Article
Public, Environmental & Occupational Health
Chandrika Gibson, Moira O'Connor, Rohen White, Melanie Jackson, Siddhartha Baxi, Georgia K. B. Halkett
Summary: This qualitative study explores the experiences of head and neck cancer (HNC) patients in communicating with health professionals. The loss of speech capacity is found to be distressing and traumatic for survivors of HNC. Tensions arise in the communication between patients and health professionals, including abrupt, hurried communication versus slower, more mindful communication. Disparities in health literacy levels and a lack of empathy are also observed.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Computer Science, Interdisciplinary Applications
Quoc Cuong Ngo, Mohammod Abdul Motin, Nemuel Daniel Pah, Peter Drotar, Peter Kempster, Dinesh Kumar
Summary: This study summarizes the literature on speech and voice in detecting and assessing the severity of Parkinson's disease (PD). Speech and voice may be valuable markers for PD, but there are differences between datasets and limitations in analysis methods.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Psychology, Multidisciplinary
Hannah S. Sarvasy, Weicong Li, Jaydene Elvin, Paola Escudero
Summary: In many communities, speech to infants and small children has distinct features compared to speech to adults, which can also be observed in speech directed to foreigners. This study examines the vowel acoustics in the Nungon language of Papua New Guinea, specifically in child-directed speech, conversational speech, and monologues directed towards a non-native speaker. The findings show that Nungon child-directed speech lacks vowel hyper-articulation but displays other prosodic traits common to child-directed speech. Furthermore, the vowel patterns in Nungon foreigner-directed speech are significantly different from those in child-directed speech and conversational speech. This study contributes to the understanding of speech variation and its cultural implications in different linguistic communities.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Oncology
Francesca De Felice, Carlo Guglielmo Cattaneo, Pierfrancesco Franco
Summary: This review explores the current radio(chemo)therapy strategy for head and neck squamous cell carcinoma (HNSCC) in order to improve understanding of the disease and potentially enhance patient care. The best practice for managing HNSCC should involve discussion within a multidisciplinary team. Currently, radiation therapy (RT) with or without chemotherapy is the standard treatment for locally advanced disease, and intensity-modulated photon therapy (IMRT) is the recommended RT technique.
Article
Oncology
Sachin R. Jhawar, Marcelo Bonomi, Paul M. Harari
Summary: The Oncology Grand Rounds series aims to help readers apply the results of key studies in clinical practice, using case presentations, literature reviews, and treatment recommendations to enhance understanding of the latest developments in oncology.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thorsteinn Astradsson, Felix Sellberg, Ylva Tiblom Ehrsson, Karl Sandstrom, Goran Laurell
Summary: This real-world study aimed to evaluate the expression of inflammatory proteins in head and neck cancer patients before and after treatment, and to compare the expression differences associated with different treatment modalities. The results showed that the expression levels of certain proteins significantly decreased at 7 weeks after the start of treatment, with the largest decrease observed in the group receiving cisplatin-based chemoradiation. Most of the inflammatory proteins returned to their pretreatment levels after 12 months.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Chemistry, Multidisciplinary
Prateek Bhardwaj, Vikram Gota, Komal Vishwakarma, Venkatesh Pai, Pradip Chaudhari, Bhabani Mohanty, Rahul Thorat, Subhash Yadav, Murari Gurjar, Jayant Sastri Goda, Rinti Banerjee
Summary: This study developed a dual nanocarrier hydrogel for site-specific delivery of radio sensitizers in the treatment of locally advanced unresectable head and neck squamous cell carcinoma (HNSCC). The hydrogel improved drug accumulation in the tumor and reduced systemic absorption, leading to enhanced therapeutic efficacy and safety compared to commercial formulations. The nanoparticles in the hydrogel also facilitated intracellular uptake of radiosensitizers and enhanced radiation-induced DNA damage and cell apoptosis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Otorhinolaryngology
Anna C. H. Willemsen, Walmari Pilz, Ann Hoeben, Frank J. P. Hoebers, Annemie M. W. J. Schols, Laura W. J. Baijens
Summary: This study investigates the relationship between cancer cachexia and oropharyngeal dysphagia in patients with head and neck cancer. The findings suggest that cachexia independently predicts the presence of patient-reported dysphagia.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Oncology
Emer Fahy, Rachel C. C. Brooker, Jason C. C. Fleming, Joanne M. M. Patterson
Summary: Non-surgical treatment for head and neck cancer often leads to unplanned hospital admissions, with patients undergoing chemoradiotherapy being the most vulnerable. The common reasons for admission are nausea and vomiting, and decreased oral intake/dehydration.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Chemistry, Multidisciplinary
Yun Zhu, Shunan Zhang, Yi Lai, Jiaxing Pan, Fangmin Chen, Tingting Wang, Fengyang Wang, Zhiai Xu, Wenjun Yang, Haijun Yu
Summary: This study presents a self-cooperative prodrug nanovesicle for highly tumor-specific chemoradiotherapy, which can target tumors efficiently and overcome immune evasion mechanisms.
