Article
Oncology
Mille Vissing, Mascha Pervan, John Ploen, Mazen Schnefeldt, Soren Rafael Rafaelsen, Lars Henrik Jensen, Achim Rody, Julie Gehl
Summary: Calcium electroporation is a local therapy that selectively kills cancer cells in cutaneous metastases. This multicentre study showed that it has a treatment response in various types of cutaneous metastases and can relieve symptoms.
Article
Oncology
Razia Moorad, Edwards Kasonkanji, Joe Gumulira, Yolanda Gondwe, Morgan Dewey, Yue Pan, Alice Peng, Linda J. J. Pluta, Evaristar Kudowa, Richard Nyasosela, Tamiwe Tomoka, Hannock Tweya, Tom Heller, Salem Gugsa, Sam Phiri, Dominic T. T. Moore, Blossom Damania, Matthew Painschab, Mina C. C. Hosseinipour, Dirk P. P. Dittmer
Summary: A prospective cohort study in Malawi enrolled 122 HIV-positive KS patients and treated them with standard care. The one-year overall survival was 61%, progression-free survival was 58%, and the 48-week complete response rate was 35%. The study found that KS lesions can be differentiated into two types with different molecular compositions, suggesting heterogeneous clinical response to treatment and the development of KS in PLWH with well-controlled HIV infection.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Letter
Dermatology
Rafael Salido-Vallejo, Alberto Gonzalez-Menchen, Carmen Alcantara-Reifs, Agustin Espana
Summary: This case report presents the medical history of a HIV-negative man in his 60s from the Mediterranean region. The patient has a background of hypertension, osteoporosis, flaccid paralysis after polio syndrome, and a progressive development of purplish, reddish cutaneous plaques and nodules limited to the lower limbs for the past 4 years.
Article
Medicine, Research & Experimental
Bryan Valcarcel-Valdivia, Daniel Enriquez-Vera, Luis Enrique Piedra, Alexis Holguin, Gabriel De la Cruz Ku
Summary: This study retrospectively assessed the treatment approaches and outcomes of patients with KS in Peru. The majority of patients had a high severity status and received systemic chemotherapy. Paclitaxel was the most commonly used first-line drug and showed relatively high overall response rates for both AIDS-related KS and CKS. The 5-year OS rates were slightly lower for AIDS-related KS patients compared to CKS patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Warren Phipps, Scott V. Adams, Peter Mooka, James Kafeero, Semei Sekitene, Dennis Mubiru, Janet Nankoma, Constance Namirembe, Lazarus Okoche, Elizabeth B. Namubiru, Shadiah Kayemba, Kelsey K. Baker, Mary W. Redman, Corey Casper, Jackson Orem, Edus H. Warren
Summary: This study aimed to understand the impact of HIV infection on Kaposi sarcoma (KS) patients and identify factors associated with survival and treatment response. Results showed low survival rates for both HIV-positive and HIV-negative KS patients, highlighting the need for new staging and therapeutic approaches.
Article
Medicine, General & Internal
Athanasia Tourlaki, Gianluca Nazzaro, Yiran Wei, Stefano Buffon, Maria A. Mattioli, Angelo V. Marzano, Lucia Brambilla
Summary: This study compared the clinical, dermoscopic, and ultrasonographic features of Kaposi's sarcoma (KS) and KS-like lesions. It suggested that dermoscopy and Doppler ultrasonography can be helpful in diagnosing both KS lesions and equivocal KS-like lesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Noah Osei, Gerald Fletcher, Abosede Showunmi, Meena Ahluwalia
Summary: Kaposi sarcoma is a common malignancy in AIDS patients, usually presenting as pigmented papules and nodules on the skin. This case report describes a 31-year-old smoker with AIDS who developed a throat mass with hoarseness of voice, which was diagnosed as laryngeal Kaposi sarcoma. It highlights the importance of considering laryngeal involvement of Kaposi sarcoma in immunodeficient patients, especially when there are no skin lesions.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Carmen Cantisani, Alexandru-Vasile Baja, Luca Gargano, Giovanni Rossi, Marco Ardigo, Giuseppe Soda, Mehdi Boostani, Norbert Kiss, Giovanni Pellacani
Summary: Kaposi sarcoma is a rare disease that is difficult to diagnose early, but advanced imaging techniques such as dermoscopy and optical coherence tomography show potential for improving diagnosis and management.
Article
Oncology
A. Zer, O. Icht, L. Yosef, D. Avram, O. Jacobi, E. Fenig, N. Kurman, I Peretz, S. Shamai, O. Merimsky, E. Ben-Ami, R. Shapira Frommer, A. E. Schwarzbach, H. Bernstine, R. Weitzen, O. Vornicova, G. Bar-Sela, S. M. Stemmer, M. Lotem
Summary: This study evaluated the efficacy and safety of nivolumab in combination with ipilimumab in cKS patients. The combination therapy showed promising activity and low toxicity in cKS patients. This study provides a new treatment option for cKS patients.
