Article
Biochemistry & Molecular Biology
Rosario Amato, Vincenzo Dattilo, Carolina Brescia, Lucia D'Antona, Rodolfo Iuliano, Francesco Trapasso, Nicola Perrotti, Davide Costa, Nicola Ielapi, Francesco Aiello, Michele Provenzano, Umberto Marcello Bracale, Michele Andreucci, Raffaele Serra
Summary: This study aimed to validate the correlation between Th17 response and the development of chronic venous disease and chronic venous limb ulcers (CVLUs), and identify Th17 markers as intrinsic risk factors and diagnostic markers for disease development. The results demonstrated that the main expression markers of the CD4 + Th17+ switch were strongly activated in chronic venous insufficiency and advanced ulceration. Th17 markers behaved as empirical risk factors for chronic venous disease development. These findings provide a new hypothesis for the pathogenesis of chronic venous disease and suggest the development of new diagnostic, preventive, and therapeutic approaches.
Article
Clinical Neurology
Gauruv Bose, Brian C. Healy, Christian Barro, Bonnie Glanz, Hrishikesh A. Lokhande, Mariann Polgar-Turcsanyi, Charles R. G. Guttmann, Rohit Bakshi, Howard L. Weiner, Tanuja Chitnis
Summary: For patients with multiple sclerosis (MS) who have a disease duration of more than 10 years, an earlier age at onset is associated with worse outcomes at age 50, including higher disability, increased risk of secondary-progressive MS, more brain lesions, worse brain parenchymal fraction, and higher likelihood of unemployment due to MS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Jun Yang, Na Zhang, Cong Ding, Xiuying He, Meihua Li, Wei Meng, Taohui Ouyang
Summary: Multiple studies have suggested that chronic cerebrospinal venous insufficiency may be a potential cause of multiple sclerosis, but this conclusion is still uncertain. This meta-analysis examined the correlation between multiple sclerosis and chronic cerebrospinal venous insufficiency. The results showed that chronic cerebrospinal venous insufficiency is significantly associated with multiple sclerosis and is more prevalent in patients with multiple sclerosis than in healthy individuals, although there is considerable heterogeneity in the results.
Article
Cardiac & Cardiovascular Systems
Richard A. Baylis, Nicholas L. Smith, Derek Klarin, Eri Fukaya
Summary: Venous disease encompasses venous thromboembolic disease and chronic venous disease, with different pathophysiology caused by hemostasis imbalance and prolonged venous hypertension. Although environmental factors play a role, family history is also a significant risk factor.
CIRCULATION RESEARCH
(2021)
Article
Clinical Neurology
Luca Prosperini, Matteo Lucchini, Serena Ruggieri, Carla Tortorella, Shalom Haggiag, Massimiliano Mirabella, Carlo Pozzilli, Claudio Gasperini
Summary: This study shows a trend of older age at onset for multiple sclerosis (MS) and a decrease in the interval between onset and diagnosis. Additionally, among patients aged 40 and above, there is a higher female-to-male ratio, more frequent spinal cord onset, and less frequent supratentorial onset.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Matthias Grothe, David Ellenberger, Paulus S. Rommer, Alexander Stahmann, Uwe K. Zettl
Summary: This study analyzed the data of 30,713 multiple sclerosis patients and found that patients with epileptic seizures at onset had a faster disease progression. Among them, patients with polysymptomatic onset had a more severe progression.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Clinical Neurology
Manuel Comabella, Mar Tintore, Augusto Sao Aviles, Pere Carbonell-Mirabent, Sunny Malhotra, Alex Rovira, Nicolas Fissolo, Jan D. Luenemann, Xavier Montalban
Summary: This study evaluated the impact of viral infections on multiple sclerosis (MS) disease progression and found that antibody responses against viruses at disease onset are associated with long-term disease outcomes. The results suggest that immune responses against human cytomegalovirus (HCMV) at early stages have protective effects on long-term disability and inflammation disease outcomes, and immune responses against Epstein-Barr virus (EBV) may influence long-term disease prognosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Sapir Dreyer-Alster, Anat Achiron, Gavin Giovannoni, Benjamin M. M. Jacobs, Ruth Dobson
Summary: This study examined the relationship between alcohol consumption and multiple sclerosis (MS) and found no evidence of an association. The study also revealed a strong association between the HLA-DRB1*15:01 gene and MS.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Jurgen H. Prochaska, Natalie Arnold, Andrea Falcke, Sabrina Kopp, Andreas Schulz, Gregor Buch, Sophie Moll, Marina Panova-Noeva, Claus Juenger, Lisa Eggebrecht, Norbert Pfeiffer, Manfred Beutel, Harald Binder, Stephan Grabbe, Karl J. Lackner, Arina Ten Cate-Hoek, Christine Espinola-Klein, Thomas Munzel, Philipp S. Wild
Summary: The study found that chronic venous insufficiency (CVI) is highly prevalent in the population and closely associated with cardiovascular risk factors and disease. Patients with CVI face an increased risk of death, independent of factors such as age, gender, and other cardiovascular risk factors.
