Article
Nutrition & Dietetics
Fadlina Chany Saputri, Nuriza Ulul Azmi, Meidi Utami Puteri, Gracia Damayanti, Vivi Novita, Gracia Marisi, Elin Oktavira, Aninda Novika Sari, Khairunisa Ronaningtyas, Enny Herawati
Summary: This study assessed the impact of a high-fat diet on platelet activation and its association with PCSK9, as well as its effects on blood pressure in an animal model. The results showed that high-fat diet-induced hypercholesterolemia and hypertriglyceridemia significantly increased platelet activation and PCSK9 levels. These findings suggest a potential link between high-fat diet, PCSK9, and cardiovascular diseases.
Article
Food Science & Technology
Tengfei Zhu, Jingyu Zhao, Shu Zhuo, Zhimin Hu, Shuyu Ouyang, Wunier, Shuting Yu, Yan Chen, Yu Li, Yingying Le
Summary: This study found that high-fat diet can reduce vitamin D levels in mice, while dietary restriction can help increase serum 25(OH)D-3 levels and improve hypercholesterolemia, hyperglycemia, and hypertriglyceridemia.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Anastasios Liberis, Stamatis Petousis, Panagiotis Tsikouras
Summary: Dyslipidemia in pregnancy poses risks for both mother and fetus, with increases in LDL-C and triglyceride levels requiring monitoring. Dietary control is the primary management approach, while apheresis may be considered for severe cases. Further research on the safety of lipid-lowering agents during pregnancy is needed.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Biotechnology & Applied Microbiology
Jianzhao Huang, Nan Xiao, Yiying Sun, Shanshan Wu, Wenni Tian, Yujian Lai, Pan Li, Bing Du
Summary: The probiotic Bacillus sp. DU-106 was found to have a hypocholesterolemic effect in hypercholesterolemic rats, significantly reducing body weight, liver index, and total cholesterol levels. This effect was associated with changes in gut microbiota composition and metabolites, indicating potential probiotic benefits for intestinal health.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Sean T. Anderson, Hu Meng, Thomas G. Brooks, Soon Yew Tang, Ronan Lordan, Arjun Sengupta, Soumyashant Nayak, Antonijo Mrela, Dimitra Sarantopoulou, Nicholas F. Lahens, Aalim Weljie, Gregory R. Grant, Frederic D. Bushman, Garret A. FitzGerald
Summary: Longitudinal studies suggest a relationship between shiftwork and cardiometabolic disorders, but the causes and mechanisms are not clear. We developed a mouse model to study circadian misalignment in both sexes and found that female mice showed preserved rhythmicity and were protected from the cardiometabolic effects of misalignment on a high-fat diet. Differences were observed in the liver transcriptome and proteome, as well as gut microbiome dysbiosis, which only occurred in male mice. Antibiotic treatment reduced the impact of misalignment. In the UK Biobank, female shiftworkers demonstrated stronger circadian rhythmicity and a lower incidence of metabolic syndrome compared to males. Our findings suggest that females are more resilient to chronic circadian misalignment, and this difference is conserved in humans.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Beihua Zhong, Shuangtao Ma, Donna H. Wang
Summary: This study investigates the role of TRPV1 in Western diet-induced hypertension. The findings suggest that TRPV1 ablation increases salt sensitivity during Western diet intake due to impaired renal NO production and sodium excretion. Activation of TRPV1 enhances renal NO production and sodium excretion, resulting in the prevention of increased salt sensitivity during Western diet intake.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zixuan Chen, Yiwen E, Jun Xiong, Weike Li, Xuemei Chen, Na Li, Jing Long, Chao Tong, Junlin He, Fangfang Li, Cuihua Zhang, Yingxiong Wang, Rufei Gao
Summary: Pregnancy complications are more likely to occur in obese women due to defective decidualization. Obesity-induced endometrial glycolysis modifications and key glycolytic enzyme downregulation during early pregnancy might cause abnormal decidualization, leading to an unsustainable pregnancy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Nutrition & Dietetics
Toini Pemmari, Mari Hamalainen, Riitta Ryyti, Rainer Peltola, Eeva Moilanen
Summary: This study found that cloudberry supplementation helps protect against the development of metabolic inflammation and provides partial protection against disturbed lipid and glucose metabolism. These results encourage further research on the effects of cloudberry and cloudberry-derived ellagitannins and support the use of cloudberries as part of a healthy diet to prevent obesity-associated metabolic diseases.
