Article
Biochemistry & Molecular Biology
Marialuisa Perrotta, Daniela Carnevale
Summary: Hypertension is a multifactorial disease with pathophysiological mechanisms involving not only classical factors but also the immune system. Studies have shown the important role of neuroimmune interactions in hypertension, with specific brain areas modulating immune responses playing a crucial role in the development of high blood pressure.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Cell Biology
Ulrich O. Wenzel, Heimo Ehmke, Marlies Bode
Summary: This article highlights the role of inflammation in hypertension and hypertensive end-organ damage, noting that immune cells from both the innate and adaptive immune systems are involved. It also discusses the impact of sodium intake on immune cell function and the potential benefits of modulating the immune response to reduce the severity of hypertension and end-organ damage.
CELL AND TISSUE RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Xiaolin Liao, Yuanshan Han, Ying He, Jianjun Liu, Yuhong Wang
Summary: Hypertension commonly leads to target organ damage in the heart, brain, kidney, and blood vessels, including atherosclerosis, plaque formation, cardiovascular and cerebrovascular events, and renal failure. Mitochondrial dysfunction has been identified as a crucial factor in hypertensive target organ damage, leading to increasing interest in mitochondria-targeted therapies. Natural compounds have shown potential in ameliorating mitochondrial dysfunction in hypertensive target organ damage. This review summarizes the contribution of mitochondrial dysfunction to the development of target organ damage in hypertension and discusses therapeutic strategies based on natural compounds that target mitochondrial dysfunction, which may be beneficial for preventing and treating hypertensive target organ damage.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Abhishek Shastri, Ahmad Al Aiyan, Uday Kishore, Maria Elena Farrugia
Summary: Dysfunction of the immune system can lead to peripheral nervous system damage. The immune mechanisms involve inflammation and proliferation of Schwann cells and result in demyelination and axonal degeneration. Animal models have contributed to understanding the pathophysiology of inflammatory polyradiculoneuropathies. Detection of specific antibodies aids in diagnosis. Paraneoplastic neuropathies are immune-mediated reactions to tumor cells. This review discusses the immunological and pathophysiological mechanisms, as well as the electrophysiological characteristics, laboratory features, and treatment options of dysimmune neuropathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Qing Tu, Yi Li, Jiali Zhu, Long Guo, Chenchen Liu, Lu Liu, Yuan Yuan, Yun Zou, Feng Chen, Liangfang Yao, Jinbao Li
Summary: This study demonstrated that mtDNA promotes immunoparalysis of DCs and contributes to sepsis-associated immunosuppression by activating STING signaling. Our findings suggest that mtDNA mediates immunoparalysis of DCs in sepsis, providing new insights into the molecular pathogenesis of immunosuppressive DCs in sepsis.
CELL PROLIFERATION
(2022)
Article
Immunology
Owen Herrock, Evangeline Deer, Lorena M. Amaral, Nathan Campbell, Darby Whitney, Nicole Ingram, Denise C. Cornelius, Ty Turner, Ja'Nasa Hardy-Hardin, George W. Booz, Tarek Ibrahim, Babbette LaMarca
Summary: This study demonstrates that B2 cells contribute to hypertension, AT1-AA, and NK cell activation in response to placental ischemia during pregnancy. Anti-BAFF therapy can attenuate hypertension, AT1-AA, NK cell activation, and APRIL levels in RUPP rats without negatively impacting fetal outcomes.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Chemistry, Medicinal
Xiaolin Liao, Yuanshan Han, Chuanpu Shen, Jianjun Liu, Yuhong Wang
Summary: This review provides an overview of the role of NLRP3 inflammasome in hypertensive target organ damage (TOD) and the natural products and formulations that inhibit it. The activation of NLRP3 inflammasome exacerbates tissue damage and dysfunction in hypertensive TOD, and natural products such as curcumin, resveratrol, triptolide, and allicin have been shown to have protective effects.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Qi-sheng Ling, Sai-long Zhang, Jia-sheng Tian, Ming-he Cheng, Ai-jun Liu, Feng-hua Fu, Jian-guo Liu, Chao-yu Miao
Summary: In this study, ALL was found to significantly reduce stroke-related death and prolong lifespan in RHR-SP rats. Additionally, it reduced the incidence and severity of cerebrovascular damage, decreased blood pressure, and inhibited the angiotensin-aldosterone system and oxidative stress as potential molecular mechanisms.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cardiac & Cardiovascular Systems
