Article
Oncology
F. Lennie Wong, Janie M. Lee, Wendy M. Leisenring, Joseph P. Neglia, Rebecca M. Howell, Susan A. Smith, Kevin C. Oeffinger, Chaya S. Moskowitz, Tara O. Henderson, Ann Mertens, Paul C. Nathan, Yutaka Yasui, Wendy Landier, Gregory T. Armstrong, Leslie L. Robison, Smita Bhatia
Summary: This study evaluated the outcomes and cost-effectiveness of breast cancer screening using mammography and breast magnetic resonance imaging (MRI) in female chest-irradiated childhood Hodgkin lymphoma survivors. The results showed that annual mammography screening at age 30-74 years is effective and cost-effective in this population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Paolo Zola, Giovannino Ciccone, Elisa Piovano, Luca Fuso, Daniela Di Cuonzo, Anna Castiglione, Eva Pagano, Elena Peirano, Fabio Landoni, Enrico Sartori, Fabrice Narducci, Oscar Bertetto, Annamaria Ferrero
Summary: The TOTEM study conducted a randomized trial on intensive versus minimalist follow-up regimens in endometrial cancer-treated patients. The study found that intensive follow-up did not improve overall survival rates, even in high-risk patients. Routine addition of vaginal cytology, laboratory, or imaging investigations is unnecessary according to the results of this trial.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Fiona S. M. Schulte, Michaela Patton, Nicole M. Alberts, Alicia Kunin-Batson, Barbara A. Olson-Bullis, Caitlin Forbes, K. Brooke Russell, Alexandra Neville, Lauren C. Heathcote, Cynthia W. Karlson, Nicole M. Racine, Courtney Charnock, Matthew C. Hocking, Pia Banerjee, Perri R. Tutelman, Melanie Noel, Kevin R. Krull
Summary: Survivors of childhood cancer are at higher risk of experiencing pain, especially chronic pain. Females report more pain than males, and factors related to pain will require stronger evidence support. Theoretically grounded, multidimensional measurements of pain are absent from the literature.
Review
Pediatrics
Gregory M. T. Guilcher, Linda Rivard, Jennifer T. Huang, Nicola A. M. Wright, Lynette Anderson, Hesham Eissa, Wendy Pelletier, Shanti Ramachandran, Tal Schechter, Ami J. Shah, Ken Wong, Eric J. Chow
Summary: Immunological assessments are often overlooked in survivors of childhood cancer, especially those who have not undergone haematopoietic cell transplantation. More research is needed to fill existing knowledge gaps and develop better immune function testing and preventive strategies.
LANCET CHILD & ADOLESCENT HEALTH
(2021)
Article
Oncology
Jennifer M. Yeh, Kathryn P. Lowry, Clyde B. Schechter, Lisa R. Diller, Grace O'Brien, Oguzhan Alagoz, Gregory T. Armstrong, John M. Hampton, Melissa M. Hudson, Wendy Leisenring, Qi Liu, Jeanne S. Mandelblatt, Diana L. Miglioretti, Chaya S. Moskowitz, Paul C. Nathan, Joseph P. Neglia, Kevin C. Oeffinger, Amy Trentham-Dietz, Natasha K. Stout
Summary: Early initiation of breast cancer screening in childhood leukemia or sarcoma survivors may reduce breast cancer deaths by half and is cost-effective, providing valuable insights for screening guidelines.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Emma R. Lipshultz, Eric J. Chow, David R. Doody, Saro H. Armenian, Barbara L. Asselin, K. Scott Baker, Smita Bhatia, Louis S. Constine, David R. Freyer, Lisa M. Kopp, Cindy L. Schwartz, Steven E. Lipshultz, Lynda M. Vrooman
Summary: The study found that childhood cancer survivors have similar or even better cardiometabolic and lifestyle profiles compared to the general population, but are still at risk for clinically significant cardiovascular disease in the future. Further strategies to support optimal control of cardiometabolic risk factors in survivors are necessary.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Multidisciplinary Sciences
Mizan Kiros Mirutse, Michael Tekle Palm, Mieraf Taddesse Tolla, Solomon Tessema Memirie, Eden Shiferaw Kefyalew, Daniel F. Hailu, Ole Norheim, Muktar Beshir Ahmed
Summary: Despite the recent interest in expanding pediatric oncology units in Ethiopia, little is known about the cost of running such units and treating childhood cancers. This study collected cost data for a pediatric oncology unit and other departments in Tikur Anbessa Specialized Hospital from July 2018 to July 2019, and estimated the total annual cost of running the unit. The results showed that running a pediatric oncology unit in Ethiopia is likely to be affordable.
