Article
Oncology
Antoine El Asmar, Florin Pop, Etienne El Helou, Pieter Demetter, Isabelle Veys, Laura Polastro, Ali Bohlok, Gabriel Liberale
Summary: In this retrospective study, it was found that malignant cells were present in 51% of benign-looking peritoneal scar-like tissues (PST) in patients with peritoneal metastases of ovarian cancer (PMOC) undergoing complete cytoreductive surgery (CRS). The presence of malignant cells in PST was associated with poorly differentiated serous tumors, high PCI, and worse disease-free survival (DFS). These findings suggest the need for further investigation into the systematic resection of PST and its prognostic value.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Frederic Schell, Amaniel Kefleyesus, Nazim Benzerdjeb, Guillaume Passot, Pascal Rousset, Alhadeedi Omar, Laurent Villeneuve, Julien Peron, Olivier Glehen, Vahan Kepenekian
Summary: In patients with colorectal cancer peritoneal metastasis, limited extraperitoneal disease involving one site, notably the liver, does not significantly impair postoperative results. However, lymph node invasion is a poor prognostic factor in this population.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Yuanxin Zhang, Xiusen Qin, Wenle Chen, Duo Liu, Jian Luo, Huaiming Wang, Hui Wang
Summary: This meta-analysis identified several risk factors associated with metachronous peritoneal metastases after curative surgery for colorectal cancer, including perforation, poor differentiation, lymph node involvement, mucinous adenocarcinoma, bowel obstruction, synchronous ovarian metastases, elevated serum tumor markers, and positive peritoneal cytology. These factors can guide the development of early detection and proactive treatment strategies for precision medicine.
COLORECTAL DISEASE
(2021)
Review
Oncology
Margot C. E. Polderdijk, Max Brouwer, Leonie Haverkamp, Kirsten A. Ziesemer, Mark Tenhagen, Djamila Boerma, Niels F. M. Kok, Kathelijn S. Versteeg, Dirkje W. Sommeijer, Pieter J. Tanis, Jurriaan B. Tuynman
Summary: This systematic review evaluated the combined local treatment of hepatic and peritoneal metastases in CRC patients. The study found that the treatment led to a mean survival of 26.4 months, with 3-year and 5-year survival rates of 34% and 25% respectively. Surgical complications were more frequent in patients with both types of metastases, but mortality and reoperation rates did not differ significantly.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Antoine El Asmar, Martin Delcourt, Leonel Kamden, Charif Khaled, Ali Bohlok, Michel Moreau, Francesco Sclafani, Vincent Donckier, Gabriel Liberale
Summary: This study aimed to evaluate the prognostic value of preoperative serological biomarkers in patients with PMCRC treated with complete CRS +/- HIPEC. The study found that a higher neutrophil-to-lymphocyte ratio (NLR) was associated with poor overall survival (OS), while a higher platelet-to-lymphocyte ratio (PLR) predicted favorable disease-free survival (DFS).
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Antoine El Asmar, Martin Delcourt, Leonel Kamden, Charif Khaled, Ali Bohlok, Michel Moreau, Francesco Sclafani, Vincent Donckier, Gabriel Liberale
Summary: Preoperative serological biomarkers, specifically a higher neutrophil-to-lymphocyte ratio (NLR) and a higher platelet-to-lymphocyte ratio (PLR), can predict the prognosis of patients with peritoneal metastases of colorectal cancer (PMCRC) treated with complete cytoreductive surgery (CRS) +/- HIPEC.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Annamaria Agnes, Alberto Biondi, Roberto Persiani, Antonio Laurino, Rossella Reddavid, Maurizio De Giuli, Federico Sicoli, Ferdinando Cananzi, Stefano De Pascale, Uberto Fumagalli, Federica Galli, Stefano Rausei, Laura Lorenzon, Domenico D'Ugo
Summary: Two risk models (PERI-Gastric 1 and 2) were developed to assess the risk of peritoneal recurrence after curative-aim gastrectomy, based on multivariable logistic regression results and discrimination evaluation using the area under the receiver operating curve. These models could guide the use of prophylactic treatments.
