Article
Oncology
Melina Deban, Kadhim Taqi, Gregory C. Knapp, Mikael Soucisse, Matt Curry, Lucas Sideris, Pierre Dube, Maher Al Khaldi, Nicole Jedrzejko, Geoff Porter, Carman Giacomantonio, Trevor Hamilton, Andrea MacNeill, Lloyd Mack, Antoine Bouchard-Fortier
Summary: Peritoneal mesothelioma is a rare malignancy originating from the peritoneal lining. Cytoreductive surgery and heated intraperitoneal chemotherapy is the standard treatment for isolated peritoneal mesothelioma. This study aims to describe the treatment protocols and patient outcomes for peritoneal mesothelioma in Canada.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Shigeki Kusamura, Dario Baratti, Michele De Simone, Enrico Maria Pasqual, Luca Ansaloni, Daniele Marrelli, Manuela Robella, Fabio Accarpio, Mario Valle, Stefano Scaringi, Daniele Biacchi, Carmen Palopoli, Sergio Gazzanelli, Marcello Guaglio, Marcello Deraco
Summary: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare cancer that originates in the peritoneum and has a poor prognosis. Cytoreductive surgery and HIPEC are currently the standard treatments, but selecting suitable patients and managing the perioperative period is challenging.
Article
Oncology
Mason Vierra, Varun V. Bansal, Ryan B. Morgan, Hunter D. D. Witmer, Biren Reddy, Ankit Dhiman, Frederick A. Godley, Cecilia T. Ong, Erika Belmont, Blase Polite, Ardaman Shergill, Kiran K. Turaga, Oliver S. Eng
Summary: This study aimed to explore whether fragmenting surgical and systemic therapeutic care between different institutions affects the outcomes of patients undergoing cytoreductive surgery (CRS) for peritoneal metastases. The results showed that patients undergoing CRS at a high-volume center may safely receive systemic therapy at outside-network facilities with comparable survival rates and rates of serious adverse events.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Thomas Boerner, Pompiliu Piso
Summary: Peritoneal carcinomatosis of gastric origin is still considered a terminal disease with poor outcomes due to limited treatment options. However, recent evidence suggests that cytoreductive surgery may improve survival in selected patients with gastric cancer. These procedures are complex and require high surgical expertise to prevent postoperative complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Claire Y. Li, Timothy Kennedy, Henry Richard Alexander
Summary: Malignant peritoneal mesothelioma is a rare malignancy that is diagnosed through cross sectional imaging and tissue biopsy. Surgical cytoreduction and chemotherapy are the preferred treatments, providing prolonged benefits to many patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Cristian D. Valenzuela, Edward A. Levine, Christopher W. Mangieri, Rohin Gawdi, Omeed Moaven, Gregory Russell, Megan E. Lundy, Kathleen C. Perry, Konstantinos Votanopoulos, Perry Shen
Summary: In rare cases, performing multiple CRS-HIPEC operations on appropriate surgical candidates can significantly prolong survival, especially for patients with appendix cancers. Most patients undergoing repeat CRS-HIPEC achieve satisfactory resection margins, and complication rates are comparable to the first operation.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Raphael Shamavonian, Ernest Cheng, Josh B. Karpes, Shoma Barat, Nima Ahmadi, David L. Morris
Summary: The study aimed to determine the outcomes and overall survival in patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy for malignant peritoneal mesothelioma. The study found that lymph node status, PCI, and CC score were independent prognostic factors that affected patient survival.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Vahan Kepenekian, Olivia Sgarbura, Frederic Marchal, Laurent Villeneuve, Shigeki Kusamura, Marcello Deraco
Summary: Through an international consensus, it was confirmed that hyperthermic intraperitoneal chemotherapy (HIPEC) following complete cytoreductive surgery (CRS) is the first-line treatment for diffuse malignant peritoneal mesothelioma (DMPM), and the combination of cisplatin and doxorubicin is recommended as the preferred HIPEC regimen.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Paul H. H. Sugarbaker, David Chang
