Article
Neurosciences
Davide Aloi, Roya Jalali, Penelope Tilsley, R. Chris Miall, Davinia Fernandez-Espejo
Summary: Research using tDCS intervention in long-term PDOC patients successfully altered dynamic coupling between brain regions. The results indicate that M1-tDCS and cb-tDCS can improve patients' motor deficits, enhancing rehabilitation options and quality of life.
Article
Rehabilitation
Katherine Golden, Kimberly S. Erler, John Wong, Joseph T. Giacino, Yelena G. Bodien
Summary: This study investigates the significance of consistent command-following (CCF) in the diagnostic criteria for emergence from the minimally conscious state (eMCS). The findings show that CCF reemerges around the same time as functional object use (FOU) or functional communication (FC) in patients recovering from disorders of consciousness (DoC). This supports the inclusion of CCF in the existing diagnostic criteria for eMCS.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Medicine, General & Internal
Xi Luo, Xiaodong Huang, Shaoyan Liu, Xiaolei Wang, Jingwei Luo, Jianping Xiao, Kai Wang, Yuan Qu, Xuesong Chen, Ye Zhang, Jingbo Wang, Jianghu Zhang, Guozhen Xu, Li Gao, Runye Wu, Junlin Yi
Summary: This cohort study evaluated a response-adapted strategy based on an early response to radiotherapy (RT) in patients with resectable locally advanced hypopharyngeal carcinoma (LAHPC). The study found that this strategy facilitated better treatment tailoring, maximum tumor control, and higher laryngeal preservation compared with primary surgery and primary RT strategies.
Article
Clinical Neurology
Karin Diserens, Ivo A. Meyer, Jane Johr, Alessandro Pincherle, Vincent Dunet, Polona Pozeg, Philippe Ryvlin, Dafin F. Muresanu, Robert D. Stevens, Nicholas D. Schiff
Summary: Brain-injured patients with cognitive motor dissociation (CMD) show a lack of command following using conventional neurobehavioral examination tools, but demonstrate high levels of awareness and language processing using advanced imaging and electrophysiology techniques. By expanding motor testing and detecting subtle, purposeful movements, even patients classified as vegetative state/unresponsive wakefulness state may exhibit slight but determined motor responses. The term clinical CMD is proposed to describe these patients, who have hidden cognitive capabilities and potential for a good long-term outcome.
Article
Neurosciences
Yi Ling, Xinrui Wen, Jianghui Tang, Zhengde Tao, Liping Sun, Hailiang Xin, Benyan Luo
Summary: The aim of this study was to improve the topographic analysis of EEG microstates and explore indicators for diagnosis and prognosis prediction in patients with prolonged disorders of consciousness (pDoC). The optimized global explained variance (GEV) of microstate E strongly predicted the prognosis of these patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Sung Ho Jang, Soyoung Kwak, Min Young Lee
Summary: We investigated the value of videofluoroscopic swallowing study (VFSS) in predicting prognosis of impaired consciousness in stroke patients. Patients without swallowing difficulties showed better recovery of consciousness, and the degree of penetration and aspiration were correlated with prognosis.
Article
Clinical Neurology
Ayham Alkhachroum, Antonio J. Bustillo, Negar Asdaghi, Erika Marulanda-Londono, Carolina M. Gutierrez, Daniel Samano, Evie Sobczak, Dianne Foster, Mohan Kottapally, Amedeo Merenda, Sebastian Koch, Jose G. Romano, Kristine O'Phelan, Jan Claassen, Ralph L. Sacco, Tatjana Rundek
Summary: Impaired level of consciousness on presentation in patients with intracerebral hemorrhage may affect outcomes and decisions regarding life-sustaining treatment. Factors such as older age, female gender, aphasia, and higher ICH score were associated with impaired LOC and increased mortality. Early decisions to withhold or withdraw life-sustaining treatment significantly influenced mortality rates, and a reduction in early WOLST was observed in patients with impaired LOC after the release of updated treatment guidelines in 2015.
