Article
Surgery
Xin-Fei Xu, Yong-Kang Diao, Yong-Yi Zeng, Chao Li, Feng-Wei Li, Li-Yang Sun, Han Wu, Kong-Ying Lin, Lan-Qing Yao, Ming-Da Wang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study investigated the relationship between the severity in the grading of microvascular invasion (MVI) and long-term oncological outcomes in patients with early-stage hepatocellular carcinoma (HCC). The results showed that the severity in MVI grading was independently associated with recurrence and survival after HCC resection. Patients with a more severe MVI grading (M2) require more stringent recurrence surveillance and/or active adjuvant therapy against recurrence.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Jianwei Liu, Guokun Zhuang, Shilei Bai, Zhiliang Hu, Yong Xia, Caixia Lu, Jie Wang, Chunyan Wang, Liu Liu, Fengwei Li, Yeye Wu, Feng Shen, Kui Wang
Summary: This study investigated the impact of surgical margin and hepatic resection on prognosis for patients with hepatocellular carcinoma (HCC). The results showed that for patients with MVI-positive HCC, wide margins and anatomical resection were protective factors for prognosis, with wide margins being more important. In clinical practice, ensuring wide margins should be prioritized.
Article
Surgery
Xiu-Ping Zhang, Shuai Xu, Zhao-Yi Lin, Qing-Lun Gao, Kang Wang, Zi-Li Chen, Mao-Lin Yan, Fan Zhang, Yu-Fu Tang, Zhi-Ming Zhao, Cheng-Gang Li, Wan Yee Lau, Shu-Qun Cheng, Ming-Gen Hu, Rong Liu
Summary: This study aimed to evaluate the impact of anatomical resection (AR) versus nonanatomical resection (NAR) combined with resection margin (RM) on long-term prognosis in HCC patients with MVI. The results showed that AR combined with wide RM can significantly improve overall and recurrence-free survival rates for these patients.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Shi-Chuan Tang, Kai-Ling Zhang, Kong-Ying Lin, Yi-Dan Tang, Jun Fu, Wei-Ping Zhou, Jian-Xi Zhang, Jie Kong, Xiao-Lu He, Zheng-Hong Sun, Cong Luo, Hong-Zhi Liu, Yong-Ping Lai, Yong-Yi Zeng
Summary: This study demonstrated that anatomical resection decreases the risk of tumor recurrence and improves overall survival (OS) and recurrence-free survival (RFS) in patients with early-stage hepatocellular carcinoma (HCC). Anatomical resection should be adopted as long as such a surgical maneuver is feasible for initial treatment of early-stage HCC.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Zhen-Hua Chen, Xiu-Ping Zhang, Jin-Kai Feng, Le-Qun Li, Fan Zhang, Yi-Ren Hu, Cheng-Qian Zhong, Jie Shi, Wei-Xing Guo, Meng-Chao Wu, Wan Yee Lau, Shu-Qun Cheng
Summary: One-third of HCC patients with MVI achieved the long-term survival milestone of 5 years after resection. Anatomical hepatectomy, controlling intraoperative blood loss, a wide resection margin, and postoperative adjuvant TACE should be considered to improve long-term survival outcomes.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Surgery
J-H Zhong, B-C Xing, W-G Zhang, A. W-H Chan, C. C. N. Chong, M. Serenari, N. Peng, T. Huang, S-D Lu, Z-Y Liang, R-R Huo, Y-Y Wang, M. Cescon, T-Q Liu, L. Li, F-X Wu, L. Ma, M. Ravaioli, J. Neri, A. Cucchetti, P. J. Johnson, L-Q Li, B-D Xiang
Summary: This study investigated the safety and efficacy of repeat hepatic resection (rHR) and radiofrequency ablation (RFA) for recurrent hepatocellular carcinoma (HCC). The results showed that rHR was associated with longer recurrence-free survival compared with RFA, while RFA had lower morbidity and shorter hospital stay.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sheng Wang, Weizhi Zheng, Zhencheng Zhang, Guo-Hua Zhang, Dan-Jiang Huang
Summary: A risk score system based on MVI status can help stratify patients at high risk of early recurrence after resection of HCC. Tumor size > 2 cm, Prothrombin induced by vitamin K absence-II > 32 mAU/ml, irregular tumor margin, and apparent diffusion coefficient value < 1007 x 10(- 3)mm(2)/s were identified as independent risk factors correlated to MVI in HCC.