Review
Oncology
Michael P. Flood, Joseph C. H. Kong, Kasmira Wilson, Helen Mohan, Peadar S. Waters, Jacob J. McCormick, Satish K. Warrier, Jeanne Tie, Robert Ramsay, Michael Michael, Alexander G. Heriot
Summary: This study evaluated the impact of neoadjuvant chemotherapy on perioperative morbidity and mortality, and long-term survival in patients with colorectal peritoneal metastases (CRPM) undergoing cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC). The results showed that neoadjuvant chemotherapy did not increase perioperative morbidity or mortality. Patients who received neoadjuvant chemotherapy had potentially improved 5-year overall survival, although the evidence was limited. The use of neoadjuvant chemotherapy in this setting remains controversial and guided by retrospective evidence.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Sasinthiran Thiagarajan, Joey Wee-Shan Tan, Siqin Zhou, Qiu Xuan Tan, Josephine Hendrikson, Wai Har Ng, Gillian Ng, Ying Liu, Grace Hwei Ching Tan, Khee Chee Soo, Melissa Ching Ching Teo, Claramae Shulyn Chia, Chin-Ann Johnny Ong
Summary: The postoperative inflammatory marker trend did not differ between patients with and without hyperthermic intraperitoneal chemotherapy (HIPEC). Low postoperative LMR (days 4-7), high postoperative NLR (days 8-21), and high postoperative PLR (days 22-56) were optimal for predicting poor 1-year OS, whereas high postoperative PLR and NLR (days 57-90) and low postoperative LMR (days 8-21) were associated with poor 1-year RFS. A composite score of these three markers was prognostic for OS in CPC.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Medicine, General & Internal
Kevin M. Turner, Mackenzie C. Morris, Davendra Sohal, Jeffrey J. Sussman, Gregory C. Wilson, Syed A. Ahmad, Sameer H. Patel
Summary: The peritoneal cavity is a common site of metastasis from colorectal cancer, and patients often have aggressive tumor biology and poor prognosis. Cytoreductive surgery-hyperthermic intraperitoneal chemotherapy is the only effective treatment for suitable patients. The benefit of this treatment is controversial, and current strategies to prevent metastasis in high-risk individuals have been shown to be ineffective.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Ibrahim Said, Inge Ubink, Roos S. G. Ewalds, Johanna G. T. Arkesteijn, Henk M. W. Verheul, Johannes H. W. de Wilt, Helena M. Dekker, Andreas J. A. Bremers, Philip R. de Reuver
Summary: The presence of ascites on preoperative imaging does not indicate worse survival in patients with colorectal peritoneal metastases undergoing cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy. Therefore, excluding patients from this treatment based solely on the presence of ascites is not advisable.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Martina Aida Angeles, Carlos Martinez-Gomez, Mathilde Del, Federico Migliorelli, Manon Daix, Anais Provendier, Muriel Picard, Jean Ruiz, Elodie Chantalat, Helene Leray, Alejandra Martinez, Laurence Gladieff, Gwenael Ferron
Summary: Gastric perforation after CRS is a rare postoperative complication with a high mortality rate, associated with factors such as BMI and splenectomy. However, there seems to be no clear association with HIPEC.
Article
Oncology
Florian Fanget, Amaniel Kefleyesus, Julien Peron, Isabelle Bonnefoy, Laurent Villeneuve, Guillaume Passot, Pascal Rousset, Benoit You, Nazim Benzerdjeb, Olivier Glehen, Vahan Kepenekian
Summary: In this retrospective study, a FOLFIRINOX regimen as NACT seemed to result in better long-term outcomes for CRPM patients after complete CRS/HIPEC, although with higher morbidity.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jan Marie de Gooyer, Fortune M. K. Elekonawo, Andreas J. A. Bremers, Otto C. Boerman, Erik H. J. G. Aarntzen, Philip R. de Reuver, Iris D. Nagtegaal, Mark Rijpkema, Johannes H. W. de Wilt
Summary: In this study, researchers evaluated the safety and feasibility of [In-111]In-DOTA-labetuzumabIRDye800CW, a dual-labeled anti-CEA antibody conjugate, for preoperative and intraoperative imaging in patients with colorectal peritoneal metastases. The results showed that this multimodal imaging approach was well-tolerated and enabled sensitive detection of previously undetected metastases, leading to alterations in clinical strategy.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Malin Ljunggren, Caroline Nordenvall, Gabriella Palmer
Summary: The study showed that patients undergoing direct surgery with CRS-HIPEC for peritoneal metastases from colorectal cancer had a good prognosis, with a median overall survival of over 3 years and disease-free survival of approximately 12.5 months. The findings question the necessity of neoadjuvant chemotherapy in all patients eligible for CRS-HIPEC.
Article
Surgery
K. Houssaini, M. A. Majbar, A. Souadka, O. Lahnaoui, B. El Ahmadi, A. Ghannam, Z. Houssain Belkhadir, R. Mohsine, A. Benkabbou
Summary: Approximately 50 cases are needed to complete the learning curve and improve the overall safety of liver resection. The chronology of the learning curve in our setting is consistent with collective measures, including team stabilization and protocol development.
JOURNAL OF VISCERAL SURGERY
(2022)
Article
Oncology
Farida Selmouni, Laila Amrani, Catherine Sauvaget, Meryem Bakkar, Basma El Khannoussi, Amine Souadka, Amine Benkabbou, Mohammed Anass Majbar, Latifa Belekhel, Eric Lucas, Richard Muwonge, Youssef Chami Khazraji, Raouf Mohsine, Maria Bennani, Rengaswamy Sankaranarayanan, Rachid Bekkali, Partha Basu
Summary: A demonstration project was conducted in Morocco to assess the feasibility and challenges of implementing colorectal cancer screening through primary care facilities. Of the participants, 460 underwent colonoscopy, with the main reasons for noncompliance being competing life priorities, other health problems, and fear of a cancer diagnosis.
