Article
Oncology
Josefine Schardey, Can Lu, Jens Neumann, Ulrich Wirth, Qiang Li, Tianxiao Jiang, Petra Zimmermann, Joachim Andrassy, Alexandr V. Bazhin, Jens Werner, Florian Kuehn
Summary: Chronic inflammation plays a significant role in the development of colorectal cancer, particularly in colitis-associated colorectal cancer. This study examined the differences in immune infiltration patterns between colitis-associated colorectal cancer and sporadic colorectal cancer and their impact on prognosis.
Article
Oncology
Mai Iwaya, Hiroyoshi Ota, Tomoyuki Nakajima, Takeshi Uehara, Robert Riddell, James Conner
Summary: The study revealed a lower rate of LGR5 positivity in CAC patients, with a higher expression level of LGR5 in conventional type CAC compared to non-conventional type CAC. CAC showed lower expression levels of LGR5 compared to sporadic CRC, with sporadic CRCs displaying significantly higher LGR5 level scores than non-conventional type CACs.
Review
Gastroenterology & Hepatology
Anouk M. Wijnands, Michiel E. de Jong, Maurice W. M. D. Lutgens, Frank Hoentjen, Sjoerd G. Elias, Bas Oldenburg
Summary: A systematic review and meta-analysis identified 13 risk factors and 5 protective factors for advanced colorectal neoplasia in IBD patients. These findings could contribute to an improved surveillance based on CRC risk stratification in IBD.
Article
Multidisciplinary Sciences
Hongqiang Du, Huawei Xia, Tongtong Liu, Yingjie Li, Jilong Liu, Bingteng Xie, Jingxuan Chen, Tong Liu, Lili Cao, Shengde Liu, Siji Li, Peiyan Wang, Dandan Wang, Zeming Zhang, Yunfei Li, Xiaohuan Guo, Aiwen Wu, Mo Li, Fuping You
Summary: The study revealed that Elf4(-/-) mice developed colon tumors after undergoing 3 cycles of DSS treatment, indicating prevalent ELF4 suppression in both UC patients and mouse models. Oral administration of montmorillonite powder can prevent ELF4 reduction and reduce the risk of colon tumor development.
Review
Immunology
Maorun Zhang, Xiaoping Li, Qi Zhang, Jiahua Yang, Gang Liu
Summary: Colitis-associated colorectal cancer (CAC) is a severe complication of ulcerative colitis (UC), characterized by multiple lesions, worse pathological type, and poor prognosis. Macrophages, as innate immune cells, play a crucial role in both inflammatory response and tumor immunity. Enhanced macrophage infiltration in UC leads to the production of inflammatory cytokines, promoting UC tumorigenesis. Macrophage polarization into M1 has an anti-tumor effect, while M2 polarization promotes tumor growth. Targeting macrophages has shown effectiveness in preventing and treating CAC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Tawnya M. Hansen, Zoann Nugent, Charles N. Bernstein, N. Jewel Samadder, Sanjay K. Murthy, Harminder Singh
Summary: The risk of death following CRC diagnosis is not affected by a diagnosis of IBD in recent years. There is a high proportion of post colonoscopy CRC among IBD-CRC patients, which has remained unchanged over the years and requires detailed root-cause analysis and interventions.
Article
Gastroenterology & Hepatology
Alex Adams, Vipin Gupta, Waled Mohsen, Thomas P. Chapman, Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy, Sudheer Kumar, Saurabh Kedia, Colleen G. C. McGregor, Tim Ambrose, Bruce D. George, Rebecca Palmer, Oliver Brain, Alissa Walsh, Vineet Ahuja, Simon P. L. Travis, Jack Satsangi
Summary: The changes in acute severe colitis (ASC) management have resulted in improved outcomes. A simple predictive model can be used to identify patients who will not respond to steroids upon admission.
Article
Gastroenterology & Hepatology
Chen Liu, Zi-Ying Yuan, Hao Yuan, Ke-Xiang Wu, Bin Cao, Ke-Yu Ren, Ming-Juan Cui, Jun-Heng Liu, Hai-Xing Chen, Yao-Wei Pang
Summary: The hypomethylation of COX-2 gene is a common risk factor and epigenetic modification for UC and SCRC, while hypermethylation of MINT1 is a risk factor for SCRC. Alleles of IL-23R and IL-1β are related to UC but not to SCRC.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Filippos Koutroumpakis, Anna Evans Phillips, Dhiraj Yadav, Jorge D. Machicado, Maaz Ahsan, Claudia Ramos Rivers, Xiaoqing Tan, Marc Schwartz, Siobhan Proksell, Elyse Johnston, Jeffrey Dueker, Jana G. Hashash, Arthur Barrie, Janet Harrison, Michael A. Dunn, Liza Konnikova, Douglas J. Hartman, Hasieb Din, Dmitriy Babichenko, Gong Tang, David G. Binion
Summary: The study identified that IgG4 subclass deficiency is common in patients with IBD and associated with markers of disease severity. Treatment with intravenous Ig replacement therapy was beneficial in patients with IgG4-deficient severe IBD. Further research is needed to understand the mechanistic role of IgG4 deficiency in this subset of severe IBD patients.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Immunology
Chen Zhang, Jiantao Zhang, Yanli Zhang, Zian Song, Jing Bian, Huanfa Yi, Zhanchuan Ma
Summary: This study investigated the pathogenesis of ulcerative colitis (UC) and found that neutrophils may promote the conversion of UC into colitis-associated colorectal cancer (CAC). By analyzing transcriptome data, 65 differentially expressed genes related to UC were identified, as well as immune-related biological pathways. The association between neutrophils and UC was confirmed using CIBERSORT and WGCNA analysis. These findings were validated in a mouse model, and 5 genes were identified as potential biomarkers. The results contribute to a better understanding of the pathogenesis of CAC and provide new insights for its prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kit Curtius, Misha Kabir, Ibrahim Al Bakir, Chang Ho Ryan Choi, Juanda L. Hartono, Michael Johnson, James E. East, James O. Lindsay, Roser Vega, Siwan Thomas-Gibson, Janindra Warusavitarne, Ana Wilson, Trevor A. Graham, Ailsa Hart
Summary: This study identified that patients with large, unresected, multifocal LGD and recent moderate/severe inflammation are at highest risk of developing advanced neoplasia. Personalised risk prediction provided via the Ulcerative Colitis-Cancer Risk Estimator can support treatment decision-making.