Meena S. Madhur, Fernando Elijovich, Matthew R. Alexander, Ashley Pitzer, Jeanne Ishimwe, Justin P. Van Beusecum, David M. Patrick, Charles D. Smart, Thomas R. Kleyman, Justin Kingery, Robert N. Peck, Cheryl L. Laffer, Annet Kirabo
Summary: Even after blood pressure normalization, patients with hypertension still face elevated cardiovascular risk such as stroke, heart failure, and heart attack, possibly due to underlying immune cell activation. Triggers like viral infections, autoimmunity, and lifestyle factors can initiate immune activation leading to chronic inflammation and hypertension. T cells play a central role in the immune responses contributing to hypertension.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ewa Szczepanska-Sadowska
Summary: The automatism of cardiac pacemaker cells is regulated by the autonomic nervous system and multiple endocrine and paracrine factors, including cardiovascular peptides. Vasopressin and other cardiovascular peptides play important roles in the regulation of the cardiovascular system, especially in cardiovascular diseases. The interactions between vasopressin and other regulatory factors may have a significant impact on the responsiveness of the cardiovascular system in specific cardiovascular disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Yixiao Zhao, Qiaobing Sun, Jiayu Han, Yan Lu, Ying Zhang, Wei Song, Yunpeng Cheng, Tao Cong, Yan Liu, Yinong Jiang
Summary: The study aimed to evaluate left atrial mechanics in hypertension using 2DSTE and their correlations with target organ damage (TOD). The findings showed that LASI gradually increased from controls to hypertrophic LV patients, with LASI being significantly higher in patients with enlarged LA. LA reservoir and conduit function decreased gradually from healthy controls to hypertensive patients with left ventricular hypertrophy. The increased LASI could serve as an early marker for TOD in hypertension.
HYPERTENSION RESEARCH
(2021)
Article
Genetics & Heredity
Kavita Sharma, Prithvi Singh, Md Amjad Beg, Ravins Dohare, Fareeda Athar, Mansoor Ali Syed
Summary: The aim of the study is to update knowledge on primary treatment of hypertension and identify critical miRNA-mRNA-TF interactions through systematic bioinformatics analysis. Molecular modeling and docking were used to identify therapeutic targets, with telmisartan and limonin identified as potential compounds to combat the impact of hypertension. The study provides novel insight into the etiology of hypertension by identifying mRNAs, miRNAs, and associated pathways.
Review
Rheumatology
Myrto Kostopoulou, Manuel F. Ugarte-Gil, Bernardo Pons-Estel, Ronald F. van Vollenhoven, George Bertsias
Summary: Despite heterogeneity and bias in the studies reviewed, there is a modest association between abnormal serology and risk for flare in patients with stable/inactive SLE, supporting the consideration of serological markers in the treat-to-target approach. Further investigation is warranted to explore the prognostic implications, especially in lupus nephritis.
Article
Peripheral Vascular Disease
Dapeng Li, Fangyuan Cao, Jie Han, Mengke Wang, Chunhao Lai, Jingjing Zhang, Tianqi Xu, Ayache Bouakaz, Mingxi Wan, Pengyu Ren, Siyuan Zhang
Summary: The objective of this study was to investigate the sustainable antihypertensive effects and protection against target organ damage of low-intensity focused ultrasound (LIFU) stimulation in spontaneously hypertensive rats (SHRs). The results showed that LIFU stimulation can effectively lower blood pressure, improve cardiac and kidney function, and inhibit the renin-angiotensin system activity.
JOURNAL OF HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Bethany L. Goodlett, Chang Sun Kang, Eunsoo Yoo, Shobana Navaneethabalakrishnan, Dakshnapriya Balasubbramanian, Sydney E. Love, Braden M. Sims, Daniela L. Avilez, Winter Tate, Delilah R. Chavez, Gaurav Baranwal, Mary B. Nabity, Joseph M. Rutkowski, Dongin Kim, Brett M. Mitchell
Summary: Renal lymphangiogenesis can lower blood pressure and is associated with favorable alterations in renal immune cells and increased sodium excretion.
Editorial Material
Physiology
Friedrich C. Luft
Review
Physiology
Friedrich C. Luft
Summary: This article discusses the conversion of biomarkers into reliable laboratory tests, examining both early and recently propagated biomarkers. It also proposes the need for faster and better tests that can reflect decreased renal function and predict increased AKI risk.
