期刊
ANNALS OF ONCOLOGY
卷 21, 期 1, 页码 120-125出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdp264
关键词
age; gender; IPSS; MDS; prognosis
类别
资金
- Tiroler Verein zur Forderung der Krebsforschung an der Universitat Innsbruck and Osterr
- Krebshilfe Tirol
Patients and methods: In all, 897 patients with primary MDS treated with supportive care only were examined in a retrospective multicenter study. A Cox model was developed to determine the prognostic impact of age and gender on survival and to examine their modulating influence on IPSS results. Based on main effects and interactions of these variables, we established an individualized age- and gender-adapted scoring system to improve prognostication in MDS. Results: While the risk of a patient in the IPSS is best represented by the values 0 (low), +1 (intermediate-1), +2 (intermediate-2), and +3 (high), these values were found to vary between -1.9 and +3.5 in the same patients when including age and gender. Whereas in low-risk MDS, male patients were found to have a less favorable survival, a particularly high risk (+3.5) was found in younger (< 66 years) high-risk female patients. Conclusion: The inclusion of age and gender and their respective interactions contribute to improved and individualized prognostication in MDS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据