Article
Surgery
Sa-Hong Min, Yongjoon Won, Kanghaeng Lee, Sang Il Youn, Guowei Kim, Young Suk Park, Sang-Hoon Ahn, Joong Do Park, Hyung-Ho Kim
Summary: Radical gastrectomy with metastasectomy may have a potential role in stage IV gastric cancer patients. Laparoscopic gastrectomy with metastasectomy in selected stage IV gastric cancer patients is safe and feasible.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Yoojoo Lim, Songji Choi, Hyeon Jeong Oh, Chanyoung Kim, Sanghoon Song, Sukjun Kim, Heon Song, Seonwook Park, Ji-Won Kim, Jin Won Kim, Jee Hyun Kim, Minsu Kang, Sung-Bum Kang, Duck-Woo Kim, Heung-Kwon Oh, Hye Seung Lee, Keun-Wook Lee
Summary: This study evaluated the clinical significance of AI-powered spatial TIL analysis using a single H&E-stained whole-slide image for predicting prognosis in stage II-III colon cancer. The results showed that AI-powered TIL analysis can provide prognostic information in a practical manner.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Xianping Liu, Xiao Li, Chao Zhang, Jian Jin, Zhenfan Wang, Rongxin Xiao, Kunkun Sun, Jun Wang, Wenzhao Zhong, Fan Yang
Summary: The study found that EGFR mutation is not an independent prognostic factor for postoperative recurrence in completely resected NSCLC patients, and does not affect the risk of CNS metastasis. However, the hazard curve for CNS metastasis recurrence in the EGFR mutation group shows that peak risks occur later compared to the EGFR wild type group.
Article
Oncology
Steven L. Morrison, Gang Han, Faith Elenwa, John T. Vetto, Graham Fowler, Stanley P. Leong, Mohammed Kashani-Sabet, Barbara A. Pockaj, Heidi E. Kosiorek, Jonathan S. Zager, Vernon K. Sondak, Jane L. Messina, Nicola Mozzillo, Schlomo Schneebaum, Dale Han
Summary: This multicenter retrospective study assessed the predictive and prognostic value of tumor-infiltrating lymphocytes (TILs) in melanoma. The study found that the presence of TILs predicted a negative sentinel lymph node biopsy and the absence of TILs may indicate worse survival in patients with a positive sentinel lymph node. TILs can also serve as a prognostic marker of survival when the sentinel lymph node status is not considered.
Article
Multidisciplinary Sciences
Jae Hun Shin, Jaekwang Jeong, Stephen E. Maher, Heon-Woo Lee, Jaechul Lim, Alfred L. M. Bothwell
Summary: Cancer cells acquire lymphocyte membrane proteins through trogocytosis, leading to an immunosuppressive tumor microenvironment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
James Larkin, Michele Del Vecchio, Mario Mandala, Helen Gogas, Ana M. Arance Fernandez, Stephane Dalle, Charles Lance Cowey, Michael Schenker, Jean -Jacques Grob, Vanna Chiarion-Sileni, Ivan Marquez-Rodas, Marcus O. Butler, Anna Maria Di Giacomo, Mark R. Middleton, Jose Lutzky, Luis de la Cruz-Merino, Petr Arenberger, Victoria Atkinson, Andrew G. Hill, Leslie A. Fecher, Michael Millward, Paul D. Nathan, Nikhil I. Khushalani, Paola Queirolo, Corey Ritchings, Maurice Lobo, Margarita Askelson, Hao Tang, Sonia Dolfi, Paolo A. Ascierto, Jeffrey Weber
Summary: The study demonstrates that adjuvant nivolumab significantly improves recurrence-free survival and distant metastasis-free survival in high-risk melanoma patients who have undergone surgical resection, with sustained long-term benefits. Biomarkers such as tumor mutational burden, tumor PD-L1, intratumoral CD8+ T cells and IFNy-associated gene expression signature are associated with improved treatment outcomes, but their predictive value is limited.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
B. Saberzadeh-Ardestani, N. R. Foster, H. E. Lee, Q. Shi, S. R. Alberts, T. C. Smyrk, F. A. Sinicrope
Summary: The study found that the association of TIL densities with patient survival varies by primary tumor sidedness and clinical risk group in stage III colon cancer, with a higher contribution of TILs to DFS in right-sided tumors, especially in high-risk patients.
