Article
Geriatrics & Gerontology
Stefano Rizza, Pasquale Morabito, Livia De Meo, Alessio Farcomeni, Giulia Testorio, Marina Cardellini, Marta Ballanti, Francesca Davato, Chiara Pecchioli, Giovanni Di Cola, Maria Mavilio, Massimo Federici
Summary: The multidimensional prognostic index (MPI) is a useful tool for predicting mortality in frail older patients, but in a study of 80 hospitalized patients aged 75 and above, only low albumin and high IL6 levels were significantly associated with 3-month all-cause mortality, rather than the MPI score.
Article
Medicine, General & Internal
Dan-Long Zhang, Yu-Xuan Cong, Yan Zhuang, Xin Xu, Bin-Fei Zhang
Summary: This study aimed to evaluate the clinical association between the age-adjusted Charlson comorbidity index (aCCI) and postoperative mortality in elderly patients. After analyzing the data of elderly patients with hip fractures, it was found that the aCCI was associated with mortality, and the mortality risk increased by 31% when the aCCI increased by one unit.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Uri Ladabaum, Ajitha Mannalithara, Manisha Desai, Maanek Sehgal, Gurkirpal Singh
Summary: This population-based study analyzed serious events associated with colonoscopy, finding that most serious non-gastrointestinal events were not directly related to the procedure, but were more common in older individuals. The study results can inform benefit-to-risk assessments for preventive colonoscopies.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Clinical Neurology
Basem Ishak, Sven Frieler, Tarush Rustagi, Alexander von Glinski, Ronen Blecher, Daniel C. Norvell, Andreas Unterberg, Sarah Strot, Jeffrey Roh, Robert A. Hart, Rod Oskouian, Jens R. Chapman
Summary: Patients over 80 years of age with ankylosing spondylitis are at a high risk of early complications and mortality after multilevel spine surgery. In contrast, patients with osteoporosis have lower rates of major complications and mortality.
NEUROSURGICAL FOCUS
(2021)
Article
Geriatrics & Gerontology
Jane Xu, Esmee M. Reijnierse, Jacob Pacifico, Ching S. Wan, Andrea B. Maier
Summary: This study found that sarcopenia and its components were significantly associated with 3-month and 1-year mortality in geriatric rehabilitation inpatients. Differences were observed in the association between muscle abnormalities and mortality rates in females and males.
Article
Infectious Diseases
Marianne Ask Torvik, Stig Haugset Nymo, Stale Haugset Nymo, Lars Petter Bjornsen, Hanne Winge Kvarenes, Eirik Hugaas Ofstad
Summary: A retrospective chart review of deceased adults in a Norwegian hospital found a high prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths. The findings are significant for understanding sepsis-related mortality in similar populations, applicability of study results to clinical work, and future research designs.
Article
Pharmacology & Pharmacy
Andres Enriquez-Gomez, Cristina Ortega-Navarro, Clara Fernandez-Cordon, Pablo Diez-Villanueva, Manuel Martinez-Selles, Ana de Lorenzo-Pinto, Jose M. de Miguel-Yanes
Summary: The study aimed to test a polypharmacy-based scale against Charlson's Comorbidity Index (CCI) in predicting outcomes in chronic complex adult patients post-Emergency Department (ED) visit, finding that the polypharmacy-based scale outperformed the CCI in predicting 6-month mortality. These results were replicated in external validation cohorts.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Surgery
Mohammad Fathi, Nader Markazi Moghaddam, Saba Naderian Jahromi
Summary: This study found that patients with higher body temperatures at the time of postoperative ICU admission have a lower risk of 1-month mortality, while patients with multiple comorbidities and those undergoing multiple operations are at a greater risk of a poor outcome.
