Article
Multidisciplinary Sciences
Ingrid de Chazeron, F. Durif, C. Lambert, I Chereau-Boudet, M. L. Fantini, A. Marques, P. Derost, B. Debilly, G. Brousse, Y. Boirie, P. M. Llorca
Summary: The study found that patients with Parkinson's disease have a higher prevalence of food addiction and night eating syndrome, which are associated with female gender and impulsivity, but not with dopaminergic therapy.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Ana Marques, Daniel Roquet, Elie Matar, Natasha Louise Taylor, Bruno Pereira, Claire O'Callaghan, Simon J. G. Lewis
Summary: Research compared brain alterations in the reward system between idiopathic REM sleep behavior disorder (iRBD) patients, healthy controls, and PD patients, finding differences in volumetric and functional connectivity characteristics, particularly in relation to hypersexuality. The presence of impulse control disorders (ICDs) correlated with altered functional connectivity within the reward system.
JOURNAL OF NEUROLOGY
(2021)
Review
Neurosciences
Andrea Augustine, Catharine A. Winstanley, Vaishnav Krishnan
Summary: Parkinson's disease patients are not only affected by motor impairments, but also at risk for impulse control disorders. There is currently a lack of consensus on the best approach to addressing these symptoms.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
S. Jesus, M. T. Perinan, C. Cortes, D. Buiza-Rueda, D. Macias-Garcia, A. Adarmes, L. Munoz-Delgado, M. a. Labrador-Espinosa, C. Tejera-Parrado, M. P. Gomez-Garre, P. Mir
Summary: Impulse control disorders are common in patients with Parkinson's disease, with 25.1% of cases experiencing them. Younger patients with higher rates of anxiety are more likely to have ICDs. Genetic studies suggest that polymorphisms in the DDC gene may modulate the risk of ICDs in PD, with genotype data increasing predictability by 11%.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Leire Zazu, Teresa Morera-Herreras, Montserrat Garcia, Carmelo Aguirre, Unax Lertxundi
Summary: This study aimed to investigate the association between cariprazine, brexpiprazole, and impulse control symptoms (ICS), revealing a higher number of reported ICS cases for these drugs in EudraVigilance. However, further well-designed observational analytical studies are needed to confirm these results and establish a definitive safety signal.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Olivier Corbeil, Stephanie Corbeil, Michel Dorval, Pierre-Hugues Carmichael, Isabelle Giroux, Christian Jacques, Marie-France Demers, Marc-Andre Roy
Summary: This study found that individuals with first-episode psychosis and a history of gambling are at increased risk of developing problem gambling when receiving aripiprazole. The results emphasize the importance of systematically screening for problem gambling in all individuals with psychotic disorders, as this comorbidity hinders recovery.
Article
Rheumatology
Maria A. Pou, Francesc Orfila, Javier Pagonabarraga, Silvia Ferrer-Moret, Hector Corominas, Cesar Diaz-Torne
Summary: This study investigated the neuroprotective effect of gout in patients with high levels of serum urate in a large urban Mediterranean population. The results showed that gout had a protective effect against Parkinson's disease in both men and women over 75 years old.
Review
Psychiatry
Jun-Fang Zhang, Xi-Xi Wang, Ya Feng, Robert Fekete, Joseph Jankovic, Yun-Cheng Wu
Summary: ICDs in PD refer to aberrant behaviors such as pathological gambling, hypersexuality, binge eating, and compulsive buying, which typically result from dopaminergic therapy. Research has focused on the broad spectrum of ICDs-related behaviors and their significant impact on patients and their families, with recent advances improving our understanding of this issue.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Xiaopeng Zhu, Langsha Liu, Yan Xiao, Fan Li, Yongkai Huang, Deqing Han, Chun Yang, Sian Pan
Summary: The study found that PD-ICD patients had increased clustering coefficient and characteristic path length, while decreased small-world index compared with PD-nICD patients. Furthermore, the abnormality of the small-world network parameters of PD-ICD patients was accompanied by the change of nodal centrality in the default mode network, control network, and dorsal attention network.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychiatry
M. Grall-Bronnec, C. Victorri-Vigneau, T. Rouaud, A. Verholleman, B. Schreck, J. Leboucher, E. Thiabaud, F. Feuillet, M. Roy, J. B. Hardouin, M. Guillou-Landreat, P. Derkinderen, G. Challet-Bouju
Summary: This study aimed to explore the predictive genetic, psychopathological and neurological factors involved in the development of impulsive-compulsive behaviors (ICBs) in Parkinson's disease (PD) patients. The results revealed that factors associated with ICBs include younger age of PD onset, personal history of ICB prior to PD onset, and higher scores on the urgency and sensation seeking facets of impulsivity. No significant gene variant was found, but there was a close to significant association with the opioid receptor mu 1 (OPRM1) rs1799971 polymorphism.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2022)