EUROPEAN HEART JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Franz Felix Konen, Malte Johannes Hannich, Philipp Schwenkenbecher, Matthias Grothe, Konrad Gag, Konstantin Fritz Jendretzky, Stefan Gingele, Kurt-Wolfram Suhs, Torsten Witte, Thomas Skripuletz, Marie Suesse
Summary: This study investigated the cerebrospinal fluid analysis and immune response in patients with early and late onset multiple sclerosis. The results showed that there was no difference in the frequency of cerebrospinal fluid-specific oligoclonal bands between early and late onset multiple sclerosis patients. However, the sensitivity of positive cerebrospinal fluid free light chains kappa fraction was lower in late onset progressive multiple sclerosis patients. The MRZ reaction had the same frequency of positivity in both early and late onset multiple sclerosis patients.
Article
Dermatology
Olga Krizanova, Adela Penesova, Alica Hokynkova, Andrea Pokorna, Amir Samadian, Petr Babula
Summary: Chronic venous disease is a condition that affects the veins in the lower extremities, characterized by impaired blood return. This review discusses the etiology, risk factors, and pathophysiology of venous leg ulcers (VLU), and compares the treatment options.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Multidisciplinary Sciences
Dong-Hoon Yang, Mansu Kim, Joong Won Yang, Jae Man Cho, Sang Jin Park, Heum Dai Kwon
Summary: This study aimed to investigate the clinical differences in leg pain and determine the incidence of chronic venous disorder (CVD) among patients visiting a spine center. The results showed that the most common symptom area in CVD was the calf and foot, while in lumbar spinal disease it was the calf and thigh. Tingling-paresthesia was the most common symptom type for both, with pain and cramping more common in CVD and pain more common than cramping in lumbar spinal disease. The study suggested that early-stage venous reflux is a symptomatic disease and a possible cause of leg pain and other symptoms.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Marco Puthenparampil, Marta Gaggiola, Alessandro Miscioscia, Valentina Annamaria Mauceri, Federica De Napoli, Giovanni Zanotelli, Mariagiulia Anglani, Margherita Nosadini, Stefano Sartori, Paola Perini, Francesca Rinaldi, Paolo Gallo
Summary: This study evaluated the efficacy and safety of alemtuzumab (ALZ) in pediatric-onset multiple sclerosis (POMS) and adult-onset multiple sclerosis (AOMS) patients undergoing treatment switch. The results showed that ALZ was more effective in AOMS patients compared to POMS patients after switching from natalizumab (NTZ). However, these findings may underestimate the effectiveness of ALZ in POMS patients.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Neurosciences
Maria-Eleftheria Evangelopoulos, Georgios Koutsis, Fotini Boufidou, Manolis Markianos
Summary: Cholesterol levels may be associated with disease characteristics in multiple sclerosis, particularly with demyelination and immune response. This study found lower levels of plasma and cerebrospinal fluid cholesterol in patients with multiple sclerosis. Patients with positive oligoclonal bands had even lower cerebrospinal fluid cholesterol levels, which may be related to disease progression and enhanced humoral immune response.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Medicine, General & Internal
Melissa Andreia de Moraes Silva, Luis C. U. Nakano, Ligia L. Cisneros, Fausto Miranda
Summary: Chronic venous insufficiency (CVI) is a common disease that affects the lower limb venous systems. Balneotherapy, a form of water-based physiotherapy, may be a cost-effective treatment option for CVI. This review assessed the effectiveness and safety of balneotherapy for people with CVI, and found that it moderately improves disease severity and slightly improves pain and skin pigmentation changes, with uncertain effects on health-related quality of life and other symptoms.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Article
Clinical Neurology
