Article
Oncology
Dana M. Roque, Eric R. Siegel, Natalia Buza, Stefania Bellone, Dan-Arin Silasi, Gloria S. Huang, Vaagn Andikyan, Mitchell Clark, Masoud Azodi, Peter E. Schwartz, Gautam G. Rao, Jocelyn C. Reader, Pei Hui, Joan R. Tymon-Rosario, Justin Harold, Dennis Mauricio, Burak Zeybek, Gulden Menderes, Gary Altwerger, Elena Ratner, Alessandro D. Santin
Summary: This multi-center study evaluated the activity and safety of ixabepilone plus bevacizumab compared to ixabepilone alone in platinum-resistant/refractory ovarian cancer. The results showed that the combination of ixabepilone and bevacizumab had a higher overall response rate and longer progression-free survival, with good tolerability. Prior receipt of bevacizumab should not limit the use of ixabepilone plus bevacizumab in treatment.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Fuli Li, Tinglei Huang, Yao Tang, Qingli Li, Jianzheng Wang, Xiaojiao Cheng, Wenhui Zhang, Baiwen Zhang, Cong Zhou, Shuiping Tu
Summary: UTD1, a novel microtubule stabilizing agent, has shown significant anti-tumor activity in colorectal cancer by inhibiting cell proliferation, inducing cell cycle arrest in G2/M phase, and triggering apoptosis. Additionally, UTD1 exhibits a stronger apoptosis-inducing effect in ABCB1 high-expression cells.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Jocelyn C. Reader, Cong Fan, Eleanor Claire-Higgins Ory, Julia Ju, Rachel Lee, Michele I. Vitolo, Paige Smith, Sulan Wu, Mc Millan Nicol Ching, Emmanuel B. Asiedu, Christopher M. Jewell, Gautam G. Rao, Amy Fulton, Tonya J. Webb, Peixin Yang, Alessandro D. Santin, Huang-Chiao Huang, Stuart S. Martin, Dana M. Roque
Summary: Ovarian cancer can spread within the peritoneal cavity through exfoliation of malignant cells into ascites. Microtentacles (McTNs) are microtubule-based protrusions that may influence the metastatic potential and chemoresistance profile of free-floating cells. This study highlights the importance of McTNs as a therapeutic target for ovarian cancer and suggests that understanding their biology could lead to improved treatments.
Article
Chemistry, Physical
Siyu Lu, Liru Xue, Meng Yang, Jingjing Wang, Yang Li, Yuxin Jiang, Xuechuan Hong, Mingfu Wu, Yuling Xiao
Summary: Ovarian cancer is often diagnosed in the middle or late stages due to the lack of specific initial diagnostic methods. Dual-modal near-infrared II fluorescence/photoacoustic imaging shows great potential in early ovarian cancer diagnosis and image-guided surgery. A novel organic NIR-II dye and water-soluble nanoparticles were developed for targeted imaging and surgery, improving the early detection and prognosis of ovarian cancer.
Article
Chemistry, Multidisciplinary
Xiaobo Zhou, Qiyu Liu, Wei Yuan, Zhenhua Li, Yuliang Xu, Wei Feng, Congjian Xu, Fuyou Li
Summary: The development of NIR-II fluorescent polymer dots shows high brightness and potential for real-time detection of metastatic ovarian cancer. Modification with targeting peptides enhances the affinity of NIR-II Pdots to ovarian cancer, allowing for clear visualization of metastases through NIR-II fluorescence imaging. This preclinical study demonstrates the promising value of NIR-II Pdots for detecting metastatic ovarian cancer.