Article
Oncology
Sarocha Chootipongchaivat, Xin Yi Wong, Kevin Ten Haaf, Mikael Hartman, Kelvin B. Tan, Nicolien T. van Ravesteyn, Hwee-Lin Wee
Summary: The current breast cancer screening program in Singapore is cost-effective and near the efficiency frontier, with starting screening at age 40 or 45 being recommended for optimal cost-effectiveness. Increasing screening attendance rates can further enhance benefits while maintaining cost-effectiveness.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Medicine, General & Internal
Annette Hogh, Jes Sanddal Lindholt, Rikke Sogaard, Jens Refsgaard, Dorte Svenstrup, Niels-Jorgen Moeslund, Mette Bredsgaard, Marie Dahl
Summary: The study aims to evaluate the health benefits, harms, and cost-effectiveness of a population-based screening program for cardiovascular diseases and explore the perspectives of the participants.
Article
Oncology
Rahela Aziz-Bose, Renee Margossian, Bethany L. Ames, Kerry Moss, Matthew J. Ehrhardt, Saro H. Armenian, Torunn I. Yock, Larissa Nekhlyudov, David Williams, Melissa Hudson, Anju Nohria, Lisa B. Kenney
Summary: This study aims to enhance the existing guidelines by providing expert consensus-based screening practices, management approaches, and clinical rationale for the management of young adult CCS with screening-detected abnormalities, as well as identifying areas of controversy in practice.
JACC: CARDIOONCOLOGY
(2022)
Article
Medicine, General & Internal
Rebecca J. van Kalsbeek, Joke C. Korevaar, Mieke Rijken, Riccardo Haupt, Monica Muraca, Tomas Kepak, Katerina Kepakova, Anne Blondeel, Stefan Boes, Line E. Frederiksen, Samira Essiaf, Jeanette F. Winther, Rosella P. M. G. Hermens, Anita Kienesberger, Jacqueline J. Loonen, Gisela Michel, Renee L. Mulder, Kylie B. O'Brien, Helena J. H. van der Pal, Saskia M. F. Pluijm, Katharina Roser, Roderick Skinner, Marleen Renard, Anne Uyttebroeck, Cecilia Follin, Lars Hjorth, Leontien C. M. Kremer
Summary: This study aims to evaluate the feasibility and effectiveness of implementing the PanCareFollowUp Care Intervention as routine care for childhood cancer survivors in four European countries. Clinical and research data will be collected through questionnaires, clinic visits, and follow-up calls to assess the impact on survivors.
Article
Medicine, General & Internal
Eleanor Kane, Sally Kinsey, Audrey Bonaventure, Tom Johnston, Jill Simpson, Debra Howell, Alexandra Smith, Eve Roman
Summary: This study examines the morbidity and mortality rates among teenagers and young adults (TYAs) who were previously diagnosed with acute lymphoblastic leukaemia (ALL) in childhood. The results show that ALL survivors have significantly higher rates of mortality and cancer incidence compared to the general TYA population. Additionally, they experience increased hospital activity across various clinical specialties during their TYA years.
Article
Oncology
Jordan Gilleland Marchak, Karim T. Sadak, Karen E. Effinger, Regine Haardorfer, Cam Escoffery, Karen E. Kinahan, David R. Freyer, Eric J. Chow, Ann Mertens
Summary: This study aimed to assess the state of healthcare transition services for childhood cancer survivors. It found that most institutions transfer adult-aged survivors to other institutions for care and few offer recognized standards for healthcare transition. The main barriers include clinicians' lack of late-effects knowledge and survivors' unwillingness to transfer care.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Oncology
Amy L. Shaver, Theresa A. Tufuor, Jing Nie, Shauna Ekimura, Keri Marshall, Susan Hazels Mitmesser, Katia Noyes
Summary: The study investigated the prevalence and cost-effectiveness of dietary supplementation in cancer survivors, finding that supplementation can reduce hospitalization rates and improve quality of life. Further research is needed to determine the specific effects of supplementation on long-term outcomes by cancer type.
