Article
Biochemistry & Molecular Biology
Yuuki Sasaki, Noriyuki Kimura, Yasuhiro Aso, Kenichi Yabuuchi, Miki Aikawa, Etsuro Matsubara
Summary: The study found that CSF levels of MMP-2 were negatively correlated with brain amyloid deposition, especially in the parietotemporal lobe and posterior cingulate gyrus, and that CSF levels of MMP-7 were positively correlated with the severity of WMLs. These findings provide insights into the role of MMPs in amyloid beta catabolism and blood-brain barrier integration at the MCI stage.
Article
Neurosciences
Hyejin Ahn, Dahyun Yi, Kyungjin Chu, Haejung Joung, Younghwa Lee, Gijung Jung, Kiyoung Sung, Dongkyun Han, Jun Ho Lee, Min Soo Byun, Dong Young Lee
Summary: This study investigated the neural correlates of semantic verbal fluency test (SVFT) scores in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using FDG-PET. The results showed that the total score (TS) of SVFT was positively correlated with cerebral glucose metabolism in various brain regions. However, the strategy scores of switching (SW) and cluster switching (CSW) were found to be better indicators of specific language and executive functions. Furthermore, the associations between strategy scores and regional glucose metabolism varied based on the severity of the disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Matteo Bauckneht, Andrea Chincarini, Matthias Brendel, Axel Rominger, Leonie Beyer, Rose Bruffaerts, Rik Vandenberghe, Milica G. Kramberger, Maja Trost, Valentina Garibotto, Nicolas Nicastro, Giovanni B. Frisoni, Afina W. Lemstra, Bart N. M. Berckel, Andrea Pilotto, Alessandro Padovani, Miguel A. Ochoa-Figueroa, Anette Davidsson, Valle Camacho, Enrico Peira, Dario Arnaldi, Matteo Pardini, Maria Isabella Donegani, Stefano Raffa, Alberto Miceli, Gianmario Sambuceti, Dag Aarsland, Flavio Nobili, Silvia Morbelli
Summary: The study found that age was negatively correlated with DLB metabolism, while education was positively correlated, highlighting the importance of considering individual, non-disease-related variables such as age and cognitive reserve in interpreting DLB biomarkers.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Anna Pink, Janina Krell-Roesch, Jeremy A. Syrjanen, Maria Vassilaki, Val J. Lowe, Prashanthi Vemuri, Gorazd B. Stokin, Teresa J. Christianson, Walter K. Kremers, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, Yonas E. Geda
Summary: This study found that cortical amyloid deposition, anxiety, and depression independently increased the risk of incident mild cognitive impairment. Additionally, anxiety modified the association between cortical amyloid deposition and incident mild cognitive impairment.
ALZHEIMERS & DEMENTIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wan-Ming Chen, Mingchih Chen, Jeng-Guan Hsu, Tian-Shyug Lee, Ben-Chang Shia, Szu-Yuan Wu
Summary: The use of preoperative PET/CT is associated with a lower risk of death in patients with resectable stage IIIA-IIIB non-small cell lung cancer, but it does not improve survival rates in patients with stage I-II cancer.
Review
Immunology
Jie Huang
Summary: This review discusses the current status and applications of molecule-based positron emission tomography (PET) imaging in neuroinflammation. Despite certain limitations, neuroinflammation PET imaging is considered a promising approach to understanding the pathophysiological process of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Miikka-Juhani Honka, Eleni Rebelos, Simona Malaspina, Pirjo Nuutila
Summary: This review explores the use of PET in evaluating hepatic metabolism, haemodynamics, and cancer. F-18-FDG is the most commonly used tracer for assessing glucose uptake and endogenous glucose production. Other tracers such as F-18-FTHA, C-11-Palmitate, and C-11-Acetate have been applied for measuring fatty acid uptake rates, blood flow, and oxidation in the liver. O-15 labelled water is used for quantifying hepatic perfusion. The challenges and modelling approaches in utilizing PET for assessing hepatic metabolism are also discussed.
