Article
Medicine, General & Internal
Qian Guo, Yang He, Xia Liu, Xuguang Gao, Jing Xu, Xue Li, Yue Sun, Yajuan Xiang, Ru Li, Zhanguo Li
Summary: This study analyzed the clinical features and cerebral MRI changes of hyperintense white matter (WM) lesions in systemic lupus erythematosus (SLE) patients. The results showed that hyperintense WM lesions are common in SLE patients and significantly associated with systemic involvement, including neuropsychiatric SLE, lupus nephritis, polyserous effusions, cardiac involvement, and disease damage. Hyperuricemia and a higher number of CD8+ T cells were independent factors associated with hyperintense WM lesions in SLE.
CHINESE MEDICAL JOURNAL
(2022)
Article
Rheumatology
Ettore Silvagni, Francesca Inglese, Alessandra Bortoluzzi, Massimo Borrelli, Jelle J. Goeman, Alfredo Revenaz, Elisabetta Groppo, Gerda M. Steup-Beekman, Tom W. J. Huizinga, Itamar Ronen, Jeroen de Bresser, Enrico Fainardi, Marcello Govoni, Ece Ercan
Summary: Longitudinal variations in diffusion tensor imaging metrics of different white matter tracts in newly diagnosed SLE patients were found to reflect compromised WM tissue microstructure at the initial stages of the disease, even in the absence of overt neuropsychiatric symptoms, emphasizing the importance of monitoring NP involvement in SLE shortly after diagnosis.
Article
Rheumatology
Rory Caitlin Monahan, Francesca Inglese, Huub Middelkoop, Mark van Buchem, Tom W. J. Huizinga, Margreet Kloppenburg, Itamar Ronen, Gerda M. Steup-Beekman, Jeroen de Bresser
Summary: This study demonstrated an association between brain and WMH volumes and cognitive function in patients with SLE, but the relationship differed among different (NP)SLE phenotypes. WMHs were particularly associated with PS in inflammatory NPSLE, suggesting a potentially more severe underlying pathophysiological mechanism of cognitive impairment in this phenotype.
Article
Clinical Neurology
Eri Sano, Shigeki Arawaka
Summary: The deterioration of deep white matter hyperintensities (DWMH) is significantly associated with an increased risk of ischemic stroke in patients with systemic lupus erythematosus (SLE), particularly in those over 40 years old and with a history of anti-phospholipid syndrome. Monitoring DWMH on follow-up brain MRI may be useful for assessing the risk of ischemic stroke in SLE patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Rheumatology
Xing Qian, Fang Ji, Kwun Kei Ng, Amelia Jialin Koh, Beatrice Rui Yi Loo, Mary Charlotte Townsend, Ofer Pasternak, Sen Hee Tay, Juan Helen Zhou, Anselm Mak
Summary: Brain white matter microstructural changes and increased extracellular free water (FW) volume are observed in SLE patients. The increased extracellular FW is associated with reduced neurocognitive performance, particularly in sustained attention, and higher cumulative glucocorticoid dose.
