Morphogenesis and molecular considerations on congenital cardiac septal defects

N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes

(2014) Hoda Moazzen et al.   Cardiovascular Diabetology

Congenital Heart Disease

(2014) Benoit G. Bruneau et al.   CIRCULATION RESEARCH

A Single Misstep in Cardiac Development Explains the Co-Occurrence of Tetralogy of Fallot and Complete Atrioventricular Septal Defect in Down Syndrome

(2014) Hoang H. Nguyen et al.   JOURNAL OF PEDIATRICS

Association of promoter methylation statuses of congenital heart defect candidate genes with Tetralogy of Fallot

(2014) Wei Sheng et al.   Journal of Translational Medicine

Transposition of great arteries: new insights into the pathogenesis

(2014) Marta Unolt   Frontiers in Pediatrics

Association Between Maternal Chronic Conditions and Congenital Heart Defects

(2013) Shiliang Liu et al.   CIRCULATION

Genetics of Congenital Heart Disease

(2013) Akl C. Fahed et al.   CIRCULATION RESEARCH

microRNAs in cardiac development and regeneration

(2013) Enzo R. Porrello   CLINICAL SCIENCE

Recent advances in understanding the genetics of congenital heart defects

(2013) Bruce D. Gelb   CURRENT OPINION IN PEDIATRICS

Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel–Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects

(2013) Zakia A. Abdelhamed et al.   HUMAN MOLECULAR GENETICS

Titration of GLI3 Repressor Activity by Sonic Hedgehog Signaling Is Critical for Maintaining Multiple Adult Neural Stem Cell and Astrocyte Functions

(2013) R. Petrova et al.   JOURNAL OF NEUROSCIENCE

De novo mutations in histone-modifying genes in congenital heart disease

(2013) Samir Zaidi et al.   NATURE

Development of the Hearts of Lizards and Snakes and Perspectives to Cardiac Evolution

(2013) Bjarke Jensen et al.   PLoS One

An Excess of Deleterious Variants in VEGF-A Pathway Genes in Down-Syndrome-Associated Atrioventricular Septal Defects

(2012) Christine Ackerman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage

(2012) Joseph A. Wamstad et al.   CELL

Lineage Tree for the Venous Pole of the Heart

(2012) Fabienne Lescroart et al.   CIRCULATION RESEARCH

Genetic Modifiers Predisposing to Congenital Heart Disease in the Sensitized Down Syndrome Population

(2012) Huiqing Li et al.   Circulation-Cardiovascular Genetics

A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia

(2012) Karolin V. Dorn et al.   DEVELOPMENTAL CELL

Morphogenesis of outflow tract rotation during cardiac development: The pulmonary push concept

(2012) Roderick W.C. Scherptong et al.   DEVELOPMENTAL DYNAMICS

NOing the heart: Role of nitric oxide synthase-3 in heart development

(2012) Yin Liu et al.   DIFFERENTIATION

The arterial and cardiac epicardium in development, disease and repair

(2012) Adriana C. Gittenberger-de Groot et al.   DIFFERENTIATION

The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion

(2012) Laura E. Briggs et al.   DIFFERENTIATION

Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease

(2012) Scott Smemo et al.   HUMAN MOLECULAR GENETICS

Genetic analysis of the TBX1 gene promoter in ventricular septal defects

(2012) Haihua Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development

(2012) K. Lage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in ZIC3 and ACVR2B are a common cause of heterotaxy and associated cardiovascular anomalies

(2011) Lijiang Ma et al.   CARDIOLOGY IN THE YOUNG

Epigenetic factors and cardiac development

(2011) J. H. van Weerd et al.   CARDIOVASCULAR RESEARCH

Systems biology approaches to heart development and congenital heart disease

(2011) S. R. Sperling   CARDIOVASCULAR RESEARCH

Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition

(2011) Anastasia D. Egorova et al.   CIRCULATION RESEARCH

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

(2011) Ben Chih et al.   NATURE CELL BIOLOGY

KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes

(2011) Audrey Putoux et al.   NATURE GENETICS

Complex interactions between genes controlling trafficking in primary cilia

(2011) Polloneal Jymmiel R Ocbina et al.   NATURE GENETICS

Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development

(2011) I. P. Moskowitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs

(2011) Jenny Schlesinger et al.   PLoS Genetics

Loss of MicroRNAs in Neural Crest Leads to Cardiovascular Syndromes Resembling Human Congenital Heart Defects

(2010) Zhan-Peng Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle

(2010) A De Luca et al.   CLINICAL GENETICS

MicroRNA Regulatory Networks in Cardiovascular Development

(2010) Ning Liu et al.   DEVELOPMENTAL CELL

Cardiac malformations in Pdgfrα mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field

(2010) Noortje A.M. Bax et al.   DEVELOPMENTAL DYNAMICS

Dysregulation of the PDGFRA gene causes inflow tract anomalies including TAPVR: integrating evidence from human genetics and model organisms

(2010) Steven B. Bleyl et al.   HUMAN MOLECULAR GENETICS

Normal and abnormal development of pulmonary veins: State of the art and correlation with clinical entities

(2010) Yvonne L. Douglas et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation

(2010) M. Nadeau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular genetics of congenital atrial septal defects

(2009) Maximilian G. Posch et al.   Clinical Research in Cardiology

sonic hedgehog is required in pulmonary endoderm for atrial septation

(2009) A. D. Hoffmann et al.   DEVELOPMENT

Analysis of Ellis van Creveld syndrome gene products: implications for cardiovascular development and disease

(2009) Kristen Lipscomb Sund et al.   HUMAN MOLECULAR GENETICS

A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling

(2009) Scott D. Weatherbee et al.   HUMAN MOLECULAR GENETICS

Left cardiac isomerism in the Sonic hedgehog null mouse

(2009) Victoria Hildreth et al.   JOURNAL OF ANATOMY

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome

(2009) Keisuke Nimura et al.   NATURE

De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot

(2009) Steven C Greenway et al.   NATURE GENETICS

Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation

(2009) Vincent Marion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling

(2009) K. Kodo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

(2008) Andrea Ventura et al.   CELL

Primary cilia sensitize endothelial cells for fluid shear stress

(2008) Beerend P. Hierck et al.   DEVELOPMENTAL DYNAMICS

Cardiac malformations and myocardial abnormalities inpodoplanin knockout mouse embryos: Correlation with abnormal epicardial development

(2008) Edris A.F. Mahtab et al.   DEVELOPMENTAL DYNAMICS

T-box transcription factor TBX20 mutations in Chinese patients with congenital heart disease

(2008) Caixia Liu et al.   European Journal of Medical Genetics

Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression

(2008) S. A. Miller et al.   GENES & DEVELOPMENT

The developmental genetics of congenital heart disease

(2008) Benoit G. Bruneau   NATURE