Article
Oncology
Melanie Potiaumpai, Erica A. Schleicher, Ming Wang, Kristin L. Campbell, Kathleen Sturgeon, Kathryn H. Schmitz
Summary: Exercise can improve chemotherapy completion rate by reducing toxicities. Patients with breast cancer had higher completion rate compared with gastrointestinal cancer and pancreatic cancer. Every 2.72 unit increase in exercise adherence led to a 7% decrease in chemotherapy completion rate for GI patients.
Review
Biochemistry & Molecular Biology
Yang Liu, Yoshifumi Baba, Takatsugu Ishimoto, Xi Gu, Jun Zhang, Daichi Nomoto, Okadome, Hideo Baba, Peng Qiu
Summary: The gut microbiome plays a crucial role in gastrointestinal cancer, serving as potential biomarkers and predictors of response. Studies have demonstrated that altered commensal bacteria contribute to cancer susceptibility and progression. Understanding the mechanisms of the gut microbiome in cancer occurrence, prevention, and treatment is of great importance for developing new therapeutic strategies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Editorial Material
Urology & Nephrology
Shruti Bhargava, Joachim Jankowski
Summary: Fosl1, a member of the Fos family, plays a role in carcinogenesis, acute kidney injury, and fibroblast growth factor expression. It has been recently found to have a nephroprotective effect through the preservation of Klotho expression. The identification of a link between Fosl1 and Klotho expression opens up a new field of nephroprotection.
KIDNEY INTERNATIONAL
(2023)
Review
Oncology
Simona Gurzu, Ioan Jung
Summary: This article highlights the potential role of nuclear maspin in colorectal cancer and its practical value in disease progression. By detailing the expression of maspin in tumor cell differentiation, epithelial-mesenchymal transition, and proposing new observations and hypotheses, it provides new insights for the study and treatment of CRC.
Review
Cell Biology
Christina Doxaki, Konstantinos Palikaras
Summary: Disruption of mitochondrial homeostasis in neurons, particularly through impaired mitophagy, can lead to neurodegenerative disorders, while excessive mitophagy may reduce mitochondrial content and ultimately trigger neuronal cell death.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Lily V. Saadat, Thomas Boerner, Debra A. Goldman, Mithat Gonen, Timothy L. Frankel, Efsevia Vakiani, T. Peter Kingham, William R. Jarnagin, Alice C. Wei, Kevin C. Soares, David B. Solit, Michael I. D'Angelica
Summary: RAS mutations are prognostic for mCRC patients. KRAS exon 3/4 mutations are rare and may be associated with a more favorable prognosis, but the difference in oncologic outcomes based on the mutated exon appears to be smaller than previously reported.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Cell Biology
Maria Isabel Cuartero, Alicia Garcia-Culebras, Cristina Torres-Lopez, Violeta Medina, Enrique Fraga, Sandra Vazquez-Reyes, Tania Jareno-Flores, Juan M. Garcia-Segura, Ignacio Lizasoain, Maria angeles Moro
Summary: After stroke injury, there is ongoing neurogenesis in the adult mammalian brain which can contribute to recovery. However, the neurogenic response may lead to different functional consequences, suggesting a complex interplay between physiological and pathological regulation. More in-depth understanding is needed on the key cell types, cell-cell interactions, and molecular pathways involved in neurogenic response after brain damage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Alexandra Nassar, Stylianos Tzedakis, Alix Dhote, Marie Strigalev, Romain Coriat, Mehdi Karoui, Anthony Dohan, Martin Gaillard, Ugo Marchese, David Fuks
Summary: This literature review aimed to assess the feasibility of laparoscopic liver resection for multiple colorectal liver metastases. The minimally invasive approach for liver cancer has become a new standard of oncological care, and laparoscopic liver resection is a significant indication for multiple colorectal liver metastases. The purpose of this paper was to highlight the novelty and updates in the field of multiple minimally invasive liver resections and discuss the feasibility and outcomes of laparoscopic concomitant multiple liver resections for colorectal liver metastases.
Review
Nutrition & Dietetics
Franziska Stumpf, Bettina Keller, Carla Gressies, Philipp Schuetz
Summary: The interplay between inflammation and nutrition has attracted significant attention recently. Inflammation has been identified as a critical factor in disease-related malnutrition, leading to anorexia, reduced food intake, muscle catabolism, and insulin resistance. Inflammation also affects the response to nutritional treatment, with patients with high inflammation showing no response and patients with lower inflammation levels showing a response. This may explain the conflicting results of nutritional trials.
