Article
Biochemistry & Molecular Biology
Yun-Lung Chung, Pei-Yu Chou, Ming-Jyh Sheu
Summary: This study evaluated the wound-healing activity of PEDOT: PSS and found that it significantly improved wound healing in SD rats. The treatment increased angiogenic behavior and VEGF expression, indicating its angiogenic effects. The results suggest that PEDOT: PSS can be potentially used as a dressing for medical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Kuixiang Wang, Ziying Chen, Liang Jin, Lili Zhao, Libin Meng, Fanting Kong, Chenxin He, Fanlei Kong, Lingtao Zheng, Fang Liang
Summary: This study investigated the impact of LPS pretreated human adipose-derived MSCs on skin wound healing in diabetic rats. The findings revealed improvements in epithelialization and angiogenesis of diabetic wounds after LPS pre-MSCs treatment. Furthermore, LPS treatment led to increased cell viability, upregulation of VEGF and DNMT1 protein expression in MSCs. These results suggest that LPS pre-MSCs can promote wound repair and skin regeneration in the diabetic microenvironment.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Plant Sciences
Nutda Sutthammikorn, Volaluck Supajatura, Hainan Yue, Miho Takahashi, Sunee Chansakaow, Nobuhiro Nakano, Pu Song, Takasuke Ogawa, Shigaku Ikeda, Ko Okumura, Hideoki Ogawa, Francois Niyonsaba
Summary: Gynura procumbens may have therapeutic effects on nonhealing diabetic wounds, promoting wound healing by accelerating the process and activating cells involved in the healing process. This suggests that G. procumbens could be an effective alternative therapeutic option for nonhealing diabetic wounds.
Article
Cell & Tissue Engineering
Rosalinda D'Amico, Camilla Malucelli, Andrea Uccelli, Andrea Grosso, Nunzia Di Maggio, Priscilla S. Briquez, Jeffrey A. Hubbell, Thomas Wolff, Lorenz Gurke, Edin Mujagic, Roberto Gianni-Barrera, Andrea Banfi
Summary: Chronic wounds in type-2 diabetic patients often have severe local skin ischemia despite normal blood flow. By using fibrin hydrogels decorated with engineered growth factors, wound closure and microvascular growth can be promoted.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Keng-Fan Liu, Su-Shin Lee, Shu-Hung Huang, Yi-Chia Wu, Yun-Nan Lin, Chun-Ting Wang, Yur-Ren Kuo
Summary: The study revealed that FIR therapy could significantly accelerate diabetic wound healing, associated with suppressed inflammatory response, increased neovascularization, and tissue regeneration.
Article
Biochemistry & Molecular Biology
Mohammed Z. Z. Nasrullah
Summary: Caffeic acid phenethyl ester-loaded PEG-PLGA nanoparticles have potent healing effects in diabetic wounds by accelerating wound closure and exhibiting antioxidant, anti-inflammatory, pro-collagen, and angiogenic activities.
Article
Pharmacology & Pharmacy
Shahid Karim, Huda M. Alkreathy, Aftab Ahmad, Mohammad Imran Khan
Summary: The topical application of Saudi pomegranate peel extract in gel significantly enhanced wound healing in experimentally induced diabetic conditions, promoting wound contraction, increasing hydroxyproline content, and influencing growth factor expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Yang An, Shuyan Lin, Xiaojie Tan, Shiou Zhu, Fangfei Nie, Yonghuan Zhen, Luosha Gu, Chunlei Zhang, Baicheng Wang, Wei Wei, Dong Li, Junhao Wu
Summary: ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling to inhibit scar hyperplasia in wounds. Compared with ADSCs therapeutics, ADSCs-EXOs have high stability, easy storage, immune system non-rejection, homing effect, and easily controlled dosage. In patients with diabetes mellitus, ADSCs-EXOs can improve fat grafting and promote wound healing.
