Article
Pharmacology & Pharmacy
Unai Caballero, Elena Eraso, Guillermo Quindos, Nerea Jauregizar
Summary: The study found that combinations of amphotericin B with anidulafungin or caspofungin provide better killing of Candida auris infections compared to monotherapy, with a lower dose requirement for amphotericin B.
Article
Microbiology
Parisa Badiee, Teun Boekhout, Ali Zarei Mahmoudabadi, Rasoul Mohammadi, Seyyed Amin Ayatollahi Mousavi, Mohammad Javad Najafzadeh, Jafar Soltani, Jamal Hashemi, Kambiz Diba, Abdolkarim Ghadimi-Moghadam, Ali Reza Salimi-Khorashad, Tahereh Shokohi, Maneli Amin Shahidi, Fatemeh Ghasemi, Hadis Jafarian
Summary: Aspergillus species are the leading cause of invasive aspergillosis in immunocompromised hosts, and their susceptibility to antifungal agents might vary. This study aimed to investigate the frequency of Aspergillus species among Iranian patients and their susceptibility to seven antifungals. The results showed that Aspergillus section Flavi species were the most common and that luliconazole, caspofungin, and isavuconazole were the most effective antifungal agents for treating Aspergillus infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Pharmacology & Pharmacy
Jeng-Wei Lu, Yen-Chen Chen, Chin-Kai Huang, Kuan-Chih Lin, Yi-Jung Ho
Summary: Anidulafungin exhibits antiviral activity against ZIKV by significantly reducing viral RNA levels and infectivity. Combination therapy with T-1105 shows a synergistic effect in treating ZIKV infection.
ANTIVIRAL RESEARCH
(2021)
Article
Microbiology
Tianyu Liang, Wei Chen, Xinyu Yang, Qiqi Wang, Zhe Wan, Ruoyu Li, Wei Liu
Summary: This study identified an AMB-resistant isolate of A. flavus, which showed different resistance mechanism compared to A. terreus, possibly linked to elevated endogenous ROS levels. Further research is needed to elucidate the causes of elevated endogenous ROS and the resistance mechanism in A. flavus.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Roxana G. Vitale
Summary: Candida infections can be life-threatening, with a shift towards other species noted. Combination therapy is beneficial in difficult-to-treat cases, aiming to improve efficacy and reduce toxicity. More clinical studies are needed to support this therapeutic strategy.
Article
Immunology
Oluwabunmi Olaloye, Chino Eke, Abigail Jolteus, Liza Konnikova
Summary: Spontaneous intestinal perforation (SIP) is a severe gastrointestinal complication of prematurity. Using mass cytometry time of flight (CyTOF) analysis, the study found that SIP is associated with changes in innate and adaptive mucosal immunity, including expansion of ckit+ neutrophils and infiltration of naive CD4 and CD8 T cells. These findings highlight the potential immune dysregulation in SIP and suggest the need for further investigation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Ana Alastruey-Izquierdo, Antonio J. Martin-Galiano
Summary: The increasing number of infections caused by antimicrobial resistant fungal isolates is a critical issue. Low DNA sequencing cost can help identify resistance-related genetic characteristics, known as resistome, for optimized antifungal therapies. However, there is a lack of research on resistome detection in eukaryotic pathogens compared to bacteria. Comprehensive databases of reported mutations in antifungal targets and laboratory screenings for relevant genetic changes are needed. Additionally, the complexity of antifungal resistance requires precise pathogen species and drug level considerations, as well as hybrid sequencing approaches for accurate mutation detection and analysis facilities for fatal fast infections.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yan-Li Yang, Zi-Jian Xiang, Jing-Hua Yang, Wen-Jie Wang, Zhi-Chun Xu, Ruo-Lan Xiang
Summary: Echinocandins are found to be the most tolerated antifungal agents with high safety through network meta-analysis, while triazole drugs mainly show adverse effects such as elevated liver enzymes and nervous system disorders. LAmB is the least tolerated antifungal agent with the most abundant adverse events.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
Hsuan-Chen Wang, Ming- Hsieh, Pui-Ching Choi, Wan-Lin Wu, Chi-Jung Wu, TSARM Hospitals
Summary: This multicentre study investigated the species distribution and antifungal susceptibility of Aspergillus isolates in Taiwan. The study found that Aspergillus fumigatus and Aspergillus flavus were the predominant species, and some isolates showed resistance to antifungal drugs. The results provide valuable information for guiding proper antifungal therapy and emphasize the importance of species identification and susceptibility testing of disease-causing Aspergillus.
