Article
Crystallography
Radoslav Chayrov, Reni Kalfin, Maria Lazarova, Lyubka Tancheva, Hrisitna Sbirkova-Dimitrova, Boris Shivachev, Ivanka Stankova
Summary: Newly synthesized DMG-Am shows promising antiparkinsonian activity by improving motor and memory impairment in Parkinson's disease.
Article
Clinical Neurology
Francesco Cavallieri, Carla Budriesi, Annalisa Gessani, Sara Contardi, Valentina Fioravanti, Elisa Menozzi, Serge Pinto, Elena Moro, Franco Valzania, Francesca Antonelli
Summary: The study demonstrates that levodopa has a negative effect on speech acoustic parameters in Parkinson's disease patients. The intensity and location of dyskinesia negatively impact speech quality.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Paul E. Greene, Stanley Fahn, David Eidelberg, Kimberly B. Bjugstad, Robert E. Breeze, Curt R. Freed
Summary: In this study, five patients with Parkinson's disease developed persistent dyskinesias after fetal dopaminergic tissue transplantation. These involuntary movements could not be effectively treated with medications, leading to the need for pallidal stimulators in some cases. Despite the small number of patients experiencing these dyskinesias, they demonstrated significant improvement post-transplant.
NPJ PARKINSONS DISEASE
(2021)
Review
Clinical Neurology
Peter A. Barbuti, Roger A. Barker, Patrik Brundin, Serge Przedborski, Stella M. Papa, Lorraine V. Kalia, Hideki Mochizuki
Summary: This article reviews the latest progress in stem cell-based dopamine neuron replacement therapy for Parkinson's disease, discussing the important criteria that must be met and highlighting the potential and key questions of stem cell therapy in PD treatment.
MOVEMENT DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Erika da Cruz Guedes, Adolfo Garcia Erustes, Anderson H. F. F. Leao, Cesar Alves Carneiro, Vanessa C. Abilio, Antonio W. Zuardi, Jaime Eduardo C. Hallak, Jose Alexandre Crippa, Claudia Bincoletto, Soraya S. Smaili, Patricia Reckziegel, Gustavo J. S. Pereira
Summary: In this study, the potential neuroprotective effect of cannabidiol (CBD) in the treatment of Parkinson's Disease (PD) was evaluated using a C. elegans model. The results showed that CBD could reverse locomotor alterations induced by reserpine and protect neurons from degeneration. Additionally, CBD also reduced the formation of reactive oxygen species (ROS) and accumulation of alpha-synuclein protein. These findings indicate that CBD acts as a neuroprotector in dopaminergic neurons and highlights its potential in the treatment of PD.
NEUROCHEMICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Theodora Ntetsika, Paraskevi-Evita Papathoma, Ioanna Markaki
Summary: Parkinson's disease is the second most common neurodegenerative disease globally, with treatment options currently limited to symptom relief without halting or reversing disease progression. Large biomarker development programs are being carried out to improve patient selection and clinical trial outcome assessment. Research on Parkinson's disease mechanisms and ongoing clinical trials are crucial for future perspectives in the field.
MOLECULAR MEDICINE
(2021)
Article
Neurosciences
Danielle Larson, Tanya Simuni
Summary: This review focuses on novel dopaminergic therapies for the treatment of motor complications in advanced Parkinson's disease. The effectiveness of rescue therapies, adjunctive medications, and longer-acting levodopa formulations in reducing off time is limited, highlighting the need for more continuous dopaminergic delivery to address underlying pathophysiology and achieve clinically meaningful improvement in motor complications.