CELL PROLIFERATION
(2021)
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
Article
Endocrinology & Metabolism
Qingsong Zhao, Jinmei Xu, Xu Han, Zheqi Zhang, Jiahui Qu, Zhifeng Cheng
Summary: This study investigated the role of growth differentiation factor 10 (GDF-10) in wound healing in diabetic foot ulcers (DFU) by regulating the transforming growth factor-beta 1 (TGF-beta 1)/Smad3 pathway. The results suggest that GDF-10 may promote angiogenesis by activating the TGF-beta 1/Smad3 signaling pathway, thereby promoting wound healing in DFU rats.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Yue Zhang, Meng Li, Yunchuan Wang, Fei Han, Kuo Shen, Liang Luo, Yan Li, Yanhui Jia, Jian Zhang, Weixia Cai, Kejia Wang, Ming Zhao, Jing Wang, Xiaowen Gao, Chenyang Tian, Baolin Guo, Dahai Hu
Summary: Chronic diabetic wounds are a globally recognized clinical challenge, and this study found that using exosome-based bioactive dressings as an alternative method for diabetic wound healing has great potential. However, research on multifunctional hydrogels loaded with drugs and bioactive substances that synergistically promote wound repair is lacking, and the mechanism of their combinatorial effect remains unclear.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Environmental
Han Peng, Huichen Li, Xi Zhang, Jiezhang Tang, Yongping Liang, Lipeng Qiao, Yun Zhu, Mengmeng Hou, Siming Wei, Zhaoxiang Zhang, Chaohua Liu, Xinmao Li, Baoyan Liang, Baoqiang Song, Baolin Guo, Jie Zhang
Summary: In this study, a multi-functional hydrogel with 3D-exosome-sustained release features was developed to improve diabetic wound healing. It exhibited tissue-adhesive, self-healing, antibacterial, anti-inflammatory, and antioxidant properties. The hydrogel promoted angiogenesis and collagen deposition, accelerated the recovery of diabetic wounds, and achieved rapid hemostasis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Chang Sik Pak, Chan Yeong Heo, Jisoo Shin, Soo Young Moon, Seung-Woo Cho, Hyo Jin Kang
Summary: The combination of HA-CA and ADSCs showed synergistic effects in diabetic wound healing, providing significant healing effects by maximizing paracrine signaling and angiogenesis. This combination might represent a novel strategy for the treatment of diabetic wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Giuseppe Caruso, Anna Privitera, Osama A. A. Ahmed, Usama A. Fahmy, Shadab Md, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Basma G. Eid, Ashraf B. Abdel-Naim, Filippo Caraci
Summary: Impaired diabetic wound healing is a global concern for healthcare professionals. This study developed a fluoxetine ecofriendly nanoemulsion (FLX-EFNE) and demonstrated its significant efficacy in promoting wound healing in diabetic rats.
Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kalliopi Lampropoulou-Adamidou, Efthymia Karlafti, Chrysoula Argyrou, Konstantinos Makris, George Trovas, Ismene A. Dontas, Symeon Tournis, Ioannis K. Triantafyllopoulos
Summary: The study demonstrates that supplementation with calcium, vitamin D, and CPs can improve trabecular and cortical bone parameters, prevent a decline in aBMD, and decrease bone turnover in postmenopausal women with osteopenia.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Review
Rheumatology
Dimitrios Vasileiadis, Georgios Drosos, Georgios Charitoudis, Ismene Dontas, John Vlamis
Summary: This systematic review suggests that preoperative rehabilitation has a positive effect on reducing pain and improving functional performance after total knee arthroplasty. However, its impact on knee motion and long-term function is limited.
MUSCULOSKELETAL CARE
(2022)
Article
Clinical Neurology
Aigli Vakrakou, Theofanis Chatzistamatiou, Christos Koros, Dimitris Karathanasis, Vasileios Tentolouris-Piperas, Dimitrios Tzanetakos, Panos Stathopoulos, Georgios Koutsis, Maria Spyropoulou-Vlachou, Maria-Eleftheria Evangelopoulos, Leonidas Stefanis, Catherine Stavropoulos-Giokas, Maria Anagnostouli
Summary: This study reports two cases of thymectomized patients with acetylcholine receptor antibody-positive myasthenia gravis who eventually developed AQP4-NMO. Genetic sequencing analysis suggests the involvement of specific HLA alleles in rare forms of combined human peripheral and central nervous system autoimmunity.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Medicine, Research & Experimental
Anna Aikaterini Neri, Dimitrios Galanis, Antonis Galanos, Angeliki Eirini Pepe, Konstantinos Soultanis, Alexandros Zervas, Spyridon Zoitsis, Stavros K. Kourkoulis, Ermioni D. Pasiou, Argyro Vontzalidou, Dimitris Michailidis, Sofia Mitakou, Efstathios Chronopoulos, Georgios Karamanolis, Ismene A. Dontas, Theodore Karatzas
Summary: This study aimed to investigate the effect of Ceratonia siliqua on bone mineral density (BMD) as a nonpharmaceutical alternative treatment for postmenopausal osteoporosis. The results showed that long-term administration of C. siliqua significantly increased BMD compared to the control group and the ovariectomized group after 3 and 6 months of intervention. Therefore, C. siliqua may be considered a non-pharmaceutical alternative treatment for postmenopausal osteoporosis.
Article
Biochemistry & Molecular Biology
Nikolaos Markoglou, George Simeakis, Maria Alevizaki, Georgios Velonakis, Theofanis Chatzistamatiou, Maria Spyropoulou-Vlachou, Catherine Stavropoulos-Giokas, Leonidas Stefanis, Maria Anagnostouli
Summary: This article presents a case of a female patient with pediatric-onset MS and multiple endocrine neoplasia 2B, and analyzes the immunological impact of these diseases on therapeutical choice. The study suggests that an anti-CD20 agent may be the most suitable treatment for this case.
Article
Agriculture, Dairy & Animal Science
Katerina A. Marinou, Ismene A. Dontas
Summary: The Directive 2010/63/EU has been in force for more than a decade, bringing significant improvements and novel requirements for animal welfare and research integrity in scientific experiments. The Directive provides clear provisions for various aspects such as scope, authorization procedures, animal welfare bodies, national committees, cost/benefit analysis, severity classification, retrospective assessment, and statistical reporting. The authors, based on their experience working in this field, have identified indicative areas in existing legislative texts and guidance documents that may impact animal welfare and scientific integrity. They discuss suggested solutions to address these areas through potential future revisions in legislation or other actions to benefit animal welfare, aiming to clarify and simplify these issues for all stakeholders involved.
