4.7 Article

Quantitative Magnetic Resonance Imaging Analyses and Clinical Significance of Hyperintense White Matter Lesions in Systemic Lupus Erythematosus Patients

期刊

ANNALS OF NEUROLOGY
卷 64, 期 6, 页码 635-643

出版社

WILEY
DOI: 10.1002/ana.21483

关键词

-

资金

  1. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [03/01527-0, 06/50260-5]

向作者/读者索取更多资源

Objective: To analyze the clinical significance of hyperintense white matter (WM) lesions in both symptomatic and asymptomatic systemic lupus erythematosus (SLE) patients. Methods: We studied 120 consecutive SLE patients and 44 healthy volunteers. Fluid attenuated inversion recovery and T2-weighted magnetic resonance images (MRI) were used for visual and semiautomatic volumetric measurements. Results: At baseline, 61 MRI were normal and 59 had hyperintense WM lesions. Mean volumes of WM lesions were 96.14 (SD = 85.14) mm(3) in T2 weighted and 197.2 (161.13) mm(3) in FLAIR images. The Volume of WM lesions was associated with age (r = 0.45; p = 0.01), total corticosteroid dose (r = 0.53; p = 0.001), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index scores (r = 0.55; p = 0.002). After a median follow-up time of 24 months (SD = 2.3; range = 12-28 months), 20 patients had still normal MRIs, 30 patients had stable MRI findings, and 30 had new WM lesions. Predictors for new or increased WM lesions were past central nervous system manifestations (p = 0.001; OR = 12.2; 95% CI = 3.5-21.2), antiphospholipid antibodies (p = 0.003; OR = 6.9; 95% CI = 2.1-15.3); Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index scores (p = 0.002; OR = 7.2; 95% CI = 1.4-17.8) and higher dose of total corticosteroid dose (p = 0.01; OR = 2.4; 95% CI = 1.4-6.7). Conclusion: Small hyperintense WM lesions in SLE are associated with central nervous system symptoms and antiphospholipid antibodies, and progress over time in patients with more severe SLE. Therefore, in the on context of SLE, these lesions arc likely consequences of central nervous system damage and not mere incidental finding.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Editorial Material Behavioral Sciences

International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke

Nishant K. Mishra, Jerome Engel, David S. Liebeskind, Vijay K. Sharma, Lawrence J. Hirsch, Scott Kasner, Jacqueline A. French, Orrin Devinsky, Alon Friedman, Jesse Dawson, Terence J. Quinn, Magdy Selim, Adam de Havenon, Clarissa L. Yasuda, Fernando Cendes, Felix Benninger, Hitten P. Zaveri, Jorge G. Burneo, Padma Srivastava, Mamta Bhushan Singh, Rohit Bhatia, V. Y. Vishnu, Carla Bentes, Jose Ferro, Shennan Weiss, Adithya Sivaraju, Jennifer A. Kim, Marian Galovic, Emily J. Gilmore, Asla Pitkanen, Kathryn Davis, Lauren H. Sansing, Kevin N. Sheth, Jeanne T. Paz, Anuradha Singh, Sunil Sheth, Bradford B. Worrall, James C. Grotta, Pablo M. Casillas-Espinos, Zhibin Chen, John-Paul Nicolo, Bernard Yan, Patrick Kwan

EPILEPSY & BEHAVIOR (2022)

Correction Rheumatology

2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren's syndrome (vol 61, 54, 2021)

Fabiola Reis Oliveira, Valeria Valim, Sandra Gofnet Pasoto, Marilena Leal Mesquita Silvestre Fernandes, Maria Lucia Lemos Lopes, Sonia Cristina de Magalhaes Souza Fialho, Aysa Cesar Pinheiro, Laura Caldas dos Santos, Simone Appenzeller, Tania Fidelix, Sandra Lucia Euzebio Ribeiro, Danielle Christinne Soares Egypto de Brito, Tatiana Liborio, Maria Carmen Lopes Ferreira Silva Santos, Leandro Tanure, Juliana DAgostino Gennari, Vinicius Tassoni Civile, Ana Carolina Pereira Nunes Pinto, Cesar Ramos Rocha-Filho, Samira Tatiyama Miyamoto, Lissiane Karine Noronha Guedes, Alisson Pugliesi, Virginia Fernandes Moca Trevisani

ADVANCES IN RHEUMATOLOGY (2022)

