Article
Genetics & Heredity
Oleksii Nikolaienko, Hans P. Eikesdal, Elisabet Ognedal, Bjornar Gilje, Steinar Lundgren, Egil S. Blix, Helge Espelid, Jurgen Geisler, Stephanie Geisler, Emiel A. M. Janssen, Synnove Yndestad, Laura Minsaas, Beryl Leirvaag, Reidun Lillestol, Stian Knappskog, Per E. Lonning
Summary: This study found that approximately 20% of TNBC and low-ER expression breast cancers may be caused by prenatal BRCA1 epimutations. The constitutional mosaic BRCA1 methylation likely arises through gender-related mechanisms in utero, independent of Mendelian inheritance.
Article
Oncology
Per E. Lonning, Oleksii Nikolaienko, Kathy Pan, Allison W. Kurian, Hans P. Eikesdal, Mary Pettinger, Garnet L. Anderson, Ross L. Prentice, Rowan T. Chlebowski, Stian Knappskog
Summary: This study found a significant association between constitutional normal tissue BRCA1 promoter methylation and the risk of developing triple-negative breast cancer (TNBC) and high-grade serous ovarian cancer (HGSOC).
Review
Medicine, Research & Experimental
Eun Choi, Gil-im Mun, Joohyun Lee, Hanhee Lee, Jaeho Cho, Yun-Sil Lee
Summary: Mutations in the BRCA1 gene increase the risk of developing breast cancer, but only a minority of patients carry these mutations. A recent study suggests that reduced BRCA1 levels, rather than mutations, are responsible for almost half of all triple-negative breast cancer (TNBC) cases. Understanding the function and regulation of BRCA1 can help improve treatment strategies for BRCA1-related breast cancer patients, especially those with TNBC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Katrina Cristall, Francois-Clement Bidard, Jean-Yves Pierga, Michael J. Rauh, Tatiana Popova, Clara Sebbag, Olivier Lantz, Marc-Henri Stern, Christopher R. Mueller
Summary: mDETECT is a next-generation sequencing-based blood test designed for the optimal detection and monitoring of metastatic triple-negative breast cancer. It offers superior performance, high sensitivity, and specificity in detecting TNBC, providing potential improvements in patient management.
NPJ PRECISION ONCOLOGY
(2021)
Editorial Material
Oncology
Priyanka Sharma
Summary: Pathologic response is an important tool for optimizing the escalation and deescalation of adjuvant treatment. Neoadjuvant carboplatin-taxane combination shows promise as a chemotherapy deescalation strategy for triple-negative breast cancer. However, several key points, including trial design/patient selection, response biomarkers, role of immunotherapy, and patient advocate input, need to be carefully considered for the advancement of neoadjuvant chemotherapy deescalation investigations.
CLINICAL CANCER RESEARCH
(2022)
Article
Genetics & Heredity
Justine Marsolier, Pacome Prompsy, Adeline Durand, Anne-Marie Lyne, Camille Landragin, Amandine Trouchet, Sabrina Tenreira Bento, Almut Eisele, Sophie Foulon, Lea Baudre, Kevin Grosselin, Mylene Bohec, Sylvain Baulande, Ahmed Dahmani, Laura Sourd, Eric Letouze, Anne-Vincent Salomon, Elisabetta Marangoni, Leila Perie, Celine Vallot
Summary: The persistence of drug-resistant cancer cells is a major clinical challenge, particularly in triple-negative breast cancer. This study reveals that the repressive histone mark H3K27me3 plays a crucial role in regulating cell fate and chemotherapy tolerance in cancer cells. Manipulating H3K27me3 levels effectively enhances the potential of cancer cells to tolerate chemotherapy and delays tumor recurrence. These findings underscore the importance of understanding chromatin landscapes in shaping cancer cell response to initial therapy.
Review
Nanoscience & Nanotechnology
Siyan Liu, Jing Li, Lin Gu, Kunzhe Wu, Hua Xing
Summary: Chemoimmunotherapy shows promise for treating TNBC, but challenges remain in improving efficacy and reducing side effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Oncology
Juan Zhang, Lu Yao, Yiqiang Liu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie
Summary: This study found that in BRCA1/2-mutated triple-negative breast cancer, adding carboplatin to the standard A-T chemotherapy regimen can improve survival rates for patients.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Takayuki Ueno, Shigehisa Kitano, Norikazu Masuda, Daiki Ikarashi, Makiko Yamashita, Tomohiro Chiba, Takayuki Kadoya, Hiroko Bando, Takashi Yamanaka, Shoichiro Ohtani, Shigenori Nagai, Takahiro Nakayama, Masato Takahashi, Shigehira Saji, Kenjiro Aogi, Ravi Velaga, Kosuke Kawaguchi, Satoshi Morita, Hironori Haga, Shinji Ohno, Masakazu Toi
Summary: This study found that the density of CD4+ T cells in both the tumor and stromal regions is an independent predictor of pathological complete response (pCR) in patients with triple-negative breast cancer (TNBC). This predictive value is particularly strong in patients receiving platinum-containing chemotherapy.