Review
Medicine, Research & Experimental
Mona M. Saber, Nada Monir, Azza S. Awad, Marwa E. Elsherbiny, Hala F. Zaki
Summary: The innate immune system uses Toll-like receptor 9 (TLR9) to provide protection, but the interaction between mtDNA and TLR9 can lead to inflammation and autoimmune disorders in pathological conditions. The role of TLR9 in different diseases is controversial and further research is needed to develop therapeutic strategies.
Editorial Material
Hematology
Tomomi Toubai
Summary: In this study, the role of G protein-coupled receptor 109A (GPR109A) was examined in the pathophysiology of experimental graft-versus-host disease (GVHD). GPR109A is a receptor for the short chain fatty acid butylate and the B vitamin niacin.
Review
Biochemistry & Molecular Biology
Kamila Stokowa-Soltys, Kamil Wojtkowiak, Karolina Jagiello
Summary: Fusobacterium nucleatum (F. nucleatum) is a common Gram-negative anaerobic bacteria found in the gut and oral cavity, which can be associated with various human diseases. It has the ability to migrate to other parts of the body, causing additional health issues.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Review
Biotechnology & Applied Microbiology
Jiankang Wu, Yiming Ma, Yan Chen
Summary: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease characterized by progressive airflow limitation. Extracellular vesicles (EVs) play an important role in the pathogenesis of COPD and can serve as diagnostic markers and a potential therapy for the disease. EVs are released by various cell types and carry bioactive substances that enable communication between cells and affect the physiological and pathological functions of the body.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Daniel-Clement Osei-Bordom, Sivesh Kamarajah, Niki Christou
Summary: In the clinical management of liver metastasis of colorectal cancer, surgeons and oncologists categorize the metastasis into resectable and non-resectable groups to initiate tailored therapeutics. The combination of targeted therapies and biotherapies around these two entities is being actively explored to determine the ideal conditions for their application to improve patient survival and quality of life.
Review
Pharmacology & Pharmacy
Timothy D. Bryson, Pamela Harding
Summary: This review article summarizes the role of prostaglandin E2 (PGE2) and its receptors (EP1-EP4) in inflammatory cardiomyopathy, myocarditis, and focuses on myocarditis associated with COVID-19.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Surgery
Joshua R. Kapp, Philip C. Mueller, Philippe Gertsch, Christoph Gubler, Pierre-Alain Clavien, Kuno Lehmann
Summary: The management of perforated duodenal diverticula has evolved over the past decade, with a trend towards conservative treatment in stable patients. However, for patients who do not respond to conservative treatment, a step-up approach to surgical intervention may be necessary.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Oncology
Martin Hubner, Mohammad Alyami, Laurent Villeneuve, Delia Cortes-Guiral, Maciej Nowacki, Jimmy So, Olivia Sgarbura
Summary: This study aimed to reach a consensus on best practice of pressurized intraperitoneal aerosol chemotherapy (PIPAC) treatment. Through expert discussions and a Delphi process, consensus was reached on different aspects of PIPAC treatment, while important controversies were identified that require further research and resolution.
Article
Gastroenterology & Hepatology
Christian E. Oberkofler, Dimitri A. Raptis, Philip C. Mueller, Richard X. Sousa da Silva, Kuno Lehmann, Takahiro Ito, Timothy Owen, Joerg-Matthias Pollok, Alessandro Parente, Andrea Schlegel, Peregrina Peralta, Erin Winter, Markus Selzner, Margot Fodor, Manuel Maglione, Manuel Jaklitsch, Hugo P. Marques, Mariana Chavez-Villa, Alan Contreras, Philipp Kron, Peter Lodge, Scott Alford, Abbas Rana, Paolo Magistri, Fabrizio Di Benedetto, Bethany Johnson, Varvara Kirchner, Francis Bauldrick, Karim J. Halazun, Omid Ghamarnedjad, Arianeb Mehrabi, Samanta Teixeira Basto, Eduardo S. M. Fernandes, Jose Paladini, Martin de Santibanes, Sander Florman, Parissa Tabrizian, Philipp Dutkowski, Pierre-Alain Clavien, Ronald W. Busuttil, Fady M. Kaldas, Henrik Petrowsky
Summary: This study found that the use of low-dose aspirin after adult liver transplantation can decrease the risk of acute cellular rejection and hepatic artery thrombosis, and improve the survival rate of the transplanted liver.
