Article
Biochemistry & Molecular Biology
Lucia Palumbo, Salvatore Genovese, Chiara Collevecchio, Francesco Epifano, Serena Fiorito
Summary: This manuscript investigates the biomolecular mechanism of action of 4'-geranyloxyferulic acid, a natural colon cancer chemopreventive agent, in cultured Caco-2 cells. The application of this phytochemical leads to a time- and dose-dependent decrease in cell viability, accompanied by the generation of reactive oxygen species and induction of caspases 3 and 9, ultimately causing apoptosis. Key pro-apoptotic targets, including CD95, DR4 and 5, cytochrome c, Apaf-1, Bcl-2, and Bax, undergo significant modifications, explaining the observed apoptosis in Caco-2 cells treated with 4'- geranyloxyferulic acid.
Review
Oncology
Leandro de Lima Coutinho, Tharcisio Citrangulo Tortelli Junior, Maria Cristina Rangel
Summary: Cancer is a global public health problem with high morbidity and mortality rates. Plant-derived compounds, particularly sulforaphane (SFN), have shown chemopreventive and anticancer effects. SFN has also demonstrated the ability to target cancer stem cells (CSCs), a specific population of cancer cells with stem-like properties. This is particularly significant as most conventional chemotherapeutic agents cannot effectively target CSCs, which often exist in a quiescent state. SFN has the potential to be used in combination with conventional antineoplastic drugs in clinical settings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Esperanza Medina-Gutierrez, Maria Virtudes Cespedes, Alberto Gallardo, Elisa Rioja-Blanco, Miquel Angel Pavon, Laura Asensio-Puig, Lourdes Farre, Lorena Alba-Castellon, Ugutz Unzueta, Antonio Villaverde, Esther Vazquez, Isolda Casanova, Ramon Mangues
Summary: CXCR4 overexpression in advanced endometrial cancer (EC) can be targeted for therapy. The establishment of CXCR4(+) EC mouse models improves metastasis and allows for the development of novel CXCR4-targeted treatments. The CXCR4-targeted nanocarrier accumulates in tumors without toxicity in non-tumor organs.
Article
Biochemistry & Molecular Biology
Eun-Ryeong Hahm, Su-Hyeong Kim, Krishna B. Singh, Shivendra Singh
Summary: The study revealed that Withaferin A (WA) may prevent breast cancer by downregulating genes associated with cellular senescence, upregulating p21, affecting cellular response to stress, and decreasing glycolysis-related proteins. Additionally, NRF2 knockout cells were found to be more resistant to WA-induced apoptosis, suggesting a potential mechanism for WA's chemopreventive efficacy in breast cancer.
MOLECULAR CARCINOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Juan Pablo Rendon, Ana Isabel Canas, Elizabeth Correa, Vanesa Bedoya-Betancur, Marlon Osorio, Cristina Castro, Tonny W. Naranjo
Summary: Colorectal Cancer (CRC) is the third most common cancer and the second leading cause of cancer-associated deaths and prevalence worldwide. The commonly used chemotherapy drug, 5-fluorouracil (5-FU), produces various toxic effects in the body. Therefore, new therapeutic strategies are being explored as neoadjuvant or adjuvant treatments. Recent research suggests that natural compounds, such as genistein, have chemotherapeutic and anticancer effects, but their mechanisms of action and molecular targets in human colon cells are not fully understood. Additionally, the selectivity of these compounds in non-malignant cell lines remains unclear.
Article
Medicine, General & Internal
Richard T. Bryan, Sarah J. Pirrie, Ben Abbotts, Shanna Maycock, Vinnie During, Carolyn Lewis, Margaret Grant, Deborah Bird, Adam J. Devall, D. Michael A. Wallace, Nicholas D. James, Lucinda J. Billingham, Maurice P. Zeegers, K. K. Cheng, SELENIB Investigators
Summary: In this multicenter clinical trial, selenium and vitamin E were found to have no significant effect on the risk of recurrence in patients with newly diagnosed non-muscle-invasive bladder cancer (NMIBC). However, vitamin E supplementation was associated with an increased risk of recurrence.
Article
Oncology
Dag Holmberg, Eivind Gottlieb-Vedi, Jakob Hedberg, Mats Lindblad, Fredrik Mattsson, Jesper Lagergren
Summary: This study analyzed data from esophageal cancer patients who underwent esophagectomy in Sweden from 2006 to 2015 and found that the use of aspirin and statins did not significantly decrease the 5-year disease-specific mortality.
Article
Polymer Science
Jerry C. Ku, Yuta Dobashi, Christopher R. Pasarikovski, Joel Ramjist, Clement Hamani, Chinthaka Heyn, Konrad Walus, Victor X. D. Yang
Summary: By using photosensitive hydrogel polymer embolization and photopolymerization with balloon assistance, complete aneurysm filling with no recurrence was achieved in the treatment of wide-necked aneurysms.
Article
Oncology
Rong Qiu, Soichiro Murata, Chao Cheng, Akihiro Mori, Yunzhong Nie, Satoshi Mikami, Shunsuke Hasegawa, Tomomi Tadokoro, Satoshi Okamoto, Hideki Taniguchi
Summary: This study aims to develop a new method to generate an HCC mouse model with human tumors and imitates the tumor microenvironment of clinical patients. By generating human HCC organoids in vitro and implanting them into immune-deficient mice, the study successfully introduced controllable tumor microenvironments and studied their roles in HCC tumor growth. The results showed the importance of immune response in slowing down tumor growth at an early stage, providing insights for studying HCC development and developing new treatment options.