Article
Nutrition & Dietetics
Rola Hammoud, Emanuela Pannia, Ruslan Kubant, Adam Metherel, Rebecca Simonian, Zdenka Pausova, G. Harvey Anderson
Summary: This study found that gestational choline supplementation may improve biomarkers of metabolic syndrome in male Wistar rat offspring fed a high-fat diet, but has no significant effect on offspring fed a normal-fat diet.
Review
Biochemistry & Molecular Biology
Dorothy F. Graham, Frederick J. Raal
Summary: Managing familial hypercholesterolemia during pregnancy poses challenges, such as the impact of medication on both the mother and fetus, long-term risks of cardiovascular disease, but there are numerous treatment options and ongoing research available at present.
CURRENT OPINION IN LIPIDOLOGY
(2021)
Article
Nutrition & Dietetics
Lin Ding, Shan Ren, Yaoxin Song, Chuangang Zang, Yuchao Liu, Hao Guo, Wenqing Yang, Hong Guan, Jicheng Liu
Summary: This study found that corn silk could reduce cholesterol levels by altering gut microbiota and regulating host bile acid metabolism, resulting in reduced chronic inflammation damage, body weight, and cholesterol intake.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Yi Huang, Jazmin Osorio Mendoza, Min Li, Zengguang Jin, Baoguo Li, Yingga Wu, Jacques Togo, John R. Speakman
Summary: The study found that maternal dietary fat content was positively related to offspring body weight and adiposity, with offspring of mothers exposed to HFD having higher levels. The effects of different levels of maternal dietary fat on offspring were nonlinear and sex dependent. Offspring of mothers on 8.3% and 25% fat diets had the highest daily energy expenditure and respiratory exchange ratio.
Article
Biochemistry & Molecular Biology
Shujauddin Mohammed, Syed Shah Yousuf Qadri, Irfan Ahmad Mir, Narendra Babu Kondapalli, Sanjay Basak, Hemalatha Rajkumar
Summary: Maternal intake of fructooligosaccharide during pregnancy and lactation may reduce placental inflammation and prevent adverse effects on offspring's lipid metabolism and adiposity caused by a high-fat diet, providing potential benefits for lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Medicine, General & Internal
Saranya Serirukchutarungsee, Ippei Watari, Pornchanok Sangsuriyothai, Masato Akakura, Takashi Ono
Summary: This study examined the impact of two-generation exposure to a high-fat diet on the craniofacial growth of rat offspring. Male offspring from the high-fat diet group showed increased body weight and larger neurocranial parameters compared to the control group. There were also slight differences in body weight and viscerocranial parameters between female offspring in the high-fat diet group and the control group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shuang-Quan Yu, Shuangtao Ma, Donna H. Wang
Summary: Activating the TRPV1 channel in renal afferent nerves can suppress renal sympathetic nerve activity in obese rats, preventing renal dysfunction and hypertension. These findings highlight the role of TRPV1-positive renal afferent nerves in obesity-induced renal disease and hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Pediatrics
Neena Modi, Gabriella Conti, Mark Hanson
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Biochemistry & Molecular Biology
E. Antoun, P. Titcombe, K. Dalrymple, N. T. Kitaba, S. J. Barton, Ac Flynn, R. Murray, E. S. Garratt, P. T. Seed, S. L. White, Cyrus Cooper, H. M. Inskip, M. Hanson, L. Poston, K. M. Godfrey, K. A. Lillycrop
Summary: The study identified neonatal methylation changes associated with birthweight and specific maternal factors, suggesting potential insights into developmental pathways affecting birthweight and surrogate markers for adverse prenatal exposures linked to non-communicable diseases.