Article
Gastroenterology & Hepatology
Jose Maria Huguet, Luis Ferrer-Barcelo, Patricia Suarez, Eva Sanchez, Jose David Prieto, Victor Garcia, Javier Sempere
Summary: The detection of dysplasia in IBD patients is important and chromoendoscopy with targeted biopsy remains the preferred technique. However, other techniques such as virtual chromoendoscopy are being compared due to their similar results and fewer technical difficulties. New endoscopy techniques and improved devices have the potential to revolutionize the screening and follow-up of dysplasia in IBD patients. Further research is needed to define the optimal follow-up strategy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Rish K. Pai, Douglas J. Hartman, Jonathan A. Leighton, Shabana F. Pasha, Claudia Ramos Rivers, Miguel Regueiro, David G. Binion, Reetesh K. Pai
Summary: Persistent histologic activity during multiple surveillance episodes is an independent predictor of colorectal neoplasia. Mean RHI and mean NHI during a 5-year colonoscopic surveillance period can be used to assess risk for colorectal neoplasia and optimize UC surveillance.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Adam Faye, James C. Slaughter, Noam Harpaz, Steven H. Itzkowitz, Shailja C. Shah
Summary: Colorectal strictures in patients with inflammatory bowel disease (IBD) are not independently associated with the risk of advanced colorectal neoplasia (ACRN) or colectomy, according to a retrospective cohort analysis. Further multicenter, prospective studies are needed to confirm these findings.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Cell & Tissue Engineering
Gang Guo, Zhaobang Tan, Yaping Liu, Feiyu Shi, Junjun She
Summary: For the treatment of UC and CRC, MSC-Exo can exert beneficial effects through modulating immune responses and inducing anti-tumor responses via different mechanisms.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Henry Leonhardt, Andreas Ziegler, Guenter Lauer, Adrian Franke
Summary: This retrospective study investigated the clinical and radiologic outcomes of osteosynthesis of mandibular condyle fractures with biodegradable magnesium-based compression screws in 6 patients. The results showed that this treatment method provided good clinical results and avoided implant removal, even in cases of screw penetration through the condylar surface.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Computer Science, Information Systems
Andreas Ziegler, Kristin Forssmann, Sabine Konopka, Katja Krockenberger
Summary: The European Medical Device Regulation requires manufacturers to establish postmarket surveillance systems and develop postmarket clinical follow-up plans. This study presents a modular approach to combine PMS and PMCF studies into a single study, aiming to streamline the conduct of multiple studies.
METHODS OF INFORMATION IN MEDICINE
(2021)
Book Review
Mathematical & Computational Biology
Andreas Ziegler
BIOMETRICAL JOURNAL
(2022)
Article
Oncology
Benedek Bozoky, Carlos Fernandez Moro, Carina Strell, Natalie Geyer, Rainer L. Heuchel, J. Matthias Lohr, Ingemar Ernberg, Laszlo Szekely, Marco Gerling, Bela Bozoky
Summary: PDAC tumor cells integrated into the duodenal epithelium show a reversal to non-destructive growth and adopt the traits of intestinal cell differentiation, leading to phenotypical stabilization of the classical subtype. This phenomenon is conserved across species, highlighting the influence of microenvironmental cues on pancreatic cancer plasticity.
Article
Oncology
C. Stromberg, L. Martinez de la Maza, C. Fernandez Moro, M. Gerling, C. Jorns, E. Sparrelid, M. J. Lohr, C. Villard
Summary: Heterogeneous response to neoadjuvant chemotherapy in patients with colorectal liver metastases is associated with prognosis and can be used as a marker for post-operative therapy decisions.