Article
Immunology
Shan Song, Jing-Yuan Zhang, Fang-Yue Liu, He-Yi Zhang, Xiao-Feng Li, Sheng-Xiao Zhang
Summary: This study identified hub genes and key pathways associated with naive and memory B cells, providing novel insights into the behavior of B cells and the pathogenesis of SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Alessio Buonavoglia, Patrizia Leone, Marcella Prete, Antonio Giovanni Solimando, Chiara Guastadisegno, Gianvito Lanave, Michele Camero, Vito Martella, Lorenzo Lo Muzio, Vito Racanelli
Summary: This study reveals a significant association between EBV and both SLE and SLE-related oral lesions, providing a basis for further investigation into the role of EBV in SLE pathogenesis. The detection rate of EBV varies among different populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Monique Pereira Rego Muniz, Laise Pereira Arcoverde Fechine Brito, Pedro Henrique Cavalcante Vale, Felipe Leite Guedes, Thina Klicia Mendonca Oliveira, Dyego Jose de Araujo Brito, Natalino Salgado Filho, Marcio Dantas, Gyl Eanes Barros Silva
Summary: There is a lack of information regarding tubular, interstitial, and vascular changes in the classification of lupus nephritis. This study emphasizes the importance of these less explored lesions and their role in the pathogenesis and prognosis of the disease.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ming-long Cai, Lan Gui, He Huang, Yu-kun Zhang, Li Zhang, Zhu Chen, Yu-jun Sheng
Summary: This study revealed heterogeneity in the pathogenesis of SLE between male and female patients, with male SLE showing higher levels of neutrophil activation. These findings provide a basis for the development of gender-specific treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xingwang Zhao, Lan Ge, Juan Wang, Zhiqiang Song, Bing Ni, Xiaochong He, Zhihua Ruan, Yi You
Summary: This study aimed to explore the m6A immune regulation in systemic lupus erythematosus (SLE) and identified IGFBP3 and two pivotal immune genes as potential diagnostic and therapeutic targets in SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Huai-Chia Chuang, Wei-Ting Hung, Yi-Ming Chen, Pu-Ming Hsu, Jeng-Hsien Yen, Joung-Liang Lan, Tse-Hua Tan
Summary: Multiple germline and somatic variants of the MAP4K3 (GLK) gene were found in patients with SLE, leading to increased GLK expression through mRNA or protein stability.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Summary: Serum metabolic fingerprints can be used for disease diagnosis and biomarker discovery. By analyzing the serum metabolic fingerprints of systemic lupus erythematosus (SLE) patients and healthy controls, early diagnosis and precision medicine for SLE can be achieved. This study identified the unique metabolic pattern of SLE patients and screened out a panel of metabolic biomarkers.
Editorial Material
Behavioral Sciences
Nishant K. Mishra, Jerome Engel, David S. Liebeskind, Vijay K. Sharma, Lawrence J. Hirsch, Scott Kasner, Jacqueline A. French, Orrin Devinsky, Alon Friedman, Jesse Dawson, Terence J. Quinn, Magdy Selim, Adam de Havenon, Clarissa L. Yasuda, Fernando Cendes, Felix Benninger, Hitten P. Zaveri, Jorge G. Burneo, Padma Srivastava, Mamta Bhushan Singh, Rohit Bhatia, V. Y. Vishnu, Carla Bentes, Jose Ferro, Shennan Weiss, Adithya Sivaraju, Jennifer A. Kim, Marian Galovic, Emily J. Gilmore, Asla Pitkanen, Kathryn Davis, Lauren H. Sansing, Kevin N. Sheth, Jeanne T. Paz, Anuradha Singh, Sunil Sheth, Bradford B. Worrall, James C. Grotta, Pablo M. Casillas-Espinos, Zhibin Chen, John-Paul Nicolo, Bernard Yan, Patrick Kwan
EPILEPSY & BEHAVIOR
