimovska, R. Glassey, N. Zdenkowski, C. Saunders, D. Porter, P. Butow
Summary: The study found that a decision aid about contralateral prophylactic mastectomy is feasible and acceptable, but there are questions regarding the role of decision aids in situations where one option has limited medical benefit. Some patients have a high need for information to make an informed decision, indicating a need for more support tools in these types of decisions.
PATIENT EDUCATION AND COUNSELING
(2022)
Review
Oncology
Josien C. C. Scheepens, Laura van 't Veer, Laura Esserman, Jeff Belkora, Rita A. Mukhtar
Summary: Research evaluates the evidence for contralateral prophylactic mastectomy (CPM), patient rationales for choosing CPM, and factors that may impact patient preferences. Studies indicate a significant gap between patient preferences for radical risk reduction with CPM and the current approaches recommended by important guidelines.