Article
Biochemistry & Molecular Biology
Huseyin Fatih Gul, Necip Ilhan, Nevin Ilhan, Ibrahim Hanifi Ozercan, Tuncay Kuloglu
Summary: The study aimed to investigate the protective effects of pomegranate extract and tangeretin alone or in combination in a rat breast cancer model. The results showed that the combined application of pomegranate extract and tangeretin may be more beneficial in preventing breast cancer development, by reducing tumor markers, angiogenesis parameters, and influencing protein expressions to decrease apoptosis and proliferation of cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Engineering, Biomedical
Alexandra I. Mercel, Kathleen Marulanda, David C. Gillis, Kui Sun, Tristan D. Clemons, Smaranda Willcox, Jack Griffith, Erica B. Peters, Mark R. Karver, Nick D. Tsihlis, Rob Maile, Samuel I. Stupp, Melina R. Kibbe
Summary: This study successfully identified proteins upregulated in the lung after smoke inhalation injury and developed nanofibers that target these proteins, showing promising lung localization effects in vivo, especially with angiotensin-converting enzyme-targeted nanofibers.
Article
Biochemistry & Molecular Biology
Su-Hyeong Kim, Shivendra Singh
Summary: This study reveals that MCT1 is a novel target for bCSC inhibition by DATS treatment. The findings show that DATS can suppress MCT1 protein expression and decrease lactate levels in breast cancer cells. Additionally, the expression level of MCT1 is associated with the inhibition of bCSCs.
MOLECULAR CARCINOGENESIS
(2022)
Article
Genetics & Heredity
Yang Liu, Miaomiao Wang, Yang Lu, Shuyan Zhang, Lin Kang, Guona Zheng, Yanan Ren, Xiaowan Guo, Huanfen Zhao, Han Hao
Summary: Proteomics analysis identified 8 proteins associated with the prognosis of esophageal cancer. A risk model was constructed to predict the prognosis of patients and guide treatment decisions.
FRONTIERS IN GENETICS
(2022)
Review
Immunology
Xueyin Zhou, Ting Ren, Hongyuan Zan, Chunyan Hua, Xufeng Guo
Summary: Esophageal cancer is the sixth most common cause of cancer death globally, and current conventional therapeutic strategies still have limited efficacy. New immune checkpoint pathways have become a focus of research, but only a small fraction of patients benefit from existing immune checkpoint inhibitors, posing a challenge of immunoresistance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Balsam Rizeq, Ishita Gupta, Hadeel Kheraldine, Dana Elkhalifa, Halema F. Al-Farsi, Ala-Eddin Al Moustafa, Ashraf Khalil
Summary: Novel nitrogen chalcone-based compounds DK-13 and DK-14 exhibit significant inhibitory effects on cell proliferation, induce apoptosis, and reduce invasion and colony formation ability of HER2-positive breast cancer cells. Additionally, these compounds also demonstrate inhibitory effects on angiogenesis and modulate key signaling pathways such as ERK1/2 and JNK1/2/3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Anne F. Peery, Toshitaka Hoppo, Katherine S. Garman, Evan S. Dellon, Norma Daugherty, Susan Bream, Alejandro F. Sanz, Jon Davison, Melissa Spacek, Diane Connors, Ashley L. Faulx, Amitabh Chak, James D. Luketich, Nicholas J. Shaheen, Blair A. Jobe
GASTROINTESTINAL ENDOSCOPY
(2012)
Article
Surgery
Alejandro F. Sanz, Toshitaka Hoppo, Bart P. Witteman, Bryan N. Brown, Thomas W. Gilbert, Stephen F. Badylak, Blair A. Jobe, Alejandro Nieponice
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
(2014)
Article
Sport Sciences
Alejandro Sanz, Carlos Pablos, Rafael Ballester, Jose Vicente Sanchez-Alarcos, Florentino Huertas
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2020)
Meeting Abstract
Hematology
Ivan Martin, Eva Villamon, Rosario Abellan, Maria Jose Calasanz, Aroa Irigoyen, Guillermo F. Sanz, Esperanza Such, Elvira Mora Castera, Miriam Gutierrez, Rosa Collado, Miriam Vara, Laura Blanco, Itziar Oiartzabal, Sara Alvarez, Teresa Bernal del Castillo, Isabel Granada, Blanca Xicoy, Lurdes Zamora, Andres Jerez, Raquel Fernandez, Marisa Calabuig, Francisca Garcia, Alejandro Sanz, Rosana Diez, Angela Gil, Raquel de Paz, Francisca Lopez, Teresa Gonzalez, Carlos Solano, Mar Tormo
Meeting Abstract
Hematology
Rafael Alonso Fernandez, Maria Teresa Cedena, Rafael Rios, Javier Lopez Jimenez, Alejandro Sanz, Fernando Martin, Antonio Valeri, Juan Jose Lahuerta, Joaquin Martinez-Lopez
Meeting Abstract
Gastroenterology & Hepatology
Toshitaka Hoppo, Alejandro F. Sanz, Katie S. Nason, Thomas Carroll, Clark Rosen, Daniel P. Normolle, Nicholas J. Shaheen, James D. Luketich, Blair A. Jobe