Article
Gastroenterology & Hepatology
K. Rajender Reddy, Dale McLerran, Tracey Marsh, Neehar Parikh, Lewis R. Roberts, Myron Schwartz, Mindie H. Nguyen, Alex Befeler, Stephanie Page-Lester, Runlong Tang, Sudhir Srivastava, Jo Ann Rinaudo, Ziding Feng, Jorge A. Marrero
Summary: This is the largest prospective and geographically diverse study of a U.S. cohort of patients with cirrhosis, validating known risk factors for HCC.
Article
Chemistry, Multidisciplinary
Bozhao Li, Xiuping Zhang, Zhouliang Wu, Tianjiao Chu, Zhenlin Yang, Shuai Xu, Suying Wu, Yunkai Qie, Zefang Lu, Feilong Qi, Minggen Hu, Guodong Zhao, Jingyan Wei, Yuliang Zhao, Guangjun Nie, Huan Meng, Rong Liu, Suping Li
Summary: A wound-targeted nanodrug has been developed to decrease the risk of relapse after hepatocellular carcinoma (HCC) surgery, leading to improved 5-year survival rate. This nanodrug combines an immune checkpoint inhibitor and an angiogenesis inhibitor to effectively target the surgical margin and inhibit HCC relapse. Animal studies have shown promising results in terms of anti-tumor effects and overall survival.
Review
Biochemistry & Molecular Biology
Clare E. Weeden, William Hill, Emilia L. Lim, Eva Gronroos, Charles Swanton
Summary: The recent discovery of oncogenic cells in healthy tissues and the prevalence of indolent cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than previously thought. Understanding how this defense is overcome to trigger tumorigenesis and why cancer is so rare at the cellular level is vital to future prevention therapies.
Article
Gastroenterology & Hepatology
Grace L. Su, Osama Altayar, Robert O'Shea, Raj Shah, Bassam Estfan, Candice Wenzell, Shahnaz Sultan, Yngve Falck-Ytter
Summary: This article presents the research and recommendations for systemic therapies for HCC, providing evidence-based guidelines for patients.
Article
Multidisciplinary Sciences
Rui Wang, Jinhu Zhu, Shu Yang, Xiaoqin Chen, Cairu Gu, Tong Liang, Ling Li, Dan Liu, Yanqing Cao
Summary: The study investigated the efficacy of I-125 seed implantation for pelvic recurrence after early cervical cancer surgery and identified it as an effective, safe, and promising treatment method. The diameter of the recurrent pelvic tumour was identified as a significant independent prognostic factor in patients who received I-125 implantation.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Ah Hwang, Ji Hye Min, Tae Wook Kang, Woo Kyoung Jeong, Young Kon Kim, Seong Eun Ko, Seo-Youn Choi
Summary: The study identified independent imaging and histopathologic factors affecting the washout appearance of hepatocellular carcinoma (HCC) in CT images, including hepatic steatosis, tumor capsule, and mosaic appearance on CT image. Additionally, CT-diagnosed hepatic steatosis was found to be an independent factor for the absence of washout appearance of HCC.
EUROPEAN RADIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yingqi Feng, Wei Wu, Muzi Li
Summary: Metal organic frameworks (MOFs) have potential applications in cancer therapy, including enhancing the anticancer effects of photodynamic therapy and photothermal therapy, as well as drug delivery and protection. However, there is a lack of reviews on the application of MOFs in hepatocellular carcinoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Alberto Zanetto, Marco Senzolo, Elena Campello, Cristiana Bulato, Sabrina Gavasso, Sarah Shalaby, Martina Gambato, Alessandro Vitale, Umberto Cillo, Fabio Farinati, Francesco Paolo Russo, Paolo Simioni, Patrizia Burra
Summary: The study reveals a significant association between altered platelet function and hepatocellular carcinoma in patients with cirrhosis, suggesting the potential benefit of inhibiting hyper-functional platelets. The differences in platelet function may have important clinical implications for treatment.
Review
Gastroenterology & Hepatology
Katherine A. McGlynn, Jessica L. Petrick, Hashem B. El-Serag
Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), is a major global health concern. While HBV and HCV remain important risk factors for HCC, efforts in vaccination and treatment are showing promise. However, the increasing prevalence of metabolic risk factors like obesity and diabetes, as well as other factors like excessive alcohol consumption, present ongoing challenges in the prevention of liver cancer.
Review
Medicine, Research & Experimental
Enjun Lv, Jiaqi Sheng, Chengpeng Yu, Dean Rao, Wenjie Huang
Summary: Long noncoding RNAs (lncRNAs) have gained widespread attention as new and crucial molecules involved in biological function regulation, particularly in tumor metastasis such as hepatocellular carcinoma; despite the incomplete understanding of their mechanisms, lncRNAs have been shown to be closely associated with various stages of tumor growth, invasion, and metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Jana M. Kobeissi, Lara Hilal, Charles B. Simone, Haibo Lin, Christopher H. Crane, Carla Hajj
Summary: This review provides a concise and comprehensive summary on the use of proton therapy in the management of hepatocellular carcinoma (HCC). Proton radiation therapy plays a central role in the treatment of HCC, and evidence suggests it may be superior to photons in terms of survival and toxicity outcomes.
Review
Oncology
Jessica Elderkin, Najeeb Al Hallak, Asfar S. Azmi, Hussein Aoun, Jeffrey Critchfield, Miguel Tobon, Eliza W. Beal
Summary: Hepatocellular carcinoma is the most common primary liver cancer. High-risk patients should be monitored semi-annually. The management of HCC is complex and requires a multidisciplinary team evaluation. Early-stage cancer is best treated with curative-intent treatment methods, while intermediate-stage and advanced-stage require different approaches.
Article
Oncology
Mohd Yasser, Silvia Ribback, Katja Evert, Kirsten Utpatel, Katharina Annweiler, Matthias Evert, Frank Dombrowski, Diego F. F. Calvisi
Summary: Our electron microscopic findings suggest that plasmid transfer to hepatocytes may occur through active or passive endocytosis, with plasmids being trapped in membrane-bound vesicles and vacuoles. We observed vacuole formation in the proximity of the nucleus, which is believed to be the site of DNA-entry. However, the exact mechanisms by which plasmids are incorporated into hepatocytes and how vesicle generation is involved remain unclear.
Review
Pharmacology & Pharmacy
Jiahui Yu, Mengnan Li, Boxu Ren, Le Cheng, Xiaoxiao Wang, Zhaowu Ma, Wei Peng Yong, Xiaoguang Chen, Lingzhi Wang, Boon Cher Goh
Summary: This article summarizes the factors influencing the effectiveness of immunotherapy in HCC treatment, identifies potential combination therapies that may improve patient response rates to ICIs, and offers an overview of ongoing clinical trials focusing on ICI-based combination therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Gastroenterology & Hepatology
Hai-Tao Zhao, Jian-Qiang Cai
Summary: Low resection and high recurrence rates in HCC present challenges, with neoadjuvant and conversion therapies offering safe, feasible, and effective strategies. A consensus among Chinese experts aims to standardize the application of these therapies for managing HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)