Article
Behavioral Sciences
Gerhard S. Drenthen, Jacobus F. A. Jansen, Erik Gommer, Lalit Gupta, Paul A. M. Hofman, Vivianne H. van Kranen-Mastenbroek, Danny M. Hilkman, Marielle C. G. Vlooswijk, Rob P. W. Rouhl, Walter H. Backes
Summary: This study assessed the predictive value of physiological signals measured using EEG and fMRI in predicting seizure recurrence in epilepsy patients. A regression model combining EEG and fMRI features showed significant improvements in predictive accuracy compared to clinical diagnosis. The findings suggest that temporal metrics derived from EEG and fMRI signals can synergistically enhance the predictive value for seizure recurrence in clinical practice.
EPILEPSY & BEHAVIOR
(2021)
Article
Neurosciences
Christian O'Reilly, Mayada Elsabbagh
Summary: This study demonstrates that most interhemispheric connectivity between homotopic cerebral regions is zero-lagged and this type of connectivity is ubiquitous. The findings should guide future electrophysiological connectivity studies and emphasize the importance of considering the role of zero-lag connectivity in our understanding of communication between cell assemblies.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Clinical Neurology
Adrish Anand, John F. Magnotti, David N. Smith, Ron Gadot, Ricardo A. Najera, Mohamed I. R. Hegazy, Jay R. Gavvala, Ben Shofty, Sameer A. Sheth
Summary: This study analyzed MEG data and found that MEG clusters with 14 or more dipoles are strongly associated with ictal activity in epilepsy patients. These findings are important for guiding preoperative planning of sEEG implantation.
JOURNAL OF NEUROSURGERY
(2022)
Article
Oncology
Mingjian Lin, Wenbo Wang, Lejian Tang, Yunxiang Zhou, Wencai Li, Jing Xiao, Zhizhu Peng, Xuewei Xia
Summary: The suprasellar extension (SSE) value on sagittal MRI can predict the risk of intracranial infection in patients with suprasellar extended pituitary adenoma after endoscopic endonasal transsphenoidal resection (EETA). Neurosurgeons should pay attention to the imaging characteristics of pituitary adenomas and select appropriate treatment plans based on intraoperative conditions to reduce the incidence of intracranial infection.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Zhihao Guo, Chao Zhang, Xiu Wang, Chang Liu, Baotian Zhao, Jiajie Mo, Zhong Zheng, Xiaoqiu Shao, Jianguo Zhang, Kai Zhang, Wenhan Hu
Summary: This retrospective study aimed to explore whether intracranial monitoring is necessary in MRI-negative neocortical epilepsy surgery and identify factors affecting the decision. The results showed that intracranial monitoring was not mandatory if the PET hypometabolic areas were consistent with the findings of semiology and scalp EEG in patients with MRI-negative neocortical epilepsy.
JOURNAL OF NEUROSURGERY
(2023)
Editorial Material
Clinical Neurology
Louis R. Caplan
Summary: Intracranial atherosclerosis is one of the causes of stroke and transient ischemic attacks, with a high recurrence rate. A autopsy study from France found that a significant number of stroke patients had intracranial plaques and stenosis.
Article
Clinical Neurology
Manjari Tripathi, Kirandeep Kaur, Bhargavi Ramanujam, Vibhin Viswanathan, Kamal Bharti, Gaurav Singh, Vivek Singh, Ajay Garg, Chandra Sekhar Bal, Madhavi Tripathi, Mehar Chand Sharma, Ravindra Pandey, Deepa Dash, Pravat Mandal, Poodipedi Sarat Chandra
Summary: MEG provides valuable nonredundant information in presurgical evaluation for epilepsy surgery, significantly influencing the surgical strategy. Patients who underwent surgical resection in sublobes concordant with MSI localization had a good outcome rate of 76% in long-term follow-up, indicating a high accuracy of MSI localization.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Psychiatry
Sheng-Min Wang, Nak-Young Kim, Dong Woo Kang, Yoo Hyun Um, Hae-Ran Na, Young Sup Woo, Chang Uk Lee, Won-Myong Bahk, Hyun Kook Lim
Summary: The study found that rs-fMRI may reflect the impact of beta-amyloid pathology on brain activity in the early stages of AD, with functional connectivity maps showing the best classification performance.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Oguz Oren, Cemile Haki, Halil Kaya, Melih Yuksel
Summary: This study aimed to investigate whether the baseline neutrophil/lymphocyte ratio (NLR) predicts symptomatic intracranial hemorrhage (SICH) due to intravenous thrombolytic therapy. However, the results showed that NLR did not provide strong specificity and sensitivity for predicting SICH, and a precise cut-off value could not be found to predict hemorrhagic transformation.
