Article
Multidisciplinary Sciences
M. Kathiravan, S. Kavitha, R. Shanthi
Summary: The study reveals that long-term phenytoin treatment significantly impacts the concentration of Folate and Vitamin B12 among epileptic patients, potentially leading to anemia. The mean values of Folate and Vitamin B12 decrease as the duration of phenytoin treatment increases, with significant differences compared to the short-term treatment group.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Faruk Tas, Kayhan Erturk, Hilal Oguz Soydinc
Summary: Serum levels of folate were found significantly lower in melanoma cases, especially in patients with metastatic disease, as compared to other malignancies and healthy subjects. However, no significant association was found between melanoma and serum vitamin B12 levels.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Education, Scientific Disciplines
Nazmi Mutlu Karakas
Summary: The study revealed high prevalence of vitamin D, vitamin B12, folate deficiencies, and low ferritin levels among adolescents, with females being more susceptible to these deficiencies compared to males.
Article
Nutrition & Dietetics
Winner Kucha, Daniel Seifu, Abenezer Tirsit, Mahlet Yigeremu, Markos Abebe, Dawit Hailu, Dareskedar Tsehay, Solomon Genet
Summary: The study found that deficiency in folate and vitamin B12 in the blood of pregnant women may be associated with neural tube defects. There is a correlation between the use of folate/multivitamins and neural tube defects.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Sabiye Akbulut
Summary: This study aimed to investigate the correlation between serum vitamin B12 and folate levels in Crohn's disease patients and disease activation, localization, duration, and age at onset. The results showed that vitamin B12 and folate levels were significantly lower in Crohn's disease patients compared to the control group. Regular monitoring and supplementation of vitamin B12 and folate are important for Crohn's disease patients.
Article
Oncology
Yaping Wei, Benjamin Xu, Qiangqiang He, Ping Chen, Qi Zhang, Xi Zhang, Hui Yuan, Yong Duan, Zhuo Wang, Ziyi Zhou, Lishun Liu, Yun Song, Guangyun Mao, Xianhui Qin, Genfu Tang, Binyan Wang, Hao Zhang, Huiyuan Guo, Hanping Shi
Summary: This study found an inverse, nonlinear association between 5-methyltetrahydrofolate (5-mTHF) and the risk of lung cancer, while vitamin B12 was not associated with lung cancer risk. The inverse association was more pronounced among ever smokers.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Lijuan Ma, Jing Li, Yuan Yuan, Wenwen Chen, Jun Zhao
Summary: The MTHFR 677TT variant, gender, folate, and Vit B12 were identified as risk factors for the occurrence of H-type hypertension. Folate level decreased with the C to T substitution of the MTFHR C677T gene, while Vit B12 level was not associated with the gene. These factors should be considered in the prevention and treatment of hypertension.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Neurosciences
Lei Zhao, Lili Guan, Jinyan Sun, Xiaoming Li
Summary: This study aimed to investigate the association between B vitamins and depression and cognitive dysfunction. The results showed that patients with depression and cognitive dysfunction had the lowest levels of B vitamins compared with the other two groups, and serum folate, vitamin B6, and vitamin B12 were positively correlated with cognitive dysfunction.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Nutrition & Dietetics
Haofeng Hong, Longting Chen, Yiming Zhong, Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: This study used a Mendelian randomization approach to investigate the potential causal effects of homocysteine, folate, and vitamin B12 on site- and gender-specific osteoarthritis (OA). The results showed that genetically predicted homocysteine had adverse effects on OA, while genetically predicted folate and vitamin B12 had protective effects on OA.
Article
Immunology
Hong Yang, Jie Song, Aole Li, Linshuoshuo Lv, Xiaohui Sun, Yingying Mao, Ding Ye
Summary: Using Mendelian randomization, this study found an inverse association between serum folate level and vitiligo risk, as well as a positive association between vitamin B-12 and inflammatory bowel disease risk. However, the association between vitamin B-12 and inflammatory bowel disease did not remain significant after Bonferroni correction. Further research is needed to clarify the possible association between vitamin B-12 and inflammatory bowel disease risk.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Shuying Li, Xiubiao Tian, Yiyun Wang, Xumei Zhang, Liwen Zhang, Chen Li, Jing Li, Chunhua Wang, Huihuan Liu, Juan Liu, Hongjuan Liu, Xueli Yang, Weiqin Li, Junhong Leng, Xilin Yang, Naijun Tang, Qiang Zhang
Summary: This study found that higher folate concentrations were associated with increased risk of GDM, while higher B-12 concentrations were associated with reduced risk. Pregnancies with the MTHFR rs1801131 TT genotype were more susceptible to OCM nutrient-related GDM.
