Article
Oncology
Emad Matanes, Neta Eisenberg, Susie Lau, Shannon Salvador, Alex Ferenczy, Manuela Pelmus, Walter H. Gotlieb, Liron Kogan
Summary: This study evaluated the prognostic value of LVSI in endometrial cancer patients and found that the prognostic value disappears in patients with negative nodes after SLN staging, while LVSI still has favorable survival outcomes in patients who have undergone LND.
GYNECOLOGIC ONCOLOGY
(2021)
Editorial Material
Oncology
Amanda W. Lund
Summary: An objective approach was used to study the sentinel lymph node landscape in patients with stage I-III cutaneous melanoma, revealing that micrometastasis is associated with progressive immune dysfunction. Tumor-induced lymph node dysfunction may lead to new hypotheses for neoadjuvant therapy that aims to reinvigorate the body's own anti-tumor immunity.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yu-Ling Liu, Wen-Ling Kuo, Yong-Feng Lo, Hsiu-Pei Tsai, Shih-Che Shen, Chi-Chang Yu, Hsu-Huan Chou, Chia-Huei Chu, Shin-Cheh Chen
Summary: In sentinel lymph node biopsy for early breast cancer, the metastasis of non-hot nodes is correlated with the T stage, and tumors larger than 2.5cm are the best predictors of non-hot node metastasis. Patients with non-hot node metastasis have worse locoregional relapse-free survival.
BIOMEDICAL JOURNAL
(2022)
Article
Oncology
Vincent Balaya, Benedetta Guani, Julie Mereaux, Laurent Magaud, Basile Pache, Helene Bonsang-Kitzis, Charlotte Ngo, David Desseauve, Patrice Mathevet, Fabrice Lecuru
Summary: Lymph node involvement is an important prognostic factor for early-stage cervical cancer. This study aimed to determine if pathologic features in conization specimens can predict the sentinel lymph node (SLN) status. Patients with depth of stromal invasion less than 10 mm and no LVSI in conization specimens had lower risk of micro- and macrometastatic SLN, suggesting that full node dissection may not be necessary in this subpopulation.
Article
Oncology
Katherine M. Marsh, Courtney M. Lattimore, Christopher L. Cramer, Craig L. Slingluff, Lynn T. Dengel
Summary: This study reports cases of primary melanoma draining to subcostal lymph nodes and provides characterization of the locations of these nodes. The study found that subcostal nodes are typically located under ribs 10-12 and have size limitations.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gianni Gerlini, Paola Di Gennaro, Nicola Pimpinelli, Serena Sestini, Lorenzo Borgognoni
Summary: Langerhans cells (LCs) are important regulators of anti-cancer immune responses, but cancer can alter their functions, leading to immune tolerance. In this study, IDO1 expression was investigated in LCs from sentinel lymph nodes (SLNs) of melanoma patients. The results showed that a subset of Langerin(+) LCs in the T cell-rich area of SLNs expressed IDO1. The expression of IDO1 did not significantly differ between SLNs with or without metastases, but was higher in SLN LCs of patients with mitotic rate > 1 in primary melanoma. Immature SLN LCs could be induced to mature after in vitro stimulation by inflammatory cytokines. These findings provide new insights for immunotherapy targeting LCs in melanoma patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Jonathan A. Harounian, Nicole Molin, Thomas J. Galloway, Drew Ridge Facs, Jessica Bauman, Jeffrey Farma, Sanjay Reddy, Miriam N. Lango
Summary: This study found that Merkel cell carcinoma patients with lymphovascular invasion (LVI) and positive sentinel lymph node (SLN) had worse prognostic outcomes. Sentinel lymph node biopsy assists in risk stratification and radiation treatment planning in MCC.
Article
Oncology
Kavitha Yaddanapudi, Bryce F. Stamp, Priyanka B. Subrahmanyam, Andrei Smolenkov, Sabine J. Waigel, Rahul Gosain, Michael E. Egger, Robert C. G. Martin, Robert Buscaglia, Holden T. Maecker, Kelly M. McMasters, Jason A. Chesney
Summary: The study identified immunologic changes in the sentinel lymph nodes of melanoma patients that may impact melanoma treatment. These changes include a potential activation of immune response, as well as a decrease in NK cells and an increase in cells with low melanoma killing capabilities.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Xinyi Lin, Wei Sun, Min Ren, Yu Xu, ChunMeng Wang, Wangjun Yan, YunYi Kong, Charles M. Balch, Yong Chen
Summary: A prediction model for non-sentinel lymph node (non-SLN) metastasis in acral melanoma (AM) can assist clinicians in determining appropriate treatment options.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Zhenyan Gao, Huihua Cao, Xiang Xu, Qing Wang, Yugang Wu, Qicheng Lu
Summary: LVI is an independent prognostic risk factor for stage II CRC patients. Combining LVI with the 8th TNM staging system improved the predictive accuracy for CRC prognosis. ACT in stage II CRC patients with LVI+ is beneficial for survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Mikko Vuoristo, Timo Muhonen, Virve Koljonen, Susanna Juteau, Micaela Hernberg, Suvi Ilmonen, Tiina Jahkola
Summary: In this study, outcomes of 285 melanoma patients who underwent sentinel lymph node biopsy of the inguinal/iliac lymph node basin were analyzed. Pelvic sentinel lymph nodes had minimal impact on survival and staging of melanoma patients, and removal of pelvic sentinel lymph nodes may be considered when they are the most radioactive nodes in lymphoscintigraphy or during surgery.
Article
Surgery
Jianyi Li, Shi Jia, Yitong Wang, Yang Zhang, Linna Kong, Yanan Cao, Yushi Liu, Yan Zhang, Bo Chen
Summary: In breast cancer patients who underwent neoadjuvant chemotherapy, the regression of positive nodes follows a specific pattern related to lymphovascular invasion. Long-term staining and tracing using carbon nanoparticles can be used to study the regression of nodes, providing a potential method for NAC-treated patients.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Klaudia Kvakova, Martin Ondra, Jiri Schimer, Milos Petrik, Zbynek Novy, Helena Raabova, Marian Hajduch, Petr Cigler
Summary: This study developed a sensitive approach using fluorescent nanodiamonds for visualizing tumor-draining sentinel lymph nodes. The results showed that the modified nanodiamonds have potential as a tracer for cancer diagnostics and fluorescence-guided surgery.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Oncology
Weili Zhou, Yang Bai, Yangyang Yue
Summary: The study found that SLNB significantly prolonged CSS and OS in VSCC surgery patients without distant metastasis and adjacent organ invasion compared to RLND and NA, especially in the LN+ cohort. Age was a significant prognostic factor for CSS and OS, while tumor size, surgery type, and invasion depth were not.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Soulaimane Aboulouard, Maxence Wisztorski, Marie Duhamel, Philippe Saudemont, Tristan Cardon, Fabrice Narducci, Anne-Sophie Lemaire, Firas Kobeissy, Eric Leblanc, Isabelle Fournier, Michel Salzet
Summary: The study identifies significant variations in the SLN protein landscape in EC and shows correlation between SLN and tumor grade, emphasizing the potential of certain proteins as markers for overall survival. Five major proteins for EC and SLN were identified and validated, improving stratification and diagnosis of individuals with EC.
CELL REPORTS MEDICINE
(2021)