(2022)
Correction
Rheumatology
Fabiola Reis Oliveira, Valeria Valim, Sandra Gofnet Pasoto, Marilena Leal Mesquita Silvestre Fernandes, Maria Lucia Lemos Lopes, Sonia Cristina de Magalhaes Souza Fialho, Aysa Cesar Pinheiro, Laura Caldas dos Santos, Simone Appenzeller, Tania Fidelix, Sandra Lucia Euzebio Ribeiro, Danielle Christinne Soares Egypto de Brito, Tatiana Liborio, Maria Carmen Lopes Ferreira Silva Santos, Leandro Tanure, Juliana DAgostino Gennari, Vinicius Tassoni Civile, Ana Carolina Pereira Nunes Pinto, Cesar Ramos Rocha-Filho, Samira Tatiyama Miyamoto, Lissiane Karine Noronha Guedes, Alisson Pugliesi, Virginia Fernandes Moca Trevisani
ADVANCES IN RHEUMATOLOGY
(2022)
Article
Clinical Neurology
Thiago J. R. Rezende, Isaac M. Adanyeguh, Filippo Arrigoni, Benjamin Bender, Fernando Cendes, Louise A. Corben, Andreas Deistung, Martin Delatycki, Imis Dogan, Gary F. Egan, Sophia L. Goericke, Nellie Georgiou-Karistianis, Pierre-Gilles Henry, Diane Hutter, Neda Jahanshad, James M. Joers, Christophe Lenglet, Tobias Lindig, Alberto R. M. Martinez, Andrea Martinuzzi, Gabriella Paparella, Denis Peruzzo, Kathrin Reetz, Sandro Romanzetti, Ludger Schoels, Joerg B. Schulz, Matthis Synofzik, Sophia I. Thomopoulos, Paul M. Thompson, Dagmar Timmann, Ian H. Harding, Marcondes C. Franca
Summary: This study characterized cervical spinal cord structural damage in a large multisite cohort of Friedreich's ataxia (FRDA) patients. The results showed that FRDA patients had significantly reduced cross-sectional area (CSA) and increased eccentricity in the cervical spinal cord compared to control subjects. The CSA had significant correlations with disease severity, while eccentricity did not. Subgroup analyses revealed abnormal CSA and eccentricity at all disease stages, with CSA appearing to decrease progressively and eccentricity remaining stable over time.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Liara Rizzi, Thamires Naela Cardoso Magalhaes, Natalie Lecce, Adriel dos Santos Moraes, Raphael Fernandes Casseb, Camila Vieira Ligo Teixeira, Brunno Machado de Campos, Thiago Junqueira Ribeiro de Rezende, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthazar
Summary: This study aimed to evaluate the ability of cerebrospinal fluid (CSF) AD biomarkers, hippocampal volumes, and Default Mode Network functional connectivity to predict clinical response to ChEIs treatment in mild AD. The functional connectivity of the right hippocampus showed a direct relationship with the clinical response to cholinesterase inhibitors (ChEIs) treatment in patients with mild Alzheimer's disease. Transposing our findings to clinical settings could allow physicians to prescribe ChEIs for patients for whom treatment would be most beneficial.
BRAIN CONNECTIVITY
(2023)
Review
Clinical Neurology
Lennart Walger, Sophie Adler, Konrad Wagstyl, Leonie Henschel, Bastian David, Valeri Borger, Elke Hattingen, Hartmut Vatter, Christian E. Elger, Torsten Baldeweg, Felix Rosenow, Horst Urbach, Albert Becker, Alexander Radbruch, Rainer Surges, Martin Reuter, Fernando Cendes, Zhong Irene Wang, Hans-Juergen Huppertz, Theodor Rueber
Summary: Focal cortical dysplasias (FCDs) are common pathologies causing treatment-resistant focal epilepsy. Resective neurosurgery can be successful, but the visual assessment of magnetic resonance imaging is not always accurate in locating FCDs. Computational approaches using artificial intelligence show promise in automatic FCD detection. However, challenges remain in organizing imaging data, evaluating algorithmic output, and making research accessible and reproducible.