Article
Oncology
Nicoletta Colombo, Federica Tomao, Pierluigi Benedetti Panici, Maria Ornella Nicoletto, Germana Tognon, Alessandra Bologna, Andrea Alberto Lissoni, Andrea DeCensi, Mariateresa Lapresa, Rosanna Mancari, Innocenza Palaia, Giulia Tasca, Francesca Tettamanzi, Maria Francesca Alvisi, Eliana Rulli, Davide Poli, Luciano Carlucci, Valter Torri, Roldano Fossati, Elena Biagioli
Summary: The combination of cediranib and olaparib did not improve the progression-free survival (PFS) compared to chemotherapy in heavily pretreated platinum-resistant ovarian cancer patients. However, this oral doublet is still an effective option for this difficult-to-treat population.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Mathew Cowan, Wendy M. Swetzig, Valery Adorno-Cruz, Mario J. Pineda, Nikki L. Neubauer, Emily Berry, John R. Lurain, Shohreh Shahabi, Deanna Taiym, Valerie Nelson, Kaitlyn Lucrezia O'Shea, Masha Kocherginsky, Daniela Matei
Summary: The study evaluated the activity of Tivozanib in patients with recurrent, platinum-resistant ovarian cancer, demonstrating a certain level of efficacy with partial responses in some patients. The drug showed moderate toxicity and no treatment-related deaths, indicating potential for further development.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Florence Joly, Michel Fabbro, Philippe Follana, Justine Lequesne, Jacques Medioni, Anne Lesoin, Jean-Sebastien Frenel, Sophie Abadie-Lacourtoisie, Anne Floquet, Laurence Gladieff, Benoit You, Celine Gavoille, Elsa Kalbacher, Melanie Briand, Pierre-Emmanuel Brachet, Florence Giffard, Louis-Bastien Weiswald, Pierre-Alexandre Just, Cecile Blanc-Fournier, Alexandra Leconte, Benedicte Clarisse, Alexandra Leary, Laurent Poulain
Summary: This study aimed to evaluate the efficacy of Navitoclax monotherapy in patients with high-grade serous platinum-resistant ovarian tumors. The results showed that Navitoclax monotherapy had promising activity in these patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Marek T. Wlodarczyk, Sylwia A. Dragulska, Ying Chen, Mina Poursharifi, Maxier Acosta Santiago, John A. Martignetti, Aneta J. Mieszawska
Summary: In this study, a poly(lactic-co-glycolic acid) nanoparticle encapsulating platinum (II) was developed and targeted towards a cell-spanning protein overexpressed in late-stage ovarian cancer. The nanoparticle displayed pH-dependent drug release and successfully accumulated in cancer cells at a lower pH. Biodistribution studies confirmed effective delivery of platinum (II) to tumor sites. These findings demonstrate the potential of this nanoparticle for enhanced platinum therapy in ovarian cancer and other solid tumors.
Review
Oncology
Julia H. Gelissen, Naomi N. Adjei, Blair McNamara, Levent Mutlu, Justin A. Harold, Mitchell Clark, Gary Altwerger, Peter R. Dottino, Gloria S. Huang, Alessandro D. Santin, Masoud Azodi, Elena Ratner, Peter E. Schwartz, Vaagn Andikyan
Summary: HIPEC is a treatment modality for ovarian cancer that combines intraperitoneal chemotherapy with hyperthermia during cytoreductive surgery to target tumor dissemination in the peritoneum. Currently, only cisplatin HIPEC after neoadjuvant chemotherapy is supported by high-quality evidence for stage III ovarian cancer. There are many unresolved questions regarding the timing and candidates for HIPEC, as well as the specifics of HIPEC protocols.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Akshaya Chandrasekaran, Kevin M. Elias
Summary: This article summarizes key information on overcoming chemoresistance in ovarian cancer using synthetic lethality strategies, including the biological rationale and clinical evaluation of targeting BRCA-PARP synthetic lethality. In addition, it also discusses how to apply synthetic lethality strategies in non-BRCA mutant cancers, along with the combination of PARP inhibitors and other methods to target ovarian cancer.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Lucie Melounkova, Miriam Sykova, Robert Jirasko, Roman Jambor, Radim Havelek, Eva Peterova, Jan Honzicek, Jaromir Vinklarek