NEUROLOGICAL SCIENCES
(2022)
Article
Anesthesiology
Eloy S. Fehrlin, Darren Hight, Heiko A. Kaiser, Markus M. Luedi, Markus Huber, Frederic Zubler, Friedrich Lersch
Summary: A new index called FO-RPAB was proposed to monitor the ratio of alpha and beta activity between the frontal and occipital regions during general anesthesia. FO-RPAB was found to serve as a marker of unconsciousness and was not affected by additional administration of ketamine for analgesia.
ANESTHESIA AND ANALGESIA
(2023)
Article
Neurosciences
Brandon J. Thio, Warren M. Grill
Summary: This article investigates the sources of the EEG signal through computational modeling and finds that in addition to the traditionally acknowledged postsynaptic currents, action potentials and presynaptic activity can also generate electric fields. Experimental results show that while postsynaptic currents are the main contributor, action potentials and presynaptic activity also make significant contributions.
Article
Neurosciences
Ronglin Zheng, Zhongmin Wang, Yan He, Jie Zhang
Summary: This study proposed a method for functional synchronization analysis of brain regions based on EEG signals, which achieved differentiation of fatigue and awake states through extraction and classification of the topological properties of brain fatigue. The results showed that connections between brain regions increased in fatigue state and decreased in awake state, indicating more orderly and efficient information interaction between brain regions.
COGNITIVE NEURODYNAMICS
(2022)
Article
Medicine, Research & Experimental
Wei Nie, Guangyu Tao, Zhenghai Lu, Jie Qian, Yaqiong Ge, Shuyuan Wang, Xueyan Zhang, Hua Zhong, Hong Yu
Summary: This study aimed to develop and validate a radiomic signature for predicting overall survival and candidacy for adjuvant chemotherapy in stage I lung adenocarcinoma patients. The results demonstrated that the radiomic signature was associated with overall survival and could predict the benefit of adjuvant chemotherapy, especially in stage IB patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biology
Elaine A. Corbett, L. Alexandra Martinez-Rodriguez, Cian Judd, Redmond G. O'Connell, Simon P. Kelly
Summary: Perceptual decisions are biased toward higher-value options and are influenced by anticipation, detection, and discrimination processes. Motor preparation for higher-value actions begins earlier, providing a starting point advantage, while slower preparation for lower-value actions creates a value-opposed buildup-rate bias. However, this bias is countered by a transient deflection towards the higher-value action during stimulus detection. A neural process model incorporating anticipatory urgency, biased detection, and accumulation of stimulus-discriminating evidence successfully captures both behavior and motor preparation dynamics.