ANNALS OF ONCOLOGY
(2022)
Review
Oncology
Martina Ferioli, Andrea Galuppi, Milly Buwenge, Silvia Cammelli, Anna Myriam Perrone, Gabriella Macchia, Francesco Deodato, Savino Cilla, Alice Zamagni, Francesca De Terlizzi, Luca Tagliaferri, Pierandrea De Iaco, Alessio Giuseppe Morganti
Summary: Electrochemotherapy (ECT) shows promise in treating KS skin lesions with high response rates and mild toxicity. Further studies are needed to fully evaluate long-term disease control and compare ECT with other local therapies for KS.
MOLECULAR AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Angela Buonadonna, Simona Scalone, Davide Lombardi, Arianna Fumagalli, Alessandra Guglielmi, Chiara Lestuzzi, Jerry Polesel, Vincenzo Canzonieri, Stefano Lamon, Petros Giovanis, Sara Gagno, Giuseppe Corona, Maurizio Mascarin, Claudio Belluco, Antonino De Paoli, Gianpiero Fasola, Fabio Puglisi, Gianmaria Miolo
Summary: This study investigates the combination of non-pegylated liposomal doxorubicin (NPLD) with ifosfamide as a first-line treatment for advanced/metastatic soft tissue sarcoma (STS). The results show a significant overall response rate and disease control rate, indicating that this drug combination is effective and well-tolerated. This finding provides a basis for further research on the clinical application of this drug combination in STS.
Article
Medicine, General & Internal
Shau-Kong Lai, Lii-Jye Tan, Huzlinda Hussin, Amizatul Aini Salleh, Ikmal Hisyam Bakrin
Summary: HIV-infected patients are at high risk of multiple pathologies, making accurate identification and diagnosis critical for patient management. This case study highlights the importance of careful histopathological examination and judicious use of adjunct diagnostic tests.
CLINICAL CASE REPORTS
(2021)
Article
Dermatology
Begum Gunes, Omer Mert, Nahide Onsun
Summary: This study reviewed the clinical features, treatment methods, and outcomes of Kaposi sarcoma patients in Turkey. Among 27 patients, most tested positive for HHV8 and were treated with interferon alpha, showing good response without serious side effects. Systemic involvement was not observed except in one patient with lymph node involvement.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Immunology
Katherine R. Sabourin, Margaret Borok, Samantha Mawhinney, Maxwell Matimba, Francis Jaji, Suzanne Fiorillo, Dickson D. Chifamba, Claudios Muserere, Busisiwe Mashiri, Chenjerai Bhodheni, Patricia Gambiza, Rachael Mandidewa, Mercia Mutimuri, Ivy Gudza, Matthew Mulvahill, Camille M. Moore, Jean S. Kutner, Eric A. F. Simoes, Thomas B. Campbell
Summary: A study on KS training interventions at primary care clinics in urban and rural Zimbabwe found that these interventions significantly increased overall and incorrect KS diagnosis rates, but did not improve early KS diagnosis rates, 90-day return rates, or survival.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2022)
Article
Oncology
Mark Agulnik, Brian Schulte, Steven Robinson, Angela C. Hirbe, Kevin Kozak, Sant P. Chawla, Steven Attia, Alfred Rademaker, Hui Zhang, Susan Abbinanti, Rasima Cehic, Varun Monga, Mohammed Milhem, Scott Okuno, Brian A. Van Tine
Summary: Regorafenib is a safe and effective treatment for refractory metastatic and unresectable angiosarcoma, showing good efficacy with acceptable rates of adverse events.