Summary: Two series of heterobimetallic compounds, including neutral Pt-Sn complexes and ionic Pt-Ag complexes, were synthesized and showed high cytotoxicity against ovarian cancer cells, particularly cisplatin resistant ones. Mechanistic studies revealed the induction of cell apoptosis through regulation of apoptotic proteins and activation of caspase pathways.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yichen Li, Qian Zhang, Mandi Wu, Peidong Zhang, Liang Huang, Xiaolin Ai, Zhengnan Yang, Qiuhong Shen, Yiran Wang, Ping Wang, Shengtao Zhou, Ming-Liang He
Summary: A study has found that a LncRNA associated with ovarian cancer metastasis, LncOVM, is highly correlated with poor prognosis and survival. LncOVM interacts with and stabilizes PPIP5K2, promoting the secretion of complement C5 from ovarian cancer cells, which then attracts myeloid-derived suppressor cells (MDSCs) infiltration in the tumor microenvironment (TME) to facilitate metastasis. Targeting the LncOVM-PPIP5K2-complement axis can inhibit MDSC infiltration and restore the suppression of tumorigenesis and metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Deborah K. Armstrong, Ronald D. Alvarez, Jamie N. Bakkum-Gamez, Lisa Barroilhet, Kian Behbakht, Andrew Berchuck, Lee-may Chen, Mihaela Cristea, Maria DeRosa, Eric L. Eisenhauer, David M. Gershenson, Heidi J. Gray, Rachel Grisham, Ardeshir Hakam, Angela Jain, Amer Karam, Gottfried E. Konecny, Charles A. Leath, Joyce Liu, Haider Mahdi, Lainie Martin, Daniela Matei, Michael McHale, Karen McLean, David S. Miller, David M. O'Malley, Sanja Percac-Lima, Elena Ratner, Steven W. Remmenga, Roberto Vargas, Theresa L. Werner, Emese Zsiros, Jennifer L. Burns, Anita M. Engh
Summary: Epithelial ovarian cancer is a leading cause of gynecologic cancer death in the United States. The NCCN Guidelines discuss various ovarian cancers, focusing on primary treatment aspects and including recommendations for both common and rare subtypes.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Oncology
Ignace Vergote, Antonio Gonzalez-Martin, Domenica Lorusso, Charlie Gourley, Mansoor Raza Mirza, Jean-Emmanuel Kurtz, Aikou Okamoto, Kathleen Moore, Frederic Kridelka, Iain McNeish, Alexander Reuss, Benedicte Votan, Andreas du Bois, Sven Mahner, Isabelle Ray-Coquard, Elise C. Kohn, Jonathan S. Berek, David S. P. Tan, Nicoletta Colombo, Rongyu Zang, Nicole Concin, Dearbhaile O'Donnell, Alejandro Rauh-Hain, C. Simon Herrington, Christian Marth, Andres Poveda, Keiichi Fujiwara, Gavin C. E. Stuart, Amit M. Oza, Michael A. Bookman
Summary: The sixth Ovarian Cancer Conference on Clinical Research by the Gynecologic Cancer InterGroup (GCIG) was held virtually, aiming to achieve harmonisation on design elements, select important questions, and identify unmet needs in ovarian cancer research. Consensus was reached among the member groups on most statements, confirming the applicability of virtual consensus process. These consensus statements, along with the categorisation of unmet needs, will promote the harmonisation of international clinical research in ovarian cancer.
Article
Oncology
Osnat Elyashiv, Jonathan Ledermann, Gita Parmar, Laura Farrelly, Nicholas Counsell, Amanda Feeney, Fatima El-Khouly, Ian Macdonald, Andreia Neto, Esther Arthur-Darkwa, Eva Burnett, Gordon C. Jayson, Linda Mileshkin, Charlie Gourley, Shibani Nicum
Summary: The ICON9 trial aims to investigate the efficacy of maintenance treatment with cediranib and olaparib in recurrent ovarian cancer, with an estimated completion of recruitment in 2024 and presentation of results in 2025.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Robert D. Morgan, Iain A. McNeish, Adrian D. Cook, Elizabeth C. James, Rosemary Lord, Graham Dark, Rosalind M. Glasspool, Jonathan Krell, Christine Parkinson, Christopher J. Poole, Marcia Hall, Dolores Gallardo-Rincon, Michelle Lockley, Sharadah Essapen, Jeff Summers, Anjana Anand, Abel Zachariah, Sarah Williams, Rachel Jones, Kate Scatchard, Axel Walther, Jae-Weon Kim, Sudha Sundar, Gordon C. Jayson, Jonathan A. Ledermann, Andrew R. Clamp
Summary: This study investigated the radiological and CA125 responses in patients with advanced-stage ovarian cancer receiving platinum-based neoadjuvant chemotherapy followed by delayed primary surgery. The results suggest that neither RECIST nor GCIG CA125 responses should be used as individual predictive markers for stratifying patients for optimal treatment, but rather in conjunction with clinical evaluation.