Article
Public, Environmental & Occupational Health
Gunn-Helen Moen, Robin N. Beaumont, Niels Grarup, Christine Sommer, Beverley M. Shields, Deborah A. Lawlor, Rachel M. Freathy, David M. Evans, Nicole M. Warrington
Summary: This study found a positive causal effect of maternal folate levels on offspring birthweight, while no causal effect of B12 levels on offspring birthweight was observed. The results are consistent with evidence from randomized controlled trials.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Orthopedics
Jae Hwa Kim, Go-Tak Kim, Siyeoung Yoon, Hyun Il Lee, Kyung Rae Ko, Sang-Cheol Lee, Do Kyung Kim, Jaeyeon Shin, So-young Lee, Soonchul Lee
Summary: The study found that low serum levels of Vitamin B-12 were independently associated with degenerative rotator cuff tears. Further research is needed to determine if Vitamin B-12 supplementation can reduce the risk of this condition.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Medicine, General & Internal
Yujie Liu, Tingting Geng, Zhenzhen Wan, Qi Lu, Xuena Zhang, Zixin Qiu, Lin Li, Kai Zhu, Liegang Liu, An Pan, Gang Liu
Summary: This prospective cohort study found that both low and high serum levels of vitamin B-12 as well as low serum levels of folate were significantly associated with higher risk of cardiovascular disease mortality among individuals with type 2 diabetes.
Article
Nutrition & Dietetics
Yu-Mei Hsueh, Ya-Li Huang, Yuh-Feng Lin, Horng-Sheng Shiue, Ying-Chin Lin, Hsi-Hsien Chen
Summary: This study found that high plasma vitamin B-12 levels may increase the risk of chronic kidney disease, especially in the presence of high levels of blood lead and cadmium, as well as total urinary arsenic levels.
Review
Oncology
Kirit Singh, Kristen A. Batich, Patrick Y. Wen, Aaron C. Tan, Stephen J. Bagley, Michael Lim, Michael Platten, Howard Colman, David M. Ashley, Susan M. Chang, Rifaquat Rahman, Evanthia Galanis, Alireza Mansouri, Vinay K. Puduvalli, David A. Reardon, Solmaz Sahebjam, John H. Sampson, John Simes, Donald A. Berry, Gelareh Zadeh, Tim F. Cloughesy, Minesh P. Mehta, Steven Piantadosi, Michael Weller, Amy B. Heimberger, Mustafa Khasraw
Summary: Immunotherapy has not shown significant improvement in outcomes for glioblastoma patients due to the multiple and unique mechanisms of immune evasion and escape in this highly heterogeneous tumor. Combinatorial approaches of immune-oriented therapy are required to overcome these mechanisms. The design of clinical trials evaluating these approaches needs careful consideration.
CLINICAL CANCER RESEARCH
(2022)
Correction
Oncology
Michael Weller, Martin van den Bent, Matthias Preusser, Emilie Le Rhun, Jorg C. Tonn, Giuseppe Minniti, Martin Bendszus, Carmen Balana, Olivier Chinot, Linda Dirven, Pim French, Monika E. Hegi, Asgeir S. Jakola, Michael Platten, Patrick Roth, Roberta Ruda, Susan Short, Marion Smits, Martin J. B. Taphoorn, Andreas von Deimling, Manfred Westphal, Riccardo Soffietti, Guido Reifenberger, Wolfgang Wick
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Article
Oncology
Antonio Omuro, Alba A. Brandes, Antoine F. Carpentier, Ahmed Idbaih, David A. Reardon, Timothy Cloughesy, Ashley Sumrall, Joachim Baehring, Martin van den Bent, Oliver Bahr, Giuseppe Lombardi, Paul Mulholland, Ghazaleh Tabatabai, Ulrik Lassen, Juan Manuel Sepulveda, Mustafa Khasraw, Elodie Vauleon, Yoshihiro Muragaki, Anna Maria Di Giacomo, Nicholas Butowski, Patrick Roth, Xiaozhong Qian, Alex Z. Fu, Yanfang Liu, Von Potter, Alexandros-Georgios Chalamandaris, Kay Tatsuoka, Michael Lim, Michael Weller
Summary: This study showed that TMZ + RT had better efficacy than NIVO + RT in newly diagnosed GBM patients with unmethylated MGMT promoter. However, no new safety signals were detected with NIVO in this study.