Article
Cardiac & Cardiovascular Systems
Aakash Bavishi, Celeste Witting, James Guo, Erik Wu, Jordan John, Madeline Jankowski, Abigail S. Baldridge, Daisy Meng, Kameswari Maganti
Summary: Relative apical longitudinal sparing (RALS) is a commonly used tool for evaluating cardiac amyloidosis (CA), but its predictive value is unclear. This retrospective study analyzed data from a single tertiary care center over 3 years and found that less than half of the patients with RALS were likely to have CA.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Clinical Neurology
Jeffrey P. Blount
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Clinical Neurology
Pedram Maleknia, Timothy D. McWilliams, Ariana Barkley, Dagoberto Estevez-Ordonez, Curtis Rozzelle, Jeffrey P. Blount
Summary: This study reviewed the longer-term safety and efficacy of vagus nerve stimulator (VNS) placement in children younger than 6 years with generalized medically refractory epilepsy. The results showed that seizure reduction rate >= 50% was observed in both patients younger than 4 years and patients aged 4-6 years at multiple follow-up periods. The study suggests that VNS implantation is feasible and effective for children younger than 6 years of age.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Review
Clinical Neurology
Nathan A. Shlobin, Jordan T. Roach, Vijaya Kancherla, Adrian Caceres, Eylem Ocal, Kemel A. Ghotme, Sandi Lam, Kee B. Park, Gail Rosseau, Jeffrey P. Blount, Frederick A. Boop
Summary: The global neurosurgery movement aims to address the global burden of neurosurgical disease by focusing on public health intervention in addition to individual treatment. The Global Alliance for the Prevention of Spina Bifida-F (GAPSBiF) advocates for folic acid fortification (FAF) of staple foods worldwide. This paper reviews the work of GAPSBiF in promoting universal FAF to prevent spina bifida caused by folic acid insufficiency.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Betsy Hopson, Madeline Eckenrode, Brandon G. Rocque, Jeffrey Blount, Emily Hooker, Virginia Rediker, Emma Cao, Nancy Tofil, Yung Lau, Carlie Stein Somerville
Summary: This article describes the development of the STEP program and the innovative use of Individualized Transition Plans (ITP) in the clinic setting. The STEP program improves the transition from pediatric to adult healthcare by conducting a provider needs' assessment, creating a transition policy, and establishing an interdisciplinary medical home. The ITP focuses on 5 individualized goals and has been implemented through interdisciplinary patient visits in collaboration with adult healthcare departments.
DISABILITY AND HEALTH JOURNAL
(2023)
Letter
Clinical Neurology
Adrian Caceres, Jeffrey Parker Blount
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Jeffrey P. Blount, Betsy D. Hopson, James M. Johnston, Brandon G. Rocque, Curtis J. Rozzelle, Jerry W. Oakes
Summary: Spina bifida (SB) is the most serious and common congenital anomaly of the human nervous system, which requires multi-disciplinary care. In utero myelomeningocele closure (IUMC) has revolutionized initial care for SB, but hydrocephalus remains a major concern. The development of a holistic and transitional care approach is crucial for the overall health and well-being of SB patients.
CHILDS NERVOUS SYSTEM
(2023)
Article
Oncology
Michael Dewan, Albert Isaacs, Michael J. Cools, Aaron Yengo-Kahn, Robert Naftel, Hailey Jensen, Ron W. Reeder, Richard Holubkov, Joseline Haizel-Cobbina, Jay Riva-Cambrin, Ryan J. Jafrani, Jonathan A. Pindrik, Eric Jackson, Brendan F. Judy, Elena Kurudza, Ian Pollack, Michael Mcdowell, Todd Hankinson, Susan Staulcup, Jason Hauptman, Koko Hall, Mandeep S. Tamber, Alex Cheong, Nebras Warsi, Brandon Rocque, Benjamin W. Saccomano, Rita Snyder, Abhaya Kulkarni, John R. W. Kestle, John Wellons III, Hydrocephalus Clinical Res Network
Summary: This study compared the treatment outcomes of VPS and ETV for persistent hydrocephalus following posterior fossa brain tumor resection. The overall success rates were similar between the two methods, but ETV had earlier failure time while VPS had persistent risk of failure beyond 5 years.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Editorial Material
Clinical Neurology
Jeffrey P. Blount, Brandon G. Rocque
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Clinical Neurology
Roxanna M. Garcia, Kemel A. Ghotme, Anastasia Arynchyna-Smith, Priyanka Mathur, Marinus Koning, Frederick Boop, Dan Peterson, Natalie Sheneman, Walter D. Johnson, Kee B. Park, Dylan Griswold, Camilla G. Aukrust, Ernest J. Barthelemy, Geoffrey Ibbotson, Jeffrey P. Blount, Gail L. Rosseau
Summary: This article reviews the significant progress and international efforts in global surgery/neurosurgery, focusing on policy advocacy and support for a new World Health Assembly resolution to prevent neural tube defects.