Article
Biology
Smaragda Koudouna, Dimitrios S. Evangelopoulos, Michail Sarantis, Efstathios Chronopoulos, Ismene A. Dontas, Spiridon Pneumaticos
Summary: This study aims to evaluate prognostic tools for predicting patient recovery after hip fractures and investigate the correlation between pre-fracture motor and functional statuses. The study included 80 patients with hip fractures and evaluated patient history, previous falls, fracture type, and overall survival. The results showed that patients' physical and functional statuses were correlated with their postoperative recovery.
Article
Biotechnology & Applied Microbiology
George Skepastianos, Panagiotis Mallis, Epameinondas Kostopoulos, Efstathios Michalopoulos, Vasileios Skepastianos, Chrysoula Palazi, Lucia Pannuto, Gerasimos Tsourouflis
Summary: The aim of this study was to evaluate the efficacy of a decellularization protocol for producing a completely acellular full-thickness abdominal wall scaffold. The results showed that the protocol successfully removed all cells from the abdominal wall samples and the resulting decellularized scaffolds had good biochemical and mechanical properties. This study provides a useful method for producing acellular abdominal wall scaffolds from larger animal models or human cadaveric donors.
BIOENGINEERING-BASEL
(2023)
Article
Endocrinology & Metabolism
E. Karlafti, I. Dontas, I. Lambrinoudaki, I. Vlamis, K. Lampropoulou-Adamidou, K. Makris, I. Trifonidi, A. Galanos, G. Trovas, E. Chronopoulos, S. Tournis
Summary: This study aimed to evaluate the impact of Primary Hyperparathyroidism (PHPT) on volumetric Bone Mineral Density (vBMD) and bone geometry. The study found that both trabecular and cortical bone were adversely affected in postmenopausal women with PHPT, with greater effects on cortical bone at the radius compared to the tibia, indicating attenuation of deleterious effects on weight-bearing bone.
Review
Medicine, General & Internal
Smaragda Koudouna, Dimitrios S. Evangelopoulos, Michail Sarantis, Efstathios Chronopoulos, Ismene A. Dontas, Spiros Pneumaticos
Summary: Hip fractures in the elderly are a growing concern, with post-operative rehabilitation being crucial for improved outcomes. However, there is a lack of evidence-based guidelines for the most effective rehabilitation pathways. This review aims to explore these pathways and provide objective evaluation through pre-operative and post-operative scores.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Irena Karabella, Efstathios Chronopoulos, George Panagiotakopoulos, Ismene A. Dontas
Summary: Tuberculosis is a commonly misdiagnosed infectious disease that can mimic bone tumors or metastatic lesions in the spine. In patients with cancer and signs of lymph node involvement and bone lesions, exploring other potential causes is crucial for diagnosis. This case study highlights the importance of maintaining a high level of suspicion, as a lytic lesion initially misdiagnosed as a metastatic lesion turned out to be renal cell carcinoma.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Panagiotis Mallis, Efstathios Michalopoulos, Eirini Faidra Sarri, Elena Papadopoulou, Vasiliki Theodoropoulou, Michalis Katsimpoulas, Catherine Stavropoulos-Giokas
Summary: This study evaluated the benefits of cord blood platelet lysate (CB-PL) and cord blood platelet poor plasma (CB-PPP) in corneal wound healing applications. The results showed that CB-PL had better cell migration capacity and could be considered as an alternative source for eye drop production.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Neurosciences
Apostolos Tsolakis, Lubna Khaldi, Aliki Rontogianni, Maria Georgaki, Isidora Christopoulou, Ismene A. Dontas
Summary: This study investigated the effect of orthodontic tooth forces on the alveolar bone distal to the loaded teeth in ovariectomized female rats. The results showed reduced bone remodeling in the alveolar bone of ovariectomized rats.
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2022)
Article
Medicine, General & Internal
Dimitrios Vasileiadis, Georgios Drosos, Georgios Charitoudis, Ismene A. Dontas, John Vlamis
Summary: The purpose of this study was to investigate the efficacy of a six-week supervised high-intensity preoperative training program on muscle strength, functional performance, and patient-reported outcomes in patients undergoing total knee arthroplasty (TKA). The study found that the training program can decrease knee pain, improve knee function, and enhance daily living activities.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Neurosciences
Aliki Rontogianni, Ismene A. Dontas, Demetrios Halazonetis, Konstantinos Tosios, Pavlos Lelovas, Kyriaki Venetsanou, Antonios Galanos, Apostolos I. Tsolakis
Summary: This study aimed to investigate the effect of IUGR on the bone mineral density of the mandible and tibia, as well as the quality of the mandibular and condylar bone in growing rats. The results showed that restricted nutrition during gestation can affect the BMD of the mandible and tibia in offspring animals.
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2022)