Article
Biochemistry & Molecular Biology
Philip Titcombe, Robert Murray, Matthew Hewitt, Elie Antoun, Cyrus Cooper, Hazel M. Inskip, Joanna D. Holbrook, Keith M. Godfrey, Karen Lillycrop, Mark Hanson, Sheila J. Barton
Summary: This study extensively investigated non-CpG DNA methylation, revealing that CAC methylation may have tissue-specific patterns, while CAT methylation is influenced by individual effects.
Article
Endocrinology & Metabolism
Kathryn Dalrymple, Christina Vogel, Keith M. Godfrey, Janis Baird, Nicholas C. Harvey, Mark A. Hanson, Cyrus Cooper, Hazel M. Inskip, Sarah R. Crozier
Summary: Mother-offspring dietary trajectories are stable across early life, with poorer diet quality associated with maternal socio-demographic and other factors, and linked to childhood adiposity. Promoting positive maternal dietary changes during the preconception period may improve childhood outcomes.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Editorial Material
Public, Environmental & Occupational Health
Michael Penkler, Chandni M. Jacob, Ruth Mueller, Martha Kenney, Shane A. Norris, Clarissa P. da Costa, Sarah S. Richardson, Tessa J. Roseboom, Mark Hanson
Summary: The COVID-19 pandemic has highlighted inequalities in health outcomes, especially impacting disadvantaged communities. The DOHaD Society believes that by adopting a social justice framework, they can contribute to improving community resilience and promoting health equity. Aligning research and policy recommendations with a social justice perspective is seen as crucial in ensuring a fair and socially just improvement in health for present and future generations.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Food Science & Technology
Eloise Keeling, Savannah A. Lynn, Yen Min Koh, Jenny A. Scott, Aaron Kendall, Maureen Gatherer, Anton Page, Felino R. Cagampang, Andrew J. Lotery, J. Arjuna Ratnayaka
Summary: This study demonstrates that prolonged exposure to an unhealthy Western-style diet alone can lead to the development of early-intermediate AMD-like features in wildtype mice, highlighting the importance of diet and nutrition in the etiology of sight-loss.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Debbie S. Thompson, Patrice M. Francis-Emmanuel, Alan T. Barnett, Clive Osmond, Mark A. Hanson, Christopher D. Byrne, Peter D. Gluckman, Terrence E. Forrester, Michael S. Boyne
Summary: Adults who had non-edematous severe acute malnutrition (SAM) during infancy display worse glucose tolerance and beta-cell function compared to survivors of edematous SAM, suggesting that wasting and/or stunting during SAM may be associated with lower glucose disposal rate and insulin clearance in adulthood. However, in lean, young, adult survivors of SAM, wasting and stunting during infancy are not linked to insulin sensitivity and insulin clearance.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Nutrition & Dietetics
Kathryn V. Dalrymple, Christina Vogel, Keith M. Godfrey, Janis Baird, Mark A. Hanson, Cyrus Cooper, Hazel M. Inskip, Sarah R. Crozier
Summary: There is a growing interest in modeling longitudinal dietary data to identify subgroups with similar trajectories. This paper compares two latent class methods, group-based trajectory modeling (GBTM) and growth mixture modeling (GMM), to analyze dietary data from a longitudinal study. Both methods suggest that five classes are optimal, with strong correlation between class assignments. Results show stable dietary trajectories with varying levels of quality. GBTM is recommended as it is less computationally intensive, but results can be confirmed using GMM.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Ainul N. M. Hanafiah, Jens Aagaard-Hansen, Julius C. H. Cheah, Shane A. Norris, Zulkarnain B. A. Karim, Jutta K. H. Skau, Zainudin M. Ali, Regien Biesma, Priya Matzen, Lokman H. Sulaiman, Mark Hanson
Summary: The Jom Mama pre-conception intervention, which aimed to target prospective parents and reduce transmission of risk factors such as obesity, did not lead to significant changes in waist circumference or other secondary outcomes. However, there was a significantly smaller weight gain in the intervention group, particularly in women with pre-existing obesity.