ANNALS OF ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinying Wang, Shohei Asami, Daisuke Kitamura
Summary: Evidence suggests a correlation between tumor infiltrating B cells (TiBcs) and a good prognosis for cancer. In experiments, TiBcs have shown potential for cell-mediated immunotherapies and were able to suppress tumor growth and extend survival in mouse models.
Article
Medicine, General & Internal
Liyu Su, Shen Zhao, Yi Yin, Feng Huang, Jinfeng Zhu, Luchuan Chen, Rongbo Lin
Summary: This study aims to compare the efficacy of triplet and doublet regimens in the treatment of stage III gastric cancer, and the results will provide important clinical evidence for postoperative treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Hon-Yi Lin, Chih-Chia Yu, Chen-Lin Chi, Chang-Kuo Wei, Wen-Yao Yin, Chih-En Tseng, Szu-Chin Li
Summary: This study evaluated the prognostic value of PADI2 protein expression in biliary tract cancer (BTC) patients. The results showed that high PADI2 expression was associated with shorter PFS, DSS, and OS. Therefore, PADI2 protein expression can serve as an independent poor prognostic factor for BTC patients.
Article
Pathology
Marta Mendiola, Teijo Pellinen, Jorge L. Ramon-Patino, Alberto Berjon, Oscar Bruck, Victoria Heredia-Soto, Riku Turkki, Javier Escudero, Annabrita Hemmes, Luis E. Garcia de la Calle, Roberto Crespo, Alejandro Gallego, Alicia Hernandez, Jaime Feliu, Andres Redondo
Summary: The study showed that T-cell infiltration plays a significant prognostic role in early-stage endometrial carcinoma, with CD3+ PD-1+ stromal cells emerging as a promising novel prognostic biomarker. Specifically, the high stromal T-cell fraction of CD3+ PD-1+ cells was associated with a 5-year relapse-free survival rate of 93.7%, highlighting their prognostic significance in predicting patient outcomes.
Article
Surgery
Emily Z. Ma, Julia H. Terhune, Zafar Zafari, Kyle W. Blackburn, John A. Olson, C. Daniel Mullins, Yinin Hu
Summary: Universal adjuvant therapy for stage IIIA melanoma is costly and provides limited clinical benefit in patients older than 75 years.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Surgery
Dong Zhou, Quan-Xing Liu, Hong Zheng, Xiao Lu, Ji-Gang Dai
Summary: This study aimed to analyze the impact of radiotherapy on overall survival and disease-free survival in thymoma patients. The results showed that postoperative radiotherapy did not significantly improve survival outcomes for stage II thymoma patients, but it did have a beneficial effect on disease-free survival for stage III thymoma patients.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Oncology
Akikazu Yago, Shusuke Haruta, Masaki Ueno, Yosuke Hamada, Yusuke Ogawa, Yu Ohkura, Masayuki Urabe, Harushi Udagawa
Summary: This study found that the appropriate follow-up duration for resected gastric cancer may vary by stage. While the follow-up duration for stage I disease could potentially be shortened to less than 5 years, advanced gastric cancer such as stage III or IV disease has a risk of recurrence beyond 5 years and therefore requires additional follow-up.
Article
Cell Biology
Joerg Lindenmann, Melanie Fediuk, Nicole Fink-Neuboeck, Iurii Mykoliuk, Elisabeth Taucher, Martin Pichler, Josef Smolle, Freyja Maria Smolle-Juettner
Summary: Chronic obstructive pulmonary disease (COPD) is a risk factor for the development of lung cancer and has prognostic impact after surgery for non-small cell lung cancer (NSCLC). This study aimed to investigate the impact of COPD and postoperative mucostasis on long-term survival after resected NSCLC. The analysis of 342 patients showed that postoperative mucostasis, but not COPD, was associated with worse overall survival, recurrence-free survival, and cancer-specific survival after curative resection of NSCLC.
