Article
Oncology
Goksen Inanc Imamoglu, Arzu Oguz, Sanem Cimen, Tuelay Eren, Cengiz Karacin, Dilsen Colak, Mustafa Altsbas, Sema Turker, Dogan Yazilita
Summary: The study found that positive lymph node ratio (PLNR) is a significant prognostic factor for survival in Stage III colorectal cancer patients, with a ratio above 0.31 indicating a poor prognosis. Prospective trials with larger patient groups are needed to further validate the role of PLNR as a prognostic indicator.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Surgery
Muhammer Ergenc, Tevfik Kivilcim Uprak, Muhammed Ikbal Akin, Ece Elif Hekimoglu, cigdem Ataizi Celikel, Cumhur Yegen
Summary: This study evaluated the relationship between lymph node ratio (LNR) and survival in patients who underwent curative gastric cancer (GC) surgery, and found that a high LNR was significantly associated with poor overall survival (OS). LNR can serve as an independent prognostic predictor in GC patients.
Article
Medicine, General & Internal
Emir Capkinoglu, Aydin Eray Tufan, Sinan Omeroglu, Mert Tanal, Onur Guven, Uygar Demir
Summary: This study aims to evaluate the prognostic significance of positive lymph nodes following surgery in patients with gastric adenocarcinoma. A total of 193 patients who underwent curative gastrectomy were included in this retrospective study. The results suggest that the positive lymph node ratio has some predictive value for prognosis in these patients.
Article
Oncology
Jinyoung Kim, Jun Park, Hyunju Park, Min Sun Choi, Hye Won Jang, Tae Hyuk Kim, Sun Wook Kim, Jae Hoon Chung
Summary: The study suggests using the metastatic lymph node ratio (LNR) as a quantitative evaluation tool for lymph node metastasis in patients with medullary thyroid cancer (MTC), which can potentially predict structural recurrence.
Article
Cell Biology
Zhe Wang, Wei Chong, Huikun Zhang, Xiaoli Liu, Yawen Zhao, Zhifang Guo, Li Fu, Yongjie Ma, Feng Gu
Summary: LNR is an accurate prognostic indicator in breast cancer, but previous studies have ignored the impact of APN(+) patients. This study found that excluding APN(+) patients is necessary for the effective implementation of the LNR system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Surgery
Hao Zhang, Yunxiao Liu, Chunlin Wang, Zilong Guan, Hang Yu, Chao Xu, Mingyu Zheng, Yuliuming Wang, Hanqing Hu, Rui Huang, Guiyu Wang
Summary: A modified TNM staging system was constructed for stage I-III colon cancer patients with lymph nodes examined less than 12, using lymph node ratio to predict prognosis accurately. The mStage system showed superior predictive power compared to the conventional TNM staging system in predicting cancer-specific survival for these patients.
WORLD JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Xi-Lin Yang, Nan Huang, Ming-Ming Wang, Hua Lai, Da-Jun Wu
Summary: Comparing the prognostic predictive performance of six lymph node staging schemes in node-positive endometrioid endometrial cancer patients, it was found that lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) had better predictive performance for prognosis assessment than other number-based lymph node schemes, suggesting that LNR and LODDS may be more useful in prognosis assessment for these patients than the AJCC N stage.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Chuyang Huang, Qian Long, Yangxun Pan, Leilei Wu, Xiaonan Wang, Hailin Xu, Fufu Zheng
Summary: The study found that in patients with testicular germ cell tumors, LNR was a better predictor for long-term prognosis and was closely associated with clinical pathological characteristics compared to LNC.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Il Ku Kang, Joonseon Park, Ja Seong Bae, Jeong Soo Kim, Kwangsoon Kim
Summary: The American Thyroid Association risk stratification system indicates that having more than 5 metastatic lymph nodes (LNs) increases the risk of recurrence in patients with papillary thyroid carcinoma (PTC). This study aimed to stratify PTC patients with fewer than 5 harvested LNs based on lymph node ratios (LNRs). The results showed that LNR can be used to stratify the risk of recurrence in patients with low-LNY PTC.
Article
Oncology
Filipa Macedo, Hugo Sequeira, Katia Ladeira, Nuno Bonito, Charlene Viana, Sandra Martins
Summary: The lymph node ratio (LNR) may be a better prognostic indicator than pN categories in colon cancer patients. Total number of dissected lymph nodes is significantly correlated with pN, but not with LNR.
Article
Oncology
Yoon Hee Lee, Gun Oh Chong, Su Jeong Kim, Ja Hyun Hwang, Jong Mi Kim, Nora Jee-Young Park, Dae Gy Hong
Summary: The study evaluated the prognostic value of various lymph node characteristics, with LNR identified as a potential biomarker for predicting disease recurrence in cervical cancer patients treated with radical hysterectomy. High LNR was significantly associated with tumor recurrence, while total retrieved LN counts and level of lymphadenectomy did not impact survival outcomes.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Hongjiang Pu, Xiaolin Pang, Jiangping Fu, Rui Zheng, Yaxue Chen, Dafu Zhang, Xiangdong Fang
Summary: The study found that the number of tumor deposits is closely associated with the risk of recurrence in patients with stage III CRC, especially in those with more than 4 tumor deposits. Therefore, it is important to incorporate both the number of tumor deposits and the number of lymph node metastases to assess patients' prognostic risk.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Medicine, General & Internal
Haixia Cui, Yuan Huang, Weibo Wen, Xiangdan Li, Dongyuan Xu, Lan Liu
Summary: This study found through meta-analysis that high lymph node ratio (LNR) is an adverse prognostic factor for cervical cancer (CC). The median LNR of approximately 0.0625 and 0.066 was identified as a prominent risk factor. Further clinical studies are needed to validate whether LNR can independently predict CC prognosis.
Article
Multidisciplinary Sciences
Masatoshi Kitakaze, Shiki Fujino, Norikatsu Miyoshi, Yuki Sekido, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Summary: Approximately 10% of colorectal cancer patients with submucosal invasion have lymph node metastasis. Tumor-infiltrating T cells have been found to be associated with lymph node metastasis in these patients, and the levels of CD8(+) tumor-infiltrating T cells are positively correlated with lymph node metastasis. Combining the numbers of CD8(+) tumor-infiltrating T cells and CD103(+) tumor-infiltrating T cells can provide high predictive values for lymph node metastasis.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Ramazan Topcu, Ibrahim T. Sahiner, Murat Kendirci, Murathan Erkent, Ismail Sezikli, Mehmet B. Tutan
Summary: This study investigated the influence of the metastatic lymph node/total lymph node ratio (N-ratio) on survival and prognosis in surgically treated gastric carcinomas. The results found that a N-ratio higher than 0.32 was associated with poorer survival and prognosis. Additionally, the N-ratio was also found to be useful in identifying patients with a higher risk of mortality.
SAUDI MEDICAL JOURNAL
(2022)