Article
Clinical Neurology
Ying Zhou, Yaode He, Shenqiang Yan, Lin Chen, Ruoxia Zhang, Jinjin Xu, Haitao Hu, David S. Liebeskind, Min Lou
Summary: This study aimed to investigate the presence of reperfusion injury in acute ischemic stroke patients with recanalization after mechanical thrombectomy and analyze its impact on neurological outcome. The results showed that reperfusion injury was relatively frequent in stroke patients with recanalization after mechanical thrombectomy and was associated with poor prognosis.
Review
Clinical Neurology
Evan M. Krueger, Aaron J. Gustin, Paul J. Gustin, Zachary Jaffa, Hamad Farhat
Summary: This study analyzed 48 cases of intraparenchymal hemorrhage (IPH) after evacuation of chronic subdural hematoma (cSDH), finding that males were the majority with a mean age of 67.5 years. Headache was the main symptom, and surgical technique and reperfusion pathophysiology may play a role in prevention.
WORLD NEUROSURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Ting Liu, Andrew G. Howarth, Yinyin Chen, Anand R. Nair, Hsin-Jung Yang, Daoyuan Ren, Richard Tang, Jane Sykes, Michael S. Kovacs, Damini Dey, Piotr Slomka, John C. Wood, Robert Finney, Mengsu Zeng, Frank S. Prato, Joseph Francis, Daniel S. Berman, Prediman K. Shah, Andreas Kumar, Rohan Dharmakumar
Summary: Reperfusion therapy for acute myocardial infarction can lead to myocardial hemorrhage, which increases the size of the infarction. Myocardial hemorrhage drives the expansion of myocardial infarction after reperfusion and compromises myocardial salvage. This has implications for acute care management, risk assessment, and future therapeutics.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Clinical Neurology
Mahmoud H. Mohammaden, Mohamed Fahmy Doheim, Mohamed Elfil, Alhamza R. Al-Bayati, Agostinho Pinheiro, Thanh N. Nguyen, Nirav R. Bhatt, Diogo C. Haussen, Raul G. Nogueira
Summary: This meta-analysis study suggests that the direct transfer to angiography suite (DTAS) approach for patients with suspected large vessel occlusion stroke can shorten treatment times and improve outcomes compared with the direct transfer to conventional imaging (DTCI) model. The DTAS approach shows improved time metrics and functional outcomes with comparable safety to the DTCI approach.
Article
Cell Biology
Jan Van Slambrouck, Dirk Van Raemdonck, Robin Vos, Cedric Vanluyten, Arno Vanstapel, Elena Prisciandaro, Lynn Willems, Michaela Orlitova, Janne Kaes, Xin Jin, Yanina Jansen, Geert M. Verleden, Arne P. Neyrinck, Bart M. Vanaudenaerde, Laurens J. Ceulemans
Summary: Primary graft dysfunction (PGD) is the clinical syndrome of acute lung injury after lung transplantation, involving various levels including clinical, physiological, radiological, histological, and cellular. Understanding these aspects of PGD can provide insights into acute lung failure after transplantation and contribute to the development of novel therapies.
Review
Clinical Neurology
Nathan Beucler, Pierre-Julien Cungi, Arnaud Dagain
Summary: DBH is a hemorrhage in the brainstem caused by sudden downward displacement of the brainstem after an episode of increased intracranial pressure. The systematic literature review and meta-analysis revealed the limited evidence on the epidemiology, pathophysiology, clinical presentation, and outcome of DBH.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Felix C. Ng, Nawaf Yassi, Gagan Sharma, Scott B. Brown, Mayank Goyal, Charles B. L. M. Majoie, Tudor G. Jovin, Michael D. Hill, Keith W. Muir, Jeffrey L. Saver, Francis Guillemin, Andrew M. Demchuk, Bijoy K. Menon, Luis San Roman, Philip White, Aad van der Lugt, Marc Ribo, Serge Bracard, Peter J. Mitchell, Stephen M. Davis, Kevin N. Sheth, W. Taylor Kimberly, Bruce C. Campbell
Summary: This study investigated the correlation between NWU measured postthrombectomy and volumetric markers of cerebral edema and its association with functional outcomes. The results showed that NWU correlated poorly with conventional markers of cerebral edema and was not associated with clinical outcome in the presence of hemorrhagic transformation and thrombectomy.