Article
Medicine, General & Internal
P. Schmid, J. Cortes, R. Dent, L. Pusztai, H. McArthur, S. Kummel, J. Bergh, C. Denkert, Y. H. Park, R. Hui, N. Harbeck, M. Takahashi, M. Untch, P. A. Fasching, F. Cardoso, J. Andersen, D. Patt, M. Danso, M. Ferreira, M-A Mouret-Reynier, S-A Im, J-H Ahn, M. Gion, S. Baron-Hay, J-F Boileau, Y. Ding, K. Tryfonidis, G. Aktan, V Karantza, J. O'Shaughnessy
Summary: The addition of pembrolizumab to neoadjuvant chemotherapy followed by adjuvant pembrolizumab after surgery significantly prolonged event-free survival in patients with early triple-negative breast cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ji-Yeon Kim, Sabin Park, Eun Yoon Cho, Jeong Eon Lee, Hae Hyun Jung, Byung Joo Chae, Seok Won Kim, Seok Jin Nam, Soo Youn Cho, Yeon Hee Park, Jin Seok Ahn, Semin Lee, Young-Hyuck Im
Summary: This study compared the genetic characteristics of apocrine carcinoma, a rare subtype of breast cancer, with triple negative breast cancer (TNBC) with low Ki-67 expression (LK-TNBC). The most frequently mutated driver gene in apocrine carcinoma was TP53, followed by PIK3CA, ZNF717, and PIK3R1. Apocrine carcinoma exhibited defective DNA mismatch repair and APOBEC activity-associated mutational signatures, and had better five-year disease-free survival and overall survival rates compared to LK-TNBC.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Francesco Pavese, Ettore Domenico Capoluongo, Margherita Muratore, Angelo Minucci, Concetta Santonocito, Paola Fuso, Paola Concolino, Enrico Di Stasio, Luisa Carbognin, Giordana Tiberi, Giorgia Garganese, Giacomo Corrado, Alba Di Leone, Daniele Generali, Simona Maria Fragomeni, Tatiana D'Angelo, Gianluca Franceschini, Riccardo Masetti, Alessandra Fabi, Antonino Mule, Angela Santoro, Paolo Belli, Giampaolo Tortora, Giovanni Scambia, Ida Paris
Summary: In this retrospective observational study, the impact of germline BRCA1/2 mutation status on outcomes in patients with triple-negative breast cancer (TNBC) treated with neoadjuvant chemotherapy (NACT) was evaluated. Patients with BRCA1/2 mutation had a higher pathologic complete response (pCR) rate than non-mutated patients, especially among those who received a platinum-based NACT. Achieving pCR after NACT was associated with improved Event Free Survival (EFS) and Overall Survival (OS), regardless of BRCA1/2 mutation status and type of NACT received. Further long-term follow-up analyses are needed to determine the role of gBRCA mutation status in early-stage TNBC patients.
Review
Engineering, Biomedical
Pallabita Chowdhury, Upasana Ghosh, Kamalika Samanta, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Summary: Management of aggressive breast cancer, particularly TNBC, remains challenging despite advances in treatment. New therapies like atezolizumab, olaparib, and sacituzumab show limited survival benefits. Current research aims to improve treatment strategies by enhancing bioavailability, targetability, and reducing toxicity for better therapeutic outcomes.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Medicinal
Shoghag Panjarian, Jean-Pierre J. Issa
Summary: Triple-negative breast cancers (TNBCs) are highly heterogeneous and molecularly diverse, with a distinct DNA methylation profile characterized by hypomethylation and lower gains of methylations compared to other subtypes. The balance between DNA methylases (DNMTs) and DNA demethylases (TETs) plays a crucial role in regulating DNA methylation in TNBCs.
Review
Pharmacology & Pharmacy
Onyinyechi Obidiro, Gantumur Battogtokh, Emmanuel O. Akala
Summary: Triple negative breast cancer (TNBC) is a subtype of breast cancer that lacks estrogen receptors, progesterone receptors, and human epidermal growth factor receptors. The survival rate for TNBC is generally lower than other subtypes. Chemotherapy is the most common treatment option, but resistance to drugs and off-target toxicity pose challenges. Researchers, clinicians, and pharmaceutical companies must collaborate to develop effective treatments for TNBC. Nanotechnology has shown promise as a potential solution for improving TNBC treatment.