EUROPEAN JOURNAL OF CANCER
(2021)
Editorial Material
Oncology
Pietro Quaglino, Paolo Fava, Matteo Brizio, Elena Marra, Marco Rubatto, Martina Merli, Luca Tonella, Simone Ribero, Maria Teresa Fierro
Letter
Dermatology
Caterina Cariti, Pietro Quaglino, Tommaso Lupia, Mauro Novelli, Elena Marra, Paolo Fava, Virginia Caliendo, Luca Tonella, Francesco Giuseppe De Rosa, Maria Teresa Fierro, Simone Ribero
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
Giuseppe Gallo, Elisabetta Rostagno, Niccolo Siliquini, Elena Stroppiana, Anna Verrone, Michela Ortoncelli, Pietro Quaglino, Paolo Dapavo, Simone Ribero
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2021)
Letter
Dermatology
Federicai Repetto, Lorenza Burzi, Alice Ramondetta, Giulia Rozzo, Matteo Licciardello, Simone Ribero, Pietro Quaglino, Paolo Dapavo
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Luca Mastorino, Paolo Dapavo, Gianluca Avallone, Martina Merli, Caterina Cariti, Marco Rubatto, Valentina Pala, Pietro Quaglino, Simone Ribero
Summary: Available evidence on the management of psoriasis patients with a history of malignancies is scarce. However, treatment with biologics targeting TNFalpha, IL17, IL23, and IL12 appears to be safe in patients with previously diagnosed cancer. The use of Risankizumab and brodalumab in this special population is also reported.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Paolo Dapavo, Niccolo Siliquini, Luca Mastorino, Gianluca Avallone, Martina Merli, Andrea Agostini, Caterina Cariti, Riccardo Viola, Elena Stroppiana, Anna Verrone, Michela Ortoncelli, Pietro Quaglino, Simone Ribero
Summary: This study compared the efficacy, safety, and drug survival of anti TNF-alpha, anti-IL-17, and anti-IL-23 in psoriasis treatment. Ixekizumab showed superior efficacy in terms of PASI90 and PASI100, but did not have higher drug survival as expected. Secukinumab was the only drug with higher drug survival among bio-naive patients.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Letter
Dermatology
Christiane Querfeld, Youn H. Kim, Joan Guitart, Julia Scarisbrick, Pietro Quaglino
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
Gabriele Roccuzzo, Francesco Cavallo, Gianluca Avallone, Paolo Fava, Luca Conti, Simone Ribero, Maria Teresa Fierro, Pietro Quaglino
DERMATOLOGIC THERAPY
(2022)
Letter
Dermatology
Luca Mastorino, Michela Ortoncelli, Gianluca Avallone, Pietro Quaglino, Simone Ribero
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Giuseppe Gallo, Luca Conti, Pietro Quaglino, Simone Ribero
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
M. Zenone, L. Zocchi, C. Moccia, S. G. Passerini, T. Sanavia, P. Fariselli, P. Broganelli, S. Ribero, M. Maule, P. Quaglino
Summary: The study demonstrates that integrating dynamic and static evaluations of melanocytic lesions is a safe approach that can significantly boost the diagnostic accuracy for cutaneous melanoma. Two diagnostic tools were proposed to increase the accuracy in discriminating melanoma from nevi during digital dermoscopy monitoring.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
C. Pellegrini, S. Raimondi, L. Di Nardo, P. Ghiorzo, C. Menin, M. A. Manganoni, G. Palmieri, G. Guida, P. Quaglino, I. Stanganelli, D. Massi, L. Pastorino, L. Elefanti, G. Tosti, P. Queirolo, A. Leva, A. Maurichi, M. Rodolfo, M. C. Fargnoli
Summary: The study analyzed major high and intermediate melanoma risk genes in a large multicentre cohort of Italian children and adolescents. Results showed most patients carried MC1R variants, while CDKN2A pathogenic variants were found in 9% of cases. Children under 12 years old more frequently presented Spitzoid histotype, with melanoma located on the head/neck and upper limbs and higher Breslow thickness.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Letter
Dermatology
C. Cariti, P. Dapavo, L. Mastorino, M. Ortoncelli, N. Siliquini, M. Merli, G. Avallone, S. Giordano, R. Fabrizio, S. Susca, A. Verrone, E. Stroppiana, P. Quaglino, S. Ribero
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Oncology
Ignazio Stanganelli, Francesco Spagnolo, Giuseppe Argenziano, Paolo A. Ascierto, Franco Bassetto, Paolo Bossi, Vittorio Donato, Daniela Massi, Cesare Massone, Roberto Patuzzo, Giovanni Pellacani, Pietro Quaglino, Paola Queirolo, Iris Zalaudek, Giuseppe Palmieri, Italian MelanomaIntergrp IMI
Summary: Cutaneous squamous cell carcinoma is a common form of cancer with a high risk of relapse. Chemotherapy is not curative with severe toxicities. Anti-PD-1 inhibitors have shown potential in the treatment of this cancer.
Article
Pediatrics
Roberta Rotunno, Andrea Diociaiuti, Elisa Pisaneschi, Claudia Carnevale, Marialisa Dentici, May El Hachem
Summary: Megalencephaly-capillary malformation syndrome is a rare multiple-malformation syndrome caused by mutations in the PI3K-AKT-MTOR pathway. We report a case of a 22-month-old female with genetic mosaicism in the PIK3CA gene. The phenotypic variability of this syndrome is based on the distribution of mutations.
ITALIAN JOURNAL OF PEDIATRICS
(2022)