Article
Oncology
L. Belgioia, C. Becherini, A. Bacigalupo, P. Bonomo
Summary: Immunotherapy plays a significant role in the treatment of head and neck squamous cell carcinoma, but its role in upfront management of locally advanced disease and its integration with standard of care remains unclear.
Review
Health Care Sciences & Services
Francesca De Felice, Daniela Musio, Vincenzo Tombolini
Summary: Tailored approaches are needed in head and neck cancer management to optimize clinical outcomes. Recent studies focus on the combination of immune check-point inhibitors and (chemo)radiotherapy, aiming to improve survival rates and reduce toxicity for patients. These strategies provide a useful clinical tool for further research in the field.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Reinout H. de Roest, Martijn van der Heijden, Frederik W. R. Wesseling, Emma J. de Ruiter, Martijn W. Heymans, Chris Terhaard, Marije R. Vergeer, Jan Buter, Lot A. Devriese, Jan Paul de Boer, Arash Navran, Ann Hoeben, Conchita Vens, Michiel van den Brekel, Ruud H. Brakenhoff, C. Rene Leemans, Frank Hoebers
Summary: This study collected real-world outcome data from 513 patients with HPV-negative advanced stage HNSCC treated with CRT and found that clinical variables and treatment parameters had a stronger association with overall survival. The association of RT-boost technique with distant metastasis is an important finding that requires further study.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Ya-Wen Ho, Kun-Yun Yeh, Shun-Wen Hsueh, Chia-Yen Hung, Chang-Hsien Lu, Ngan-Ming Tsang, Hung-Ming Wang, Yu-Shin Hung, Wen-Chi Chou
Summary: This study found that early nutritional counseling is essential for improving treatment tolerance and survival outcomes in head and neck cancer patients, even if they have normal nutritional status before treatment.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Otorhinolaryngology
Rebecca T. Karsten, Najiba Chargi, Lisette van der Molen, Rob J. J. H. van Son, Remco de Bree, Abrahim Al-Mamgani, Jan P. de Boer, Frans J. M. Hilgers, Michiel W. M. van den Brekel, Ludi E. Smeele, Martijn M. Stuiver
Summary: The study aimed to evaluate swallowing, mouth opening and speech function of patients with stage III-IV oropharyngeal carcinoma (OPC) during the first year after radiation-based treatment (RT(+)) with the introduction of a dedicated preventive rehabilitation program. Results show that functional outcomes deteriorated until 6 months post-treatment, improved by 12 months but did not return to baseline levels, with a significant proportion of patients still experiencing dysphagia, trismus and speech problems. Despite successful implementation, there is room for improvement in the current rehabilitation program, with pretreatment sarcopenia identified as a potential target for rehabilitation strategies.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joris L. Vos, Charlotte L. Zuur, Laura A. Smit, Jan Paul de Boer, Abrahim Al-Mamgani, Michiel W. M. van den Brekel, John B. A. G. Haanen, Wouter V. Vogel
Summary: The study explored the utility of [F-18]FDG-PET as an imaging biomarker for pathological response in HNSCC patients receiving neoadjuvant immune checkpoint blockade. Results showed that assessing primary tumor response using Delta MTV and Delta TLG accurately identifies pathological responses early, outperforming the EORTC criteria.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Otorhinolaryngology
Anne N. Heirman, Vincent van der Noort, Rob van Son, Japke F. Petersen, Lisette van der Molen, Gyorgy B. Halmos, Richard Dirven, Michiel W. M. van den Brekel
Summary: Objective voice prosthesis leakage significantly affects the quality of life of laryngectomy patients. However, the concept of prophylactic voice prosthesis replacement was found to be unfeasible due to high inter- and intrapatient variability in device lifetime.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Margot Baudelet, Frederic Duprez, Leen Van den Steen, Sandra Nuyts, Daan Nevens, Ann Goeleven, Caroline Vandenbruaene, Hanne Massonet, Alice Vergauwen, Heleen Bollen, Sarah Deschuymer, Kristien Wouters, Marc Peeters, Carl Van Laer, Steven Marien, Michiel Van den Brekel, Lisette van der Molen, Tom Vauterin, Joost van Dinther, Hilde Verstraete, Isabel Hutsebaut, Sabine Meersschout, Olivier Vanderveken, Marc De Bodt, Gwen Van Nuffelen
Summary: This multicenter RCT investigated the effect of three different service-delivery modes on patients' adherence to prophylactic swallowing exercises during radiotherapy. The study found that adherence decreased over time in all groups, but the therapist-supported group achieved the highest adherence rates. Increasing face-to-face contact with a speech-language therapist can overcome the problem of low adherence in this population.