LIVER TRANSPLANTATION
(2022)
Article
Surgery
Dilmurodjon Eshmuminov, Debora J. Studer, Victor Lopez Lopez, Marcel A. Schneider, Jan Lerut, Mary Lo, Linda Sher, Thomas J. Musholt, Oana Lozan, Nabila Bouzakri, Carlo Sposito, Rosalba Miceli, Shoma Barat, David Morris, Helga Oehler, Teresa Schreckenbach, Peri Husen, Charles B. Rosen, Gregory J. Gores, Toshihiko Masui, Tan-To Cheung, Corina Kim-Fuchs, Aurel Perren, Philipp Dutkowski, Henrik Petrowsky, Espen Thiis-Evensen, Pal-Dag Line, Michal Grat, Stefano Partelli, Massimo Falconi, Lulu Tanno, Ricardo Robles-Campos, Vincenzo Mazzaferro, Pierre-Alain Clavien, Kuno Lehmann
Summary: This multicenter study compares the outcomes of liver resection (LR) and liver transplantation (LT) in patients with neuroendocrine liver metastasis (NELM). The results suggest that LT provides a survival benefit over LR, but adherence to selection criteria is important.
Article
Oncology
Michel Adamina, Maxime Warlaumont, Martin D. Berger, Silvio Daster, Raphael Delaloye, Antonia Digklia, Beat Gloor, Ralph Fritsch, Dieter Koeberle, Thibaud Koessler, Kuno Lehmann, Phaedra Mueller, Ralph Peterli, Frederic Ris, Thomas Steffen, Christian Stefan Weisshaupt, Martin Huebner
Summary: This study provides comprehensive treatment algorithms for peritoneal cancer, including cytoreductive surgery, systemic immunochemotherapy, and intraperitoneal chemotherapy. These algorithms have been endorsed by Swiss clinicians and can provide guidance for the interdisciplinary care of patients with peritoneal cancer.
Article
Oncology
Lilian Roth, Dilmurodjon Eshmuminov, Linda Russo, Felix Laminger, Friedrich Kober, Sebastian Roka, Kuno Lehmann
Summary: This study aimed to assess the sensitivity and specificity of blood and serum markers after CRS/HIPEC. It found that HIPEC alters the diagnostic sensitivity and specificity of these markers, with PCT identified as a highly specific marker for diagnosing infectious complications after CRS/HIPEC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Dilmurodjon Eshmuminov, Botirjon Aminjonov, Russell F. Palm, Giuseppe Malleo, Ryan K. Schmocker, Raef Abdallah, Changhoon Yoo, Walid L. Shaib, Marcel Andre Schneider, Elena Rangelova, Yoo Jin Choi, Hongbeom Kim, J. Bart Rose, Sameer Patel, Gregory C. Wilson, Sarah Maloney, Lea Timmermann, Klaus Sahora, Fabian Roessler, Victor Lopez-Lopez, Emanuel Boyer, Laura Maggino, Thomas Malinka, Jeong Youp Park, Matthew H. G. Katz, Laura Prakash, Syed A. Ahmad, Scott Helton, Jin-Young Jang, Sarah E. Hoffe, Roberto Salvia, Julien Taieb, Jin He, Pierre-Alain Clavien, Ulrike Held, Kuno Lehmann
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Dilmurodjon Eshmuminov, Botirjon Aminjonov, Russell F. Palm, Kuno Lehmann
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Dilmurodjon Eshmuminov, Botirjon Aminjonov, Russell F. Palm, Giuseppe Malleo, Ryan K. Schmocker, Raef Abdallah, Changhoon Yoo, Walid L. Shaib, Marcel Andre Schneider, Elena Rangelova, Yoo Jin Choi, Hongbeom Kim, J. Bart Rose, Sameer Patel, Gregory C. Wilson, Sarah Maloney, Lea Timmermann, Klaus Sahora, Fabian Rossler, Victor Lopez-Lopez, Emanuel Boyer, Laura Maggino, Thomas Malinka, Jeong Youp Park, Matthew H. G. Katz, Laura Prakash, Syed A. Ahmad, Scott Helton, Jin-Young Jang, Sarah E. Hoffe, Roberto Salvia, Julien Taieb, Jin He, Pierre-Alain Clavien, Ulrike Held, Kuno Lehmann
Summary: Pancreatic cancer often presents as locally advanced or borderline resectable. It is currently unclear which chemotherapy is preferred for patients in these categories. This study found that initial treatment with FOLFIRINOX appears to provide a survival benefit for patients that are ultimately unresectable, compared to gemcitabine-based chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Rahel Stiefel, Kuno Lehmann, Thomas Winder, Alexander R. Siebenhuener
Summary: This study aimed to analyze the outcomes of GEP-NETs treatment and compare them with the latest treatment recommendations. The results showed that treatment steps and stages of GEP-NETs were related to survival rates. Surgery was commonly used in both early and advanced stages, while the use of Somatostatine-Agonist as a drug treatment was also common.