Summary: In patients with mucinous appendiceal adenocarcinoma, a secondary cytoreductive surgery may be considered if cancer progression is documented after surgery. Statistically analyzing the variables, it is found that patients who undergo a secondary cytoreductive surgery within 24 months after the initial surgery have a higher mortality rate.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Manuel Duran-Martinez, Gonzalo Gomez-Duenas, Lidia Rodriguez-Ortiz, Juan Manuel Sanchez-Hidalgo, Antonio Gordon Suarez, Angela Casado-Adam, Sebastian Rufian-Pena, Blanca Rufian Andujar, Francisca Valenzuela-Molina, Maria Carmen Vazquez-Borrego, Antonio Romero-Ruiz, Javier Briceno-Delgado, Alvaro Arjona-Sanchez
Summary: This study aimed to evaluate the learning curve of L-CRS + HIPEC and its impact on perioperative outcomes. The learning curve was divided into a learning phase and a consolidation phase, which could be achieved after 14 procedures. There was a significant decrease in operative time with no differences in complexity, number of procedures, or morbidity.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Review
Oncology
Daniel Ren Yi Yap, Jolene Si Min Wong, Qiu Xuan Tan, Joey Wee-Shan Tan, Claramae Shulyn Chia, Chin-Ann Johnny Ong
Summary: The study aimed to compare the effectiveness of HIPEC in improving peritoneal recurrence rates in PM of different origins. Results showed good effectiveness of HIPEC in gastric PM, but limited utility in ovarian and colorectal PM. Findings were limited by a lack of data, lack of homogeneity, and consideration of novel and personalized treatment regimens.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Yutaka Yonemura, Haruaki Ishibashi, Akiyoshi Mizumoto, Takuji Fujita, Yang Liu, Satoshi Wakama, Syouzou Sako, Nobuyuki Takao, Toshiyuki Kitai, Kanji Katayama, Yasuyuki Kamada, Keizou Taniguchi, Daisuke Fujimoto
Summary: This review analyzed the effect of treatment modalities on response rates, side effects, morbidity and mortality, and survival in patients with peritoneal mesothelioma (PM). Comprehensive treatment including cytoreductive surgery (CRS) + perioperative chemotherapy (POC) showed longer median survival time and higher 10-year survival rates compared to systemic chemotherapy alone, though postoperative morbidity and mortality rates were higher. Therefore, specialized peritoneal surface malignancy centers are recommended for CRS + POC.
JOURNAL OF CANCER METASTASIS AND TREATMENT
(2022)
Article
Oncology
Vahan Kepenekian, Julien Peron, Diane Goere, Olivia Sgarbura, Jean-Baptiste Delhorme, Clarisse Eveno, Nazim Benzerdjeb, Isabelle Bonnefoy, Laurent Villeneuve, Pascal Rousset, Karine Abboud, Marc Pocard, Olivier Glehen
Summary: This study analyzed MCPM patients treated with CRS from the French RENAPE database between 1999 and 2019. The study found that HIPEC after complete surgery can reduce the risk of recurrence, but the difference was not statistically significant. Twenty-two percent of patients experienced severe post-operative adverse events, leading to reoperation. The majority of patients with a desire for childbearing were successful after laparoscopic-CRS-HIPEC surgery.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Oncology
Asad Ullah, Abdul Waheed, Jaffar Khan, Ankita Mishra, Bisma Tareen, Noor Nama, Nabin Raj Karki, Muhammad Saleem Panezai, Luis Velasquez Zarate, Joseph White, Frederick D. Cason, Nathaniel Matolo, Subhasis Misra, Nagla Abdel Karim
Summary: Primary peritoneal mesothelioma (PPM) is a rare and aggressive tumor that arises from the peritoneum. This study investigated the factors affecting patient prognosis and survival in PPM. The majority of PPM patients were male and Caucasian, and the prognosis was worse for patients with poorly differentiated tumors, tumor size > 4 cm, Caucasian race, and distant spread of disease.