JOURNAL OF GLOBAL HEALTH
(2022)
Article
Endocrinology & Metabolism
Chandni Maria Jacob, Mark Hanson
Summary: There is growing evidence that parental risk factors for NCDs before conception can impact lifelong health and increase the risk of NCDs in their children. Although many of these risks are influenced by socio-economic factors, healthcare practitioners can identify and screen for these risk factors in clinical settings and provide appropriate preventive interventions.
PRACTICAL DIABETES
(2022)
Article
Nutrition & Dietetics
Chandni Maria Jacob, Hazel M. Inskip, Wendy Lawrence, Carmel McGrath, Fionnuala M. McAuliffe, Sarah Louise Killeen, Hema Divakar, Mark Hanson
Summary: Proper nutrition and weight before and during pregnancy can lower the risk of pregnancy-related conditions, but user-friendly tools to support healthcare practitioners in implementing them are lacking in most clinical settings. This study found that the FIGO nutrition checklist is an valuable resource that can be used in clinical practice to provide long-term and intergenerational benefits for both mother and baby.
Review
Pediatrics
Kiran Meka, Chandni M. Jacob, Neena Modi, Flavia Bustreo, Gian Carlo Di Renzo, Ariadne Malamitsi-Puchner, Despina Briana, Domenico G. Iaia, Helga Fogstad, Jagannadha P. Tamvada, Ivan Ochoa Moreno, Mark Hanson
Summary: This study discusses the implications of maternal, newborn, child and adolescent health (MNCAH) on gross domestic product (GDP), and suggests that unremunerated work largely conducted by women should be included in GDP due to its positive impact on future health and prosperity, while industries that harm health should be excluded. In light of the current challenges from COVID, climate change, and conflict, there is a need to redefine economic progress with equitable models and metrics that consider the societal value of activities improving MNCAH in the short, medium, and long term.
Review
Family Studies
Sharon James, Jessica E. Moulton, Anisa Assifi, Jessica Botfield, Kirsten Black, Mark Hanson, Danielle Mazza
Summary: Engaging in lifestyle risk reduction during the interconception period can help reduce adverse outcomes, but there are challenges such as information needs, managing competing priorities, physical and mental health, self-perception and motivation, access to services and professional support, and family and peer networks.
BMJ SEXUAL & REPRODUCTIVE HEALTH
(2023)
Article
Clinical Neurology
Diego A. Ojeda, Oliver Hutton, Robert Hopkins, Felino Cagampang, Neil R. Smyth, Tom P. Fleming, Judith Eckert, Sandrine Willaime-Morawek
Summary: Maternal high-fat diet during the preimplantation period or throughout pregnancy and lactation, without obesity, leads to changes in metabolic-related parameters and hippocampal neurogenesis and glial density in the adult offspring mice.
BRAIN COMMUNICATIONS
(2023)
Review
Pediatrics
Ariadne Malamitsi-Puchner, Laura Addati, Guony Bjork Eydal, Despina D. D. Briana, Flavia Bustreo, Gian Carlo Di Renzo, Margaret O'Brien, Mark Hanson, Neena Modi
Summary: Cohesive families and stimulating environments with caregiver attachment are crucial for a child's growth. Parental involvement in daily activities like breastfeeding, playing, reading, and storytelling supports early development. Universally accessible and equitable parental leave addresses the challenge of balancing child well-being, career, and gender equality for parents.