Article
Endocrinology & Metabolism
Kristina M. Utzschneider, David A. Ehrmann, Silva A. Arslanian, Elena Barengolts, Thomas A. Buchanan, Sonia Caprio, Sharon L. Edelstein, Tamara S. Hannon, Steven E. Kahn, Alexandra Kozedub, Kieren J. Mather, Kristen J. Nadeau, Susan Sam, Mark Tripputi, Anny H. Xiang, Laure El ghormli
Summary: Weight loss can improve insulin sensitivity and beta-cell function, and its contribution after surgical or medical intervention can be compared using different treatment methods. L + M treatment can enhance beta-cell function independent of weight loss, while laparoscopic gastric banding does not provide a net benefit to beta-cell function.
Article
Clinical Neurology
Saima Nazish, Azra Zafar, Erum Shariff, Rizwana Shahid, Sara Alamri, Aisha Albakr
Summary: This study aimed to investigate the different electroencephalographic patterns in critically ill patients and their correlation with clinical outcomes. It was found that certain EEG patterns are associated with specific underlying etiologies, while some patterns have prognostic value in critically ill patients but cannot be used alone for prognostic assessment. Further larger prospective studies are needed for a better understanding.
CLINICAL EEG AND NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Ahmed Abduljawad Salim, Safaa Hussain Ali, Ansam Munadel Hussain, Wisam Nabeel Ibrahim
Summary: This study aimed to investigate gray matter brain lesions in MS patients by evaluating the resting state alpha rhythm of brain electrical activity. It found that MS patients had significantly lower PDR frequency and amplitude values, with PDR frequency being negatively associated with functional disability level. Additionally, background slowing of resting alpha rhythms and epileptiform discharges may help in predicting and monitoring cortical damage and functional disabilities in MS patients.
Article
Endocrinology & Metabolism
Chi-Chao Chao, Paul-Chen Hsieh, Chien-Ho Janice Lin, Shin-Leh Huang, Sung-Tsang Hsieh, Ming-Chang Chiang
Summary: This study aimed to investigate the structural brain network changes in patients with chronic diabetic neuropathic pain (PDN). The results showed that PDN patients had reduced white matter connectivity in the limbic and temporal regions, as well as altered topology of the brain networks with decreased global efficiency and betweenness centrality.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Clinical Neurology
Saima Nazish
Summary: This study aimed to determine the clinical and radiological correlates of different EEG patterns in hospitalized patients. While some EEG patterns were significantly associated with abnormal imaging findings, certain patterns could not be precisely correlated, suggesting potential confounding factors. Further larger prospective clinical studies are recommended to better understand the relationship between EEG patterns and imaging results.
CLINICAL EEG AND NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Virginie Lambrecq, Aurelie Hanin, Esteban Munoz-Musat, Lydia Chougar, Salimata Gassama, Cecile Delorme, Louis Cousyn, Alaina Borden, Maria Damiano, Valerio Frazzini, Gilles Huberfeld, Frank Landgraf, Vi-Huong Nguyen-Michel, Phintip Pichit, Aude Sangare, Mario Chavez, Capucine Morelot-Panzini, Elise Morawiec, Mathieu Raux, Charles-Edouard Luyt, Pierre Rufat, Damien Galanaud, Jean-Christophe Corvol, Catherine Lubetzki, Benjamin Rohaut, Sophie Demeret, Nadya Pyatigorskaya, Lionel Naccache, Vincent Navarro
Summary: This retrospective cohort study in France investigated clinical, biological, and brain MRI findings in relation to EEG features for hospitalized adults with COVID-19, identifying patterns that could help guide treatment strategies for COVID-19-related encephalopathy.