Article Clinical Neurology

Progressive Spinal Cord Degeneration in Friedreich's Ataxia: Results from ENIGMA-Ataxia

Thiago J. R. Rezende, Isaac M. Adanyeguh, Filippo Arrigoni, Benjamin Bender, Fernando Cendes, Louise A. Corben, Andreas Deistung, Martin Delatycki, Imis Dogan, Gary F. Egan, Sophia L. Goericke, Nellie Georgiou-Karistianis, Pierre-Gilles Henry, Diane Hutter, Neda Jahanshad, James M. Joers, Christophe Lenglet, Tobias Lindig, Alberto R. M. Martinez, Andrea Martinuzzi, Gabriella Paparella, Denis Peruzzo, Kathrin Reetz, Sandro Romanzetti, Ludger Schoels, Joerg B. Schulz, Matthis Synofzik, Sophia I. Thomopoulos, Paul M. Thompson, Dagmar Timmann, Ian H. Harding, Marcondes C. Franca

Summary: This study characterized cervical spinal cord structural damage in a large multisite cohort of Friedreich's ataxia (FRDA) patients. The results showed that FRDA patients had significantly reduced cross-sectional area (CSA) and increased eccentricity in the cervical spinal cord compared to control subjects. The CSA had significant correlations with disease severity, while eccentricity did not. Subgroup analyses revealed abnormal CSA and eccentricity at all disease stages, with CSA appearing to decrease progressively and eccentricity remaining stable over time.

MOVEMENT DISORDERS (2023)

Article Neurosciences

Cholinesterase Inhibitors Response Might Be Related to Right Hippocampal Functional Connectivity in Mild Alzheimer's Disease

Liara Rizzi, Thamires Naela Cardoso Magalhaes, Natalie Lecce, Adriel dos Santos Moraes, Raphael Fernandes Casseb, Camila Vieira Ligo Teixeira, Brunno Machado de Campos, Thiago Junqueira Ribeiro de Rezende, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthazar

Summary: This study aimed to evaluate the ability of cerebrospinal fluid (CSF) AD biomarkers, hippocampal volumes, and Default Mode Network functional connectivity to predict clinical response to ChEIs treatment in mild AD. The functional connectivity of the right hippocampus showed a direct relationship with the clinical response to cholinesterase inhibitors (ChEIs) treatment in patients with mild Alzheimer's disease. Transposing our findings to clinical settings could allow physicians to prescribe ChEIs for patients for whom treatment would be most beneficial.

BRAIN CONNECTIVITY (2023)

Review Clinical Neurology

Artificial intelligence for the detection of focal cortical dysplasia: Challenges in translating algorithms into clinical practice

Lennart Walger, Sophie Adler, Konrad Wagstyl, Leonie Henschel, Bastian David, Valeri Borger, Elke Hattingen, Hartmut Vatter, Christian E. Elger, Torsten Baldeweg, Felix Rosenow, Horst Urbach, Albert Becker, Alexander Radbruch, Rainer Surges, Martin Reuter, Fernando Cendes, Zhong Irene Wang, Hans-Juergen Huppertz, Theodor Rueber

Summary: Focal cortical dysplasias (FCDs) are common pathologies causing treatment-resistant focal epilepsy. Resective neurosurgery can be successful, but the visual assessment of magnetic resonance imaging is not always accurate in locating FCDs. Computational approaches using artificial intelligence show promise in automatic FCD detection. However, challenges remain in organizing imaging data, evaluating algorithmic output, and making research accessible and reproducible.

EPILEPSIA (2023)

Article Behavioral Sciences

Whole-brain DTI parameters associated with tau protein and hippocampal volume in Alzheimer's disease

Thamires Naela Cardoso Magalhaes, Raphael Fernandes Casseb, Christian Luiz Baptista Gerbelli, Luciana Ramalho Pimentel-Siva, Mateus Henrique Nogueira, Camila Vieira Ligo Teixeira, Ana Flavia Mac Knight Carletti, Thiago Junqueira Ribeiro de Rezende, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthazar

Summary: The causes of neurodegenerative processes in Alzheimer's disease are not fully understood. Recent studies have shown that damage in white matter may be more severe and widespread than cortical atrophy in the brain, appearing even before gray matter damage. Amyloid-beta and tau proteins in AD can directly affect white matter and spread across brain networks. This study aimed to evaluate whole-brain white matter integrity using diffusion tensor imaging in mild AD and amnestic mild cognitive impairment (aMCI) due to AD. Widespread white matter alterations were found, with correlations between tau proteins and tracts linked to the mesial temporal lobe. However, hippocampal volume better explained the variation in diffusion tensor imaging measures compared to CSF proteins.