Article
Multidisciplinary Sciences
David Andrijevic, Zvonimir Vrselja, Taras Lysyy, Shupei Zhang, Mario Skarica, Ana Spajic, David Dellal, Stephanie L. Thorn, Robert B. Duckrow, Shaojie Ma, Phan Q. Duy, Atagun U. Isiktas, Dan Liang, Mingfeng Li, Suel-Kee Kim, Stefano G. Daniele, Khadija Banu, Sudhir Perincheri, Madhav C. Menon, Anita Huttner, Kevin N. Sheth, Kevin T. Gobeske, Gregory T. Tietjen, Hitten P. Zaveri, Stephen R. Latham, Albert J. Sinusas, Nenad Sestan
Summary: Researchers have developed a technology called OrganEx that can maintain tissue integrity, reduce cell death, and restore molecular and cellular processes in multiple vital organs in a pig's whole body. Single-nucleus transcriptomic analysis revealed gene expression patterns specific to organ and cell type, reflecting specific molecular and cellular repair processes. This study reveals the underappreciated potential for cellular recovery after prolonged whole-body warm ischemia in large mammals.
Review
Neurosciences
Xiaopeng Li, Lang Zeng, Xuanzhen Lu, Kun Chen, Maling Yu, Baofeng Wang, Min Zhao
Summary: Early brain injury (EBI) following subarachnoid hemorrhage (SAH) is strongly associated with delayed cerebral ischemia and poor prognosis. Various pathological processes, such as microvascular alterations, ionic imbalances, blood-brain barrier disruption, immune-inflammatory responses, oxidative stress, and cell death activation, contribute to neurovascular dysfunction after SAH. Promising therapeutic approaches for preserving neurological function after SAH include calcium channel antagonists, endothelin-1 receptor blockers, antiplatelet agents, anti-inflammatory agents, and anti-oxidative stress agents. Mitigating EBI through neuroprotective measures is critical, and understanding the molecular pathways involved in brain injury, including brain ischemia-hypoxic injury, neuroimmune inflammation activation, and cell-signaling pathway activation, is essential for better treatment outcomes.
Article
Clinical Neurology
Mohammad Anadani, Benjamin Maier, Simon Escalard, Julien Labreuche, Adam de Havenon, Candice Sabben, Bertrand Lapergue, Benjamin Gory, Sebastien Richard, Igor Sibon, Jean-Philippe Desilles, Raphael Blanc, Michel Piotin, Mikael Mazighi
Summary: The study found that Delta SBP had a linear relationship with poor outcome after successful reperfusion, and the risk of poor outcome was higher with less reduction from the baseline SBP. Additionally, Delta SBP was associated with intraparenchymal hemorrhage.
Article
Clinical Neurology
Nicholas A. Morris, Gaurav Jindal, Seemant Chaturvedi
Summary: The optimal blood pressure targets following successful mechanical thrombectomy are still uncertain. Observational studies have shown conflicting results, suggesting either a U-shaped curve or a linear relationship between blood pressure and outcomes. Recent trials have not found a benefit to intensive blood pressure lowering, but there are concerns regarding their generalizability and safety. Further research is needed to determine the most appropriate approach.
Review
Neurosciences
Katherine Holste, Fan Xia, Hugh J. L. Garton, Shu Wan, Ya Hua, Richard F. Keep, Guohua Xi
Summary: Intracerebral hemorrhage (ICH) leads to activation of the complement cascade, resulting in brain edema/injury, but inhibition of specific components of the complement cascade can reduce edema and improve functional outcomes. Additionally, complement plays a significant role in neurologic recovery after ICH.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Critical Care Medicine
Sarah Wahlster, Monisha Sharma, Frances Chu, Justin H. Granstein, Nicholas J. Johnson, W. T. Longstreth, Claire J. Creutzfeldt
Summary: The study shows that approximately one in three patients with severe acute brain injury who undergo tracheostomy may eventually achieve independence. Further research is needed to understand the reasons for heterogeneity between studies and identify patients with promising outcomes and influencing factors.
NEUROCRITICAL CARE
(2021)
Review
Biochemistry & Molecular Biology
Eman Maher Zahran, Ahmed M. Sayed, Rania Alaaeldin, Mahmoud A. Elrehany, Amira R. Khattab, Usama Ramadan Abdelmohsen
Summary: This article conducts a comprehensive survey on functional food bioactives for managing or protecting against the health consequences of myocardial and cerebral ischemia. Mechanistic studies and in silico-based analyses were performed to explore their potential in targeting the complex pathophysiology of ischemic conditions. The results suggest that these functional food bioactives exhibit multifactorial effects and can be used as valuable therapeutic agents in combination with conventional drugs.
Article
Clinical Neurology
Imad R. Khan, Yang Gu, Benjamin P. George, Laura Malone, Kyle S. Conway, Fabienne Francois, Jack Donlon, Nadim Quazi, Ashwin Reddi, Cheng-Ying Ho, Daniel L. Herr, Mahlon D. Johnson, Gunjan Y. Parikh
Summary: Neuropathological findings after ECMO are common, diverse, and associated with various clinical factors. Some patients with normal neuroimaging results were found to have pathology on autopsy, indicating that imaging cannot completely rule out brain injury.