Article
Clinical Neurology
Irit Titlestad, Leiv Otto Watne, Gideon A. Caplan, Adrian McCann, Per Magne Ueland, Bjorn Erik Neerland, Marius Myrstad, Nathalie Bodd Halaas, Christian Thomas Pollmann, Kristi Henjum, Anette Hylen Ranhoff, Lene B. Solberg, Wender Figved, Colm Cunningham, Lasse M. Giil
Summary: Our study aimed to investigate the relationship between metabolites related to energy metabolism in the serum and cerebrospinal fluid (CSF) of patients with hip fracture and delirium. We collected CSF samples from all 406 participants and serum samples from 213 participants. We found that ketone body concentrations and branched-chain amino acids were significantly elevated in the CSF of patients with delirium, indicating altered glucose utilization and a shift to ketone body metabolism in the brain during delirium.
Article
Biochemistry & Molecular Biology
Neeru A. Vallabh, Jane Armstrong, Gabriela Czanner, Brian McDonagh, Anshoo Choudhary, David N. Criddle, Colin E. Willoughby
Summary: Glaucoma is a progressive optic neuropathy that leads to irreversible visual impairment and eventual blindness. The mitochondrial function of ocular fibroblasts in glaucoma patients is compromised, with elevated oxidative stress levels. Therapeutic interventions targeting oxidative stress or providing mitochondrial energetic support are important in managing glaucoma.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Daniel J. Thengone, Henning U. Voss, Esteban A. Fridman, Nicholas D. Schiff
Science Translational Medicine
(2016)
Article
Neurosciences
Peter B. Forgacs, Esteban A. Fridman, Andrew M. Goldfine, Nicholas D. Schiff
FRONTIERS IN NEUROSCIENCE
(2016)
Letter
Clinical Neurology
Peter B. Forgacs, Mary M. Conte, Esteban A. Fridman, Henning U. Voss, Jonathan D. Victor, Nicholas D. Schiff
ANNALS OF NEUROLOGY
(2015)
Article
Neurosciences
Esteban A. Fridman, Jorge Calvar, Mariana Bonetto, Elkan Gamzu, Ben Zion Krimchansky, Francisco Meli, Ramon C. Leiguarda, Ross Zafonte
Article
Neurosciences
Esteban A. Fridman, Ben Zion Krimchansky, Mariana Bonetto, Tatyana Galperin, Elkan R. Gamzu, Ramon C. Leiguarda, Ross Zafonte
Article
Neurosciences
S. Bohlhalter, N. Hattori, L. Wheaton, E. Fridman, E. A. Shamim, G. Garraux, M. Hallett
Article
Clinical Neurology
Lewis Wheaton, Esteban Fridman, Stephan Bohlhalter, Sherry Vorbach, Mark Hallett
CLINICAL NEUROPHYSIOLOGY
(2009)
Review
Neurosciences
Esteban A. Fridman, Nicholas D. Schiff
CURRENT OPINION IN NEUROBIOLOGY
(2014)
Article
Clinical Neurology
Esteban A. Fridman, Marcos Crespo, Santiago Gomez Argueello, Lorena Degue, Mirta Villarreal, Stephan Bohlhalter, Lewis Wheaton, Mark Hallett
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2010)
Correction
Neurosciences
Lewis A. Wheaton, Stephan Bohlhalter, Guido Nolte, Hiroshi Shibasaki, Noriaki Hattori, Esteban Fridman, Sherry Vorbach, Jordan Grafman, Mark Hallett
NEUROSCIENCE LETTERS
(2009)
Article
Multidisciplinary Sciences
Mirta F. Villarreal, Esteban A. Fridman, Ramon C. Leiguarda
Article
Multidisciplinary Sciences
Esteban A. Fridman, Bradley J. Beattie, Allegra Broft, Steven Laureys, Nicholas D. Schiff
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Clinical Neurology
Esteban A. Fridman, Joseph R. Osborne, Paul D. Mozley, Jonathan D. Victor, Nicholas D. Schiff
Review
Clinical Neurology
Esteban A. Fridman, Nicholas D. Schiff
Summary: Organizing a rational treatment strategy for patients with multifocal structural brain injuries and disorders of consciousness is a challenging clinical goal. The use of the anterior forebrain mesocircuit model has been considered in approaching this problem, and it can guide therapeutic interventions to improve communication and patients' quality of life. This model has implications for both chronic and acute patients.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2022)