Article
Oncology
Damien J. McHugh, Nuria Porta, Ross A. Little, Susan Cheung, Yvonne Watson, Geoff J. M. Parker, Gordon C. Jayson, James P. B. O'Connor
Summary: This study evaluates the repeatability of radiomic features from different MR sequences in predicting therapy response in oncology patients. It highlights the impact of scan acquisition parameters and the use of contrast agents on radiomic feature repeatability. The findings emphasize the importance of evaluating feature-specific repeatability and choosing appropriate metrics in specific studies for robust biomarker selection.
Article
Oncology
Reem D. Mahmood, Danielle Shaw, Tine Descamps, Cong Zhou, Robert D. Morgan, Saifee Mullamitha, Mark Saunders, Nerissa Mescallado, Alison Backen, Karen Morris, Ross A. Little, Susan Cheung, Yvonne Watson, James P. B. O'Connor, Alan Jackson, Geoff J. M. Parker, Caroline Dive, Gordon C. Jayson
Summary: Metastatic colorectal cancer patients receiving standard chemotherapy show changes in cell- and protein-based biomarkers, with no association to survival outcomes. However, an increase in the MRI imaging biomarker K-trans is associated with worse overall survival, indicating potential for directing molecularly targeted therapies.
Article
Medicine, General & Internal
Robert D. Morgan, Cristina Ferreras, Isabel Peset, Egle Avizienyte, Andrew G. Renehan, Richard J. Edmondson, Alexander D. Murphy, Shibani Nicum, Thomas Van Brussel, Andrew R. Clamp, Diether Lambrechts, Cong Zhou, Gordon C. Jayson
Summary: This study evaluated the clinical significance of co-localisation of c-MET and VEGFR-2, as well as the association between VEGF pathway-related gene polymorphisms and survival outcomes in women with epithelial ovarian cancer receiving bevacizumab treatment. The results showed that high c-MET/VEGFR-2 co-localisation and VEGFR-2 rs2305945 G/G variant were associated with worse survival outcomes.
Review
Oncology
Alexander D. Murphy, Robert D. Morgan, Andrew R. Clamp, Gordon C. Jayson
Summary: Advanced epithelial ovarian, fallopian tube, and primary peritoneal cancers are a leading cause of gynecological cancer-related mortality, with angiogenesis playing a key role in their growth. Vascular endothelial growth factor inhibitors can improve response rate, progression-free survival, and overall survival, regardless of platinum sensitivity in EOC.
BRITISH JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Chloe A. Logue, Julia Pugh, Philip Foden, Reem D. Mahmood, Robert D. Morgan, Claire Mitchell, Jurjees Hasan, Andrew R. Clamp, Gordon C. Jayson
Summary: This study aims to assess whether women with gBRCAm ovarian cancer experience distinct psychosexual morbidity. The results showed that women with gBRCAm ovarian cancer were younger and expressed more interest for specialist psychosexual support, and they may have different psychosexual problems compared to women with gBRCAwt ovarian cancer.
Article
Oncology
Aya El Helali, Ruth Plummer, Gordon C. Jayson, Vicky M. Coyle, Yvette Drew, Nerissa Mescallado, Noor Harris, Andrew R. Clamp, Janine McCann, Helen Swaisland, Richard D. Kennedy, Aaron N. Cranston, Richard H. Wilson
Summary: This study evaluated the safety and tolerability of a novel anti-angiogenic peptide, ALM201. The results showed that ALM201 subcutaneous doses up to 300 mg were feasible and well-tolerated. Further investigation of this agent would benefit from patient selection biomarkers in specific tumor types/settings.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Robert D. Morgan, George J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. Clamp, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Emma R. Woodward, Fiona Lalloo, Emma J. Crosbie, Richard J. Edmondson, Andrew J. Wallace, Gordon C. Jayson, D. Gareth R. Evans
Summary: This study validates the recommendation of testing for BRCA1/2 pathogenic variants in both blood and tumor samples in cases of non-mucinous epithelial ovarian cancer. The findings suggest that reflex tumor BRCA1/2 testing should be performed in all NMEOC cases, and germline BRCA testing may not be necessary for older women without identified tumor BRCA1/2 variants or a family history of specific cancers.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
C. Zhou, J. O'Connor, A. Backen, J. W. Valle, J. Bridgewater, C. Dive, G. C. Jayson
Summary: In this study, it was found that plasma Tie2 (pTie2) can serve as a response biomarker for vascular endothelial growth factor inhibitors (VEGFi) treatment, predicting treatment response and disease progression. By integrating data from different types of cancer, it was demonstrated that pTie2 can guide the optimal use of VEGFi in clinical practice.