Article
Multidisciplinary Sciences
Wen-yu Yin, Jiao Yuan, Zhi-min Zhang, Cheng Mei, Wei Xu, Yong-xiang Tang, Fang Peng, Ning Li
Summary: Stressed red blood cells showed differences in various indicators compared to untreated red blood cells, being more prone to phagocytosis by macrophages and mainly trapped in the spleen as shown by F-18-FDG PET/CT imaging, while the untreated red blood cells continued to circulate in the system.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Elise Brochner Rischel, Michael Gejl, Birgitte Brock, Jorgen Rungby, Albert Gjedde
Summary: This article proposes a hypothesis that amyloid beta accumulation is a protective mechanism that ultimately fails in Alzheimer's disease. It predicts that A beta accumulates more in regions with higher rates of glucose metabolism, leading to progression of pathology. Through a study on AD patients, it is found that the accumulation level of A beta does not correlate with cognitive decline, suggesting the need for revision on the significance of A beta accumulation in the brains of AD patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Computer Science, Artificial Intelligence
Rashmi Kumari, Akriti Nigam, Shashank Pushkar
Summary: This paper proposes a multimodal approach to improve the classification accuracy of early Alzheimer's disease using additional information from multiple image modalities. The use of the Adaptive Hyperparameter Tuning Random Forest Ensemble Classifier allows for faster computation and achieves the best binary classification performance in the ADNI dataset.
NEURAL COMPUTING & APPLICATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moath Said Alfawara, Ahmed Ibrahim Ahmed, Jean Michel Saad, Yushui Han, Fares Alahdab, Mahmoud Al Rifai, Mahwash Kassi, Talal Alnabelsi, William A. Zoghbi, Mouaz H. Al-Mallah
Summary: This study evaluated the use of serum beta-hydroxybutyrate (BHB) to identify adequate suppression of the left ventricle (LV) in patients undergoing cardiac inflammatory/infectious studies. The results showed that serum BHB level can be used to determine sufficient LV suppression.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Clinical Neurology
Murat Bilgel, Yang An, Keenan A. A. Walker, Abhay R. R. Moghekar, Nicholas J. J. Ashton, Przemyslaw R. Kac, Thomas K. K. Karikari, Kaj Blennow, Henrik Zetterberg, Bruno M. M. Jedynak, Madhav Thambisetty, Luigi Ferrucci, Susan M. M. Resnick
Summary: Understanding the longitudinal changes in plasma biomarkers in relation to brain amyloid changes is important for assessing Alzheimer's progression.
ALZHEIMERS & DEMENTIA
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sangwon Han, Sungmin Woo, Yong-il Kim, Dok Hyun Yoon, Jin-Sook Ryu
Summary: The systematic review and meta-analysis showed that (18)F-FDG PET/CT is a significant predictor for disease progression and survival in patients with newly diagnosed multiple myeloma. The presence of extramedullary disease, more than three focal lesions, and high FDG uptake were associated with shorter overall survival and progression-free survival.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Kazuhiro Kitajima, Kazuo Abe, Masanaka Takeda, Hiroo Yoshikawa, Mana Ohigashi, Keiko Osugi, Hidenori Koyama, Koichiro Yamakado
Summary: This study aimed to evaluate the clinical impact of adding C-11-PiB PET for the diagnosis of mild cognitive impairment (MCI) progressing to Alzheimer's disease (AD) dementia. The study found that C-11-PiB-PET showed higher accuracy than SPECT in selecting MCI patients who may progress to AD, indicating its potential usefulness in clinical diagnosis.