Article
Oncology
Chelsea J. Siwik, Kinnari Jhaveri, Jamie Alexis Cohen, Mikela Barulich, Alison Chang, Anna O. Levin, Neha G. Goyal, Michelle Melisko, Margaret A. Chesney, Dianne Shumay
Summary: This study evaluated the acceptability and preliminary outcomes of a group intervention called Survivorship Wellness Group Program (SWGP) in cancer centers. The results showed that SWGP is an acceptable and replicable model that can improve quality of life, reduce mental health symptoms, and increase knowledge in multiple domains of wellness for cancer survivors.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Funda Meric-Bernstam, James M. Ford, Peter J. O'Dwyer, Geoffrey I. Shapiro, Lisa M. McShane, Boris Freidlin, Roisin E. O'Cearbhaill, Suzanne George, Julia Glade-Bender, Gary H. Lyman, James Tricoli, David Patton, Stanley R. Hamilton, Robert J. Gray, Douglas S. Hawkins, Bhanumati Ramineni, Keith T. Flaherty, Petros Grivas, Timothy A. Yap, Jordan Berlin, James H. Doroshow, Lyndsay N. Harris, Jeffrey A. Moscow
Summary: In the past decade, there have been multiple trials to determine the effectiveness of treating cancer based on specific genomic alterations. However, most patients do not respond to single-agent therapies targeting a single alteration, and drug resistance often develops. To address this, the NCI has developed NCI-ComboMATCH, a study to explore genomically-directed combination therapies and overcome drug resistance.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Danielle Novetsky Friedman, Pamela J. Goodman, Wendy M. Leisenring, Lisa R. Diller, Susan L. Cohn, Rebecca M. Howell, Susan A. Smith, Emily S. Tonorezos, Suzanne L. Wolden, Joseph P. Neglia, Kirsten K. Ness, Todd M. Gibson, Paul C. Nathan, Brent R. Weil, Leslie L. Robison, Kevin C. Oeffinger, Gregory T. Armstrong, Charles A. Sklar, Tara O. Henderson
Summary: This study examines the risk of late mortality, subsequent malignant neoplasms, and chronic health conditions in survivors of neuroblastoma diagnosed in infancy. The results show that the overall risk is relatively low, and there has been a decline in chronic health conditions with reduced exposure to radiation therapy in recent treatment eras.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Brent R. Weil, Andrew J. Murphy, Qi Liu, Rebecca M. Howell, Susan A. Smith, Christopher B. Weldon, Elizabeth A. Mullen, Arin L. Madenci, Wendy M. Leisenring, Joseph P. Neglia, Lucie M. Turcotte, Kevin C. Oeffinger, Amanda M. Termuhlen, Sogol Mostoufi-Moab, Jennifer M. Levine, Kevin R. Krull, Yutaka Yasui, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow, Saro H. Armenian
Summary: This study evaluated long-term morbidity and mortality rates among unilateral, nonsyndromic Wilms tumor (WT) survivors based on conventional treatment regimens. The results showed that survivors in different treatment groups were at risk for late mortality and chronic health conditions, especially an elevated risk for intestinal obstruction and kidney failure. The intensity of treatment was associated with an increased risk for severe chronic health conditions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Madeline R. Horan, Jin-ah Sim, Kevin R. Krull, Kirsten K. Ness, Yutaka Yasui, Leslie L. Robison, Melissa M. Hudson, Justin N. Baker, I-Chan Huang
Summary: Patient-reported outcome measures (PROMs) are useful in assessing the subjective experiences of childhood cancer survivors and can be used to monitor health status and inform medical decision making. This article provides 10 important considerations for clinicians when assessing PROMs for childhood cancer survivors, addressing practical barriers and solutions. An example framework for integrating PROMs into clinical workflow using cutting-edge technologies is also discussed.
Editorial Material
Oncology
Gary H. Lyman
CANCER INVESTIGATION
(2023)
Article
Oncology
Ramon Mohanlal, Stephan Ogenstad, Gary H. Lyman, Lan Huang, Douglas W. Blayney
Summary: Neutropenia caused by myelosuppressive cancer chemotherapy is a significant toxicity, and grade 4 neutropenia (Gr4N) is a measure of its severity. Through a meta-analysis, we found that the incidence of Gr4N is closely correlated with febrile neutropenia (FN), days of severe neutropenia (DSN), and nadir absolute neutrophil count (ANC), all of which are important predictors of morbidity. By setting a threshold of 65% for Gr4N, the risks of FN and DSN were below the levels for adverse CIN outcomes. Gr4N is highly predictive for adverse CIN outcomes, and a 65% threshold distinguishes between low and high risks for FN and other adverse CIN outcomes.