Article
Clinical Neurology
Mariana L. Laporta, S. Chandralekha Kruthiventi, Cole D. Stang, Emanuele Camerucci, David P. Martin, Toby N. Weingarten, Andrew C. Hanson, Darrell R. Schroeder, David O. Warner, Rodolfo Savica, Juraj Sprung
Summary: This study did not find a significant association between exposure to general anesthesia and the development of alpha-synucleinopathies.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Ana Marques, Michela Figorilli, Celine Lambert, Bruno Pereira, Tiphaine Vidal, Jacques Montplaisir, Franck Durif, Maria Livia Fantini
Summary: The study identified a clinical association between impulse control disorders (ICDs) and restless legs syndrome (RLS) in Parkinson's disease patients, with ICDs leading to increased subjective discomfort during the SIT test.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Health Care Sciences & Services
Mauricio Ivan Garcia-Rubio, Maria Elisa Otero-Cerdeira, Christian Gabriel Toledo-Lozano, Sofia Lizeth Alcaraz-Estrada, Juan Antonio Suarez-Cuenca, Ramon Mauricio Coral-Vazquez, Paul Mondragon-Teran, Juan Antonio Pineda-Juarez, Luis Fernando Diaz-Lopez, Silvia Garcia
Summary: This study identified dopamine agonists as being associated with the development of ICDs in PD patients, while the tremorgenic form may have a protective effect. Positive associations were found between the rigid-akinetic form and compulsive shopping, and between males and hypersexuality. Binge eating, compulsive shopping, and hypersexuality were the most common ICDs observed.
Article
Clinical Neurology
Sara C. Staubo, Ole Martin Fuskevag, Mathias Toft, Ingeborg H. Lie, Kirsti M. J. Alvik, Pal Jostad, Stein H. Tingvoll, Hallvard Lilleng, Kristina Rosqvist, Elisabet Storset, Per Odin, Espen Dietrichs, Erik Sveberg Dietrichs
Summary: The study suggests that the occurrence of impulse control disorders (ICDs) among patients using ropinirole is dependent on serum concentration and drug exposure, while the use of pramipexole may inherently increase ICD risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Yoshinori Sasaki, Masahide Usami, Shoko Sasaki, Hikaru Sunakawa, Yusuke Toguchi, Shuichi Tanese, Kiyoshi Saito, Rena Shinohara, Toshinari Kurokouchi, Kaori Sugimoto, Yuki Hakoshima, Kumi Inazaki, Yuta Yoshimura, Yuki Mizumoto, Takayuki Okada
Summary: This study aimed to evaluate the clinical characteristics of child and adolescent psychiatric patients with child-to-parent violence (CPV). The results showed that patients in the CPV group had significantly higher proportions of experiencing physical abuse, psychological abuse, and witnessing violence between parents. Additionally, there was a significant correlation between neurodevelopmental disorders and CPV, with impulsivity potentially being related to CPV.
Letter
Clinical Neurology
Irene Litvan, Anthony E. Lang, Melissa Armstrong
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Thomas F. Tropea, Teresa Waligorska, Sharon X. Xie, Ilya M. Nasrallah, Katheryn A. Q. Cousins, John Q. Trojanowski, Murray Grossman, David J. Irwin, Daniel Weintraub, Edward B. Lee, David A. Wolk, Alice S. Chen-Plotkin, Leslie M. Shaw
Summary: The objective of this study was to determine if plasma tau phosphorylated at threonine 181 (p-tau181) can distinguish Alzheimer's disease (AD) from normal cognition (NC) in adults, predict cognitive and functional decline, and validate findings in an external cohort. The results showed that plasma p-tau181 can accurately differentiate AD pathology from NC, and higher levels of p-tau181 are associated with faster cognitive and functional decline.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
John L. Robinson, Sharon X. Xie, Daniel R. Baer, EunRan Suh, Vivianna M. Van Deerlin, Nicholas J. Loh, David J. Irwin, Corey T. McMillan, David A. Wolk, Alice Chen-Plotkin, Daniel Weintraub, Theresa Schuck, Virginia M. Y. Lee, John Q. Trojanowski, Edward B. Lee
Summary: In this retrospective study, the incidence of 10 pathologies in neurodegenerative disease (ND) and normal aging was examined, with up to seven pathologies observed concurrently resulting in 161 different combinations. The presence of multiple additive pathologies was associated with factors such as longer disease duration, clinical dementia, older age, and APOE e4 status.
Article
Clinical Neurology
Antigony Rigas, Tina Mainka, Tamara Pringsheim, Alexander Muenchau, Irene Malaty, Yulia Worbe, Andrea E. Cavanna, Andrew John Lees, Anthony E. Lang, Davide Martino, Christos Ganos
Summary: This study revealed that the diagnostic distinction between primary and functional tics is often difficult, even for expert clinicians, in the absence of clinical information.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Tiago A. Mestre, Michael P. McDermott, Raquel Lobo, Joaquim J. Ferreira, Anthony E. E. Lang
Summary: This study evaluated the "lessebo effect" in disease modification trials in Parkinson's disease and found that it did not exist in these trials. However, the use of placebo instead of an active comparator was a limitation. Prospective measurement of expectation of benefit could help assess the various impacts of placebo use.