BRAIN AND BEHAVIOR (2023)

Article Clinical Neurology

Are we ready to define cognitive worsening in MS? How different cutoffs detect future cognitive worsening after six years of follow-up

Alfredo Damasceno, Luciana Ramalho Pimentel-Silva, Benito Pereira Damasceno, Fernando Cendes

Summary: This study analyzed the cognitive performance of 42 RRMS patients and 30 controls over six years. Different cutoffs were used to evaluate the behavior of cognitive progression. The results showed that fixed cutoffs led to misclassification of many patients as having cognitive worsening, while the relative cutoff performed better.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2023)

Article Cell Biology

Microstructural Changes in the Corpus Callosum in Systemic Lupus Erythematous

Paulo Rogerio Julio, Thais Caldeira, Gustavo Retuci Pinheiro, Carla Helena Capello, Renan Bazuco Fritolli, Roberto Marini, Fernando Cendes, Paula Teixeira Fernandes, Lilian T. L. Costallat, Leticia Rittner, Simone Appenzeller

Summary: Central nervous system (CNS) involvement is common in childhood-onset systemic lupus erythematosus (cSLE), with structural magnetic resonance imaging (MRI) showing global cerebral atrophy and specific involvement of the corpus callosum and hippocampus. A cross-sectional study compared 71 cSLE patients to two control groups, revealing reduced mid-sagittal area of the corpus callosum in both cSLE and adult-onset SLE (aSLE) patients, compared to healthy controls. Microstructural changes, including lower FA values and higher MD, RD, and AD values, were observed in cSLE patients, particularly in the posterior region of the corpus callosum. These changes were associated with low complement levels, presence of anticardiolipin antibodies, and cognitive impairment. Overall, adults with cSLE showed greater microstructural changes in the corpus callosum compared to aSLE, potentially explaining the more severe cognitive impairment and disability observed in cSLE.
Article Clinical Neurology

Multimodal mapping of regional brain vulnerability to focal cortical dysplasia

Hyo M. Lee, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, Dewi Schrader, Fabrice Bartolomei, Maxime Guye, Kyoo Ho Cho, Carmen Barba, Sanjay Sisodiya, Graeme Jackson, R. Edward Hogan, Lily Wong-Kisiel, Gregory D. Cascino, Andreas Schulze-Bonhage, Iscia Lopes-Cendes, Fernando Cendes, Renzo Guerrini, Boris Bernhardt, Neda Bernasconi, Andrea Bernasconi

Summary: This study explores the associations between Focal cortical dysplasia (FCD) and cytoarchitecture, gene expression, and axes of cortical organization. The findings suggest that the vulnerability of the frontal lobe to FCD may be due to early termination of prenatal neurogenesis and aberrant postnatal synaptogenesis.
Article Clinical Neurology

Focal epilepsies: Update on diagnosis and classification

Fabio A. Nascimento, Daniel Friedman, Jurriaan M. Peters, Meriem K. Bensalem-Owen, Fernando Cendes, Stefan Rampp, Elaine Wirrell, Ingmar Bluemcke, William Tatum, Sandor Beniczky

Summary: Correct diagnosis and classification of seizures and epilepsies are crucial to provide optimal care for epilepsy patients. Focal seizures are divided into focal aware, focal impaired awareness, and focal to bilateral tonic-clonic seizures. Focal epilepsies are common in both children and adults, with different causes and subgroups. Neuroimaging, neurophysiology, and neuropathology are important in the diagnostic evaluation of focal epilepsies.