CANCER INVESTIGATION
(2023)
Review
Oncology
Maryam B. Lustberg, Nicole M. Kuderer, Aakash Desai, Cristiane Bergerot, Gary H. Lyman
Summary: Despite the lack of systematic efforts, this review provides a comprehensive analysis of the most common long-term and late adverse events associated with chemotherapy and other anticancer treatments. It discusses the underlying mechanisms, management strategies, and clinical practice guidelines for these adverse events. Additionally, it highlights the need for effective management of treatment-related events in oncology.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Letter
Hematology
Julian Lindsay, Carla S. Walti, Anna B. Halpern, Hu Xie, E. Lisa Chung, Kelda G. Schonhoff, Emily M. Huebner, Guang-Shing Cheng, Louise E. Kimball, Wendy M. Leisenring, Matthew Greenwood, Sharon C. -A. Chen, David C. M. Kong, Monica A. Slavin, Michael Boeckh, David N. Fredricks, Catherine Liu, Steven A. Pergam, Roland B. Walter, Joshua A. Hill
Article
Oncology
Brian Bourbeau, Gary H. Lyman, Xiudong Jennifer Lei, Lee Jones, Jon Rosenthal, Mary May Kozlik, Kurt R. Oettel, Alfred Tinger, Ray Page
Summary: Biosimilars have increased in usage over the past 3 years, with utilization rates ranging from 51% to 80% depending on the specific biologic. Independent physician practices had higher utilization of biosimilars for certain biologics, while Medicaid plans and traditional Medicare had lower utilization rates compared to commercial health plans. The average cost per dose decreased by 24% to 41% for the studied biologics.
JCO ONCOLOGY PRACTICE
(2023)
Editorial Material
Oncology
Gary H. Lyman
CANCER INVESTIGATION
(2023)
Editorial Material
Oncology
Gary H. Lyman, Nicole M. Kuderer
CANCER INVESTIGATION
(2023)
Editorial Material
Oncology
Gary H. Lyman, Christopher H. Lyman, Nicole M. Kuderer
CANCER INVESTIGATION
(2023)
Article
Oncology
Cindy Im, Noha Sharafeldin, Yan Yuan, Zhaoming Wang, Yadav Sapkota, Zhanni Lu, Logan G. Spector, Rebecca M. Howell, Michael A. Arnold, Melissa M. Hudson, Kirsten K. Ness, Leslie L. Robison, Smita Bhatia, Gregory T. Armstrong, Joseph P. Neglia, Yutaka Yasui, Lucie M. Turcotte
Summary: This study evaluated SMNs among long-term childhood cancer survivors of European and African genetic ancestry, finding that a polygenic risk score (PRS) could significantly impact SMN risk in survivors who did not receive radiation therapy and were treated with specific chemotherapies.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Fabien N. Belle, Christina Schindera, Marc Ansari, Gregory T. Armstrong, Maja Beck-Popovic, Rebecca Howell, Wendy M. Leisenring, Lillian R. Meacham, Jochen Rossler, Ben D. Spycher, Emily Tonorezos, Nicolas X. von der Weid, Yutaka Yasui, Kevin C. Oeffinger, Claudia E. Kuehni
Summary: The study compared the prevalence of overweight and obesity among childhood acute lymphoblastic leukemia survivors in North America and Switzerland, finding that survivors in North America had significantly higher rates of overweight and obesity compared to Swiss survivors and siblings. Risk factors for obesity among survivors included living in North America, being male, older age, non-Hispanic Black ethnicity, and younger age at diagnosis.
Review
Oncology
Pragya G. Poudel, Madeline R. Horan, Tara M. Brinkman, Zhaoming Wang, Leslie L. Robison, Melissa M. Hudson, I-Chan Huang
Summary: This article presents a systematic review of intervention studies addressing social integration or social connectedness issues among young- and middle-aged cancer patients/survivors. The findings suggest that utilizing technology- and non-technology-based platforms can improve social outcomes and enhance the quality of life for patients/survivors.