Article
Oncology
Jesper Lagergren, Matteo Bottai, Giola Santoni
Summary: Esophagectomy for esophageal cancer in older patients is associated with a slightly higher risk of short-term and long-term mortality. Patients aged 75 years or older have an independent risk factor for higher short-term mortality and lower long-term survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Domenico Scrutinio, Pietro Guida, Maria Aliani, Giorgio Castellana, Patrizia Guido, Mauro Carone
Summary: This study found that comorbidities in patients with severe OSAS are closely related to all-cause mortality, with age and comorbidities being key predictors of death. Recursive-partitioning analysis showed that patients with a combination of CKD and CVD or COPD have the highest mortality risk.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Michael Tan, Neil Pearce, Aurelio Tobias, Mark J. Cook, Wendyl J. D'Souza
Summary: This study aims to determine the contribution of comorbidities to excess psychogenic nonepileptic seizures (PNES) mortality. A retrospective cohort study was conducted to investigate the relationship between comorbidities and PNES mortality. The importance of this study lies in better understanding and managing the bidirectional relationship between these wider somatic treatments and PNES, which could potentially reduce the risk of death.
Article
Surgery
Jee Yeon Lee, Hyejeong Park, Mi Kyoung Kim, Im-kyung Kim
Summary: This study aimed to compare postoperative and clinical outcomes according to age and analyze the effect of age on mortality in patients admitted to the intensive care unit immediately after gastrointestinal cancer surgery. The results showed that although older patients had more comorbidities, there were no significant differences in postoperative and clinical outcomes related to age. Therefore, older patients can successfully undergo major operations if adequate perioperative management is provided.
Article
Cardiac & Cardiovascular Systems
Norma E. Farrow, Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Betty C. Tong, David H. Harpole, Thomas A. D'Amico
Summary: As patients age, survival rates after esophagectomy for locally advanced esophageal cancer decrease significantly. However, esophagectomy is associated with improved survival compared to definitive chemoradiation in most age groups, including octogenarians. Esophagectomy may be considered as a treatment option over chemoradiation regardless of age for patients who can tolerate surgery.
ANNALS OF THORACIC SURGERY
(2021)
Article
Public, Environmental & Occupational Health
Kazzem Gheybi, Elizabeth Buckley, Agnes Vitry, David Roder
Summary: This study explores the association between age and mortality risk in colorectal cancer (CRC) patients. The results indicate that younger age and lower comorbidity are associated with lower all-cause and CRC-specific mortality. Age has a stronger association with mortality in early-stage CRC and rectal cancer compared to advanced-stage CRC and right colon cancer. Only a limited number of comorbidities are associated with CRC-specific mortality. These findings highlight the need for greater attention to factors that contribute to poor prognosis in older individuals.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Elliot D. K. Cha, Conor P. Lynch, Caroline N. Jadczak, Shruthi Mohan, Cara E. Geoghegan, Kern Singh
Summary: This study found that patients undergoing anterior cervical discectomy and fusion (ACDF) for cervical pathology achieved similar rates of reaching minimum clinically important difference (MCID) for VAS neck, VAS arm, NDI, and PROMIS PF regardless of comorbidity burden. ACDF can have significant benefits for patients regardless of their Charlson Comorbidity Index (CCI) score.
Article
Surgery
Laura F. C. Fransen, Thijs H. J. B. Janssen, Martijn Aarnoudse, Grard A. P. Nieuwenhuijzen, Misha D. P. Luyer
Summary: This study aimed to compare the effects of direct oral feeding (DOF) to standard of care in patients who underwent minimally invasive esophagectomy (MIE). The results showed that DOF resulted in faster functional recovery and lower 30-day postoperative complication rate compared to conventional fasting.
Article
Surgery
Marianne C. Kalff, Laura F. C. Fransen, Eline M. de Groot, Suzanne S. Gisbertz, Grard A. P. Nieuwenhuijzen, Jelle P. Ruurda, Rob H. A. Verhoeven, Misha D. P. Luyer, Richard van Hillegersberg, Mark I. van Berge Henegouwen
Summary: This study compared long-term survival between minimally invasive esophagectomy (MIE) and open surgery (OE) for esophageal cancer. The results showed that the long-term survival rates were similar for MIE and OE in patients undergoing transthoracic or transhiatal procedures. MIE resulted in a more extensive lymphadenectomy, but transhiatal MIE had more postoperative complications.