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Anthony E. Lang
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Danielle S. Abraham, Thanh Phuong Pham Nguyen, Leah J. Blank, Dylan Thibault, Shelly L. Gray, Sean Hennessy, Charles E. Leonard, Daniel Weintraub, Allison W. Willis
Summary: This study examined the differential prescribing patterns between new and established treatments for common neurological conditions. Using data from a national sample of US commercially insured adults from 2005-2019, the study compared new users of recently approved medications for three conditions: diabetic peripheral neuropathy, Parkinson disease psychosis, and epilepsy. The results showed that newer medications were more frequently prescribed to individuals with prior treatment, suggesting potential bias in comparative effectiveness and safety studies. The study emphasizes the importance of reporting propensity score non-overlap in comparative studies involving newer medications and suggests methodological approaches to address channeling bias.
Article
Clinical Neurology
Katheryn A. Q. Cousins, David J. Irwin, Alice Chen-Plotkin, Leslie M. Shaw, Sanaz Arezoumandan, Edward B. Lee, David A. Wolk, Daniel Weintraub, Meredith Spindler, Andres Deik, Murray Grossman, Thomas F. Tropea
Summary: This study found that plasma GFAP may be sensitive to concomitant AD pathology in LBSD, especially accumulation of beta-amyloid plaques.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Kalpana M. Merchant, Tanya Simuni, Janel Fedler, Chelsea Caspell-Garcia, Michael Brumm, Kelly N. H. Nudelman, Elizabeth Tengstrandt, Frank Hsieh, Roy N. Alcalay, Christopher Coffey, Lana Chahine, Tatiana Foroud, Andrew Singleton, Daniel Weintraub, Samantha Hutten, Todd Sherer, Brit Mollenhauer, Andrew Siderowf, Caroline Tanner, Ken Marek
Summary: We quantified concentrations of three isoforms of BMP in different cohorts of Parkinson's disease patients and found that LRRK2 and GBA1 gene mutations were associated with elevated BMP levels. However, BMP is not a prognostic or disease progression biomarker.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Daniel Weintraub, Marina Picillo, Hyunkeun Ryan Cho, Chelsea Caspell-Garcia, Cornelis Blauwendraat, Ethan G. Brown, Lana M. Chahine, Christopher S. Coffey, Roseanne D. Dobkin, Tatiana Foroud, Doug Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Tanya Simuni, Andrew Siderowf, Andrew Singleton, John Seibyl, Caroline M. Tanner
Summary: This study used data from a multi-site, international, prospective cohort study to investigate the impact of dopamine system-related biomarkers on cognitive impairment in Parkinson's disease. The results showed that alterations in the dopamine system were associated with the development of cognitive impairment in Parkinson's disease. If confirmed causative, these findings suggest that the dopamine system is instrumental to cognitive health status throughout the disease course.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Daniel G. Di Luca, Carolina Ramirez-Gomez, Jurgen Germann, Brendan Santyr, Alexandre Boutet, Luka Milosevic, Anthony E. Lang, Suneil K. Kalia, Andres M. Lozano, Alfonso Fasano
Summary: This study aimed to evaluate the safety and efficacy of deep brain stimulation on the globus pallidus pars interna and externa in MSA-P patients. The surgery did not result in major complications, but did not provide significant clinical benefit as measured by MDS-UPDRS III.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Daniel Weintraub
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Hubert H. Fernandez, Daniel Weintraub, Eric Macklin, Irene Litvan, Michael A. Schwarzschild, Jamie Eberling, Aleksandar Videnovic, Christopher J. Kenney
Summary: In patients with Parkinson disease dementia (PDD), SYN120 did not improve cognition significantly but showed potential benefits in cognitive activities of daily living and apathy.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Thanh Phuong Pham Nguyen, Shelly L. Gray, Craig W. Newcomb, Qing Liu, Ali G. Hamedani, Daniel Weintraub, Sean Hennessy, Allison W. Willis
Summary: This study found that there were no significant differences in medication prescriptions between Parkinson disease (PD) patients hospitalized for serious injury and those hospitalized for other reasons, indicating a missed opportunity to deprescribe high-risk medications during care transitions.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Elahe Amini, Mohammad Rohani, Anthony E. Lang, Zahra Azad, Seyed Amir Hassan Habibi, Afagh Alavi, Gholamali Shahidi, Maziar Emamikhah, Ahmad Chitsaz
Summary: Among 122 genetically confirmed NBIA patients, KRS had the best survival and longest preservation of ambulation ability, while classical PKAN and MPAN patients showed similar progression patterns in loss of ambulation ability, with MPAN patients having a slower progression to death. Spasticity was identified as the most significant factor associated with death.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)