期刊
ANNALS OF MEDICINE
卷 43, 期 4, 页码 302-311出版社
INFORMA HEALTHCARE
DOI: 10.3109/07853890.2010.549143
关键词
Apolipoprotein E; HDL biogenesis; HDL gene transfer; LCAT
资金
- National Institutes of Health [HL68216, HL48739]
- NIH [HL007969]
Introduction. We have studied the functions of truncated apoE4 forms in vitro and in vivo in order to identify the domains of apoE4 required for the biogenesis of apoE-containing high-density lipoprotein (HDL). Results. We have found that apoE4-185, -202, -229, or -259 could promote ATP-binding cassette transporter A1 (ABCA1)-dependent cholesterol efflux in vitro, although less efficiently than Full-length apoE4, and had diminished capacity to activate lecithin cholesterol acyltransferase (LCAT). Formation of HDL in vivo was assessed by various methods following gene transfer in apolipoprotein A-I
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