Article
Biochemistry & Molecular Biology
Shanshan Chen, Yu Song, Huimin Wu, Honglin Ge, Wenzhang Qi, Yue Xi, Jiayi Wu, Yuxiang Ji, Kexin Chen, Xingjian Lin, Jiu Chen
Summary: In patients with amnestic mild cognitive impairment (aMCI), anosognosia is associated with increased tau accumulation in specific brain regions, disrupted functional connectivity, and accelerates progression to Alzheimer's disease dementia.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Matti Sillanpaa, Bruce Hermann, Juha O. Rinne, Riitta Parkkola, Maiju M. Saarinen, Mira Karrasch, Jani Saunavaara, Eero Rissanen, Juho Joutsa, Shlomo Shinnar
Summary: The study revealed that neurologic signs were more common in COE participants not in remission, particularly cerebellar signs. MRI white matter abnormalities were associated with absence of vocational education, and MRI hippocampal atrophy in COE subjects was associated with arterial hypertension. In the long-term follow-up, there were tendencies to accelerated brain aging in COE participants, especially in focal epilepsy.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Oncology
Simona Malaspina, Pekka Taimen, Markku Kallajoki, Vesa Oikonen, Anna Kuisma, Otto Ettala, Kalle Mattila, Peter J. Bostroem, Heikki Minn, Kari Kalliokoski, Ernst J. Postema, Matthew P. Miller, Mika Scheinin
Summary: The study evaluated the tracer uptake and lesion detectability of F-18-radiohybrid (rh)PSMA-7.3 in patients with prostate cancer. The results showed that F-18-rhPSMA-7.3 PET/CT demonstrated good detection of primary and metastatic PCa lesions, especially lesions with GS >= 4 + 3/GG >= 3.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Geriatrics & Gerontology
Minna Alenius, Tiia Ngandu, Sanna Koskinen, Ilona Hallikainen, Tuomo Haenninen, Mira Karrasch, Miia Kivipelto, Minna M. Raivio, Marja-Liisa Laakkonen, Johanna Krueger, Noora-Maria Suhonen, Laura Hokkanen
Summary: This study examined the impact of education, age, and gender on cognitive screening for early Alzheimer's disease and found that education was the strongest predictor of cognitive performance. Corrected cutoff scores based on education had better accuracy in differentiating between the control group and AD patients.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2022)
Article
Clinical Neurology
Anniina Snellman, Laura L. Ekblad, Mikko Koivumaeki, Noora Lindgren, Jouni Tuisku, Merja Peraelae, Lila Kallio, Riina Lehtonen, Virva Saunavaara, Jani Saunavaara, Vesa Oikonen, Richard Aarnio, Eliisa Loyttyniemi, Riitta Parkkola, Mira Karrasch, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne
Summary: The ASIC-E4 study aims to investigate the early pathophysiological changes in preclinical Alzheimer's disease by combining neuroimaging and fluid-based biomarker measurements. It focuses on the interplay of beta-amyloid deposition, neuroinflammation, synaptic dysfunction, and loss in cognitively normal individuals with different levels of genetic risk for late-onset AD. The study design, protocols, and baseline demographics of the ASIC-E4 study are described in this article.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychology, Multidisciplinary
Minna Alenius, Laura Hokkanen, Sanna Koskinen, Ilona Hallikainen, Tuomo Haenninen, Mira Karrasch, Minna M. Raivio, Marja-Liisa Laakkonen, Johanna Krueger, Noora-Maria Suhonen, Miia Kivipelto, Tiia Ngandu
Summary: The study aimed to evaluate the feasibility of using real-world register data to identify persons with mild Alzheimer's disease (AD) and to describe their cognitive performance at the time of diagnosis. The results showed that patients with late-onset AD performed the worst in word list recognition, while patients with mixed cerebrovascular disease and AD performed the worst in constructional praxis and clock drawing tests.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihua Sun, Richard Aarnio, Erika Atencio Herre, Salli Karna, Senthil Palani, Helena Virtanen, Heidi Liljenback, Jenni Virta, Aake Honkaniemi, Vesa Oikonen, Chunlei Han, Sanna Laurila, Marco Bucci, Semi Helin, Emrah Yatkin, Lauri Nummenmaa, Pirjo Nuutila, Jing Tang, Anne Roivainen
Summary: Photoperiod affects the availability of mu-opioid receptors (MOR) in brown adipose tissue (BAT), and sympathetic innervation may regulate thermogenesis via the peripheral MOR system.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olli Moisio, Jenni Virta, Emrah Yatkin, Heidi Liljenback, Senthil Palani, Riikka Viitanen, Maxwell W. G. Miner, Vesa Oikonen, Tuula Tolvanen, Danielle J. Vugts, Pekka Taimen, Xiang-Guo Li, Maija Hollmen, Sirpa Jalkanen, Anne Roivainen
Summary: Bexmarilimab is a new humanized monoclonal antibody targeting CLEVER-1 and is currently being tested for macrophage-guided cancer immunotherapy. This study evaluated the biodistribution and stability of radiolabeled bexmarilimab in rabbits, and found that it rapidly cleared from the blood circulation and showed higher uptake in fibrotic renal cortex. These findings support future human PET studies for bexmarilimab treatment and disease monitoring.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elina Rauhala, Jarkko Johansson, Mira Karrasch, Olli Eskola, Tuula Tolvanen, Riitta Parkkola, Kirsi A. Virtanen, Juha O. Rinne
Summary: In the early stage of aMCI, the presence of amyloid pathology at baseline strongly predicted the accumulation of amyloid and decline in cognitive abilities during the follow-up period. Some patients remained amyloid negative at the end of the study without significant changes in F-18-Flutemetamol uptake or cognition.