BMC MEDICAL IMAGING
(2022)
Article
Oncology
Changying Shi, Yong Li, Li Geng, Weifeng Shen, Chengjun Sui, Binghua Dai, Jiongjiong Lu, Mianshun Pan, Jiamei Yang
Summary: This study aimed to investigate the efficacy of SBRT targeting suboptimal resection margin as adjuvant therapy in MVI-positive HCC. The results showed that SBRT group had significantly better DFS and OS compared to the surgery alone group.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Xiang-Pan Meng, Tian-Yu Tang, Zhi-Min Ding, Jitao Wang, Chun-Qiang Lu, Qian Yu, Cong Xia, Tao Zhang, Xueying Long, Wenbo Xiao, Yuan-Cheng Wang, Shenghong Ju
Summary: This study developed two prediction models for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) using clinical factors and preoperative computed tomography images. The models were compared and it was found that the model incorporating radiomics provided a more accurate estimation of MVI. This has the potential to assist in choosing the appropriate surgical procedure for HCC patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Surgery
Zhen Sun, Zhe Li, Xiao-Lei Shi, Xiu-Wen He, Jian Chen, Jing-Hai Song
Summary: Anatomical resection (AR) showed higher overall survival (OS) and disease-free survival (DFS) rates compared to non-anatomical resection (NR) in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI). Therefore, AR is recommended for well-presented liver function HCC patients predicted to have positive MVI.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Wentao Wang, Yaxun Guo, Jingtao Zhong, Qi Wang, Xin Wang, Honglong Wei, Jie Li, Peng Xiu
Summary: The review highlights the importance of developing a comprehensive and sequential treatment plan for HCC patients, especially those with MVI, to support long-term survival. Preoperative prediction of MVI can guide surgical strategies, while comprehensive postoperative pathological detection can provide a basis for treatment decisions.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Zong-Han Liu, Zong-Tao Chai, Jin-Kai Feng, Yu-Chao Hou, Xiu-Ping Zhang, Zhen-Hua Chen, Yan-Jun Xiang, Wei-Xing Guo, Jie Shi, Shu-Qun Cheng
Summary: The definition of early recurrence for hepatocellular carcinoma (HCC) remains controversial. This study aimed to identify the early recurrence time for HCC and evaluate the efficacy of postoperative adjuvant TACE for HCC with MVI within this interval. The results showed that 13 months may be a reasonable early recurrence time point for HCC patients with MVI who underwent R0 resection, and within this interval, adjuvant TACE may result in longer survival.
Article
Oncology
Jiang-Min Zhou, Chen-Yang Zhou, Xiao-Ping Chen, Zhi-Wei Zhang
Summary: In patients with tumors ranging from 2-5 cm, anatomic resection (AR) can effectively remove peritumoral microvascular invasion (MVI) by obtaining a wide surgical margin, reducing postoperative recurrence, and improving prognosis.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Oncology
Leonardo Centonze, Stefano Di Sandro, Andrea Lauterio, Riccardo De Carlis, Samuele Frassoni, Antonio Rampoldi, Bruno Tuscano, Vincenzo Bagnardi, Angelo Vanzulli, Luciano De Carlis
Summary: Li-RADS classification has shown potential prognostic value in the oncological outcomes of single HCC, with surgical resection demonstrating superiority over percutaneous ablation for Li-RADS-5 subclass.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Eun Ko, Min Woo Lee, Soohyun Ahn, Hyunchul Rhim, Tae Wook Kang, Kyoung Doo Song, Jong Man Kim, Gyu-Seong Choi, Dong Ik Cha, Ji Hye Min, Dong Hyun Sinn, Moon Seok Choi, Hyo Keun Lim
Summary: This study compared the therapeutic outcomes of laparoscopic hepatic resection (LHR) and laparoscopic radiofrequency ablation (LRFA) for single subcapsular hepatocellular carcinoma (HCC) measuring 1-3 cm. The results showed no significant difference in therapeutic outcomes between the two methods.
KOREAN JOURNAL OF RADIOLOGY
(2022)