Article
Pharmacology & Pharmacy
Awid Adnan, Andrew M. Borman, Zoltan Toth, Lajos Forgacs, Renato Kovacs, David Balazsi, Bence Balazs, Gergely Udvarhelyi, Gabor Kardos, Laszlo Majoros
Summary: This study evaluated the killing activities of anidulafungin and micafungin with and without the chitin synthase inhibitor nikkomycin Z against C. auris isolates. Results showed that anidulafungin and micafungin alone had weak fungistatic activity against wild-type isolates, but when combined with nikkomycin Z, they exhibited a significant fungicidal effect.
Review
Biotechnology & Applied Microbiology
Flora Bohner, Csaba Papp, Attila Gacser
Summary: The authors discuss the importance of studying the relationship between fungal infections, antifungal resistance development, and the virulence attributes of pathogens for more efficient therapeutic practice.
FEMS YEAST RESEARCH
(2022)
Article
Immunology
Kazue Morikawa, Masatoshi Nozaki, Katsuya Hirata, Takatoshi Abe, Itaru Yanagihara, Kazuko Wada
Summary: A 1-day-old girl developed peritonitis and bacteremia due to Clostridium tertium following congenital intestinal atresia, with suspicion of splenic infarction. The infection was identified using mass spectrometry and 16S rRNA sequencing, and the patient was successfully treated with emergency laparotomy and broad-spectrum antibiotics.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Dermatology
Athanasios Chatzimoschou, Athina Giampani, Jacques F. Meis, Emmanuel Roilides
Summary: Candida auris exhibits higher MICs for fluconazole and relatively low MICs for itraconazole, posaconazole, and voriconazole. Echinocandins and liposomal amphotericin B also show lower activity against C auris biofilms compared to deoxycholate amphotericin B.
Article
Microbiology
Michael A. Pfaller, Shawn A. Messer, Lalitagauri M. Deshpande, Paul R. Rhomberg, Eric A. Utt, Mariana Castanheira
Summary: A total of 36 Candida auris isolates were evaluated for antifungal susceptibility and synergy against anidulafungin plus voriconazole or isavuconazole. The isolates showed resistance to multiple antifungal classes, with varying degrees of synergy observed with different combinations of antifungal drugs. Genetic analysis revealed isolates from different regions were genetically related but distinct. Erg11 alterations were associated with resistance to some antifungal agents.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Shio-Shin Jean, Hung-Jen Yang, Po-Chuen Hsieh, Yu-Tsung Huang, Wen-Chien Ko, Po-Ren Hsueh
Summary: Resistance changes in clinically important fungi, such as Aspergillus and Candida species, were explored using the ATLAS database. In vitro antifungal susceptibilities were assessed against a variety of isolates, demonstrating varying levels of susceptibility to different antifungal agents. The study highlights the importance of considering specific species, geographical location, and antifungal drugs when prescribing appropriate treatments.