Article
Pathology
Robert D. Morgan, George J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. Clamp, Jurjees Hasan, Claire Mitchell, Zena Salih, Emma R. Woodward, Fiona Lalloo, Joseph Shaw, Sudha Desai, Emma J. Crosbie, Richard J. Edmondson, Helene Schlecht, Andrew J. Wallace, Gordon C. Jayson, D. Gareth R. Evans
Summary: According to this study, some mutations in the tumor BRCA1/2 genes may be somatic mutations, and it may not be necessary to test all non-mucinous high-grade epithelial ovarian cancer cases for germline BRCA1/2 mutations.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Meeting Abstract
Oncology
R. D. Morgan, A. R. Clamp, B. Barnes, H. Schlecht, L. Yarram-Smith, Y. Wallis, S. Morgan, M. Valganon, E. Hudson, S. McKenna, S. Sundar, S. Nicum, J. D. Brenton, R. Kristeleit, S. Banerjee, I. McNeish, J. A. Ledermann, S. Taylor, G. Evans, G. C. Jayson
ANNALS OF ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Maja Kopczynska, Antje Teubner, Arun Abraham, Michael Taylor, Ashley Bond, Andrew Clamp, Rebecca Wight, Zena Salih, Jurjees Hasan, Claire Mitchell, Gordon C. Jayson, Simon Lal
Summary: This study demonstrates that a centralized approach to home parenteral nutrition (HPN) management can effectively provide care for patients with advanced cancer over a wide geographic area, while maintaining low rates of HPN-related complications and hospital readmissions.
Article
Oncology
Robert D. D. Morgan, George J. J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. R. Clamp, Jurjees Hasan, Claire L. L. Mitchell, Zena Salih, Emma R. R. Woodward, Fiona Lalloo, Emma J. J. Crosbie, Richard J. J. Edmondson, Helene Schlecht, Gordon C. C. Jayson, D. Gareth R. Evans
Summary: Approximately 15% of patients diagnosed with high-grade non-mucinous epithelial ovarian cancer (EOC) have a germline BRCA1/2 mutation, with somatic mutations occurring more frequently in patients aged >= 80. Germline BRCA1/2 testing in this age group can be reserved for those with a detectable tumour BRCA1/2 mutation. Testing for tumour BRCA1/2 and homologous recombination deficiency is sufficient for patients aged >= 80 with non-mucinous high-grade EOC.
Article
Oncology
Robert D. Morgan, Andrew R. Clamp, Bethany M. Barnes, Kirsten Timms, Helene Schlecht, Laura Yarram-Smith, Yvonne Wallis, Mikel Valganon-Petrizan, Suzanne MacMahon, Rhian White, Sian Morgan, Sarah McKenna, Emma Hudson, Laura Tookman, Angela George, Ranjit Manchanda, Sudha S. Sundar, Shibani Nicum, James D. Brenton, Rebecca S. Kristeleit, Susana Banerjee, Iain A. McNeish, Jonathan A. Ledermann, Stephen S. Taylor, D. Gareth R. Evans, Gordon C. Jayson
Summary: This study reports data from the first year of routine homologous recombination deficiency testing in the NHS in England, Wales, and Northern Ireland, demonstrating the significant survival benefits of olaparib plus bevacizumab maintenance therapy in women with newly diagnosed, advanced, high-grade ovarian cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)