News Item
Clinical Neurology
Nathan A. Shlobin, Kemel Ghotme, Adrian Caceres, Eylem Ocal, Jogi V. Pattisapu, Gail Rosseau, Jeffrey P. Blount, Frederick A. Boop
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Pedram D. Maleknia, Andrew T. Hale, Cody Savage, Jeffrey P. Blount, Brandon G. Rocque, Curtis J. Rozzelle, James M. Johnston, Jesse G. A. Jones
Summary: This systematic review summarizes the published cases of pediatric dAVFs and reveals a lack of information in this field, with publication bias and difficulty in determining detailed complications.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Jonathan Roth, Lottem Bergman, Alexander G. Weil, Tristan Brunette-Clement, Howard L. Weiner, Jeffrey M. Treiber, Ben Shofty, Arthur Cukiert, Cristine Mella Cukiert, Manjari Tripathi, Poodipedi Sarat Chandra, Robert J. Bollo, Helio Rubens Machado, Marcelo Volpon Santos, William D. Gaillard, Chima O. Oluigbo, George M. Ibrahim, George I. Jallo, Nir Shimony, Brent R. O'Neill, Marcelo Budke, Maria Angeles Perez-Jimenez, Francesco T. Mangano, Masaki Iwasaki, Keiya Iijima, Jorge Gonzalez-Martinez, Kensuke Kawai, Yohei Ishishita, Samer K. Elbabaa, Luis Bello-Espinosa, Aria Fallah, Cassia A. B. Maniquis, Ido Ben-Zvi, Martin Tisdall, Manas Panigrahi, Sita Jayalakshmi, Jeffrey P. Blount, Georg Dorfmuller, Christine Bulteau, Scellig S. Stone, Jeffrey Bolton, Shimrit Uliel-Sibony
Summary: CC is vital in seizure control in children with LGS in whom VNS has failed. Surgical risks are low. A complete CC has a tendency toward better effectiveness than anterior CC for some seizure types.
Article
Clinical Neurology
Andrew T. Hale, Dagoberto Estevez-Ordonez, Jana Badrani, Wen Sha, Anastasia Arynchyna-Smith, Monisha Goyal, Ismail Mohamed, Pongkiat Kankirawatana, Curtis J. Rozzelle, Jeffrey P. Blount
Summary: The study aimed to validate the Hemispherectomy Outcome Prediction Scale (HOPS) through a 20-year retrospective study on 60 patients, but found that the HOPS score was not statistically significant in predicting seizure outcomes postoperatively. More rigorous testing is needed for seizure outcome prediction tools, with prospective, standardized, and longitudinal evaluations of patients undergoing hemispherectomy.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Clinical Neurology
Jonathan Roth, Howard L. Weiner, P. Sarat Chandra, Helio Rubens Machado, Jeffrey P. Blount, Georg Dorfmueller, Christian Dorfer, Manas Panigrahi, Shimrit Uliel-Sibony, Shlomi Constantini
Summary: There are significant disparities in access to epilepsy surgery technologies across countries and continents, highlighting the importance of collaboration between neurologists and neurosurgeons worldwide to enhance medical education, training, and increase technological availability.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Mark S. Dias, Ming Wang, Menglu Liang, Elias B. Rizk, Robin Bowman, Michael D. Partington, Jeffrey P. Blount, Brandon G. Rocque, Betsy Hopson, Amy Lee, William O. Walker
Summary: The authors analyzed the National Spina Bifida Patient Registry to determine the ongoing risk for tethered cord release among adults with myelomeningocele who had not previously undergone the surgery during childhood. They also identified the impact of lesion level, ambulation status, and prior treatments on the surgery rates.
JOURNAL OF NEUROSURGERY-SPINE
(2023)