Article
Oncology
Shadin Ghabra, David Chang, Paul H. Sugarbaker
Summary: The completeness of cytoreduction has consistently been the most important prognostic indicator in the management of peritoneal metastases in patients with colorectal cancer. Other clinical and histologic features may also impact survival. In patients with complete cytoreduction, lymph node positivity, poorly differentiated histopathology, asymptomatic status following treatment with systemic chemotherapy, incomplete response to systemic chemotherapy, and moderate to high peritoneal cancer index significantly reduce survival. However, these prognostic variables have no statistical significance in patients with incomplete cytoreduction.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Alixandra Wong, Sanjeev Naidu, Raymond P. Lancashire, Terence C. Chua
Summary: Despite greater technical challenges during surgery, obese patients undergoing emergency laparoscopic cholecystectomy for acute cholecystitis achieved similar postoperative outcomes compared to non-obese patients. Obesity should not be considered a contraindication for the procedure and can be safely performed in emergency settings.
ANZ JOURNAL OF SURGERY
(2022)
Article
Surgery
Alixandra Wong, Matthew J. J. Burstow, Peter J. J. Yuide, Sanjeev Naidu, Raymond P. P. Lancashire, Terence C. C. Chua
Summary: This study compared the outcomes of traditional emergency care and ASU models in patients with acute biliary diseases, finding that patients achieved similar surgical outcomes regardless of the care model, but the traditional model had shorter surgery times, while the ASU model had a higher proportion of cases led by consultant surgeons.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2022)
Article
Oncology
Anne-Sophie Belmont, Christophe Sajous, Amandine Bruyas, Sara Calattini, Stephanie Cartalat, Marion Chauvenet, Marc Colombel, Stephane Dalle, Tristan Dagonneau, Marie Darrason, Gilles Devouassoux, Michael Duruisseaux, Marielle Guillet, Olivier Glehen, Pierre Philouze, Francois Tronc, Thomas Walter, Benoit You, Gilles Freyer
Summary: This article discusses the protective measures implemented at IC-HCL during the first wave of the COVID-19 pandemic in France and their impact on clinical activities. The study found that there was no significant decline in the number of treatments conducted at IC-HCL, except for clinical trials and certain surgical activities. Additionally, the age and stage of cancer patients were found to be correlated with severe symptoms of COVID-19.
Review
Gastroenterology & Hepatology
Beate Rau, Linda Feldbruegge, Felix Gronau, Miguel Enrique Alberto Vilchez, Peter Thuss-Patience, Pierre Emmanuel Bonnot, Olivier Glehen
Summary: This review focuses on the prevention and treatment of peritoneal metastasis in gastric cancer. Prevention strategies aim to reduce cancer cell spillage and adherence, while treatment options include abdominal washing and chemotherapy. Treatment of existing peritoneal metastasis is effective in patients with limited disease and tumor spread.
Review
Gastroenterology & Hepatology
Aditi Bhatt, Olivier Glehen
Article
Oncology
Roy Hajjar, Frederic Mercier, Guillaume Passot, Arnaud Pasquer, Maximiliano Gelli, Edward A. Levine, Laurent Villeneuve, Gilles Poncet, Thomas Walter, Olivier Glehen
Summary: For patients with SB-NET undergoing CRS, HIPEC does not appear to provide additional treatment benefits and is associated with higher risk of complications.
Article
Oncology
Fatah Tidadini, Bertrand Trilling, Adeline Aime, Julio Abba, Jean-Louis Quesada, Alison Foote, Thierry Chevallier, Olivier Glehen, Jean -Luc Faucheron, Sihame Chkair, Catherine Arvieux
Summary: Pressurized Intraperitoneal Aerosol chemotherapy (PIPAC) is a new surgical technique for treating unresectable peritoneal carcinomatosis. This study estimated the mean cost of hospitalization for PIPAC in two French public teaching hospitals. The results showed that each PIPAC hospitalization cost the hospital an average of 2531 euros, while the fixed-rate remuneration was only 4031 euros.
Article
Oncology
Marco Tonello, Dario Baratti, Paolo Sammartino, Andrea Di Giorgio, Manuela Robella, Cinzia Sassaroli, Massimo Framarini, Mario Valle, Antonio Macri, Luigina Graziosi, Paola Fugazzola, Piero Vincenzo Lippolis, Roberta Gelmini, Daniele Biacchi, Shigeki Kasamura, Marcello Deraco, Carola Cenzi, Paola Del Bianco, Marco Vaira, Antonio Sommariva
Summary: This study aimed to analyze the prognostic role of BIOSCOPE and COMPASS scores in predicting the survival of patients with colorectal cancer liver metastases eligible for surgery. The results showed that both scores effectively stratified overall survival, with BIOSCOPE performing better at 60 months. These scores can successfully stratify cancer-related mortality risk.