Article
Oncology
Philipp Karschnia, Jacob S. Young, Antonio Dono, Levin Haeni, Tommaso Sciortino, Francesco Bruno, Stephanie T. Juenger, Nico Teske, Ramin A. Morshed, Alexander F. Haddad, Yalan Zhang, Sophia Stoecklein, Michael Weller, Michael A. Vogelbaum, Juergen Beck, Nitin Tandon, Shawn Hervey-Jumper, Annette M. Molinaro, Roberta Ruda, Lorenzo Bello, Oliver Schnell, Yoshua Esquenazi, Maximilian Ruge, Stefan J. Grau, Mitchel S. Berger, Susan M. Chang, Martin van den Bent, Joerg-Christian Tonn
Summary: This study investigated the prognostic value of the extent of resection in glioblastoma, finding that smaller volumes of residual contrast-enhancing tumor were associated with better outcomes. Additionally, removing non-contrast-enhancing tumor beyond the tumor borders resulted in improved survival. These findings have significant implications for stratification in clinical trials.
Article
Oncology
Marcel Buehler, Xiao Yi, Weigang Ge, Peter Blattmann, Elisabeth Rushing, Guido Reifenberger, Joerg Felsberg, Charles Yeh, Jacob E. Corn, Luca Regli, Junyi Zhang, Ann Cloos, Vidhya M. Ravi, Benedikt Wiestler, Dieter Henrik Heiland, Ruedi Aebersold, Michael Weller, Tiannan Guo, Tobias Weiss
Summary: In this study, the evolution of the proteomic landscape in glioblastoma from initial diagnosis to post-treatment recurrence was investigated. The authors identified BCAS1, INF2, and FBXO2 as consistently upregulated proteins at recurrence, and demonstrated that knockout of the FBXO2 gene conferred a survival benefit and reduced invasive growth. These findings suggest a potential role of FBXO2 in promoting tumor growth through glioma-microenvironment interactions.
Article
Oncology
Khe Hoang-Xuan, Martina Deckert, Andres J. M. Ferreri, Julia Furtner, Jaime Gallego Perez-Larraya, Roger Henriksson, Andreas F. Hottinger, Benjamin Kasenda, Florence Lefranc, Alexander Lossos, Catherine McBain, Matthias Preusser, Patrick Roth, Roberta Ruda, Uwe Schlegel, Riccardo Soffietti, Carole Soussain, Martin J. B. Taphoorn, Valerie Touitou, Michael Weller, Jacoline E. C. Bromberg
Summary: The management of primary central nervous system lymphoma (PCNSL) is a controversial topic in neuro-oncology. The European Association of Neuro-Oncology (EANO) formed a multidisciplinary task force to update the evidence-based guidelines and include immunosuppressed patients. The guideline provides consensus considerations and recommendations for the treatment of PCNSL, including intraocular manifestations and specific management of the elderly.
Article
Oncology
Philipp Vollmuth, Martha Foltyn, Raymond Y. Huang, Norbert Galldiks, Jens Petersen, Fabian Isensee, Martin J. van den Bent, Frederik Barkhof, Ji Eun Park, Yae Won Park, Sung Soo Ahn, Gianluca Brugnara, Hagen Meredig, Rajan Jain, Marion Smits, Whitney B. Pope, Klaus Maier-Hein, Michael Weller, Patrick Y. Wen, Wolfgang Wick, Martin Bendszus
Summary: This study aimed to assess the reproducibility and standardization of treatment response assessment using artificial intelligence (AI) decision support in MRI. The results showed that AI decision support can provide better evaluation of treatment response in patients with lower-grade gliomas compared to manual measurements.
