期刊
ANNALS OF SURGERY
卷 249, 期 5, 页码 735-737出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SLA.0b013e3181a38f11
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- Cancer Institute New South Wales
- The Cancer Council New South Wales
- National Health and Medical Research Council of Australia
- R. T. Hall Trust
Objective: To assess the potential utility of in vivo histologic surface and subsurface imaging in real-time using the Optiscan confocal laser microscope to detect diseased tissue at the time of surgery. Summary Background Data: The goal of surgical treatment of diseases such as cancer is complete microscopic resection of diseased tissue; however, current methods for the assessment of extent of disease at the time of surgery are inadequate. Methods: We assessed the potential of the Optiscan confocal laser microscope, a new device developed for real-time in vivo histologic surface and subsurface imaging during surgery. Results: Intravenous Fluorescein Sodium contrast enabled visualization of cellular and architectural morphology of intra-abdominal organs with magnification equivalent to light microscopy and enabled differentiation between normal organs and disease. Conclusions: Real time intraoperative confocal microscopy has significant potential application in detecting disease, and influencing decision-making at the time of surgery.
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