MICROBIOLOGY SPECTRUM
(2022)
Article
Physiology
Sarah Marie Young, Sheng Liu, Rashika Joshi, Matthew R. Batie, Matthew Kofron, Jinbang Guo, Jason C. Woods, Brian Michael Varisco
JOURNAL OF APPLIED PHYSIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Meghan C. Daly, Sarah J. Atkinson, Brian M. Varisco, Lindsey Klingbeil, Paul Hake, Patrick Lahni, Giovanna Piraino, David Wu, Simon P. Hogan, Basilia Zingarelli, Hector R. Wong
Article
Biochemistry & Molecular Biology
Rashika Joshi, Sheng Liu, Montell D. Brown, Sarah M. Young, Matthew Batie, J. Matthew Kofron, Yan Xu, Timmothy E. Weaver, Karen Apsley, Brian M. Varisco
Article
Biochemistry & Molecular Biology
Hammad A. Ganatra, Brian M. Varisco, Kelli Harmon, Patrick Lahni, Amy Opoka, Hector R. Wong
Article
Biochemistry & Molecular Biology
Sarah J. Atkinson, Brian M. Varisco, Mary Sandquist, Meghan N. Daly, Lindsey Klingbeil, Joshua W. Kuethe, Emily F. Midura, Kelli Harmon, Amy Opoka, Patrick Lahni, Giovanna Piraino, Paul Hake, Basilia Zingarelli, Joel E. Mortensen, James L. Wynn, Hector R. Wong
MOLECULAR MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Brian M. Varisco, Lourenco Sbragia, Jing Chen, Federico Scorletti, Rashika Joshi, Hector R. Wong, Rebeca Lopes-Figueira, Marc Oria, Jose Peiro
MOLECULAR MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Rashika Joshi, Andrea Heinz, Qiang Fan, Shuling Guo, Brett Monia, Christian E. H. Schmelzer, Anthony S. Weiss, Matthew Batie, Harikrishnan Parameshwaran, Brian M. Varisco
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2018)
Article
Physiology
Sheng Liu, Sarah Marie Young, Brian Michael Varisco
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2014)
Article
Physiology
Jose Luis Peiro, Marc Oria, Emarh Aydin, Rashika Joshi, Nichole Cabanas, Ronny Schmidt, Christoph Schroeder, Mario Marotta, Brian M. Varisco
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2018)
Article
Respiratory System
Sheng Liu, Harikrishnan Parameswaran, Sarah M. Young, Brian M. Varisco
RESPIRATORY RESEARCH
(2014)
Article
Physiology
Rashika Joshi, Mohit Ojha, Jana Lewis, Qiang Fan, Brett Monia, Shuling Guo, Brian M. Varisco
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Robert P. Thomen, Jason C. Woods, Peter F. Sturm, Viral Jain, Laura L. Walkup, Nara S. Higano, James D. Quirk, Brian M. Varisco
Article
Physiology
Rashika Joshi, Matthew R. Batie, Qiang Fan, Brian M. Varisco
Summary: Lung development occurs in the context of cyclic stretch and alteration of the mechanical microenvironment plays a role in pulmonary diseases. Two mouse lung organoid mechanotransductive models were developed to study the effects of static and cyclic strain on cell proliferation and gene expression in postnatal lung development.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Editorial Material
Critical Care Medicine
Brian M. Varisco
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Fa Wang, Christopher Ting, Kent A. Riemondy, Michael Douglas, Kendall Foster, Nisha Patel, Norihito Kaku, Alexander Linsalata, Jean Nemzek, Brian M. Varisco, Erez Cohen, Jasmine A. Wilson, David W. H. Riches, Elizabeth F. Redente, Diana M. Toivola, Xiaofeng Zhou, Bethany B. Moore, Pierre A. Coulombe, M. Bishr Omary, Rachel L. Zemans
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease caused by impaired regeneration of alveolar epithelial cells after injury. Genetic variants of human keratin 8 (KRT8) are associated with IPF. In mouse models, transitional cells and fibrosis resolve, while in human IPF, transitional AECs evolve into an aberrant basaloid state that persists with progressive fibrosis.
JOURNAL OF CLINICAL INVESTIGATION
(2023)