Article
Endocrinology & Metabolism
Alessa Fischer, Simon Kloos, Umberto Maccio, Juliane Friemel, Hanna Remde, Martin Fassnacht, Christina Pamporaki, Graeme Eisenhofer, Henri J. L. M. Timmers, Mercedes Robledo, Stephanie M. J. Fliedner, Katharina Wang, Julian Maurer, Astrid Reul, Kathrin Zitzmann, Nicole Bechmann, Gintare Zygiene, Susan Richter, Constanze Hantel, Diana Vetter, Kuno Lehmann, Hermine Mohr, Natalia S. Pellegata, Martin Ullrich, Jens Pietzsch, Christian G. Ziegler, Stefan R. Bornstein, Matthias Kroiss, Martin Reincke, Karel Pacak, Ashley B. Grossman, Felix Beuschlein, Svenja Noelting
Summary: This study investigated the relationship between SSTR2 immunoreactivity and SDHB immunoreactivity, mutational status, and clinical behavior of PPGLs. It also evaluated SSTR-based therapies in metastatic PPGLs. The results showed that SSTR2 expression was associated with SDHB/SDHx mutations and metastatic disease. Somatostatin receptor-based therapies had a high disease control rate in metastatic PPGLs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Gastroenterology & Hepatology
Ashley Kieran Clift, Morten Hagness, Kuno Lehmann, Charles B. Rosen, Rene Adam, Vincenzo Mazzaferro, Andrea Frilling
Summary: The liver is a common site for metastases, especially from gastrointestinal tumors. Liver transplantation is a promising and sometimes controversial treatment option for neuroendocrine and colorectal liver metastases. Studies have shown excellent long-term outcomes for neuroendocrine liver metastases, but questions remain regarding patient selection, the role of neoadjuvant/adjuvant treatments, and the optimal timing of transplantation. Recent studies have reinvigorated interest in liver transplantation for unresectable colorectal liver metastases, and ongoing trials aim to determine the potential benefits compared to palliative chemotherapy. This review provides a critical summary of current knowledge and highlights areas for further research.
JOURNAL OF HEPATOLOGY
(2023)
Review
Oncology
Kristjan Ukegjini, Marisa Guidi, Kuno Lehmann, Krisztian Sueveg, Paul Martin Putora, Nikola Cihoric, Thomas Steffen
Summary: This study analyzed HIPEC trials registered on ClinicalTrials.gov to identify their focus and assess publication of trial results. Among 234 identified trials, 11% were published and 6% reported results but not as full papers. Most trials were recruiting patients (36%) or completed but unpublished (20%). The majority of trials focused on treatment strategies (68%) and oncological outcomes (53%). The most studied neoplasms were peritoneally metastasized colorectal cancer, gastric cancer, and ovarian cancer.
Article
Oncology
Alessa Fischer, Umberto Maccio, Katharina Wang, Juliane Friemel, Martina A. Broglie Daeppen, Diana Vetter, Kuno Lehmann, Astrid Reul, Mercedes Robledo, Constanze Hantel, Nicole Bechmann, Karel Pacak, Kathrin Zitzmann, Christoph J. Auernhammer, Ashley B. Grossman, Felix Beuschlein, Svenja Noelting
Summary: In pheochromocytomas and paragangliomas, hypoxia upregulates the expression of PD-L1 and HIF-2 alpha, promoting tumor progression and immune microenvironment alterations. Head and neck paragangliomas undergoing embolization show significantly higher expression levels of PD-L1 and HIF-2 alpha, suggesting that targeted treatment using HIF-2 alpha and checkpoint inhibitors may be beneficial.
Review
Medicine, General & Internal
Franz von Stauffenberg, Inga Hegemann, Rahel Schwotzer, Kuno Lehmann, Jeannette Widmer
Summary: This study evaluated therapy strategies for symptomatic abdominal haemophilic pseudotumours and found that primary surgical resection can be considered as the first-line treatment, with preoperative embolisation as a bridging therapy before surgery. Diagnostic biopsy and percutaneous drainage should be avoided to prevent complications.
SWISS MEDICAL WEEKLY
(2023)