Marco Pitteri, Caterina Dapor, John DeLuca, Nancy D. Chiaravalloti, Damiano Marastoni, Massimiliano Calabrese
Summary: This study investigated the objective measures of cognitive fatigue in newly diagnosed multiple sclerosis patients by analyzing the Paced Auditory Serial Addition Test (PASAT). The results showed a decline in accuracy over time, specifically in the form of an increase in omissions, indicating that cognitive fatigue can be objectively detected in multiple sclerosis patients.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Clinical Neurology
Rachel E. James Bates, Eleanor Browne, Renee Schalks, Heather Jacobs, Li Tan, Puja Parekh, Roberta Magliozzi, Massimiliano Calabrese, Nicholas D. Mazarakis, Richard Reynolds
Summary: This study suggests that persistent increased levels of lymphotoxin-alpha in the cerebral meninges can lead to the formation of lymphoid-like structures and subsequent neurodegenerative and demyelinating pathology, similar to that seen in the progressive multiple sclerosis brain.
Article
Clinical Neurology
Gisella Guerrera, Alessandra Mandelli, Annamaria Finardi, Mario Orrico, Silvia D'Orso, Mario Picozza, Maddalena Noviello, Valeria Beretta, Bruno Bonetti, Massimiliano Calabrese, Damiano Marastoni, Nicola De Rossi, Ruggero Capra, Marco Salvetti, Maria Chiara Buscarinu, Matilde Inglese, Antonio Uccelli, Lucia Moiola, Catarina Raposo, Erwan Muros-Le Rouzic, Rosetta Pedotti, Massimo Filippi, Chiara Bonini, Luca Battistini, Giovanna Borsellino, Roberto Furlan
Summary: Development of long-lasting anti-SARS-CoV-2 T-cell responses is not impaired in ocrelizumab-treated pwMS.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Damiano Marastoni, Francesco Crescenzo, Anna Pisani, Carmela Zuco, Gianmarco Schiavi, Giulia Benedetti, Giuseppe K. Ricciardi, Stefania Montemezzi, Francesca B. Pizzini, Agnese Tamanti, Massimiliano Calabrese
Summary: The study demonstrates that dimethyl fumarate (DMF) slows down the progression of focal and diffuse gray matter (GM) damage in multiple sclerosis (MS) patients. It also reduces the accumulation of cortical lesions (CLs) and shows a positive effect on disease activity.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Stefano Ziccardi, Anna Isabella Pisani, Gian Marco Schiavi, Maddalena Guandalini, Francesco Crescenzo, Annalisa Colombi, Angela Peloso, Agnese Tamanti, Maddalena Bertolazzo, Damiano Marastoni, Massimiliano Calabrese
Summary: This study aimed to determine the associations between early clinical/neuroradiological variables and cognitive impairment (CI) after 20 years of multiple sclerosis (MS). The results showed that the number and volume of cortical lesions (CLs) were strongly associated with long-term CI, particularly when the number of CLs was equal to or greater than three. Therefore, the number of CLs could serve as a reliable prognostic marker for CI in MS patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Immunology
Francesca Bosello, Damiano Marastoni, Francesca Benedetta Pizzini, Chiara Zaffalon, Andrea Zuliani, Giulia Turri, Sara Mariotto, Erika Bonacci, Emilio Pedrotti, Massimiliano Calabrese
Summary: Post-infectious immune-mediated neurological complications of Sars-Cov-2, including Myelin Oligodendrocyte Glycoprotein (MOG) antibody-associated optic neuritis and inflammatory demyelinating polyneuropathy, have been observed in a 74-year-old patient. This is the first reported case of both complications occurring in the same patient. This case highlights the association between SarsCov-2 infection and MOG antibody-associated disease.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Stefano Ziccardi, Francesca Benedetta Pizzini, Maddalena Guandalini, Agnese Tamanti, Cecilia Cristofori, Massimiliano Calabrese
Summary: The study investigates the relationship between brain atrophy and cognitive impairment and fatigue in multiple sclerosis (MS) patients. The results show that brain atrophy is associated with cognitive and fatigue symptoms, supporting its clinical application.