Review
Cardiac & Cardiovascular Systems
Michael L. Williams, Bridget Hwang, Linna Huang, Ashley Wilson-Smith, John Brookes, Aditya Eranki, Tristan D. Yan, T. Sloane Guy, Johannes Bonatti
Summary: The meta-analysis comparing RMVS and CSMVS found that RMVS may have lower mortality and shorter ICU and hospital LOS, while CSMVS may be associated with significantly shorter cross clamp and CPB times. High-quality, randomized studies are needed to confirm these results.
ANNALS OF CARDIOTHORACIC SURGERY
(2022)
Review
Oncology
Shigeki Kusamura, Dario Baratti, Michele De Simone, Enrico Maria Pasqual, Luca Ansaloni, Daniele Marrelli, Manuela Robella, Fabio Accarpio, Mario Valle, Stefano Scaringi, Daniele Biacchi, Carmen Palopoli, Sergio Gazzanelli, Marcello Guaglio, Marcello Deraco
Summary: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare cancer that originates in the peritoneum and has a poor prognosis. Cytoreductive surgery and HIPEC are currently the standard treatments, but selecting suitable patients and managing the perioperative period is challenging.
Article
Oncology
Pamela Funk-Debleds, Julien Rossi, Lorraine Bernard, Alexandre Galan, Vahan Kepenekian, Olivier Glehen, Cecile Chambrier
Summary: Patients with advanced gastric adenocarcinoma undergoing gastrectomy and HIPEC with or without CR are at high risk of malnutrition. Post-operative weight loss has a negative impact on patient outcomes.
Article
Oncology
Bahar Canbay Torun, Olivier Glehen, Vahan Kepenekian, Armando Sardi, Alvaro Arjona-Sanchez, Yutaka Yonemura, Shoma Barat, David Morris, John Spiliotis, Federico Coccolini, Antonio Sommariva, Adrian Bartos, Sayyed Raza, Kurt Vander Speteen, Levhi Akin, Tulay Irez, Emel Canbay
Summary: The purpose of this study was to evaluate outcome data after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastasis originating from advanced epithelial ovarian carcinoma (PMOC). The study found that this treatment strategy can be safely performed with acceptable morbidity and mortality in specialized units.
Article
Oncology
Ahmed H. Mekkawy, Mohammad Breakeit, Krishna Pillai, Samina Badar, Javed Akhter, Sarah J. Valle, David L. Morris
Summary: The study investigated the effect of intraperitoneal delivery of BromAc((R)) on colon-anastomosis healing in rats. The results showed that the rats treated with BromAc((R)) did not experience any interference with the healing process. The burst pressure and collagen density in the BromAc((R)) group were slightly higher compared to the control group, although not statistically significant.
Article
Biochemistry & Molecular Biology
Shigeki Kusamura, Adele Busico, Elena Conca, Iolanda Capone, Luca Agnelli, Daniele Lorenzini, Silvia Brich, Marta Angelini, Chiara Costanza Volpi, Desire Viola Trupia, Vincenzo Lagano, Tommaso Torelli, Annunziata Gloghini, Dario Baratti, Marcello Guaglio, Massimo Milione, Marcello Deraco, Federica Perrone
Summary: This study aimed to explore the mechanisms by which KRAS and GNAS mutations contribute to immune evasion in PMP, as well as to identify potential therapeutic and prognostic targets. The study found immunosuppressive factors such as GM-CSF, A2AR, and PD-L1 in PMP, which were unrelated to GNAS and KRAS status.
Article
Respiratory System
Krishna Pillai, Ahmed H. H. Mekkawy, Javed Akhter, David L. L. Morris
Summary: In this study, the efficacy of BromAc as a mucolytic agent was tested on two gelatinous sputa models. The results showed that BromAc improved the viscosity and flow of the sputum, and had a greater effect compared to individual agents. Therefore, BromAc may be used as an effective mucolytic for clearing airway congestion caused by thick mucinous secretions.
ADVANCES IN RESPIRATORY MEDICINE
(2023)