Article
Surgery
Linda Claassen, Gerjon Hannink, Misha D. P. Luyer, Alan P. Ainsworth, Mark I. van Berge Henegouwen, Edward Cheong, Freek Daams, Marc J. van Det, Peter van Duijvendijk, Suzanne S. Gisbertz, Christian A. Gutschow, Joos Heisterkamp, Juha T. Kauppi, Bastiaan R. Klarenbeek, Ewout A. Kouwenhoven, Barbara S. Langenhoff, Michael H. Larsen, Ingrid S. Martijnse, Ernst Jan van Nieuwenhoven, Donald L. van der Peet, Jean-Pierre E. N. Pierie, Robert E. G. J. M. Pierik, Fatih Polat, Jari V. Rusanen, Ioannis Rouvelas, Meindert N. Sosef, Eelco B. Wassenaar, Frits J. H. van den Wildenberg, Edwin S. van der Zaag, Magnus Nilsson, Grard A. P. Nieuwenhuijzen, Frans van Workum, Camiel Rosman
Summary: This study investigated the pooled learning curves of Ivor Lewis totally minimally invasive esophagectomy (TMIE) in European hospitals. It found that centers with higher annual volume had more efficient learning curves, while visiting expert clinics, completing fellowships, or implementing under proctor supervision were not associated with more efficient learning.
Article
Surgery
Yassin Eddahchouri, Frans van Workum, Frits J. H. van den Wildenberg, Mark I. van Berge Henegouwen, Fatih Polat, Harry van Goor, M. Asif Chaudry, E. Cheong, F. Daams, M. J. van Det, C. Gutschow, J. Heisterkamp, R. Van Hillegersberg, A. Holscher, E. A. Kouwenhoven, M. D. P. Luyer, I. S. Martijnse, P. Nafteux, G. A. P. Nieuwenhuijzen, M. Nilsson, P. Pattyn, D. L. van der Peet, J. V. Rasanen, J. P. Ruurda, P. Schneider, W. Schroder, H. van Veer, B. P. L. Wijnhoven, Jean-Pierre E. N. Pierie, Bastiaan R. Klarenbeek, Suzanne S. Gisbertz, Camiel Rosman
Summary: Through Delphi methodology, consensus among European experts was achieved on essential surgical steps for both Ivor Lewis and McKeown minimally invasive esophagectomy, with a total of 106 essential steps identified and consensus reached in two rounds of surveys.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Sanne-Marije Hazen, Tania Sluckin, Geerard Beets, Roel Hompes, Pieter Tanis, Miranda Kusters
Summary: There is significant variation among Dutch colorectal surgeons in the assessment and treatment of lateral lymph nodes in rectal cancer patients, highlighting the need for further research and international guidelines.
ACTA CHIRURGICA BELGICA
(2023)
Article
Oncology
S. H. J. Ketelaers, R. G. Orsini, G. A. P. Nieuwenhuijzen, H. J. T. Rutten, J. W. A. Burger, J. G. Bloemen
Summary: This study focused on the outcomes of diverting ostomy in elderly patients with advanced rectal cancer after low anterior resection (LAR). The results showed that most elderly patients successfully reversed their ostomy with limited complications, but there is still a risk of non-reversal and ostomy recreation over time.
Article
Surgery
Eva L. K. Voogt, Stefi Nordkamp, Desley M. G. van Zoggel, Alette W. Daniels-Gooszen, Grard A. P. Nieuwenhuijzen, Johanne G. Bloemen, Geert-Jan Creemers, Jeltsje S. Cnossen, Gesina van Lijnschoten, Jacobus W. A. Burger, Harm J. T. Rutten, Joost Nederend
Summary: This study investigated the agreement between magnetic resonance tumour regression grade (mrTRG) and pathological regression grade (pTRG) in patients with locally recurrent rectal cancer (LRRC). The reproducibility of mrTRG was found to be limited among radiologists and the agreement with pTRG was low. However, a shorter interval between MRI and surgery improved the agreement and if assessed by a dedicated radiologist, mrTRG could predict good responders.