EPILEPTIC DISORDERS (2023)

Article Clinical Neurology

Neurocysticercosis and epilepsy: Imaging and clinical characteristics

Ildefonso Rodriguez-Leyva, Karla Cantu-Flores, Arturo Dominguez-Frausto, Anna Elisabetta Vaudano, John Archer, Boris Bernhardt, Lorenzo Caciagli, Fernando Cendes, Yotin Chinvarun, Paolo Federico, William D. Gaillard, Eliane Kobayashi, Godwin Ogbole, Stefan Rampp, Irene Wang, Shuang Wang, Luis Concha

Summary: The ILAE Neuroimaging Task Force published educational case reports on neuroimaging in epilepsy. Neurocysticercosis is highly endemic in resource-limited countries and is increasingly seen in non-endemic regions due to migration. This article presents two cases with different clinical features to illustrate the varying severity of symptoms caused by this parasitic infestation, as well as examples of imaging characteristics that emphasize the central role of neuroimaging in diagnosing neurocysticercosis.

EPILEPTIC DISORDERS (2023)

Article Clinical Neurology

Transcriptome analyses of the cortex and white matter of focal cortical dysplasia type II: Insights into pathophysiology and tissue characterization

Guilherme Rossi Assis-Mendonca, Maria Carolina Pedro Athie, Joao Vitor Gerdulli Tamanini, Arethusa de Souza, Gabriel Gerardini Zanetti, Patricia Aline Oliveira Ribeiro de Aguiar Araujo, Enrico Ghizoni, Helder Tedeschi, Marina Koutsodontis Machado Alvim, Vanessa Simao de Almeida, Welliton de Souza, Roland Coras, Clarissa Lin Yasuda, Ingmar Bluemcke, Andre Schwambach Vieira, Fernando Cendes, Iscia Lopes-Cendes, Fabio Rogerio

Summary: In this study, we analyzed the genetic material of FCD II patients and found that the cholesterol synthesis pathway was activated in the gray matter of the brain, which may be a neuroprotective response to seizures. Additionally, we identified upregulation of MTRNR2L12 and GPNMB expression, which may serve as potential neuropathological biomarkers for a cortex chronically exposed to seizures and balloon cells, respectively.

FRONTIERS IN NEUROLOGY (2023)

Article Clinical Neurology

Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy

Clarissa Lin Yasuda, Luciana Ramalho Pimentel-Silva, Guilherme Coco Beltramini, Min Liu, Brunno Machado de Campos, Ana Carolina Coan, Christian Beaulieu, Fernando Cendes, Donald William Gross

Summary: Typical aging is associated with cognitive decline and changes in brain structure. In mesial temporal lobe epilepsy patients, cognitive decline starts early in life and runs parallel to controls, suggesting initial insult rather than accelerated decline due to seizures. Whether TLE patients show similar age-related gray and white matter changes as healthy controls is uncertain.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2023)

Article Clinical Neurology

Exploring the impact of hippocampal sclerosis on white matter tracts memory in individuals with mesial temporal lobe epilepsy

Tamires A. Zanao, Johanna Seitz-Holland, Lauren J. O'Donnell, Fan Zhang, Yogesh Rathi, Tatila M. Lopes, Luciana Ramalho Pimentel-Silva, Clarissa L. Yassuda, Nikos Makris, Martha E. Shenton, Sylvain Bouix, Amanda E. Lyall, Fernando Cendes

Summary: In this study, the relationship between hippocampal sclerosis (HS) and white matter structure in mesial temporal lobe epilepsy (MTLE) was investigated. The results showed that the presence and side of HS were associated with white matter abnormalities, with left-HS demonstrating widespread abnormalities and right-HS showing lower fractional anisotropy (FA). No differences in verbal/nonverbal memory performance were found between the groups, but there were associations between higher FA of visual and verbal memory and specific tracts.

EPILEPSIA OPEN (2023)

Review Radiology, Nuclear Medicine & Medical Imaging

FDG-PET in patients with autoimmune encephalitis: a review of findings and new perspectives

Mauricio Martins Baldissin, Edna Marina de Souza, Nancy Watanabe, Elba C. S. C. Etchebehere, Fernando Cendes, Barbara Juarez Amorim

Summary: The role of brain F-18-FDG-PET and F-18-FDG-PET/CT in the diagnosis and follow-up of autoimmune encephalitis (AE) patients is discussed in this review. The review highlights the main findings and new perspectives on the use of these methods in studying the disease. The sensitivity of FDG-PET and FDG-PET/CT in detecting hyper and hypometabolism in AE patients is shown in the literature. It is suggested that specific metabolic alterations detected in imaging may be suggestive of the different antibodies causing AE. However, more prospective studies are needed for these imaging techniques to become a standard diagnostic method for AE.

CLINICAL AND TRANSLATIONAL IMAGING (2023)

暂无数据