Article
Pharmacology & Pharmacy
Arijit Mondal, Sabyasachi Banerjee, Sankhadip Bose, Sujayita Mazumder, Rebecca A. Haber, Mohammad Hosein Farzaei, Anupam Bishayee
Summary: Garlic is a plant that possesses antimicrobial, antiarthritic, antithrombotic, antitumor, hypoglycemic, and hypolipidemic activities. Its anticancer activity, among others, has been extensively studied. Garlic contains several bioactive molecules that inhibit the development of various cancers and affect multiple signaling pathways involved in cancer cell survival.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ralph John Emerson J. Molino, Klidel Fae B. Rellin, Ricky B. Nellas, Hiyas A. Junio
Summary: The ethanolic extracts of Philippine garlic cultivars were analyzed, revealing the presence of gamma-glutamyl dipeptides and probiotic oligosaccharides. These components may contribute to the superior flavor and nutritional benefits of local garlic varieties.
Review
Nutrition & Dietetics
Tarun Verma, Ankur Aggarwal, Priya Dey, Anil Kumar Chauhan, Summya Rashid, Kow-Tong Chen, Rohit Sharma
Summary: Garlic, an edible tuber from the Liliaceae family, has been used as a spice and remedy for various ailments since ancient times. It contains sulfur compounds such as allicin, ajoene, vinyl-dithiin, and other volatile organosulfur compounds, which have been found to possess antioxidant, antiviral, antimicrobial, antifungal, antihypertensive, anti-anemic, anti-hyperlipidemic, anticarcinogenic, antiaggregant, and immunomodulatory properties.
FRONTIERS IN NUTRITION
(2023)
Review
Horticulture
Sikandar Hayat, Ammar Ahmad, Husain Ahmad, Kashif Hayat, Muhammad Ali Khan, Tian Runan
Summary: Advances in recognizing plant-derived chemicals, particularly the potential antimicrobial role of garlic-derived allicin, have led to significant implications in medicine and agriculture. This review assesses the potential role of garlic as a medicinal and allelopathic crop, compiling studies on its biological functions in various fields, with a focus on its antimicrobial, allelopathic, and human health properties. Based on literature, the review discusses the futuristic possibility of using garlic extracts as plant bioprotectants to increase production and ensure crop safety against phytopathogens. The review also covers the topics of biostimulants, medicinal importance of garlic, allelopathic influence, chemical composition, and the hypothesized use of garlic extracts as next-generation biostimulants.
SCIENTIA HORTICULTURAE
(2022)
Article
Health Care Sciences & Services
Adila Awaludin, Cherry Rahayu, Nur Aizati Athirah Daud, Neily Zakiyah
Summary: This systematic review assessed the efficacy and safety of antihypertensive drugs in severe hypertension during pregnancy. The results showed that several drugs, including nifedipine and labetalol, can be used for the treatment of severe hypertension in pregnancy. There was no difference in the risk of maternal hypotension, maternal and fetal outcomes, and adverse effects between the drugs, except for dihydralazine and ketanserin, which had more adverse effects.
Review
Clinical Neurology
M. Adesuyan, Y. H. Jani, D. Alsugeir, E. C. L. Cheung, C. S. L. Chui, R. Howard, I. C. K. Wong, Ruth Brauer
Summary: A meta-analysis of nine studies found that the use of antihypertensive agents is associated with a lower incidence of Alzheimer's disease. Among antihypertensive agents, angiotensin II receptor blockers may provide the most benefit in reducing the risk of Alzheimer's disease.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Article
Nutrition & Dietetics
Jose C. E. Serrano, Eva Castro-Boque, Alicia Garcia-Carrasco, Maria Ines Moran-Valero, Daniel Gonzalez-Hedstrom, Marcelino Bermudez-Lopez, Jose Manuel Valdivielso, Alberto E. Espinel, Manuel Portero-Otin
Summary: This study validates the antihypertensive effects of an optimized extract of aged black garlic with low doses of S-allyl-cysteine (SAC) in a Grade I hypertensive population. The results show a reduction in blood pressure, an increase in nitric oxide and antioxidant capacity, and a decrease in uric acid levels and ACE activity. No changes in endothelial function and inflammatory cytokines were observed.
Article
Peripheral Vascular Disease
Douglas D. DeCarolis, Amy Gravely, Christine M. Olney, Areef Ishani
Summary: This analysis suggests that long-term exposure to thiazide-type diuretics and renin-angiotensin system blockers is associated with reduced adverse cardiovascular events, while long-term exposure to beta-blockers may increase the risk of cardiovascular events.
Review
Food Science & Technology
Sha Li, Wei Guo, Winnie Lau, Hui Zhang, Zhongqun Zhan, Xiaonan Wang, Hui Wang
Summary: Garlic is commonly used in cooking and traditional medicine in Asian countries, and its potential preventive effects on cardiovascular diseases have attracted growing attention. Previous studies have reviewed the association between garlic intake and cardiovascular diseases, but consistent conclusions have not been reached. New clinical trials are being conducted to provide more solid evidence.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Peripheral Vascular Disease
Eline H. Groenland, Monique E. A. M. van Kleef, Michiel L. Bots, Frank L. J. Visseren, Kim C. M. van der Elst, Wilko Spiering
Summary: Biochemical drug screening using liquid chromatography-tandem mass spectrometry in plasma is an accurate method for quantifying plasma concentrations of antihypertensive medications in hypertensive patients. A meta-analysis found significant heterogeneity in plasma trough concentrations of amlodipine, hydrochlorothiazide, and valsartan.