Article
Surgery
Youngbae Jeon, Kyoung-Won Han, Won-Suk Lee, Jeong-Heum Baek
Summary: This study evaluated the clinical outcomes of surgical treatment for nonagenarian patients with colorectal cancer, showing that surgery can be considered in carefully selected patients due to better overall survival compared to nonsurgical treatment.
Article
Biochemistry & Molecular Biology
Jaekyung Jung, Yeon-Hwa Lee, Xizhu Fang, Su-Jung Kim, Seong Hoon Kim, Do-Hee Kim, Na-Young Song, Hye-Kyung Na, Jeong-Heum Baek, Young-Joon Surh
Summary: IL-1β-induced upregulation of SIRT1 stimulates the production of proinflammatory cytokines via nuclear accumulation of c-Jun, leading to the growth and progression of colon cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Ha-Na Lee, Yeon-Seo Choi, Seong Hoon Kim, Xiancai Zhong, Wonki Kim, Joon Sung Park, Soma Saeidi, Byung Woo Han, Nayoung Kim, Hye Seung Lee, Yoon Jin Choi, Jeong-Heum Baek, Hye-Kyung Na, Young-Joon Surh
Summary: The research reveals a decreased level of RvD1 in blood from colorectal cancer patients and mice with inflammation-induced colon cancer, and demonstrates that RvD1 can protect against colorectal carcinogenesis by suppressing IL-6-mediated chromosomal instability. Additionally, RvD1 inhibits the STAT3 signaling pathway by blocking the IL-6 receptor, suggesting a potential novel function of RvD1 as an IL-6R antagonist that may contribute to inhibiting tumorigenesis.
Article
Optics
Jin Woo Baik, Hyojin Kim, Myeongjoo Son, Junwon Choi, Kwang Gi Kim, Jeong Heum Baek, Yeon Ho Park, Jungsuk An, Hae Young Choi, Seon Young Ryu, Jin Young Kim, Kyunghee Byun, Chulhong Kim
Summary: This study demonstrates a novel label-free high-speed reflection-mode ultraviolet photoacoustic microscopy (UV-PAM) system for intraoperative histopathology, showcasing its potential as an alternative method with minimal tissue preparation processes. The system shows promise for quick and accurate tumor margin identification in cancer resection surgeries.
LASER & PHOTONICS REVIEWS
(2021)
Article
Oncology
Jeong-Heum Baek, Youngbae Jeon, Kyoung-Won Han, Dong Hae Jung, Kyung-Ok Kim
Summary: The study evaluated the effect of mistletoe extract on tumor responses in rectal cancer patients undergoing neoadjuvant chemoradiotherapy. Patients treated with mistletoe extract showed better outcomes in terms of tumor responses, indicating potential efficacy in improving oncologic outcomes. Further prospective and randomized studies are needed to confirm and extend these results.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Yeon-Hwa Lee, Su-Jung Kim, Xizhu Fang, Na-Young Song, Do-Hee Kim, Jinyoung Suh, Hye-Kyung Na, Kyung-Ok Kim, Jeong-Heum Baek, Young-Joon Surh
Summary: SIRT1 and its phosphorylated form at serine 27 are upregulated in colon cancer patients' tissues and cells. The phosphorylated form of SIRT1 regulates the activity of Snail and transcription of interleukin by deacetylation, promoting the proliferation and tumor formation of colon cancer cells.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
So-Yeon Park, Jee-Heun Kim, Jang-Hyun Choi, Choong-Jae Lee, Won-Jae Lee, Sehoon Park, Zee-Yong Park, Jeong-Heum Baek, Jeong-Seok Nam
Summary: This study highlights the important role of lipid rafts (LRs) in colorectal cancer, where an LR-disrupting alkylphospholipid drug can suppress CSC populations and their self-renewal activities. By inhibiting the LR/CHEK1 axis, the drug forces CSCs to enter inappropriate mitosis, leading to catastrophic cell death.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Jaya Bagaria, Kyung-Ok Kim, Eva Bagyinszky, Seong Soo A. An, Jeong-Heum Baek