Article
Biochemistry & Molecular Biology
Hind Bouchaoui, Laura Mahoney-Sanchez, Guillaume Garcon, Olivier Berdeaux, Laurent Y. Alleman, David Devos, James A. Duce, Jean-Christophe Devedjian
Summary: Ferroptosis, an iron-dependent regulated cell death triggered by high lipid peroxide levels, has been implicated in neurodegenerative diseases like Parkinson's disease (PD). The exact pathways and conditions leading to the death of dopaminergic neurons in PD remain unknown. This study shows that altering the PUFA composition in dopaminergic neuron membranes can determine susceptibility to ferroptosis, and cotreatment with iron promotes lipid peroxidation and cell death. Inhibition of specific enzymes involved in the lipid peroxidation pathway could be potential targets for neuroprotective strategies in PD.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Petros Stathakos, Natalia Jimenez-Moreno, Lucy A. Crompton, Paul A. Nistor, Jennifer L. Badger, Peter A. Barbuti, Talitha L. Kerrigan, Andrew D. Randall, Maeve A. Caldwell, Jon D. Lane
Summary: Macroautophagy/autophagy cytoplasmic quality control pathways are crucial for neural development and maintaining functional neuronal populations in the adult brain. Declining neuronal autophagy pathways contribute to neurodegenerative diseases, including Parkinson's disease, highlighting the need for reliable human neuronal model systems for research and therapeutic interventions. HiPSC neural model systems show promise in meeting this demand but may face limitations in generating ventral midbrain dopaminergic neurons efficiently for functional and imaging-based in vitro assays.
Article
Pharmacology & Pharmacy
Leilei Chen, Yujv Huang, Xing Yu, Jiahong Lu, Wenting Jia, Juxian Song, Liangfeng Liu, Youcui Wang, Yingyu Huang, Junxia Xie, Min Li
Summary: Cory from Uncaria rhynchophylla has been shown to exhibit neuroprotective effects in rotenone-induced PD animal models by reducing neuroinflammation and diminishing alpha-synuclein aggregates through various pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Na Zhang, Xiaoqi Yu, Limei Song, Zhixin Xiao, Junxia Xie, Huamin Xu
Summary: This study found that ferritin released by astrocytes can enter dopaminergic cells and protect them against neurotoxicity and ferroptosis. Additionally, exogenous ferritin can inhibit cell damage by reducing reactive oxygen species and preventing an increase in the labile iron pool in these cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hwan Kim, Jonghu Jeon, Young Lee, Seung Min Kim, Miju Cheon, Jun Yup Kim
Summary: This study aimed to understand the development of dysphagia in patients with Parkinson's disease (PD) and identify potential target regions for neuromodulation by analyzing the distribution of dopamine transporter availability in the striatum. The results showed that decreased dopamine transporter availability in specific subregions of the striatum may explain the dysphagia in PD, particularly in the pharyngeal phase.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Liting Hang, Ziyin Wang, Aaron S. C. Foo, Geraldine W. Y. Goh, Huey Ching Choong, John Thundyil, Shengli Xu, Kong-Peng Lam, Kah-Leong Lim
Summary: Emerging studies suggest that energy dysregulation is a key factor in Parkinson's disease, and AMP kinase (AMPK) plays a crucial role in maintaining neuronal energy homeostasis. Loss of AMPK function can promote dopaminergic neurodegeneration and increase susceptibility to toxin-induced damage, making the AMPK pathway a promising therapeutic target for PD.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Xiaoyi Xu, Xin He, Zeyan Zhang, Yanyi Chen, Junyu Li, Shanshan Ma, Qiaoying Huang, Mingtao Li
Summary: This study identified that the inactivation of CREB and decreased expression of NURR1 are associated with nigral dopaminergic neurodegeneration in Parkinson's disease (PD). The mechanism underlying CREB inactivation involves the interaction between HDAC1/PP1y complex and CREB, and disrupting this interaction can restore CREB activity and protect dopaminergic neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Cell Biology
Natalia Jimenez-Moreno, Jon D. Lane
Summary: Parkinson's disease is caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. In our recent study, we found that the transcription factors LMX1A and LMX1B play crucial roles in autophagy gene expression for stress protection in the developed brain. We propose a novel role for ATG8 proteins as transcriptional co-factors for autophagy genes in protecting dopaminergic neurons in Parkinson's disease.