Article
Biotechnology & Applied Microbiology
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang, Chenghong Wang
Summary: miR-124-3p inhibits HCC proliferation and epithelial-mesenchymal transition (EMT) by targeting ARRDC1.
Review
Oncology
Ilaria Cavallari, Francesco Ciccarese, Evgeniya Sharova, Loredana Urso, Vittoria Raimondi, Micol Silic-Benussi, Donna M. D'Agostino, Vincenzo Ciminale
Summary: MicroRNAs of the miR-200 family play crucial roles in regulating gene expression in cancer cells, potentially serving as biomarkers for cancer detection. The mature miR-200 family microRNAs are abundantly expressed in epithelial cells, contributing to maintaining the epithelial phenotype and inhibiting cancer development. These microRNAs exhibit both tumor suppressor and pro-metastatic functions, showing promise as biomarkers for epithelial cancers.
Article
Biochemistry & Molecular Biology
Jiejie Cui, Mengjia Gong, Shuyu Fang, Chaoqun Hu, Yi Wang, Jingfang Zhang, Ni Tang, Yun He
Summary: All-trans retinoic acid (ATRA) can impact the proliferation, apoptosis, migration, and invasion abilities of hepal-6 hepatocarcinoma cell line by up-regulating specific miRNAs in the miR-200 family, as well as influencing the expression of related transcription factors, suggesting a potential role in suppressing epithelial-mesenchymal transition (EMT).
Review
Biochemistry & Molecular Biology
Vignesh Sundararajan, Ulrike C. Burk, Karolina Bajdak-Rusinek
Summary: The miR-200 family plays a significant role in cellular functions and pathological processes, impacting epithelial homeostasis, tumor suppression, neurodegenerative diseases, and tissue fibrosis. Moreover, miR-200 family members have potential as biomarkers for cancers, aiding in early cancer detection and intervention.
Article
Biochemistry & Molecular Biology
Liang Yu, Can Cao, Xu Li, Mili Zhang, Qisheng Gu, Hugh Gao, Jesse J. Balic, Duogang Xu, Lei Zhang, Le Ying, Dakang Xu, Yuqin Yang, Di Wu, Baokun He, Brendan J. Jenkins, Youdong Liu, Jikun Li
Summary: The miR-200 family plays a crucial role in maintaining the epithelial phenotype in gastric cancer, but its suppression in late-stage gastric tumors leads to EMT and affects prognosis.
Article
Oncology
Weibo Chen, Junyi Wu, Weiwei Shi, Guang Zhang, Xuemin Chen, Anlai Ji, Zhongxia Wang, Junhua Wu, Chunping Jiang
Summary: The downregulation of PRRX1 induces E-cadherin re-expression through the PITX2/miR-200a/CTNNB1 and PITX2/miR-200b/429/SLUG pathways, affecting the MET and metastasis of HCC.
Article
Biochemistry & Molecular Biology
Chiara Fischer, Andrey Turchinovich, Manuel Feisst, Fabian Riedel, Kathrin Hassdenteufel, Philipp Scharli, Andreas D. Hartkopf, Sara Y. Brucker, Laura Michel, Barbara Burwinkel, Andreas Schneeweiss, Markus Wallwiener, Thomas M. Deutsch
Summary: The miR-200 family has shown promising prognostic and predictive potential as a biomarker in metastatic breast cancer (MBC). The expression levels of miR-200s were found to be associated with systemic treatment, circulating tumor cells (CTC) count, and survival outcomes. Higher miR-200 expression and positive CTC status were correlated with poorer overall survival (OS) and progression-free survival (PFS) in MBC patients, indicating their potential as biomarkers for optimizing clinical management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du, Baocai Xing
Summary: This study found that PPP1R26 is upregulated in hepatocellular carcinoma (HCC) and is significantly associated with metastasis and poor patient survival. PPP1R26 promotes glycolysis by enhancing the splicing of PKM2 and activates epithelial-mesenchymal transition (EMT) by forming a PPP1R26-PKM2-TGIF2 complex, driving the progression of HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Kanlayanee Sawanyawisuth, Goro Sashida, Guojun Sheng
Summary: This review summarizes the mechanisms of parasitic infection in the pathogenesis of bile duct cancer, focusing on the effects of epithelial-mesenchymal transition (EMT) in bile duct epithelial cells and its association with epigenetic dysregulation. It suggests that both direct and indirect mechanisms underlie the parasitic infection-induced EMT in cholangiocarcinoma (CCA).
Retraction
Biochemistry & Molecular Biology
Qiu-Yin Zhang, Chang-Jun Men, Xue-Wei Ding
Summary: The article on the upregulation of microRNA-140-3p in hepatocellular carcinoma was retracted due to flaws and inconsistencies in experimental methods, rendering the conclusions invalid.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Mei-Tsz Su, Pei-Yin Tsai, Chia-Yih Wang, Hui-Ling Tsai, Pao-Lin Kuo
Summary: Preeclampsia is a severe gestational hypertensive disorder that poses a major threat to maternal and fetal health. Aspirin has been shown to effectively reduce the incidence of premature preeclampsia among high-risk pregnant women, possibly by suppressing miR-200 family-mediated cell functions. This study demonstrates a potential mechanism explaining aspirin's effect on preeclampsia prevention and provides a therapeutic target for disease intervention.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Takashi Iizumi, Toshiyuki Okumura, Naoyuki Hasegawa, Kazunori Ishige, Kuniaki Fukuda, Emiko Seo, Hirokazu Makishima, Hikaru Niitsu, Mizuki Takahashi, Yuta Sekino, Hiroaki Takahashi, Daichi Takizawa, Yoshiko Oshiro, Keiichiro Baba, Motohiro Murakami, Takashi Saito, Haruko Numajiri, Masashi Mizumoto, Kei Nakai, Hideyuki Sakurai
Summary: The study aimed to clarify the efficacy and safety of proton beam therapy for hepatocellular carcinoma with bile duct invasion. The results showed that proton beam therapy is a feasible and tolerable treatment option for patients with bile duct invasion hepatocellular carcinoma.
BMC GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chaokun Wang, Yichen Shuai, Chuan Zhao, Fengrui Yang, Weilian Su, Zhifen Ning, Guoxia Li
Summary: The study revealed that miR-10a and miR-10b play a role in the development of renal fibrosis by regulating PTEN and the Akt pathway to promote the EMT process.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhenglei Xu, Zeming Chen, Minsi Peng, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Lisheng Wang, Yingcai Hong
Summary: Pancreatic cancer is difficult to treat, and the main reasons for poor prognosis are cell invasion and migration. In this study, researchers found that miR-490-5p is abnormally low-expressed in pancreatic cancer and downregulation of miR-490-5p enhances the viability, migration, and invasion of pancreatic cancer cells. Additionally, miR-490-5p regulates the protein expression of MMP2, MMP9, and N-cadherin, and upregulates the protein expression of E-cadherin. The expression of MAGI2-AS3 is also associated with cell viability, migration, and invasion in pancreatic cancer. The study reveals that miR-490-5p plays an anti-cancer role in pancreatic cancer by targeting MAGI2-AS3 and regulating EMT.
Article
Biochemistry & Molecular Biology
Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun
Summary: KIAA1217 plays a crucial role in hepatocellular carcinoma (HCC) metastasis by promoting cell migration and invasion through inducing epithelial-mesenchymal transition (EMT), and activating JAK1/2 and STAT3. It interacts with the Notch and Wnt/β-catenin pathways to facilitate HCC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)