Article
Computer Science, Interdisciplinary Applications
Nicole Hessler, Andreas Ziegler
Summary: Publications and citations are crucial for the career advancement of researchers. This study examines the title and article characteristics of medical research articles published in major journals from 2011 to 2020, and identifies factors that affect citation frequency. The findings suggest that open access, more authors, and the use of active verbs increase citation frequency, while mentioning geographical locations decreases citation frequency.
Article
Cardiac & Cardiovascular Systems
Ersin Cavus, Jan N. Schneider, Ramona Bei der Kellen, Eleonora di Carluccio, Andreas Ziegler, Enver Tahir, Sebastian Bohnen, Maxim Avanesov, Ulf K. Radunski, Celeste Chevalier, Charlotte Jahnke, Francisco Ojeda, Paulus Kirchhof, Stefan Blankenberg, Gerhard Adam, Gunnar K. Lund, Kai Muellerleile
Summary: This study evaluated the impact of sex and cardiovascular risk factors on myocardial T1, extracellular volume fraction (ECV), and T2 in a population-based study. The results showed that sex was the major influencing factor for these measurements, with higher values in female participants. Cardiovascular risk factors such as hypertension and diabetes did not have a systematic effect on T1, but hypertension had an independent effect on T2.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Multidisciplinary Sciences
Raphael O. Betschart, Alexandre Thiery, Domingo Aguilera-Garcia, Martin Zoche, Holger Moch, Raphael Twerenbold, Tanja Zeller, Stefan Blankenberg, Andreas Ziegler
Summary: This study compared six WGS data pre-processing pipelines and found that the DRAGEN pipeline outperformed the GATK pipeline in terms of speed in the mapping and alignment step, as well as accuracy in the variant calling step.
SCIENTIFIC REPORTS
(2022)
Book Review
Mathematical & Computational Biology
Andreas Ziegler
BIOMETRICAL JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Ziegler, Alper Oner, Gisela Quadflieg, Raphael O. Betschart, Alexandre Thiery, Hugo Babel, Henry G. Mwambi, Henriette Neumeyer, Steffen Mackschin, Sissy Hintz, Miriam Mann, Hermann Dittrich, Christian Schmidt
Summary: The main objective of this study was to analyze the cost-effectiveness of an integrated care concept (NICC) that combines telemonitoring with the support of a care center in addition to guideline therapy. The secondary aim was to compare health utility and quality of life between NICC and standard of care (SoC). The study found that NICC was associated with higher QoL and health utility compared to SoC.
Article
Computer Science, Information Systems
Giorgos Koliopanos, Francisco Ojeda, Andreas Ziegler
Summary: This work introduces a simple-to-use R package called "Mock Data Generation (modgo)" that can be used to simulate data from existing study data for continuous, ordinal categorical, and dichotomous variables. The core method combines rank inverse normal transformation with the calculation of a correlation matrix for all variables. modgo allows for flexibility in changing the correlation between variables, performing perturbation analysis, handling multicenter data, and changing inclusion/exclusion criteria.
METHODS OF INFORMATION IN MEDICINE
(2023)
Review
Oncology
Lisa L. Liu, Marcus Skribek, Ulrika Harmenberg, Marco Gerling
Summary: Immune checkpoint inhibitors (ICIs) can cause various immune-related adverse events, including cytokine release syndrome (CRS) and hemophagocytic lymphohistiocytosis (HLH). This study provides a systematic review of CRS and related side effects of ICI treatment, and highlights the rarity of these complications. The review also suggests the potential benefits of using IL-6 inhibitors in combination with ICIs to enhance antitumoral effects and reduce hyperinflammation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Mathematical & Computational Biology
Francisco M. Ojeda, Max L. Jansen, Alexandre Thiery, Stefan Blankenberg, Christian Weimar, Matthias Schmid, Andreas Ziegler
Summary: Statistical prediction models are popular in applied research, but transferring the model to a different population poses a challenge. This study systematically evaluates various calibration approaches for two-class probability estimation. Logistic calibration and beta calibration consistently show the best results, with calibration on logit transformed probability estimates generally outperforming non-transformed estimates. Regression-based calibration approaches are recommended for validation studies.
STATISTICS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nicole Hessler, Andreas Ziegler
Summary: This study examined the differences in content and form of titles between original research articles published in major medical journals between 2011 and 2020. The analysis of 500 randomly chosen articles revealed that there were minimal mentions of results, quantitative information, declarative titles, dashes, or question marks in the titles across all journals. However, the use of subtitles and methods-related items increased over time, while the use of phrasal titles decreased. The study also found variations in the use of study names among the journals, with the Lancet having the highest usage. The findings highlight the importance for authors to carefully consider the titles of journal articles in their target journal before submission.
Article
Surgery
Lena Sonnow, Andreas Ziegler, Gesa H. Poehler, Martin H. Kirschner, Maximilian Richter, Mustafa Cetin, Melih Unal, Ozkan Kose
Summary: The study showed a significant reduction in signal loss artifacts of bioabsorbable magnesium screws in postoperative MRI over time, indicating the expected self-degradation of the Mg implants. Various MRI findings such as bone marrow edema, liquid collections, and gas formation were reported. High inter-reader agreement was found in qualitative assessments across all MRI sequences.
INNOVATIVE SURGICAL SCIENCES
(2022)