BIOENGINEERING-BASEL
(2023)
Article
Clinical Neurology
Alberto Gajofatto, Nicolo Cardobi, Francesca Gobbin, Massimiliano Calabrese, Marco Turatti, Maria Donata Benedetti
Summary: This study used resting state functional magnetic resonance imaging (fMRI) to investigate changes in brain network connectivity in multiple sclerosis (MS) patients treated with Sativex (R). The results showed that Sativex (R) treatment was associated with an increase in brain connectivity in MS patients, particularly in responders.
Article
Biochemistry & Molecular Biology
Francesco Pezzini, Annalisa Pisani, Valentina Mazziotti, Damiano Marastoni, Agnese Tamanti, Edilio Borroni, Stefano Magon, Bastian Zinnhardt, Roberta Magliozzi, Massimiliano Calabrese
Summary: By analyzing paired cerebrospinal fluid (CSF) and serum samples from 143 treatment-naive MS patients, we found that 16 CSF proteins correlated with their serum expression, with only 5 showing moderate correlation. Among these proteins, CXCL9 was the only one significantly correlated with spinal cord lesion volume. These findings suggest a partial association between intrathecal inflammation and peripheral inflammation in MS, with certain immunomodulators playing a key role in the initial immune response of MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Marco Pitteri, Manila Vannucci, Caterina Dapor, Maddalena Guandalini, Angelica Daffina, Damiano Marastoni, Massimiliano Calabrese
Summary: The study compared patients with multiple sclerosis (pwMS) to a healthy control group (HC) on Phonemic and Semantic Fluency Tests. The results showed that pwMS performed significantly worse than HC on the Phonemic Fluency Test, particularly in the late time interval. This suggests that executive dysfunction plays a crucial role in verbal fluency deficits in pwMS.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Review
Medicine, General & Internal
Marco Gambato, Nicola Scotti, Giacomo Borsari, Jacopo Zambon Bertoja, Joseph-Domenico Gabrieli, Alessandro De Cassai, Giacomo Cester, Paolo Navalesi, Emilio Quaia, Francesco Causin
Summary: This short review aims to help radiologists identify medical devices and their most common complications when interpreting a chest X-ray. Nowadays, a variety of medical devices are frequently used, especially in critical patients. It is crucial for radiologists to be knowledgeable about what to look for and to consider the technical factors associated with each device's positioning.
Review
Clinical Neurology
Roberta Magliozzi, Owain W. Howell, Massimiliano Calabrese, Richard Reynolds
Summary: Growing evidence suggests a central role for meningeal inflammation in driving multiple sclerosis (MS) pathology. The subarachnoid space and associated meningeal spaces play important roles in the entry and diffusion of immune cells and molecules into the brain tissue. Chronic meningeal inflammation is associated with a more severe clinical course of MS.
NATURE REVIEWS NEUROLOGY
(2023)
Meeting Abstract
Clinical Neurology
D. Marastoni, A. Bajrami, A. I. Pisani, E. Colato, G. Schiavi, S. Ziccardi, A. Colombi, M. Guandalini, A. Peloso, A. Tamanti, A. Scalfari, M. Calabrese
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
D. Marastoni, A. I. Pisani, A. Scartezzini, V. Mazziotti, A. Tamanti, A. Peloso, A. Colombi, V. Camera, S. Ziccardi, F. B. Pizzini, E. Turano, B. Bonetti, M. Calabrese
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
V. Mazziotti, F. Crescenzo, A. Tamanti, S. Ziccardi, M. Guandalini, C. Dapor, A. Colombi, V. Camera, A. Peloso, E. Colato, A. I. Pisani, F. Pezzini, D. Marastoni, E. Turano, M. Calabrese
MULTIPLE SCLEROSIS JOURNAL
(2022)