Article
Chemistry, Applied
Hendrik G. Mengers, Christina Schier, Martin Zimmermann, Martin C. H. Gruhlke, Eric Block, Lars M. Blank, Alan J. Slusarenko
Summary: A study used gentle secondary electrospray ionisation coupled Orbitrap mass spectrometry procedure (SESI-Orbitrap MS) to measure the gas phase concentration of evaporated allicin from a pure solution. Two major breakdown products of allicin were found. This technique can be used to track the chemistry of allicin, isoallin, and methiin in garlic, onion, and ramsons, as well as measure allicin and its metabolites in human breath after garlic consumption. The results are significant for analyzing sulfur-containing volatiles from Allium plants and capturing volatilomes of foodstuffs.
Review
Plant Sciences
Mansurah A. Abdulazeez, Suleiman Alhaji Muhammad, Yusuf Saidu, Abdullahi B. Sallau, Auwalu A. Arzai, Musa Abdulkadir Tabari, Abubakar Hafiz, Muhammad Yalwa Gwarzo, Jiradej Manosroi, Aminu Idi, Musa Bashir, Shamsudeen L. Pedro
Summary: This meta-analysis study provides evidence of the therapeutic benefits of medicinal plants for the management of hypertension. Plant extracts were found to significantly lower systolic and diastolic blood pressure in hypertensive subjects. Further well-conducted clinical trials with methodological rigor are needed to validate the effectiveness of these medicinal preparations.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Xiude Li, Wendi Teng, Guangmin Liu, Fengyu Guo, Hanzhu Xing, Yahui Zhu, Jinwang Li
Summary: This study found that garlic powder and its key component allicin can reduce the acrylamide content in food, with a significant effect on the formation stage of acrylamide.
Review
Peripheral Vascular Disease
Jun Kyoung, Rohit R. Atluri, Tao Yang
Summary: The gut microbiota plays a crucial role in drug metabolism, including antihypertensive drugs, and understanding this interaction may lead to better therapeutic outcomes. Resistant hypertension, a subset of patients with poor response to antihypertensive medications, is linked to the gut microbiota.
Review
Hospitality, Leisure, Sport & Tourism
Yin Wu, Blair T. Johnson, Shiqi Chen, Yiyang Chen, Jill Livingston, Linda S. Pescatello
Summary: Tai Ji Quan as antihypertensive lifestyle therapy can significantly reduce both systolic and diastolic blood pressure in individuals with hypertension, leading to clinically meaningful reductions and potentially lowering the incidence of cardiovascular diseases by up to 40%.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2021)
Review
Health Care Sciences & Services
Jean-Baptiste Briere, Kevin Bowrin, Craig Coleman, Laurent Fauchier, Pierre Levy, Kerstin Folkerts, Mondher Toumi, Vanessa Taieb, Aurelie Millier, Olivia Wu
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Brandon K. Martinez, William L. Baker, Anna Konopka, Devon Giannelli, Craig I. Coleman, Jeffrey Kluger, Edmond M. Cronin
Review
Endocrinology & Metabolism
C. I. Coleman, E. R. Weeda, A. Kharat, B. Bookhart, W. L. Baker
Article
Emergency Medicine
Diana M. Sobieraj, Brandon K. Martinez, Benjamin Miao, Mark X. Cicero, Richard A. Kamin, Adrian Hernandez, Craig Coleman, William L. Baker
PREHOSPITAL EMERGENCY CARE
(2020)
Article
Cardiac & Cardiovascular Systems
Craig Coleman, William L. Baker, Anna-Katharina Meinecke, Daniel Eriksson, Brandon K. Martinez, Thomas J. Bunz, Mark J. Alberts
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2020)
Article
Cardiac & Cardiovascular Systems
Benjamin Miao, Adrian V. Hernandez, Yuani M. Roman, Mark J. Alberts, Craig I. Coleman, William L. Baker
CLINICAL CARDIOLOGY
(2020)
Article
Hematology
Benjamin Miao, Nitesh Sood, Thomas J. Bunz, Craig Coleman
EUROPEAN JOURNAL OF HAEMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Kevin Bowrin, Jean-Baptiste Briere, Laurent Fauchier, Craig Coleman, Aurelie Millier, Mondher Toumi, Emilie Clay, Pierre Levy
Article
Multidisciplinary Sciences
Tabassum Salam, Amy Duhig, Aarti A. Patel, Ann Cameron, Jennifer Voelker, Brahim Bookhart, Craig I. Coleman
Article
Cardiac & Cardiovascular Systems
Benjamin Miao, Adrian V. Hernandez, Mark J. Alberts, Nicholas Mangiafico, Yuani M. Roman, Craig I. Coleman
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Pharmacology & Pharmacy
Tabassum Salam, Amy Duhig, Aarti A. Patel, Ann Cameron, Jennifer Voelker, Brahim Bookhart, Craig Coleman
CLINICAL THERAPEUTICS
(2020)
Article
Medicine, General & Internal
Olivia S. Costa, Jan Beyer-Westendorf, Veronica Ashton, Dejan Milentijevic, Kenneth Todd Moore, Thomas J. Bunz, Craig Coleman
CURRENT MEDICAL RESEARCH AND OPINION
(2020)
Article
Medicine, General & Internal
Craig Coleman, Stanley Thompson, Veronica Ashton, Michael Palladino, Thomas J. Bunz
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
(2020)
Article
Hematology
Olivia S. Costa, Stanley Thompson, Veronica Ashton, Michael Palladino, Thomas J. Bunz, Craig Coleman
THROMBOSIS JOURNAL
(2020)
Article
Health Care Sciences & Services
C. Michael White, Craig I. Coleman, Kimberly Jackman, Yuani M. Roman
JOINT COMMISSION JOURNAL ON QUALITY AND PATIENT SAFETY
(2019)