Article
Oncology
Richard van der Meer, Checca Bakkers, Felice N. van Erning, Lieke H. J. Simkens, Ignace H. J. T. de Hingh, Rudi M. H. Roumen
Summary: This study examined the impact of ovarian metastases on overall survival in female patients with stage IV colorectal cancer treated with systemic therapy. The results showed that the presence of ovarian metastases did not affect the three-year overall survival rates.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Richard van der Meer, Judith W. M. Jeuken, Steven L. L. Bosch, Felice N. N. van Erning, Lieke H. J. Simkens, Ignace H. J. T. de Hingh, Rudi M. H. Roumen
Summary: This study found a complete biomarker concordance between MMR proficient CRC and their matching ovarian metastases. Biomarker testing of MMR proficient CRC tissue appears to be sufficient, and additional testing of metastatic ovarian tissue is not necessary. Therefore, differences in therapy response between ovarian metastases and other metastases from CRC are unlikely to be caused by differences in the genetic status.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Marianne Luyendijk, Otto Visser, Hedwig M. Blommestein, Ignace H. J. T. de Hingh, Frank J. P. Hoebers, Agnes Jager, Gabe S. Sonke, Elisabeth G. E. de Vries, Carin A. Uyl-de Groot, Sabine Siesling
Summary: This study evaluated the changes in survival of patients with de novo metastatic solid cancers over the past 30 years. The proportion of M1 disease and net survival rates varied among different cancer types. Better preventive measures and early detection are needed to reduce the incidence of metastatic disease.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Roos G. F. M. van der Ven, Daan N. Westra, Felice H. van Erning, Ignace de Hingh, Steven W. M. Olde Damink, Agnes Paulus, Wouter K. G. Leclercq, Marcel den Dulk, OncoZON Consortium
Summary: This study examines whether inequalities in the utilization of resection and/or ablation for synchronous colorectal liver metastases (SCLM) between expert and non-expert hospitals changed since the implementation of a multi-hospital network. The findings show that despite the establishment of the network, patients diagnosed in expert hospitals were more likely to receive specialized treatment than those diagnosed in non-expert hospitals, and this disparity increased over time.
Article
Oncology
Cas de Jongh, Lianne Triemstra, Arjen van der Veen, Lodewijk AA. Brosens, Grard AP. Nieuwenhuijzen, Jan HMB. Stoot, Wobbe O. de Steur, Jelle P. Ruurda, Richard van Hillegersberg
Summary: This study assessed the quality of gastric cancer surgery using a photo-scoring method and implemented quality control measures during the LOGICA trial. The results showed that high radicality and nodal yield were indicators of good quality D2-gastrectomy. However, the photo-scoring method used in the study needs further improvement.
Article
Surgery
Stefi Nordkamp, Jan M. van Rees, Kim van den Berg, David M. Mens, Davy M. J. Creemers, Heike M. U. Peulen, Geert-Jan Creemers, Grard A. P. Nieuwenhuijzen, Jip L. Tolenaar, Johanne G. Bloemen, Joost Rothbarth, Harm J. T. Rutten, Cornelis Verhoef, Jacobus W. A. Burger
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Stefi Nordkamp, Floor Piqeur, Kim van den Berg, Jip L. Tolenaar, Irene E. G. van Hellemond, Geert-Jan Creemers, Mark Roef, Gesina van Lijnschoten, Jeltsje S. Cnossen, Grard A. P. Nieuwenhuijzen, Johanne G. Bloemen, Lien Coolen, Joost Nederend, Heike M. U. Peulen, Harm J. T. Rutten, Jacobus W. A. Burger
Summary: This study aimed to evaluate the oncological outcomes of patients with locally recurrent rectal cancer with a pCR, and compare them with patients without a pCR. Patients with a pCR had superior oncological outcomes. A watch-and-wait approach may be considered in highly selected patients to improve quality of life without compromising oncological outcomes.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Anouk Hiensch, Elles Steenhagen, Jonna K. van Vulpen, Jelle P. Ruurda, Grard A. P. Nieuwenhuijzen, Ewout A. Kouwenhoven, Richard P. R. Groenendijk, Donald L. van der Peet, Camiel Rosman, Bas P. L. Wijnhoven, Mark I. van Berge Henegouwen, Hanneke W. M. van Laarhoven, Richard van Hillegersberg, Peter D. Siersema, Anne M. May