Article
Behavioral Sciences
Thamires Naela Cardoso Magalhaes, Raphael Fernandes Casseb, Christian Luiz Baptista Gerbelli, Luciana Ramalho Pimentel-Siva, Mateus Henrique Nogueira, Camila Vieira Ligo Teixeira, Ana Flavia Mac Knight Carletti, Thiago Junqueira Ribeiro de Rezende, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthazar
Summary: The causes of neurodegenerative processes in Alzheimer's disease are not fully understood. Recent studies have shown that damage in white matter may be more severe and widespread than cortical atrophy in the brain, appearing even before gray matter damage. Amyloid-beta and tau proteins in AD can directly affect white matter and spread across brain networks. This study aimed to evaluate whole-brain white matter integrity using diffusion tensor imaging in mild AD and amnestic mild cognitive impairment (aMCI) due to AD. Widespread white matter alterations were found, with correlations between tau proteins and tracts linked to the mesial temporal lobe. However, hippocampal volume better explained the variation in diffusion tensor imaging measures compared to CSF proteins.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Alfredo Damasceno, Luciana Ramalho Pimentel-Silva, Benito Pereira Damasceno, Fernando Cendes
Summary: This study analyzed the cognitive performance of 42 RRMS patients and 30 controls over six years. Different cutoffs were used to evaluate the behavior of cognitive progression. The results showed that fixed cutoffs led to misclassification of many patients as having cognitive worsening, while the relative cutoff performed better.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Cell Biology
Paulo Rogerio Julio, Thais Caldeira, Gustavo Retuci Pinheiro, Carla Helena Capello, Renan Bazuco Fritolli, Roberto Marini, Fernando Cendes, Paula Teixeira Fernandes, Lilian T. L. Costallat, Leticia Rittner, Simone Appenzeller
Summary: Central nervous system (CNS) involvement is common in childhood-onset systemic lupus erythematosus (cSLE), with structural magnetic resonance imaging (MRI) showing global cerebral atrophy and specific involvement of the corpus callosum and hippocampus. A cross-sectional study compared 71 cSLE patients to two control groups, revealing reduced mid-sagittal area of the corpus callosum in both cSLE and adult-onset SLE (aSLE) patients, compared to healthy controls. Microstructural changes, including lower FA values and higher MD, RD, and AD values, were observed in cSLE patients, particularly in the posterior region of the corpus callosum. These changes were associated with low complement levels, presence of anticardiolipin antibodies, and cognitive impairment. Overall, adults with cSLE showed greater microstructural changes in the corpus callosum compared to aSLE, potentially explaining the more severe cognitive impairment and disability observed in cSLE.
Article
Clinical Neurology
Hyo M. Lee, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, Dewi Schrader, Fabrice Bartolomei, Maxime Guye, Kyoo Ho Cho, Carmen Barba, Sanjay Sisodiya, Graeme Jackson, R. Edward Hogan, Lily Wong-Kisiel, Gregory D. Cascino, Andreas Schulze-Bonhage, Iscia Lopes-Cendes, Fernando Cendes, Renzo Guerrini, Boris Bernhardt, Neda Bernasconi, Andrea Bernasconi
Summary: This study explores the associations between Focal cortical dysplasia (FCD) and cytoarchitecture, gene expression, and axes of cortical organization. The findings suggest that the vulnerability of the frontal lobe to FCD may be due to early termination of prenatal neurogenesis and aberrant postnatal synaptogenesis.
Article
Clinical Neurology
Fabio A. Nascimento, Daniel Friedman, Jurriaan M. Peters, Meriem K. Bensalem-Owen, Fernando Cendes, Stefan Rampp, Elaine Wirrell, Ingmar Bluemcke, William Tatum, Sandor Beniczky
Summary: Correct diagnosis and classification of seizures and epilepsies are crucial to provide optimal care for epilepsy patients. Focal seizures are divided into focal aware, focal impaired awareness, and focal to bilateral tonic-clonic seizures. Focal epilepsies are common in both children and adults, with different causes and subgroups. Neuroimaging, neurophysiology, and neuropathology are important in the diagnostic evaluation of focal epilepsies.