Editorial Material
Physiology
Friedrich C. Luft
Editorial Material
Physiology
Qing Ye, En Yin Lai, Friedrich C. Luft, Pontus B. Persson, Jianhua Mao
Article
Peripheral Vascular Disease
Till Schuette, Sarah M. Kedziora, Nadine Haase, Florian Herse, Andreas Busjahn, Anna Birukov, Natalia Alenina, Dominik N. Mueller, Michael Bader, Michael Schupp, Ralf Dechend, Kristin Kraeker, Michaela Golic
Summary: A study conducted on a rat model found that maternal diabetes during pregnancy without obesity did not have a negative impact on the metabolic health of male offspring. There were no significant differences in blood glucose control between offspring exposed to maternal hyperglycemia and those from control pregnancies. Intrauterine exposure to hyperglycemia and hyperinsulinemia without obesity did not lead to fetal programming of diabetes and obesity in this particular model.
Article
Cardiac & Cardiovascular Systems
Ellen G. Avery, Hendrik Bartolomaeus, Andras Maifeld, Lajos Marko, Helge Wiig, Nicola Wilck, Stephan P. Rosshart, Sofia K. Forslund, Dominik N. Mueller
Summary: The pathogenesis of hypertension involves multiple factors including genetic, environmental, hormonal, hemodynamic, and inflammatory forces. There is increasing evidence that the gut microbiome plays a significant role in hypertension. Lifestyle factors such as dietary fiber consumption and fasting can impact hypertension through modulation of the microbiome.
CIRCULATION RESEARCH
(2021)
Editorial Material
Peripheral Vascular Disease
Friedrich C. Luft
Editorial Material
Cardiac & Cardiovascular Systems
Gemma Chiva-Blanch, Dominik N. Mueller
CARDIOVASCULAR RESEARCH
(2021)
Article
Endocrinology & Metabolism
Till Schuette, Sarah M. Kedziora, Nadine Haase, Florian Herse, Natalia Alenina, Dominik N. Mueller, Michael Bader, Michael Schupp, Ralf Dechend, Michaela Golic, Kristin Kraeker
Summary: Research revealed that diabetic pregnancy affects the cardiac health of rat offspring, particularly under high-fat diet conditions. Offspring of diabetic pregnancies showed cardiac dysfunction and changes in cardiomyocytes after consuming a high-fat diet, highlighting the importance of diet in the development of heart dysfunction in offspring of diabetic pregnancies.
Letter
Peripheral Vascular Disease
Lajos Marko, Anne Dorr, Peter Linz, Anton H. van den Meiracker, Ingrid M. Garrelds, Titus Kuehne, Ralf Dechend, A. H. Jan Danser, Anne Floercken, Dominik N. Mueller
Editorial Material
Cardiac & Cardiovascular Systems
Friedrich C. Luft
EUROPEAN HEART JOURNAL
(2022)
Correction
Multidisciplinary Sciences
Julia Schewe, Eric Seidel, Sofia Forslund, Lajos Marko, Jorg Peters, Dominik N. Muller, Christoph Fahlke, Gabriel Stolting, Ute Scholl
NATURE COMMUNICATIONS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Friedrich C. Luft
Article
Peripheral Vascular Disease
Irene Matre Thowsen, Tore Reikvam, Trude Skogstrand, Anne-Maj Samuelsson, Dominik N. Muller, Olav Tenstad, Kari Alitalo, Tine Karlsen, Helge Wiig
Summary: Our results suggest that dermal lymphatic vessels are not involved in salt storage or blood pressure regulation in these mouse models of salt-sensitive hypertension.
Article
Cardiac & Cardiovascular Systems
Anne-Maj Samuelsson, Theda Ulrike Patricia Bartolomaeus, Harithaa Anandakumar, Irene Thowsen, Elham Nikpey, Jianhua Han, Lajos Marko, Kenneth Finne, Olav Tenstad, Johannes Eckstein, Nikolaus Berndt, Titus Kuehne, Sarah Kedziora, Ibrahim Sultan, Trude Skogstrand, Tine Karlsen, Harri Nurmi, Sofia K. Forslund, Entela Bollano, Kari Alitalo, Dominik N. Muller, Helge Wiig
Summary: This study investigates the role of VEGF-B in cardiac proteomic and metabolic adaptation in heart failure, and finds that VEGF-B TG accelerates metabolic maladaptation, leading to structural cardiomyopathy and systolic heart failure.
CARDIOVASCULAR RESEARCH
(2023)