Article
Oncology
Wei Tian, Yantao Du, Yuwan Ma, Baozhen Zhang, Liankun Gu, Jing Zhou, Dajun Deng
Article
Multidisciplinary Sciences
Paiyun Li, Xuehong Zhang, Liankun Gu, Jing Zhou, Dajun Deng
Article
Biochemistry & Molecular Biology
Paiyun Li, Ying Gan, Sisi Qin, Xiao Han, Chenghua Cui, Zhaojun Liu, Jing Zhou, Liankun Gu, Zhe-Ming Lu, Baozhen Zhang, Dajun Deng
Article
Biochemistry & Molecular Biology
Wanru Ma, Juanli Qiao, Jing Zhou, Liankun Gu, Dajun Deng
Article
Gastroenterology & Hepatology
Wan-Ru Ma, Peng Xu, Zhao-Jun Liu, Jing Zhou, Lian-Kun Gu, Jun Zhang, Da-Jun Deng
WORLD JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Oncology
Yu Shi, Yang Zhang, Lian Zhang, Jun-Ling Ma, Tong Zhou, Zhe-Xuan Li, Wei-Dong Liu, Wen-Qing Li, Da-Jun Deng, Wei-Cheng You, Kai-Feng Pan
FRONTIERS IN ONCOLOGY
(2019)
Article
Genetics & Heredity
Meiyi Xiang, Wensu Liu, Wei Tian, Abin You, Dajun Deng
Article
Oncology
Yu Qin, Jing Zhou, Zhiyuan Fan, Jianhua Gu, Xinqing Li, Dongmei Lin, Dajun Deng, Wenqiang Wei
Summary: This study investigated the intratumoral heterogeneity (ITH) of esophageal cancer (EC) using a systematic sampling method. It found that there is inadequate concordance between tumor biopsy and tissue in pathological diagnosis and P16 methylation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Juanli Qiao, Yuan Tian, Xiaojing Cheng, Zhaojun Liu, Jing Zhou, Liankun Gu, Baozhen Zhang, Lianhai Zhang, Jiafu Ji, Rui Xing, Dajun Deng
Summary: The study suggests that somatic copy number deletion of the CDKN2A gene may drive gastric cancer metastasis and could serve as a predictor for hematogenous metastasis of gastric cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhiyuan Fan, Yu Qin, Jing Zhou, Ru Chen, Jianhua Gu, Minjuan Li, Jiachen Zhou, Xinqing Li, Dongmei Lin, Jinwu Wang, Dajun Deng, Wenqiang Wei
Summary: P16 methylation was found to be associated with the development of esophageal squamous cell dysplasia (ESCdys) and esophageal squamous cell carcinoma (ESCC). P16 methylation in cytology specimens was positively associated with the risk of ESCC and ESCdys, while P16 methylation in biopsy specimens was only associated with a higher risk of developing ESCC. Adding P16 methylation in cytology specimens to the prediction model significantly improved its predictive capacity for ESCC and high-grade ESCdys.
Article
Oncology
Wei Tian, Hongfan Yuan, Sisi Qin, Wensu Liu, Baozhen Zhang, Liankun Gu, Jing Zhou, Dajun Deng
Summary: The study found that AKT1 can phosphorylate the Kaiso protein, causing its accumulation in the cytoplasm and de-repressing the Kaiso target gene CDH1 through binding to 14-3-3 proteins/P120ctn. Decreased phosphorylation of Kaiso may contribute to the development of gastrointestinal cancer.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abin You, Wei Tian, Hongfan Yuan, Liankun Gu, Jing Zhou, Dajun Deng
Summary: TTC22 interacts with RPL4 to promote the binding of WTAP mRNA to RPL4, enhancing the stability and translation efficiency of WTAP mRNA and increasing the level of WTAP protein. TTC22 also triggers a positive feedback loop between WTAP expression and WTAP mRNA m6A modification, leading to an increased m6A level in total RNA. Additionally, TTC22 upregulates SNAI1 expression by increasing m6A level, promoting colon cancer metastasis.
Article
Cell Biology
Zhuoqi Li, Juanli Qiao, Wanru Ma, Jing Zhou, Liankun Gu, Dajun Deng, Baozhen Zhang
Summary: This study reveals that CBX7 is essential for P14AS to upregulate the expression of P16 (INK4A), P14 (ARF), P15 (INK4B), and ANRIL genes. P14AS may upregulate these genes' expression through competitively blocking CBX7-binding to ANRIL lncRNA and target gene promoters.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Hongfan Yuan, Qianwen Ren, Yantao Du, Yuwan Ma, Liankun Gu, Jing Zhou, Wei Tian, Dajun Deng
Summary: In this study, it was found that miR663AHG is mainly distributed in the nucleus of colon cancer cells and is positively correlated with miR663a. The expression level of miR663AHG is downregulated in colon cancer tissues and is associated with advanced disease stage, lymph metastasis, and shorter overall survival. Furthermore, miR663AHG can inhibit colon cancer cell proliferation, migration, and invasion, and its function is mediated through its binding to miR663a/pre-miR663a.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Zhaojun Liu, Hongmei Lin, Ying Gan, Chenghua Cui, Baozhen Zhang, Liankun Gu, Jing Zhou, Guangying Zhu, Dajun Deng