Summary: This study aimed to investigate genes responsible for locally advanced rectal cancer patients not reacting to radiotherapy, identifying specific genes more commonly mutated in non-complete response patients and potentially serving as genetic biomarkers for early detection of radiation-resistant rectal cancer patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Youngbae Jeon, Kug Hyun Nam, Seok Won Choi, Tae Sik Hwang, Jeong-Heum Baek
Summary: This study compared the oncologic outcomes between surgical T4 and T3 in pathologic stage IIA right colon cancer patients. It found significant differences in the 5-year overall survival rate and 5-year disease-free survival rate between the two groups, with surgical T4 being an independent predictive factor for recurrence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Xizhu Fang, Yeon-Hwa Lee, Jeong-Hoon Jang, Su-Jung Kim, Seong Hoon Kim, Do-Hee Kim, Hye-Kyung Na, Kyung-Ok Kim, Jeong-Heum Baek, Young-Joon Surh
Summary: This study found that ARD1 stabilizes NRF2 by increasing its acetylation levels, thereby enhancing the oncogenic function of NRF2 in human colon cancer.
Article
Oncology
Youngbae Jeon, Sun Jin Sym, Bong Kyu Yoo, Jeong-Heum Baek
Summary: This study evaluated the safety and tolerability of a dietary supplement of G-NLC in patients with colorectal cancer, showing comparable long-term survival outcomes with acceptable toxicity. Further research is needed to establish the efficacy of this treatment regimen.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Spectroscopy
Kyung-Ok Kim, Van-An Duong, Na-Young Han, Jong-Moon Park, Jung Ho Kim, Hookeun Lee, Jeong-Heum Baek
Summary: This study aimed to identify possible biomarkers for predicting the response of rectal cancer patients to neoadjuvant chemoradiotherapy (nCRT). Comparative proteomic analysis was performed on rectal tissue samples before and after nCRT, and several potential biomarkers were identified, including lyso-phosphatidylcholine acyltransferase 2, annexin A13, aldo-ketose reductase family 1 member B1, and cathelicidin antimicrobial peptide.
MASS SPECTROMETRY LETTERS
(2022)
Article
Surgery
Sun-Ho Kwon, Yea-Il Joo, Seon Hahn Kim, Dae Ho Lee, Jeong-Heum Baek, Soon Sup Chung, Ji-Yeon Shin, Chang Soo Eun, Nam Kyu Kim
Summary: This meta-analysis aimed to assess the safety and efficacy of TaTME for rectal cancer in South Korea. Results showed comparable outcomes between TaTME and LaTME, with the benefit of low conversion rate for TaTME.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2021)
Article
Medicine, Research & Experimental
So-Yeon Park, Ji-Young Kim, Gyu-Beom Jang, Jang-Hyun Choi, Jee-Heun Kim, Choong-Jae Lee, Sunjae Lee, Jeong-Heum Baek, Kwan-Kyu Park, Jin-Man Kim, Hee Jin Chang, Nam-Chul Cho, Jeong-Seok Nam
Summary: This study identified an increased expression of CD45 in CRC (EpCAM+) epithelial cells after CRT treatment. High CD45 expression promoted CRC cell survival upon 5-fluorouracil or radiation treatment, while CD45 depletion sensitized CRC cells to CRT. CD45 was found to be preferentially expressed in cancer stem-like cells (CSCs) and played a crucial role in CSC functions such as cancer initiation, repopulation, and metastasis.
Meeting Abstract
Oncology
Joon-Hyop Lee, Jeong-Heum Baek, Young Jae Kim, Kwang-Gi Kim
ANNALS OF SURGICAL ONCOLOGY
(2021)