Letter
Oncology
Amine Souadka, Hajar Essangri, Nezha El Bahaoui, Abdelilah Ghannam, Brahim El Ahmadi, Amine Benkabbou, Mohammed Anass Majbar, Basma El Khannoussi, Halima Abahssain, Raouf Mohsine, Zakaria Houssain Belkhadir
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Hamza Sekkat, Amine Souadka, Lise Courtot, Ali Rafik, Laila Amrani, Amine Benkabbou, Pierre Peyrafort, Urs Giger-Pabst, Elias Karam, Raouf Mohsine, Anass M. Majbar, Mehdi Ouaissi
Summary: This study aimed to evaluate the accuracy of four predictive scores for conversion to open surgery after rectal laparoscopic resection. The results showed that all four scores had low accuracy. The study suggests the need for further well-designed research analyzing more specific variables to ensure generalizability of the results.
Review
Oncology
Amine Souadka, Hajar Essangri, Mohammed Anass Majbar, Amine Benkabbou, Saber Boutayeb, Benoit You, Olivier Glehen, Raouf Mohsine, Naoual Bakrin
Summary: The umbrella review summarized the outcomes of heated intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) association in ovarian cancer. The study found that the combination of CRS and HIPEC significantly improved overall survival, disease-free survival, and progression-free survival for both primary and recurrent ovarian cancers. This suggests that HIPEC at the end of CRS may be an effective complementary asset for managing ovarian cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Amine Souadka, Hajar Essangri, Amin Makni, Mourad Abid, Mouna Ayadi, Feriel Ksantini, Zakia Kordjani, Yousri Ballah, Jemila Bouka, Amine Benkabbou, Mohammed Anass Majbar, Basma El Khannoussi, Raouf Mohsine, Saber Boutayeb, Martin Hubner
Summary: The management of peritoneal surface malignancy (PSM) in North Africa varies in terms of knowledge, availability of treatments, and priorities. The establishment of referral structures and PSM networks may be necessary to standardize PSM management in the region.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Frederic Dumont, Cecile Loaec, Romuald Wernert, Blandine Maurel, Emilie Thibaudeau, Laurence Vilcot
Summary: This study aimed to identify prognostic factors and determine the optimal extent of surgery for local recurrence following colorectal cancer. The results showed that complete compartmental surgery is safe and improves local control.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Frederic Dumont, Vahan Kepenekian, Valeria De Franco, Clarisse Eveno, Patrick Rat, Charles Sabbagh, Jean-Jacques Tuech, Jean-Marc Bereder, Maxime Gerard, Cecile Loaec, Elodie Martin, Loic Campion, Olivier Glehen
Summary: Multimodal treatment, including perioperative chemotherapy and complete resection, improves survival in patients with peritoneal metastases from colorectal cancer. However, the impact of treatment delays on oncologic outcomes remains uncertain.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Youssef Mahdi, Mouna Khmou, Amine Souadka, Hajar El Agouri, Soumaya Ech-charif, Chaimaa Mounjid, Basma El Khannoussi
Summary: This study reports the largest analysis of NRAS and KRAS status in colorectal metastatic patients in North Africa. The study found that KRAS mutations occurred in approximately 51.7% of tumors, mainly in exon 12, while NRAS mutations were found in only 3% of tumors. The study also found a significant correlation between NRAS mutations and age.
BMC GASTROENTEROLOGY
(2023)
Letter
Oncology
Amine Souadka, Brahim El Ahmadi
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Letter
Oncology
Mohammed Oussama Louafi, Oumayma Lahnaoui, Amine Benkabbou, Mohammed Anass Majbar, Raouf Mohsine, Basma El Khannoussi, Saber Boutayeb, Amine Souadka
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Oumayma Lahnaoui, Hajar Essangri, Nezha El Bahaoui, Mohammed Anass Majbar, Amine Benkabbou, Raouf Mohsine, Amine Souadka
Summary: In ULRC patients, PCPC is a cost-effective alternative to the standard definitive colostomy without alteration of the QOL or additional perineal complications during the first 6 months following the surgery.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Hamza Sekkat, Amine Souadka, Leila Alaoui, Ali Rafik, Zakaria Belkhadir, Laila Amrani, Amine Benkabbou, Raouf Mohsine, Anass Mohammed Majbar
Summary: This study aimed to analyze the learning curve of two millennial surgeons during the implementation of the first laparoscopic rectal cancer surgery program in a low- and middle-income country cancer center. The study found that both surgeons had a safe and short learning curve in terms of operative duration and conversion to open surgery.
JOURNAL OF MINIMAL ACCESS SURGERY
(2023)
Letter
Oncology
Amine Souadka, Saber Boutayeb, Basma El Khannoussi, Hanane El Kacimi, Oumayma Lahnaoui, Amine Benkabbou, Mohammed Anass Majbar, Abdelilah Ghannam, Zakaria Houssain Belkhadir, Raouf Mohsine, Brahim El Ahmadi
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Surgery
Hajar Essangri, Nezha El Bahaoui, Abdelilah Souadka, Mohammed Anass Majbar, Amine Benkabbou, Raouf Mohsine, Amine Souadka
BRITISH JOURNAL OF SURGERY
(2022)