Article
Oncology
Sied Kebir, Vivien Ullrich, Pia Berger, Celia Dobersalske, Sarah Langer, Laurel Rauschenbach, Daniel Trageser, Andreas Till, Franziska K. Lorbeer, Anja Wieland, Timo Wilhelm-Buchstab, Ashar Ahmad, Holger Froehlich, Igor Cima, Shruthi Prasad, Johann Matschke, Verena Jendrossek, Marc Remke, Barbara M. Gruener, Alexander Roesch, Jens T. Siveke, Christel Herold-Mende, Tobias Blau, Kathy Keyvani, Frank K. H. van Landeghem, Torsten Pietsch, Jorg Felsberg, Guido Reifenberger, Michael Weller, Ulrich Sure, Oliver Bruestle, Matthias Simon, Martin Glas, Bjoern Scheffler
Summary: This study aimed to identify and target tumor cells that can survive, adapt, and expand under primary therapy in glioblastoma. The researchers found that ALDH1A1+/pAKT+ subclones accumulate and acquire drug resistance in response to temozolomide treatment. They propose a combination therapy of temozolomide and AKT inhibitors as a potential treatment strategy.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Emilie Le Rhun, Felix Boakye Oppong, Martin van den Bent, Wolfgang Wick, Alba A. Brandes, Martin J. B. Taphoorn, Michael Platten, Ahmed Idbaih, Paul M. Clement, Matthias Preusser, Vassilis Golfinopoulos, Thierry Gorlia, Michael Weller
Summary: This study retrospectively analyzed the incidence of lomustine-induced thrombocytopenia and its impact on treatment exposure and survival in patients with recurrent glioblastoma. The results showed that thrombocytopenia induced by lomustine is a major limitation to adequate exposure to lomustine chemotherapy and is associated with inferior progression-free survival, particularly in patients with MGMT promoter-methylated tumors.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
Julie J. Miller, L. Nicolas Gonzalez Castro, Samuel McBrayer, Michael Weller, Timothy Cloughesy, Jana Portnow, Ovidiu Andronesi, Jill S. Barnholtz-Sloan, Brigitta G. Baumert, Mitchell S. Berger, Wenya Linda Bi, Ranjit Bindra, Daniel P. Cahill, Susan M. Chang, Joseph F. Costello, Craig Horbinski, Raymond Y. Huang, Robert B. Jenkins, Keith L. Ligon, Ingo K. Mellinghoff, L. Burt Nabors, Michael Platten, David A. Reardon, Diana D. Shi, David Schiff, Wolfgang Wick, Hai Yan, Andreas von Deimling, Martin van den Bent, William G. Kaelin, Patrick Y. Wen
Summary: This article discusses the diagnosis and management of IDH-mutant gliomas, as well as new treatment methods and future research directions.
Article
Clinical Neurology
Katharina Seystahl, Juliane Schweizer, Mira Katan, Sung Ju Weber, Alessia Hug, Miriam Wanner, Andreas R. Luft, Sabine Rohrmann, Susanne Wegener, Michael Weller
Summary: Cancer is not a risk factor for stroke-associated infections in stroke patients. The incidence, characteristics, and treatment of infections did not differ significantly between stroke patients with and without cancer. However, both cancer and stroke-associated infections were associated with in-hospital mortality.
NEURO-ONCOLOGY PRACTICE
(2023)
Article
Oncology
Anna M. Di Giacomo, Maximilian J. Mair, Michele Ceccarelli, Andrea Anichini, Ramy Ibrahim, Michael Weller, Michael Lahn, Alexander M. M. Eggermont, Bernard Fox, Michele Maio
Summary: The conditions that promote immunotherapy responses in primary or secondary brain malignancies were discussed during the V Siena Immuno-Oncology (IO) Think Tank meeting in 2021. Important publications in 2021 and 2022 have reinforced the core elements of these discussions. While current immunotherapies have failed to benefit patients with primary brain tumors like glioblastoma, they have shown positive responses in brain metastases. The differences between these conditions seem to be influenced by intrinsic and extrinsic factors, such as driver mutations, the blood-brain barrier, and the immune suppressive microenvironment. Future therapeutic interventions may focus on rebalancing the immune cell population to enable better responses to current and future immunotherapies.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Corinna Seliger, Felix Boakye Oppong, Florence Lefranc, Olivier Chinot, Roger Stupp, Burt Nabors, Thierry Gorlia, Michael Weller, EORTC Brain Tumor Group
Summary: Depressive symptoms are common in glioblastoma patients, but they are often not treated with antidepressants. Limited evidence suggests that the use of antidepressants is not significantly associated with progression-free or overall survival in glioblastoma patients. However, using antidepressants at the start of maintenance cycle 4 is significantly associated with worse overall survival. Antidepressant use is not significantly associated with seizures, cognitive changes, or fatigue, except for an increase in fatigue during maintenance treatment. Confirmation and further study are needed to assess the impact of antidepressant use on the survival of glioblastoma patients. Prospective trials should evaluate the efficacy, side effects, and outcomes of antidepressant treatment in glioblastoma.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Evelina Blomberg, Manuela Silginer, Patrick Roth, Michael Weller
Summary: Despite various treatment approaches, the survival rate for glioblastoma patients remains low. This study implicates that constitutive type I interferon signaling in gliomas may promote tumor growth, but only in a microenvironment with a proficient type I interferon signaling in the host.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Katharina Seystahl, Dorothee Gramatzki, Miriam Wanner, Sung Ju Weber, Alessia Hug, Andreas R. Luft, Sabine Rohrmann, Susanne Wegener, Michael Weller
Summary: The occurrence of cancer in stroke patients can be associated with elevated levels of white blood cells, platelets, and d-dimers. Additionally, the presence of ischemic lesions in multiple vascular territories is also linked to cancer diagnosis within one year after stroke.
SCIENTIFIC REPORTS
(2023)