Article
Medicine, Research & Experimental
Hanne Massonet, Ann Goeleven, Leen Van den Steen, Alice Vergauwen, Margot Baudelet, Gilles Van Haesendonck, Olivier Vanderveken, Heleen Bollen, Lisette van der Molen, Frederic Duprez, Peter Tomassen, Sandra Nuyts, Gwen Van Nuffelen
Summary: This multicenter randomized trial aims to compare the efficacy and possible detraining effects of different treatments in 105 C-RAD patients. It will provide new insights into the rehabilitation of C-RAD and optimizing swallowing function.
Article
Audiology & Speech-Language Pathology
Klaske E. van Sluis, Ellen Passchier, Rob J. J. H. van Son, Lisette van der Molen, Martijn Stuiver, Michiel W. M. van den Brekel, Leen Van den Steen, Johanna G. Kalf, Gwen van Nuffelen
Summary: The Dutch translation of the CPIB short form has been validated as a reliable tool for assessing communicative participation in adults with speech problems resulting from a neurological etiology or head and neck cancer. This tool can be used in clinical practice and research to systematically investigate the impact of speech problems on communicative participation in the Dutch-speaking population.
INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
(2023)
Review
Otorhinolaryngology
Coralie R. Arends, Josephine E. Lindhout, Lisette van der Molen, Erica A. Wilthagen, Michiel W. M. van den Brekel, Martijn M. Stuiver
Summary: This systematic review aimed to assess the validity and reliability of measurement instruments for head and neck lymphedema. Eight studies were included, and the Patterson scale and the patient reported LIDS-H&N showed good validity and reliability. However, there is a lack of reliable instruments for measuring external lymphedema in the head and neck region.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Maartje Leemans, Maarten J. A. van Alphen, Wim Vallenduuk, Richard Dirven, Michiel W. M. van den Brekel, Sara H. Mueller
Summary: Based on the developed numerical model, increasing the diameter of the heat and moisture exchangers (HMEs) improves their performance and reduces breathing resistance. HMEs intended for use in warm or dry climates should contain more hygroscopic salt, while those for use in cold humid climates should contain less.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Review
Oncology
Hedda J. van der Hulst, Robin W. Jansen, Conchita Vens, Paula Bos, Winnie Schats, Marcus C. de Jong, Roland M. Martens, Zuhir Bodalal, Regina G. H. Beets-Tan, Michiel W. M. van den Brekel, Pim de Graaf, Jonas A. Castelijns
Summary: MRI can non-invasively evaluate tumor biology, potentially enhancing clinical outcome predictions and personalized patient management for HNSCC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Paula Bos, Roland M. M. Martens, Pim de Graaf, Bas Jasperse, Joost J. M. van Griethuysen, Ronald Boellaard, C. Rene Leemans, Regina G. H. Beets-Tan, Mark A. A. van de Wiel, Michiel W. M. van den Brekel, Jonas A. A. Castelijns
Summary: This study aims to externally validate a pre-treatment MR-based radiomics model for predicting locoregional control in OPSCC, and assess the impact of dataset differences on predictive performance. Radiomic features were extracted from the primary tumor volumes of 157 OPSCC patients in a different institute. The results show that the model's performance slightly decreases when applied to the validation cohort, but can be improved by using similar patient subgroups and harmonization techniques.
EUROPEAN RADIOLOGY
(2023)
Proceedings Paper
Acoustics
Marise Neijman, Femke Hof, NoeIle Oosterom, Roland Pfau, Bertus van Rooy, Rob J. J. H. van Son, Michiel M. W. M. van den Brekel
Summary: Total laryngectomy results in the loss of natural voice, and patients compensate for communication using speech rehabilitation techniques and nonverbal gestures.