Article
Endocrinology & Metabolism
Eleni Rebelos, Andrea Mari, Vesa Oikonen, Hidehiro Iida, Pirjo Nuutila, Ele Ferrannini
Summary: This study aimed to assess whether [18F]FDG-PET can be used in the study of renal glucose metabolism in humans. The results showed that [18F]FDG-PET can still provide relevant physiological information on regional renal glucose uptake, as long as [18F]FDG uptake is corrected for tubular radioactivity.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Clinical Neurology
Anniina Snellman, Laura L. Ekblad, Jouni Tuisku, Mikko Koivumaki, Nicholas J. Ashton, Juan Lantero-Rodriguez, Thomas K. Karikari, Semi Helin, Marco Bucci, Eliisa Loyttyniemi, Riitta Parkkola, Mira Karrasch, Michael Scholl, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne
Summary: This study used positron emission tomography (PET) and blood biomarker measurements to examine differences in neuroinflammation and beta-amyloid (Aβ) and their association in cognitively unimpaired individuals. The results showed that only Aβ burden measured by PET differed among cognitively unimpaired elderly with different APOE ε4 gene dose, while the differences in neuroinflammation markers were not significant. However, APOE ε4 gene dose seemed to modulate the association between neuroinflammation and Aβ.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Anniina Snellman, Laura L. Ekblad, Nicholas J. Ashton, Thomas K. Karikari, Juan Lantero-Rodriguez, Elina Pietila, Mikko Koivumaki, Semi Helin, Mira Karrasch, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne
Summary: Plasma phosphorylated tau (p-tau) and glial fibrillary acidic protein (GFAP) are both early markers of Alzheimer's disease (AD), reflecting different amyloid-beta-related processes. In clinically unimpaired elderly individuals, differences in p-tau levels were observed based on APOE4 gene doses, solely explained by brain amyloid-beta load. All plasma biomarkers correlated positively with amyloid-beta PET, with different spatial patterns for p-tau markers and GFAP. Only higher plasma GFAP levels were associated with lower cognitive scores.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Endocrinology & Metabolism
Laura Pekkarinen, Tatu Kantonen, Vesa Oikonen, Merja Haaparanta-Solin, Richard Aarnio, Alex M. Dickens, Annie von Eyken, Aino Latva-Rasku, Prince Dadson, Anna K. Kirjavainen, Johan Rajander, Kari Kalliokoski, Tapani Roennemaa, Lauri Nummenmaa, Pirjo Nuutila
Summary: This study aimed to investigate CB1R availability in peripheral tissue and brain in young men with overweight versus lean men. The results suggest endocannabinoid dysregulation already in the preobesity state, as CB1R availability in abdominal adipose tissue was lower in the high-risk group and correlated with insulin sensitivity and unfavorable lipid profile.
Article
Psychology, Multidisciplinary
Julia Simonsen, Mira Karrasch, Matti Laine, Ase Fagerlund
Summary: Burnout rates among adolescents have increased significantly. This study examined coping strategies, resilience, and school atmosphere as predictors for burnout symptoms in adolescents. Results showed that problem-solving and seeking social support coping strategies were associated with fewer symptoms. A positive school atmosphere, particularly instilling meaning in students, had a similar relationship with burnout. However, resilience was unexpectedly associated with more symptoms, and females reported higher rates of burnout symptoms than males.
Article
Radiology, Nuclear Medicine & Medical Imaging
Oona Rainio, Chunlei Han, Jarmo Teuho, Sergey V. Nesterov, Vesa Oikonen, Sauli Piirola, Timo Laitinen, Marko Tattalainen, Juhani Knuuti, Riku Klen
Summary: Carimas is a versatile tool for processing medical imaging data, allowing visualization, analysis, and modeling of various medical images in research. Originally designed for positron emission tomography data, it has expanded to include other tomography imaging modalities like computed tomography and magnetic resonance imaging. Carimas excels in analyzing three- and four-dimensional image data and creating polar maps for cardiac perfusion modeling.
JOURNAL OF DIGITAL IMAGING
(2023)