EPILEPTIC DISORDERS
(2023)
Article
Clinical Neurology
Ildefonso Rodriguez-Leyva, Karla Cantu-Flores, Arturo Dominguez-Frausto, Anna Elisabetta Vaudano, John Archer, Boris Bernhardt, Lorenzo Caciagli, Fernando Cendes, Yotin Chinvarun, Paolo Federico, William D. Gaillard, Eliane Kobayashi, Godwin Ogbole, Stefan Rampp, Irene Wang, Shuang Wang, Luis Concha
Summary: The ILAE Neuroimaging Task Force published educational case reports on neuroimaging in epilepsy. Neurocysticercosis is highly endemic in resource-limited countries and is increasingly seen in non-endemic regions due to migration. This article presents two cases with different clinical features to illustrate the varying severity of symptoms caused by this parasitic infestation, as well as examples of imaging characteristics that emphasize the central role of neuroimaging in diagnosing neurocysticercosis.
EPILEPTIC DISORDERS
(2023)
Article
Clinical Neurology
Guilherme Rossi Assis-Mendonca, Maria Carolina Pedro Athie, Joao Vitor Gerdulli Tamanini, Arethusa de Souza, Gabriel Gerardini Zanetti, Patricia Aline Oliveira Ribeiro de Aguiar Araujo, Enrico Ghizoni, Helder Tedeschi, Marina Koutsodontis Machado Alvim, Vanessa Simao de Almeida, Welliton de Souza, Roland Coras, Clarissa Lin Yasuda, Ingmar Bluemcke, Andre Schwambach Vieira, Fernando Cendes, Iscia Lopes-Cendes, Fabio Rogerio
Summary: In this study, we analyzed the genetic material of FCD II patients and found that the cholesterol synthesis pathway was activated in the gray matter of the brain, which may be a neuroprotective response to seizures. Additionally, we identified upregulation of MTRNR2L12 and GPNMB expression, which may serve as potential neuropathological biomarkers for a cortex chronically exposed to seizures and balloon cells, respectively.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Clarissa Lin Yasuda, Luciana Ramalho Pimentel-Silva, Guilherme Coco Beltramini, Min Liu, Brunno Machado de Campos, Ana Carolina Coan, Christian Beaulieu, Fernando Cendes, Donald William Gross
Summary: Typical aging is associated with cognitive decline and changes in brain structure. In mesial temporal lobe epilepsy patients, cognitive decline starts early in life and runs parallel to controls, suggesting initial insult rather than accelerated decline due to seizures. Whether TLE patients show similar age-related gray and white matter changes as healthy controls is uncertain.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Tamires A. Zanao, Johanna Seitz-Holland, Lauren J. O'Donnell, Fan Zhang, Yogesh Rathi, Tatila M. Lopes, Luciana Ramalho Pimentel-Silva, Clarissa L. Yassuda, Nikos Makris, Martha E. Shenton, Sylvain Bouix, Amanda E. Lyall, Fernando Cendes
Summary: In this study, the relationship between hippocampal sclerosis (HS) and white matter structure in mesial temporal lobe epilepsy (MTLE) was investigated. The results showed that the presence and side of HS were associated with white matter abnormalities, with left-HS demonstrating widespread abnormalities and right-HS showing lower fractional anisotropy (FA). No differences in verbal/nonverbal memory performance were found between the groups, but there were associations between higher FA of visual and verbal memory and specific tracts.
Review
Radiology, Nuclear Medicine & Medical Imaging
Mauricio Martins Baldissin, Edna Marina de Souza, Nancy Watanabe, Elba C. S. C. Etchebehere, Fernando Cendes, Barbara Juarez Amorim
Summary: The role of brain F-18-FDG-PET and F-18-FDG-PET/CT in the diagnosis and follow-up of autoimmune encephalitis (AE) patients is discussed in this review. The review highlights the main findings and new perspectives on the use of these methods in studying the disease. The sensitivity of FDG-PET and FDG-PET/CT in detecting hyper and hypometabolism in AE patients is shown in the literature. It is suggested that specific metabolic alterations detected in imaging may be suggestive of the different antibodies causing AE. However, more prospective studies are needed for these imaging techniques to become a standard diagnostic method for AE.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)